Romidepsin (BioDeep_00000311160)
代谢物信息卡片
Romidepsin (FK228, Depsipeptide)
化学式: C24H36N4O6S2 (540.2076156)
中文名称: 罗米地辛
谱图信息:
最多检出来源 Astragalus membranaceus(plant) 85.71%
分子结构信息
SMILES: CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C
InChI: InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1
描述信息
A cyclodepsipeptide consisting of the cyclic disulfide of (2Z)-2-aminobut-2-enoyl, L-valyl, (3S,4E)-3-hydroxy-7-sulfanylhept-4-enoyl, D-valyl and D-cysteinyl residues coupled in sequence and cyclised head-to tail.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XH - Histone deacetylase (hdac) inhibitors
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
D004791 - Enzyme Inhibitors > D056572 - Histone Deacetylase Inhibitors
C471 - Enzyme Inhibitor > C1946 - Histone Deacetylase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
D000970 - Antineoplastic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:61080
- KEGGdrug: D06637
- PubChem: 5352062
- PubChem: 3425
- Metlin: METLIN85200
- DrugBank: DB06176
- ChEMBL: CHEMBL343448
- CAS: 128517-07-7
- PMhub: MS000082440
- MetaboLights: MTBLC61080
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuliang Guo, Siyu Song, Xiaoxiao DU, Li Tian, Man Zhang, Hongmin Zhou, Zhonghua Klaus Chen, Sheng Chang. Romidepsin (FK228) improves the survival of allogeneic skin grafts through downregulating the production of donor-specific antibody via suppressing the IRE1α-XBP1 pathway.
Journal of Zhejiang University. Science. B.
2022 May; 23(5):392-406. doi:
10.1631/jzus.b2100780. [PMID: 35557040] - Noriko Okuni, Yoshio Honma, Takeshi Urano, Kenji Tamura. Romidepsin and tamoxifen cooperatively induce senescence of pancreatic cancer cells through downregulation of FOXM1 expression and induction of reactive oxygen species/lipid peroxidation.
Molecular biology reports.
2022 May; 49(5):3519-3529. doi:
10.1007/s11033-022-07192-9. [PMID: 35099714] - Henning Gruell, Jesper D Gunst, Yehuda Z Cohen, Marie H Pahus, Jakob J Malin, Martin Platten, Katrina G Millard, Martin Tolstrup, R Brad Jones, Winnifer D Conce Alberto, Julio C C Lorenzi, Thiago Y Oliveira, Tim Kümmerle, Isabelle Suárez, Cecilia Unson-O'Brien, Lilian Nogueira, Rikke Olesen, Lars Østergaard, Henrik Nielsen, Clara Lehmann, Michel C Nussenzweig, Gerd Fätkenheuer, Florian Klein, Marina Caskey, Ole S Søgaard. Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial.
The Lancet. Microbe.
2022 Mar; 3(3):e203-e214. doi:
10.1016/s2666-5247(21)00239-1. [PMID: 35544074] - Deborah K McMahon, Lu Zheng, Joshua C Cyktor, Evgenia Aga, Bernard J Macatangay, Catherine Godfrey, Michael Para, Ronald T Mitsuyasu, Joseph Hesselgesser, Joan Dragavon, Curtis Dobrowolski, Jonathan Karn, Edward P Acosta, Rajesh T Gandhi, John W Mellors. A Phase 1/2 Randomized, Placebo-Controlled Trial of Romidespin in Persons With HIV-1 on Suppressive Antiretroviral Therapy.
The Journal of infectious diseases.
2021 08; 224(4):648-656. doi:
10.1093/infdis/jiaa777. [PMID: 34398236] - Daniel K Owens, Joanna Bajsa-Hirschel, Stephen O Duke, Caio A Carbonari, Giovanna L G C Gomes, Ratnakar Asolkar, Louis Boddy, Franck E Dayan. The Contribution of Romidepsin to the Herbicidal Activity of Burkholderia rinojensis Biopesticide.
Journal of natural products.
2020 04; 83(4):843-851. doi:
10.1021/acs.jnatprod.9b00405. [PMID: 32091209] - Shulin Cheng, Tao Wu, Yugen Li, Jing Huang, Tao Cai. Romidepsin (FK228) in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury is Associated with Down-Regulation of the CYP2E1 Gene.
Medical science monitor : international medical journal of experimental and clinical research.
2020 Jan; 26(?):e918528. doi:
10.12659/msm.918528. [PMID: 31954012] - Adam J Kleinman, Cuiling Xu, Mackenzie L Cottrell, Ranjit Sivanandham, Egidio Brocca-Cofano, Tammy Dunsmore, Angela Kashuba, Ivona Pandrea, Cristian Apetrei. Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques.
Frontiers in immunology.
2020; 11(?):579158. doi:
10.3389/fimmu.2020.579158. [PMID: 33362765] - Beatriz Mothe, Miriam Rosás-Umbert, Pep Coll, Christian Manzardo, Maria C Puertas, Sara Morón-López, Anuska Llano, Cristina Miranda, Samandhy Cedeño, Miriam López, Yovaninna Alarcón-Soto, Guadalupe Gómez Melis, Klaus Langohr, Ana M Barriocanal, Jessica Toro, Irene Ruiz, Cristina Rovira, Antonio Carrillo, Michael Meulbroek, Alison Crook, Edmund G Wee, Jose M Miró, Bonaventura Clotet, Marta Valle, Javier Martinez-Picado, Tomáš Hanke, Christian Brander, José Moltó. HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02).
Frontiers in immunology.
2020; 11(?):823. doi:
10.3389/fimmu.2020.00823. [PMID: 32435247] - María G Cortiguera, Lorena García-Gaipo, Simon D Wagner, Javier León, Ana Batlle-López, M Dolores Delgado. Suppression of BCL6 function by HDAC inhibitor mediated acetylation and chromatin modification enhances BET inhibitor effects in B-cell lymphoma cells.
Scientific reports.
2019 11; 9(1):16495. doi:
10.1038/s41598-019-52714-4. [PMID: 31712669] - Min Yang, Gen Chen, Xue Zhang, Yuliang Guo, Yan Yu, Li Tian, Sheng Chang, Zhonghua Klaus Chen. Inhibition of class I HDACs attenuates renal interstitial fibrosis in a murine model.
Pharmacological research.
2019 04; 142(?):192-204. doi:
10.1016/j.phrs.2019.02.011. [PMID: 30807866] - Andrew J McDonald, Katherine M Curt, Ruchi P Patel, Hanna Kozlowski, Dan L Sackett, Robert W Robey, Michael M Gottesman, Susan E Bates. Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models.
Experimental cell research.
2019 02; 375(2):106-112. doi:
10.1016/j.yexcr.2018.12.012. [PMID: 30579954] - Alexander Badamchi-Zadeh, Kelly D Moynihan, Rafael A Larocca, Malika Aid, Nicholas M Provine, M Justin Iampietro, Ekaterina Kinnear, Pablo Penaloza-MacMaster, Peter Abbink, Eryn Blass, John S Tregoning, Darrell J Irvine, Dan H Barouch. Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy.
Journal of immunology (Baltimore, Md. : 1950).
2018 11; 201(9):2744-2752. doi:
10.4049/jimmunol.1800885. [PMID: 30249811] - Raymond J Andersen, Fidele Ntie-Kang, Ian Tietjen. Natural product-derived compounds in HIV suppression, remission, and eradication strategies.
Antiviral research.
2018 10; 158(?):63-77. doi:
10.1016/j.antiviral.2018.07.016. [PMID: 30063970] - Anni Winckelmann, Vincent Morcilla, Wei Shao, Mariane H Schleimann, Jesper F Hojen, Timothy E Schlub, Paul W Denton, Lars Østergaard, Ole S Søgaard, Martin Tolstrup, Sarah Palmer. Genetic characterization of the HIV-1 reservoir after Vacc-4x and romidepsin therapy in HIV-1-infected individuals.
AIDS (London, England).
2018 08; 32(13):1793-1802. doi:
10.1097/qad.0000000000001861. [PMID: 29762162] - Janka Petravic, Thomas A Rasmussen, Sharon R Lewin, Stephen J Kent, Miles P Davenport. Relationship between Measures of HIV Reactivation and Decline of the Latent Reservoir under Latency-Reversing Agents.
Journal of virology.
2017 05; 91(9):. doi:
10.1128/jvi.02092-16. [PMID: 28202759] - Ming Jang Chua, Megan S J Arnold, Weijun Xu, Julien Lancelot, Suzanne Lamotte, Gerald F Späth, Eric Prina, Raymond J Pierce, David P Fairlie, Tina S Skinner-Adams, Katherine T Andrews. Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth.
International journal for parasitology. Drugs and drug resistance.
2017 04; 7(1):42-50. doi:
10.1016/j.ijpddr.2016.12.005. [PMID: 28107750] - Anni Winckelmann, Kirston Barton, Bonnie Hiener, Timothy E Schlub, Wei Shao, Thomas A Rasmussen, Lars Østergaard, Ole S Søgaard, Martin Tolstrup, Sarah Palmer. Romidepsin-induced HIV-1 viremia during effective antiretroviral therapy contains identical viral sequences with few deleterious mutations.
AIDS (London, England).
2017 03; 31(6):771-779. doi:
10.1097/qad.0000000000001400. [PMID: 28272134] - P S Suresh, V C Devaraj, Nuggehally R Srinivas, Ramesh Mullangi. Review of bioanalytical assays for the quantitation of various HDAC inhibitors such as vorinostat, belinostat, panobinostat, romidepsin and chidamine.
Biomedical chromatography : BMC.
2017 Jan; 31(1):. doi:
10.1002/bmc.3807. [PMID: 27511598] - Steffen Leth, Mariane H Schleimann, Sara K Nissen, Jesper F Højen, Rikke Olesen, Mette E Graversen, Sofie Jørgensen, Anne Sofie Kjær, Paul W Denton, Alejandra Mørk, Maja A Sommerfelt, Kim Krogsgaard, Lars Østergaard, Thomas A Rasmussen, Martin Tolstrup, Ole Schmeltz Søgaard. Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial.
The lancet. HIV.
2016 10; 3(10):e463-72. doi:
10.1016/s2352-3018(16)30055-8. [PMID: 27658863] - Benjamin B Policicchio, Cuiling Xu, Egidio Brocca-Cofano, Kevin D Raehtz, Tianyu He, Dongzhu Ma, Hui Li, Ranjit Sivanandham, George S Haret-Richter, Tammy Dunsmore, Anita Trichel, John W Mellors, Beatrice H Hahn, George M Shaw, Ruy M Ribeiro, Ivona Pandrea, Cristian Apetrei. Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers.
PLoS pathogens.
2016 09; 12(9):e1005879. doi:
10.1371/journal.ppat.1005879. [PMID: 27632364] - Kwai Fung Hui, Arthur Kwok Leung Cheung, Chung King Choi, Po Ling Yeung, Jaap M Middeldorp, Maria Li Lung, Sai Wah Tsao, Alan Kwok Shing Chiang. Inhibition of class I histone deacetylases by romidepsin potently induces Epstein-Barr virus lytic cycle and mediates enhanced cell death with ganciclovir.
International journal of cancer.
2016 Jan; 138(1):125-36. doi:
10.1002/ijc.29698. [PMID: 26205347] - Gregory Q Del Prete, Kelli Oswald, Abigail Lara, Rebecca Shoemaker, Jeremy Smedley, Rhonda Macallister, Vicky Coalter, Adam Wiles, Rodney Wiles, Yuan Li, Randy Fast, Rebecca Kiser, Bing Lu, Jim Zheng, W Gregory Alvord, Charles M Trubey, Michael Piatak, Claire Deleage, Brandon F Keele, Jacob D Estes, Joseph Hesselgesser, Romas Geleziunas, Jeffrey D Lifson. Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy.
Antimicrobial agents and chemotherapy.
2015 Dec; 60(3):1560-72. doi:
10.1128/aac.02625-15. [PMID: 26711758] - Ole S Søgaard, Mette E Graversen, Steffen Leth, Rikke Olesen, Christel R Brinkmann, Sara K Nissen, Anne Sofie Kjaer, Mariane H Schleimann, Paul W Denton, William J Hey-Cunningham, Kersten K Koelsch, Giuseppe Pantaleo, Kim Krogsgaard, Maja Sommerfelt, Remi Fromentin, Nicolas Chomont, Thomas A Rasmussen, Lars Østergaard, Martin Tolstrup. The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo.
PLoS pathogens.
2015 Sep; 11(9):e1005142. doi:
10.1371/journal.ppat.1005142. [PMID: 26379282] - Kasper L Jønsson, Martin Tolstrup, Johan Vad-Nielsen, Kathrine Kjær, Anders Laustsen, Morten N Andersen, Thomas A Rasmussen, Ole S Søgaard, Lars Østergaard, Paul W Denton, Martin R Jakobsen. Histone deacetylase inhibitor romidepsin inhibits de novo HIV-1 infections.
Antimicrobial agents and chemotherapy.
2015 Jul; 59(7):3984-94. doi:
10.1128/aac.00574-15. [PMID: 25896701] - P Yu, M N Petrus, W Ju, M Zhang, K C Conlon, M Nakagawa, M Maeda, R N Bamford, T A Waldmann. Augmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model.
Leukemia.
2015 Mar; 29(3):556-66. doi:
10.1038/leu.2014.241. [PMID: 25118879] - Datsen George Wei, Vicki Chiang, Elizabeth Fyne, Mini Balakrishnan, Tiffany Barnes, Michael Graupe, Joseph Hesselgesser, Alivelu Irrinki, Jeffrey P Murry, George Stepan, Kirsten M Stray, Angela Tsai, Helen Yu, Jonathan Spindler, Mary Kearney, Celsa A Spina, Deborah McMahon, Jacob Lalezari, Derek Sloan, John Mellors, Romas Geleziunas, Tomas Cihlar. Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.
PLoS pathogens.
2014 Apr; 10(4):e1004071. doi:
10.1371/journal.ppat.1004071. [PMID: 24722454] - Dong-bo Xu, Yun-ling Wang, Yuan Yue, Shuang-chan Wu, Hong Ding. [Inhibitory effect of a novel histone deacetylases inhibitor FK228 on human colon cancer HCT-116 cells in vitro and in vivo].
Zhonghua zhong liu za zhi [Chinese journal of oncology].
2013 Nov; 35(11):814-8. doi:
NULL. [PMID: 24447477] - Simon J Cooper, Christina A von Roemeling, Kylie H Kang, Laura A Marlow, Stefan K Grebe, Michael E Menefee, Han W Tun, Gerardo Colon-Otero, Edith A Perez, John A Copland. Reexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers.
Molecular cancer therapeutics.
2012 Oct; 11(10):2105-15. doi:
10.1158/1535-7163.mct-11-0873. [PMID: 22826467] - Tristan M Sissung, Erin R Gardner, Richard L Piekarz, Reuben Howden, Xiaohong Chen, Sukyung Woo, Ryan Franke, James A Clark, Laura Miller-DeGraff, Seth M Steinberg, David Venzon, David Liewehr, Steven R Kleeberger, Susan E Bates, Douglas K Price, Douglas R Rosing, Christopher Cabell, Alex Sparreboom, William D Figg. Impact of ABCB1 allelic variants on QTc interval prolongation.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2011 Feb; 17(4):937-46. doi:
10.1158/1078-0432.ccr-10-0925. [PMID: 21106724] - Jorge I Jiménez, Tifanie Vansach, Wesley Y Yoshida, Bryan Sakamoto, Peter Pörzgen, F David Horgen. Halogenated fatty acid amides and cyclic depsipeptides from an eastern Caribbean collection of the cyanobacterium Lyngbya majuscula.
Journal of natural products.
2009 Sep; 72(9):1573-8. doi:
10.1021/np900173d. [PMID: 19739598] - Elizabeth M Algar, Andrea Muscat, Vinod Dagar, Christian Rickert, C W Chow, Jaclyn A Biegel, Paul G Ekert, Richard Saffery, Jeff Craig, Ricky W Johnstone, David M Ashley. Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors.
PloS one.
2009; 4(2):e4482. doi:
10.1371/journal.pone.0004482. [PMID: 19221586] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Zhao-Cai Yu, Wen-Chao Liu, Du-Hu Liu, Ying Huang, Xiao-Ming Shi, Xiang-Hui You, Yan Chen. [FK228 promotes the IL-3 mediated proliferation and differentiation of human erythroid progenitor cells].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2008 Jul; 24(7):672-5. doi:
NULL. [PMID: 18616908] - Xiaohong Chen, Erin R Gardner, William D Figg. Determination of the cyclic depsipeptide FK228 in human and mouse plasma by liquid chromatography with mass-spectrometric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Apr; 865(1-2):153-8. doi:
10.1016/j.jchromb.2008.02.015. [PMID: 18342585] - David S Schrump, Maria R Fischette, Dao M Nguyen, Ming Zhao, Xinmin Li, Tricia F Kunst, Ana Hancox, Julie A Hong, G Aaron Chen, Evgeny Kruchin, John J Wright, Douglas R Rosing, Alex Sparreboom, William D Figg, Seth M Steinberg. Clinical and molecular responses in lung cancer patients receiving Romidepsin.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2008 Jan; 14(1):188-98. doi:
10.1158/1078-0432.ccr-07-0135. [PMID: 18172270] - Minoru Kobayashi, Takashi Okada, Takashi Murakami, Keiya Ozawa, Eiji Kobayashi, Tatsuo Morita. Tissue-targeted in vivo gene transfer coupled with histone deacetylase inhibitor depsipeptide (FK228) enhances adenoviral infection in rat renal cancer allograft model systems.
Urology.
2007 Dec; 70(6):1230-6. doi:
10.1016/j.urology.2007.09.022. [PMID: 18158067] - Zhao-cai Yu, Wen-chao Liu, Li Fan, Koshi Oishi, Naoyuki Katayama. [EPO mediated proliferation and differentiation of human erythroid progenitor inhibited by FK228].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2007 Jun; 23(6):575-7. doi:
NULL. [PMID: 17553359] - Takatsugu Okegawa, Jennifer R Sayne, Kikuo Nutahara, Rey-Chen Pong, Hossain Saboorian, Wareef Kabbani, Eiji Higashihara, Jer-Tsong Hsieh. A histone deacetylase inhibitor enhances adenoviral infection of renal cancer cells.
The Journal of urology.
2007 Mar; 177(3):1148-56. doi:
10.1016/j.juro.2006.10.034. [PMID: 17296436] - Hirotsugu Ueda. [Fermentation research on natural products derived from micro-organisms for the discovery of new drugs].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2007 Mar; 129(3):191-5. doi:
10.1254/fpj.129.191. [PMID: 17379971] - Merrill E Goldsmith, Alian Aguila, Kenneth Steadman, Alfredo Martinez, Seth M Steinberg, Michael C Alley, William R Waud, Susan E Bates, Tito Fojo. The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems.
Molecular cancer therapeutics.
2007 Feb; 6(2):496-505. doi:
10.1158/1535-7163.mct-06-0431. [PMID: 17308048] - Kenneth K W To, Z Zhan, Susan E Bates. Aberrant promoter methylation of the ABCG2 gene in renal carcinoma.
Molecular and cellular biology.
2006 Nov; 26(22):8572-85. doi:
10.1128/mcb.00650-06. [PMID: 16954373] - Naohiko Fujii, Yoshitaka Isaka, Yoshitsugu Takabatake, Masayuki Mizui, Chigure Suzuki, Shiro Takahara, Takahito Ito, Enyu Imai. Targeting of interstitial cells using a simple gene-transfer strategy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2006 Oct; 21(10):2745-53. doi:
10.1093/ndt/gfl327. [PMID: 16822795] - T Kogai, K Taki, G A Brent. Enhancement of sodium/iodide symporter expression in thyroid and breast cancer.
Endocrine-related cancer.
2006 Sep; 13(3):797-826. doi:
10.1677/erc.1.01143. [PMID: 16954431] - Walter M Stadler, Kim Margolin, Sandy Ferber, William McCulloch, John A Thompson. A phase II study of depsipeptide in refractory metastatic renal cell cancer.
Clinical genitourinary cancer.
2006 Jun; 5(1):57-60. doi:
10.3816/cgc.2006.n.018. [PMID: 16859580] - Robert W Robey, Zhirong Zhan, Richard L Piekarz, Ganesh L Kayastha, Tito Fojo, Susan E Bates. Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).
Clinical cancer research : an official journal of the American Association for Cancer Research.
2006 Mar; 12(5):1547-55. doi:
10.1158/1078-0432.ccr-05-1423. [PMID: 16533780] - April R Robbins, Sandra A Jablonski, Tim J Yen, Kinya Yoda, Rob Robey, Susan E Bates, Dan L Sackett. Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.
Cell cycle (Georgetown, Tex.).
2005 May; 4(5):717-26. doi:
10.4161/cc.4.5.1690. [PMID: 15846093] - Rebecca L Vanoosten, Jill M Moore, Aaron T Ludwig, Thomas S Griffith. Depsipeptide (FR901228) enhances the cytotoxic activity of TRAIL by redistributing TRAIL receptor to membrane lipid rafts.
Molecular therapy : the journal of the American Society of Gene Therapy.
2005 Apr; 11(4):542-52. doi:
10.1016/j.ymthe.2004.12.008. [PMID: 15771957] - Kyunghwa Hwang, Richard L Piekarz, Susan E Bates, William D Figg, Alex Sparreboom. Determination of the cyclic depsipeptide FK228, a histone deacetylase inhibitor, by liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Sep; 809(1):81-6. doi:
10.1016/j.jchromb.2004.06.007. [PMID: 15282096] - Stacey L Berg, Jeffery Stone, Jim J Xiao, Kenneth K Chan, Jed Nuchtern, Robert Dauser, Leticia McGuffey, Patrick Thompson, Susan M Blaney. Plasma and cerebrospinal fluid pharmacokinetics of depsipeptide (FR901228) in nonhuman primates.
Cancer chemotherapy and pharmacology.
2004 Jul; 54(1):85-8. doi:
10.1007/s00280-004-0766-5. [PMID: 15042312] - S B Khan, T Maududi, K Barton, J Ayers, S Alkan. Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma.
British journal of haematology.
2004 Apr; 125(2):156-61. doi:
10.1111/j.1365-2141.2004.04882.x. [PMID: 15059137] - Merrill E Goldsmith, Masaki Kitazono, Patrick Fok, Takashi Aikou, Susan Bates, Tito Fojo. The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2003 Nov; 9(14):5394-401. doi:
NULL. [PMID: 14614025] - Yuka Sasakawa, Yoshinori Naoe, Takeshi Inoue, Tatsuya Sasakawa, Masahiko Matsuo, Toshitaka Manda, Seitaro Mutoh. Effects of FK228, a novel histone deacetylase inhibitor, on tumor growth and expression of p21 and c-myc genes in vivo.
Cancer letters.
2003 Jun; 195(2):161-8. doi:
10.1016/s0304-3835(03)00184-8. [PMID: 12767524] - Jim J Xiao, John Byrd, Guido Marcucci, Michael Grever, Kenneth K Chan. Identification of thiols and glutathione conjugates of depsipeptide FK228 (FR901228), a novel histone protein deacetylase inhibitor, in the blood.
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