Thiochrome (BioDeep_00000306388)
代谢物信息卡片
化学式: C12H14N4OS (262.0888274)
中文名称: 硫色素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(CCO)SC2=Nc3nc(C)ncc3CN21
InChI: InChI=1S/C12H14N4OS/c1-7-10(3-4-17)18-12-15-11-9(6-16(7)12)5-13-8(2)14-11/h5,17H,3-4,6H2,1-2H3
描述信息
Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors[1][2].
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Zhixia Yao, Yaosheng Liu, Yongxing Diao, Guangxing Hu, Yuhong Qian, Zhuang Li. Fluorometry detection for trypsin via inner filter effect between cytochrome C and in-situ formed fluorescent thiochrome.
Talanta.
2021 Nov; 234(?):122614. doi:
10.1016/j.talanta.2021.122614. [PMID: 34364423] - Zhixia Yao, Hanmeng Liu, Yaosheng Liu, Qifang Zhang, Yongxing Diao, Yujing Sun, Zhuang Li. Fluorimetric determination of histidine by exploiting its inhibitory effect on the oxidation of thiamine by cobalt-containing Prussian Blue nanocubes.
Mikrochimica acta.
2020 01; 187(1):93. doi:
10.1007/s00604-019-3930-7. [PMID: 31900676] - Tomás Pérez-Ruiz, Carmen Martínez-Lozano, María Dolores García-Martínez. A sensitive post-column photochemical derivatization/fluorimetric detection system for HPLC determination of bisphosphonates.
Journal of chromatography. A.
2009 Feb; 1216(9):1312-8. doi:
10.1016/j.chroma.2008.12.051. [PMID: 19150069] - F Batifoulier, M-A Verny, C Besson, C Demigné, C Rémésy. Determination of thiamine and its phosphate esters in rat tissues analyzed as thiochromes on a RP-amide C16 column.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Feb; 816(1-2):67-72. doi:
10.1016/j.jchromb.2004.11.004. [PMID: 15664335] - I I Stepuro. Thiamine and vasculopathies.
Prostaglandins, leukotrienes, and essential fatty acids.
2005 Feb; 72(2):115-27. doi:
10.1016/j.plefa.2004.10.009. [PMID: 15626594] - F S Larin, V U Buko, T I Zimatkina, D O Oparin, Iu M Ostrovskiĭ. [Effect of thiochrome capronate on lipid metabolism in rats].
Ukrainskii biokhimicheskii zhurnal (1978).
1986 Sep; 58(5):89-91. doi:
". [PMID: 3775890] - V U Buko, F S Larin, Iu A Tarasov, V V Vinogradov. [Prostaglandins and 3',5'-AMP in rat tissues following administration of thiamine and its derivatives].
Ukrainskii biokhimicheskii zhurnal (1978).
1983 Jul; 55(4):453-6. doi:
NULL. [PMID: 6578633] - J Schrijver, A J Speek, J A Klosse, H J van Rijn, W H Schreurs. A reliable semiautomated method for the determination of total thiamine in whole blood by the thiochrome method with high-performance liquid chromatography.
Annals of clinical biochemistry.
1982 Jan; 19(Pt 1):52-6. doi:
10.1177/000456328201900111. [PMID: 7065633] - M H Dong, M D Green, H E Sauberlich. Determination of urinary thiamin by the thiochrome method.
Clinical biochemistry.
1981 Feb; 14(1):16-8. doi:
10.1016/0009-9120(81)90090-4. [PMID: 6453672] - V U Buko, F S Larin, A K Pavlenia, G A Dosta, Iu M Ostrovskiĭ. [Aspects of the biological activity of thiochrome].
Voprosy pitaniia.
1979 Jan; ?(1):22-6. doi:
". [PMID: 419723] - R L Roser, A H Andrist, W H Harrington, H K Naito, D Lonsdale. Determination of urinary thiamine by high-pressure liquid chromatography utilizing the thiochrome fluorscent method.
Journal of chromatography.
1978 Jul; 146(1):43-53. doi:
10.1016/s0378-4347(00)81288-8. [PMID: 670357] - J D Pipkin, V J Stella. Thiamine whole blood pharmackinetics in rats using both a specific S-thiamine liquid scintillation assay and the thiochrome fluorescence assay.
Journal of pharmaceutical sciences.
1978 Jun; 67(6):818-21. doi:
10.1002/jps.2600670624. [PMID: 660465] - T MYINT, H B HOUSER. THE DETERMINATION OF THIAMINE IN SMALL AMOUNTS OF WHOLE BLOOD AND SERUM BY A SIMPLIFIED THIOCHROME METHOD.
Clinical chemistry.
1965 Jun; 11(?):617-23. doi:
10.1093/clinchem/11.6.617. [PMID: 14300077] - H N HAUGEN. The determination of thiamine in the urine by the thiochrome method.
Scandinavian journal of clinical and laboratory investigation.
1960; 12(4):384-91. doi:
10.3109/00365516009065401. [PMID: 13712298] - E C GROB, W H SCHOPFER. Studies on the thiochrome test and its usefulness for aneurine determinations in plant material.
Helvetica physiologica et pharmacologica acta.
1947 Apr; 5(1):C15. doi:
". [PMID: 20245504] - E C GROB. Critical examination of the thiochrome test and its usability for aneurine determination in plant material.
Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie.
1947; 19(1-2):179-93. doi:
". [PMID: 18905013]