Azelastine (BioDeep_00000003055)

 

Secondary id: BioDeep_00000406205

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


4-((4-Chlorophenyl)methyl)-2- (hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)- phthalazinone HCL

化学式: C22H24ClN3O (381.1607804)
中文名称: 盐酸氮卓斯汀
谱图信息: 最多检出来源 Viridiplantae(plant) 28.42%

分子结构信息

SMILES: CN1CCCC(CC1)N1N=C(CC2=CC=C(Cl)C=C2)C2=CC=CC=C2C1=O
InChI: InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3

描述信息

Azelastine is only found in individuals that have used or taken this drug. It is a phthalazine derivative, and is an antihistamine and mast cell stabilizer available as a nasal spray for hay fever and as eye drops for allergic conjunctivitis.Azelastine competes with histamine for the H1-receptor sites on effector cells and acts as an antagonist by inhibiting the release of histamine and other mediators involved in the allergic response.
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AC - Antiallergic agents, excl. corticosteroids
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
S - Sensory organs > S01 - Ophthalmologicals > S01G - Decongestants and antiallergics
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D004791 - Enzyme Inhibitors > D016859 - Lipoxygenase Inhibitors
CONFIDENCE standard compound; INTERNAL_ID 8508
CONFIDENCE standard compound; INTERNAL_ID 2734
D018926 - Anti-Allergic Agents

同义名列表

28 个代谢物同义名

4-((4-Chlorophenyl)methyl)-2- (hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)- phthalazinone HCL; 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one; 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone; 4-(p-Chlorobenzyl)-2-(N-methylperhydroazepinyl-(4))-1-(2H)-phthalazinone; ASTA medica brand OF azelastine hydrochloride; Wallace brand OF azelastine hydrochloride; Viatris brand OF azelastine hydrochloride; Sanfer brand OF azelastine hydrochloride; Orion brand OF azelastine hydrochloride; Dagra brand OF azelastine hydrochloride; Bayer brand OF azelastine hydrochloride; Mann brand OF azelastine hydrochloride; Azelastine Hydrochloride; Muro brand OF azelastine; Vividrin akut azelastin; Azelastinum; azelastine; Allergodil; Azelastina; Rhinolast; Optilast; Corifina; Optivar; Azeptin; Astelin; Afluon; Loxin; Azelastine



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shuai Ge, Jiayu Lu, Yajing Hou, Yuexin Lv, Cheng Wang, Huaizhen He. Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2. Virology. 2021 08; 560(?):110-115. doi: 10.1016/j.virol.2021.05.009. [PMID: 34052578]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Mohammad M Ghahremanpour, Julian Tirado-Rives, Maya Deshmukh, Joseph A Ippolito, Chun-Hui Zhang, Israel Cabeza de Vaca, Maria-Elena Liosi, Karen S Anderson, William L Jorgensen. Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2. ACS medicinal chemistry letters. 2020 Dec; 11(12):2526-2533. doi: 10.1021/acsmedchemlett.0c00521. [PMID: 33324471]
  • Jasmin Kuratli, Cory Ann Leonard, Lisbeth Nufer, Hanna Marti, Robert Schoborg, Nicole Borel. Maraviroc, celastrol and azelastine alter Chlamydia trachomatis development in HeLa cells. Journal of medical microbiology. 2020 Dec; 69(12):1351-1366. doi: 10.1099/jmm.0.001267. [PMID: 33180014]
  • Mohamed M Elseweidy, Gehad M Elnagar, Marwa M Elsawy, Abdelmoneim A Ali, Nabila Zein. Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats. The Journal of pharmacy and pharmacology. 2020 Dec; 72(12):1812-1821. doi: 10.1111/jphp.13363. [PMID: 32880967]
  • Mohamed M Elseweidy, Gehad M Elnagar, Marwa M Elsawy, Nabila Zein. Azelastine a potent antihistamine agent, as hypolipidemic and modulator for aortic calcification in diabetic hyperlipidemic rats model. Archives of physiology and biochemistry. 2020 Jul; ?(?):1-8. doi: 10.1080/13813455.2020.1786129. [PMID: 32615812]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jin-Tao Chu. Histamine H1 receptor gene polymorphism acts as a biological indicator of the prediction of therapeutic efficacy in patients with allergic rhinitis in the Chinese Han population. Journal of cellular biochemistry. 2019 01; 120(1):164-170. doi: 10.1002/jcb.27278. [PMID: 30168182]
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  • Tsugunobu Andoh, Qun Zhang, Takumi Yamamoto, Manabu Tayama, Masao Hattori, Ken Tanaka, Yasushi Kuraishi. Inhibitory effects of the methanol extract of Ganoderma lucidum on mosquito allergy-induced itch-associated responses in mice. Journal of pharmacological sciences. 2010; 114(3):292-7. doi: 10.1254/jphs.10180fp. [PMID: 20948166]
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  • Kazuhiko Hanashiro, Masanori Sunagawa, Toshiyuki Nakasone, Mariko Nakamura, Tadayoshi Kosugi. Inhibition of IgE-mediated phosphorylation of FcepsilonRIgamma protein by antiallergic drugs in rat basophilic leukemia (RBL-2H3) cells: a novel action of antiallergic drugs. International immunopharmacology. 2007 Jul; 7(7):994-1002. doi: 10.1016/j.intimp.2007.02.017. [PMID: 17499203]
  • Josiane Sabbadini Neves, Luciana Pontes Coelho, Renato Sérgio Balão Cordeiro, Marcia Paranho Veloso, Patricia Machado Rodrigues e Silva, Marcelo Henrique dos Santos, Marco Aurélio Martins. Antianaphylactic properties of 7-epiclusianone, a tetraprenylated benzophenone isolated from Garcinia brasiliensis. Planta medica. 2007 Jun; 73(7):644-9. doi: 10.1055/s-2007-981534. [PMID: 17562491]
  • Ihab T Abdel-Raheem, Izumi Hide, Yuhki Yanase, Yukari Shigemoto-Mogami, Norio Sakai, Yasuhito Shirai, Naoaki Saito, Farid M Hamada, Nagh A El-Mahdy, Alaa El-Din E Elsisy, Samya S Sokar, Yoshihiro Nakata. Protein kinase C-alpha mediates TNF release process in RBL-2H3 mast cells. British journal of pharmacology. 2005 Jun; 145(4):415-23. doi: 10.1038/sj.bjp.0706207. [PMID: 15806111]
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