calphostin C (BioDeep_00000305450)

   

natural product


代谢物信息卡片


calphostin C

化学式: C44H38O14 (790.2261448)
中文名称: 卡弗他丁C
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CC1=C2C3=C(C(=C(C4=C3C(=C5C2=C(C(=O)C=C5OC)C(=C1OC)O)C(=CC4=O)OC)O)OC)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC(=O)C7=CC=CC=C7
InChI: InChI=1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45,48-49H,16-17H2,1-6H3

描述信息

D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

calphostin C



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Julliana F Sant'Anna, Vanessa S Baldez, Natalie A Razuck-Garrão, Thiago Lemos, Bruno L Diaz, Marcelo Einicker-Lamas. Lysophosphatidic acid (LPA) as a modulator of plasma membrane Ca2+-ATPase from basolateral membranes of kidney proximal tubules. Journal of physiology and biochemistry. 2021 May; 77(2):321-329. doi: 10.1007/s13105-021-00800-5. [PMID: 33704695]
  • Andrea Gerbino, Roberta De Zio, Daniela Russo, Luigi Milella, Serena Milano, Giuseppe Procino, Michael Pusch, Maria Svelto, Monica Carmosino. Role of PKC in the Regulation of the Human Kidney Chloride Channel ClC-Ka. Scientific reports. 2020 06; 10(1):10268. doi: 10.1038/s41598-020-67219-8. [PMID: 32581267]
  • Ricardo Martín, José Javier Ferrero, Andrea Collado-Alsina, Carolina Aguado, Rafael Luján, Magdalena Torres, José Sánchez-Prieto. Bidirectional modulation of glutamatergic synaptic transmission by metabotropic glutamate type 7 receptors at Schaffer collateral-CA1 hippocampal synapses. The Journal of physiology. 2018 03; 596(5):921-940. doi: 10.1113/jp275371. [PMID: 29280494]
  • Lucienne S Lara, Camille R T Bourgeois, Samir S El-Dahr, Minolfa C Prieto. Bradykinin/B2 receptor activation regulates renin in M-1 cells via protein kinase C and nitric oxide. Physiological reports. 2017 Apr; 5(7):. doi: 10.14814/phy2.13211. [PMID: 28373410]
  • Gerard G Robins, Geoffrey I Sandle. Liddle-Mutation of the β-Subunit, but not the γ-Subunit, Attenuates Protein Kinase C-Mediated Inhibition of Human Epithelial Sodium Channels (hENaC). The Journal of membrane biology. 2016 06; 249(3):271-9. doi: 10.1007/s00232-015-9866-x. [PMID: 26759146]
  • Elizabeth Portugal Velloso, Renata Lúcia Pimentel, Janaína F Braga, Antônio Carlos Vieira Cabral, Zilma Silveira N Reis, Michael Bader, Robson Augusto S Santos, Gerd Wallukat. Identification of a Novel Agonist-Like Autoantibody in Preeclamptic Patients. American journal of hypertension. 2016 Mar; 29(3):405-12. doi: 10.1093/ajh/hpv099. [PMID: 26158852]
  • Mauro C Wesseling, Lisa Wagner-Britz, Duc Bach Nguyen, Salome Asanidze, Judy Mutua, Nagla Mohamed, Benjamin Hanf, Mehrdad Ghashghaeinia, Lars Kaestner, Ingolf Bernhardt. Novel Insights in the Regulation of Phosphatidylserine Exposure in Human Red Blood Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2016; 39(5):1941-1954. doi: 10.1159/000447891. [PMID: 27771709]
  • Shiren Sun, Xiaoxuan Ning, Ying Zhai, Rui Du, Yuanyuan Lu, Lijie He, Rong Li, Weini Wu, Wenjuan Sun, Hanmin Wang. Egr-1 mediates chronic hypoxia-induced renal interstitial fibrosis via the PKC/ERK pathway. American journal of nephrology. 2014; 39(5):436-48. doi: 10.1159/000362249. [PMID: 24819335]
  • Bo Zhan, Chuize Kong, Kunfeng Guo, Zhe Zhang. PKCα is involved in the progression of kidney carcinoma through regulating netrin-1/UNC5B signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2013 Jun; 34(3):1759-66. doi: 10.1007/s13277-013-0714-2. [PMID: 23526078]
  • A Radhika, P R Sudhakaran. Upregulation of macrophage-specific functions by oxidized LDL: lysosomal degradation-dependent and -independent pathways. Molecular and cellular biochemistry. 2013 Jan; 372(1-2):181-90. doi: 10.1007/s11010-012-1459-8. [PMID: 23054190]
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  • Víctor H Olavarría, Jaime E Figueroa, Victoriano Mulero. Prolactin-induced activation of phagocyte NADPH oxidase in the teleost fish gilthead seabream involves the phosphorylation of p47phox by protein kinase C. Developmental and comparative immunology. 2012 Jan; 36(1):216-21. doi: 10.1016/j.dci.2011.08.004. [PMID: 21884725]
  • Tomoaki Inoue, Kunihisa Kobayashi, Toyoshi Inoguchi, Noriyuki Sonoda, Masakazu Fujii, Yasutaka Maeda, Yoshinori Fujimura, Daisuke Miura, Ken-Ichi Hirano, Ryoichi Takayanagi. Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-kappaB. The Journal of biological chemistry. 2011 Sep; 286(37):32045-53. doi: 10.1074/jbc.m111.285650. [PMID: 21828047]
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  • Ruimin Gu, Yan Jin, Yuanyuan Zhai, Lei Yang, Chengbiao Zhang, Wennan Li, Lijun Wang, Shumin Kong, Yunhong Zhang, Baofeng Yang, Wen-Hui Wang. PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney. Kidney international. 2008 Aug; 74(4):478-85. doi: 10.1038/ki.2008.198. [PMID: 18496512]
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  • Nguyen Khanh Hoa, Ake Norberg, Rannar Sillard, Dao Van Phan, Nguyen Duy Thuan, Dang Thi Ngoc Dzung, Hans Jörnvall, Claes-Göran Ostenson. The possible mechanisms by which phanoside stimulates insulin secretion from rat islets. The Journal of endocrinology. 2007 Feb; 192(2):389-94. doi: 10.1677/joe.1.06948. [PMID: 17283239]
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  • Chiaki Tanifuji, Yusuke Suzuki, Wong Mu Geot, Satoshi Horikoshi, Takeshi Sugaya, Marta Ruiz-Ortega, Jesus Egido, Yasuhiko Tomino. Reactive oxygen species-mediated signaling pathways in angiotensin II-induced MCP-1 expression of proximal tubular cells. Antioxidants & redox signaling. 2005 Sep; 7(9-10):1261-8. doi: 10.1089/ars.2005.7.1261. [PMID: 16115031]
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  • Yoriko Sakuma, Hiroshi Nonoguchi, Masanobu Takayama, Tianxin Yang, Yoshio Terada, Takeaki Inoue, Yushi Nakayama, Yukimasa Kohda, Sei Sasaki, Kimio Tomita. Differential effects of hyperosmolality on Na-K-ATPase and vasopressin-dependent cAMP generation in the medullary thick ascending limb and outer medullary collecting duct. Hypertension research : official journal of the Japanese Society of Hypertension. 2005 Aug; 28(8):671-9. doi: 10.1291/hypres.28.671. [PMID: 16392772]
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