Penicillin V (BioDeep_00000002974)

 

Secondary id: BioDeep_00001867851

human metabolite blood metabolite


代谢物信息卡片


(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

化学式: C16H18N2O5S (350.0936378)
中文名称: 青霉素V
谱图信息: 最多检出来源 Viridiplantae(plant) 60%

分子结构信息

SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)COC3=CC=CC=C3)C(=O)O)C
InChI: InChI=1S/C16H18N2O5S/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1

描述信息

Penicillin V is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CE - Beta-lactamase sensitive penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

49 个代谢物同义名

(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-3,3-DIMETHYL-7-oxo-6-(2-phenoxyacetamido)-4-thia-1- azabicyclo(3.2.0)heptane-2-carboxylIC ACID; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; (2S,5R,6R)-3,3-DIMETHYL-7-oxo-6-(2-phenoxyacetamido)-4-thia-1- azabicyclo(3.2.0)heptane-2-carboxylate; Phenoxymethylpenicillinic acid potassium salt; 6-Phenoxyacetamidopenicillanic acid; Phenoxymethylpenicillin potassium; Phenoxymethylenepenicillinic acid; 6-Phenoxyacetamidopenicillanate; Phenoxymethylpenicillinic acid; Phenoxymethylenepenicillinate; Phenoximethylpenicillinum; Phenoxymethylpenicillinum; Penicillin, phenoxymethyl; Penicillin phenoxymethyl; Phenoxymethylpenicilline; Phenoxymethyl penicillin; Potassium, penicillin V; Phenoxymethylpenicillin; Phenoxomethylpenicillin; Fenossimetilpenicillina; Berromycin, penicillin; Penicillin V potassium; Fenoxymethylpenicillin; Penicillin berromycin; Beromycin, penicillin; Fenoximetilpenicilina; Sodium, penicillin V; Penicillin beromycin; V Sodium, penicillin; Penicillin V sodium; Penicillin VK; Penicillin V; Penicillin-V; Vegacillin; V-Cillin K; V Cillin K; Beromycin; Fenoxypen; VCillin K; Apocillin; Oracillin; Fenospen; V-Cillin; Betapen; Pen VK; PCV; PV



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • So Young Yi, Vladimir Nekrasov, Kazuya Ichimura, Si-Yong Kang, Ken Shirasu. Plant U-box E3 ligases PUB20 and PUB21 negatively regulate pattern-triggered immunity in Arabidopsis. Plant molecular biology. 2024 Jan; 114(1):7. doi: 10.1007/s11103-023-01409-6. [PMID: 38265485]
  • Daryna B Pylypiv, Boris M Sharga, Olexandr A Rishko, Vitalii Leshak, Elena Karbovanets. Relation of Streptococcus Pyogenes tonsillitis isolate to antimicrobial agents and its infection treatment. Wiadomosci lekarskie (Warsaw, Poland : 1960). 2024; 77(1):171-177. doi: 10.36740/wlek202401122. [PMID: 38431823]
  • Kjersti Sturød, Achal Dhariwal, Ulf R Dahle, Didrik F Vestrheim, Fernanda C Petersen. Impact of narrow-spectrum penicillin V on the oral and faecal resistome in a young child treated for otitis media. Journal of global antimicrobial resistance. 2020 03; 20(?):290-297. doi: 10.1016/j.jgar.2019.08.004. [PMID: 31415828]
  • Emil List Larsen, Vanja Cejvanovic, Laura Kofoed Kjaer, Morten Thorup Pedersen, Sara Daugaard Popik, Lina Kallehave Hansen, Jon Traerup Andersen, Espen Jimenez-Solem, Kasper Broedbaek, Morten Petersen, Allan Weimann, Trine Henriksen, Jens Lykkesfeldt, Christian Torp-Pedersen, Henrik Enghusen Poulsen. Clarithromycin, trimethoprim, and penicillin and oxidative nucleic acid modifications in humans: randomised, controlled trials. British journal of clinical pharmacology. 2017 08; 83(8):1643-1653. doi: 10.1111/bcp.13261. [PMID: 28185274]
  • Alexandra E Livanos, Thomas U Greiner, Pajau Vangay, Wimal Pathmasiri, Delisha Stewart, Susan McRitchie, Huilin Li, Jennifer Chung, Jiho Sohn, Sara Kim, Zhan Gao, Cecily Barber, Joanne Kim, Sandy Ng, Arlin B Rogers, Susan Sumner, Xue-Song Zhang, Ken Cadwell, Dan Knights, Alexander Alekseyenko, Fredrik Bäckhed, Martin J Blaser. Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Nature microbiology. 2016 Aug; 1(11):16140. doi: 10.1038/nmicrobiol.2016.140. [PMID: 27782139]
  • Jochen P Windfuhr, Nicole Toepfner, Gregor Steffen, Frank Waldfahrer, Reinhard Berner. Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2016 Apr; 273(4):973-87. doi: 10.1007/s00405-015-3872-6. [PMID: 26755048]
  • Frederik Boëtius Hertz, Kristian Schønning, Steen Christian Rasmussen, Pia Littauer, Jenny Dahl Knudsen, Anders Løbner-Olesen, Niels Frimodt-Møller. Epidemiological factors associated with ESBL- and non ESBL-producing E. coli causing urinary tract infection in general practice. Infectious diseases (London, England). 2016; 48(3):241-5. doi: 10.3109/23744235.2015.1103895. [PMID: 26523346]
  • V S Avinash, Sureshkumar Ramasamy, C G Suresh, Archana Pundle. Penicillin V acylase from Pectobacterium atrosepticum exhibits high specific activity and unique kinetics. International journal of biological macromolecules. 2015 Aug; 79(?):1-7. doi: 10.1016/j.ijbiomac.2015.04.036. [PMID: 25931393]
  • Henrik Svanström, Björn Pasternak, Anders Hviid. Use of clarithromycin and roxithromycin and risk of cardiac death: cohort study. BMJ (Clinical research ed.). 2014 Aug; 349(?):g4930. doi: 10.1136/bmj.g4930. [PMID: 25139799]
  • Henrik Svanström, Björn Pasternak, Anders Hviid. Use of azithromycin and death from cardiovascular causes. The New England journal of medicine. 2013 May; 368(18):1704-12. doi: 10.1056/nejmoa1300799. [PMID: 23635050]
  • Aaron T Wolman, Michael R Gionfriddo, Gregory A Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy, Adam L Vanwert. Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. Drug metabolism and disposition: the biological fate of chemicals. 2013 Apr; 41(4):791-800. doi: 10.1124/dmd.112.049569. [PMID: 23344796]
  • Lubomír Svorc, Jozef Sochr, Miroslav Rievaj, Peter Tomčík, Dušan Bustin. Voltammetric determination of penicillin V in pharmaceutical formulations and human urine using a boron-doped diamond electrode. Bioelectrochemistry (Amsterdam, Netherlands). 2012 Dec; 88(?):36-41. doi: 10.1016/j.bioelechem.2012.04.004. [PMID: 22763423]
  • Xi Yang, James Greenhaw, Qiang Shi, Zhenqiang Su, Feng Qian, Kelly Davis, Donna L Mendrick, William F Salminen. Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. 2012 Feb; 125(2):335-44. doi: 10.1093/toxsci/kfr321. [PMID: 22112502]
  • Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. An overview of the evidence and mechanisms of herb-drug interactions. Frontiers in pharmacology. 2012; 3(?):69. doi: 10.3389/fphar.2012.00069. [PMID: 22557968]
  • K W Gammelsrud, P Sandven, E A Høiby, L Sandvik, P Brandtzaeg, P Gaustad. Colonization by Candida in children with cancer, children with cystic fibrosis, and healthy controls. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2011 Dec; 17(12):1875-81. doi: 10.1111/j.1469-0691.2011.03528.x. [PMID: 21745258]
  • Cameron Y S Lee, Francis D Pien, Jon B Suzuki. Identification and treatment of bisphosphonate-associated actinomycotic osteonecrosis of the jaws. Implant dentistry. 2011 Oct; 20(5):331-6. doi: 10.1097/id.0b013e3182310f03. [PMID: 21881516]
  • Bi Chen, Ming Ma, Xiaoli Su. An amperometric penicillin biosensor with enhanced sensitivity based on co-immobilization of carbon nanotubes, hematein, and beta-lactamase on glassy carbon electrode. Analytica chimica acta. 2010 Jul; 674(1):89-95. doi: 10.1016/j.aca.2010.06.014. [PMID: 20638504]
  • T Dejoie, M Audrain, K Bach-Ngohou, M Denis, S Legoue-Morillon, C Thomas, D Masson. [An exceptional component C3 deficiency revealed by serum protein electrophoresis]. Annales de biologie clinique. 2009 Nov; 67(6):715-9. doi: 10.1684/abc.2009.0387. [PMID: 19939777]
  • Antoni Beltran, Núria Fontanals, Rosa M Marcé, Peter A G Cormack, Francesc Borrull. Molecularly imprinted solid-phase extraction of cephalexin from water-based matrices. Journal of separation science. 2009 Oct; 32(19):3319-26. doi: 10.1002/jssc.200900268. [PMID: 19722176]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Nattharika Aumsuwan, Matthew S McConnell, Marek W Urban. Tunable antimicrobial polypropylene surfaces: simultaneous attachment of penicillin (Gram +) and gentamicin (Gram -). Biomacromolecules. 2009 Mar; 10(3):623-9. doi: 10.1021/bm8013473. [PMID: 19173575]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Enio Latini Bitarães, Benigna Maria de Oliveira, Marcos Borato Viana. Compliance with antibiotic prophylaxis in children with sickle cell anemia: a prospective study. Jornal de pediatria. 2008 Jul; 84(4):316-22. doi: 10.2223/jped.1819. [PMID: 18688558]
  • R A Moreno, L Boldrina, A Guermani, J Mazucheli, C Sverdloff, N C Borges. Comparative bioavailability study of two phenoxymethylpenicillin potassium tablet formulations in healthy volunteers. International journal of clinical pharmacology and therapeutics. 2007 Dec; 45(12):669-76. doi: 10.5414/cpp45669. [PMID: 18184536]
  • Javier L Urraca, María C Moreno-Bondi, Guillermo Orellana, Börje Sellergren, Andrew J Hall. Molecularly imprinted polymers as antibody mimics in automated on-line fluorescent competitive assays. Analytical chemistry. 2007 Jul; 79(13):4915-23. doi: 10.1021/ac070277i. [PMID: 17550229]
  • Bema K Bonsu, Marvin B Harper. Leukocyte counts in urine reflect the risk of concomitant sepsis in bacteriuric infants: a retrospective cohort study. BMC pediatrics. 2007 Jun; 7(?):24. doi: 10.1186/1471-2431-7-24. [PMID: 17567901]
  • R Kapoor, S Agrawal. Meningomylocele: An update. Indian journal of urology : IJU : journal of the Urological Society of India. 2007 Apr; 23(2):181-6. doi: 10.4103/0970-1591.32072. [PMID: 19675798]
  • Hai-Ling Qiao, Qiang Wen, Na Gao, Xin Tian, Lin-Jing Jia. Association of IL-10 level and IL-10 promoter SNPs with specific antibodies in penicillin-allergic patients. European journal of clinical pharmacology. 2007 Mar; 63(3):263-9. doi: 10.1007/s00228-006-0245-5. [PMID: 17225142]
  • H-Y Woo, Y-S Kim, N-I Kang, W-C Chung, C-H Song, I-W Choi, I-H Choi, H-K Lee. Mechanism for acute oral desensitization to antibiotics. Allergy. 2006 Aug; 61(8):954-8. doi: 10.1111/j.1398-9995.2006.01147.x. [PMID: 16867049]
  • Martin Glatz, Marjaneh Golestani, Helmut Kerl, Robert R Müllegger. Clinical relevance of different IgG and IgM serum antibody responses to Borrelia burgdorferi after antibiotic therapy for erythema migrans: long-term follow-up study of 113 patients. Archives of dermatology. 2006 Jul; 142(7):862-8. doi: 10.1001/archderm.142.7.862. [PMID: 16847202]
  • Brychan M Clark, George H Kotti, Anand D Shah, Nicholas G Conger. Severe serum sickness reaction to oral and intramuscular penicillin. Pharmacotherapy. 2006 May; 26(5):705-8. doi: 10.1592/phco.26.5.705. [PMID: 16718943]
  • Jing Yang, Hai-ling Qiao, Yue-wen Zhang, Lin-jing Jia, Xin Tian, Na Gao. HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins. Chinese medical journal. 2006 Mar; 119(6):458-66. doi: . [PMID: 16584643]
  • H-L Qiao, J Yang, Y-W Zhang. Relationships between specific serum IgE, cytokines and polymorphisms in the IL-4, IL-4Ralpha in patients with penicillins allergy. Allergy. 2005 Aug; 60(8):1053-9. doi: 10.1111/j.1398-9995.2005.00816.x. [PMID: 15969687]
  • R Neil Dalton, Charles Turner, Moira Dick, Susan E Height, Moji Awogbade, Baba Inusa, Iheanyi Okpala, Sandra O'Driscoll, Swee Lay Thein, David C Rees. The measurement of urinary hydroxyurea in sickle cell anaemia. British journal of haematology. 2005 Jul; 130(1):138-44. doi: 10.1111/j.1365-2141.2005.05583.x. [PMID: 15982356]
  • Arne Orrling, Carl Kamme, Anna Stjernquist-Desatnik. Penicillin V, loracarbef and clindamycin in tonsillar surface fluid during acute group A streptococcal pharyngotonsillitis. Scandinavian journal of infectious diseases. 2005; 37(6-7):429-35. doi: 10.1080/00365540410020947. [PMID: 16012002]
  • H-L Qiao, J Yang, Y-W Zhang. Specific serum IgE levels and FcepsilonRIbeta genetic polymorphism in patients with penicillins allergy. Allergy. 2004 Dec; 59(12):1326-32. doi: 10.1111/j.1398-9995.2004.00625.x. [PMID: 15507102]
  • Hans Ulrik K Nielsen, Helle Bossen Konradsen, Jørgen Lous, Niels Frimodt-Møller. Nasopharyngeal pathogens in children with acute otitis media in a low-antibiotic use country. International journal of pediatric otorhinolaryngology. 2004 Sep; 68(9):1149-55. doi: 10.1016/j.ijporl.2004.04.008. [PMID: 15302145]
  • Yuko Ito, Tomomi Goto, Hisao Oka, Hiroshi Matsumoto, Kazue Takeba. Application of ion-exchange cartridge clean-up in food analysis. VI. Determination of six penicillins in bovine tissues by liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of chromatography. A. 2004 Jul; 1042(1-2):107-11. doi: 10.1016/j.chroma.2004.05.057. [PMID: 15296394]
  • Jasimuddin Ahmed, M Mostafa Zaman, Shah Mohammad Keramat Ali. Immunological response to antioxidant vitamin supplementation in rural Bangladeshi school children with group A streptococcal infection. Asia Pacific journal of clinical nutrition. 2004; 13(3):226-30. doi: NULL. [PMID: 15331332]
  • Marya Cassandra, Eugene Conte, Barbara Cortez. Childhood pustular psoriasis elicited by the streptococcal antigen: a case report and review of the literature. Pediatric dermatology. 2003 Nov; 20(6):506-10. doi: 10.1111/j.1525-1470.2003.20611.x. [PMID: 14651571]
  • S Verma, U Wollina. Job's syndrome--a case report. Journal of the European Academy of Dermatology and Venereology : JEADV. 2003 Nov; 17(6):711-4. doi: 10.1046/j.1468-3083.2003.00820.x. [PMID: 14761145]
  • Kazuhiro Hatano. [Simultaneous determination of five penicillins in muscle, liver and kidney from slaughtered animals using liquid chromatography coupled with electrospray ionization tandem mass spectrometry]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan. 2003 Feb; 44(1):1-6. doi: 10.3358/shokueishi.44.1. [PMID: 12749189]
  • R Bennet, M Eriksson, C E Nord. The fecal microflora of 1-3-month-old infants during treatment with eight oral antibiotics. Infection. 2002 Jun; 30(3):158-60. doi: 10.1007/s15010-002-2140-z. [PMID: 12120942]
  • H Lennernäs, K Gjellan, R Hallgren, C Graffner. The influence of caprate on rectal absorption of phenoxymethylpenicillin: experience from an in-vivo perfusion in humans. The Journal of pharmacy and pharmacology. 2002 Apr; 54(4):499-508. doi: 10.1211/0022357021778772. [PMID: 11999127]
  • Dylan Parry Prosser, Mark Gompels. Anaphylactic shock due to cefuroxime in a patient taking penicillin prophylaxis. Paediatric anaesthesia. 2002 Jan; 12(1):73-5. doi: 10.1046/j.1460-9592.2002.00759.x. [PMID: 11849580]
  • G Colmenarejo, A Alvarez-Pedraglio, J L Lavandera. Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry. 2001 Dec; 44(25):4370-8. doi: 10.1021/jm010960b. [PMID: 11728183]
  • Z Zhao, B A Baldo, K W Baumgart, D F Mallon. Fine structural recognition specificities of IgE antibodies distinguishing amoxicilloyl and amoxicillanyl determinants in allergic subjects. Journal of molecular recognition : JMR. 2001 Sep; 14(5):300-7. doi: 10.1002/jmr.541. [PMID: 11746950]
  • W Yicong, W Ping, Y Xuesong, Z Qingtao, L Rong, Y Weimin, Z Xiaoxiang. A novel microphysiometer based on MLAPS for drugs screening. Biosensors & bioelectronics. 2001 Jun; 16(4-5):277-86. doi: 10.1016/s0956-5663(01)00138-5. [PMID: 11390215]
  • Y Ito, Y Ikai, H Oka, H Matsumoto, Y Miyazaki, K Takeba, H Nagase. Application of ion-exchange cartridge clean-up in food analysis IV. Confirmatory assay of benzylpenicillin, phenoxymethylpenicillin, oxacillin, cloxacillin, nafcillin and dicloxacillin, in bovine tissues by liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of chromatography. A. 2001 Mar; 911(2):217-23. doi: 10.1016/s0021-9673(01)00512-x. [PMID: 11293583]
  • J A Balfour, D P Figgitt. Telithromycin. Drugs. 2001; 61(6):815-29; discussion 830. doi: 10.2165/00003495-200161060-00016. [PMID: 11398913]
  • M Roehr. History of biotechnology in Austria. Advances in biochemical engineering/biotechnology. 2000; 69(?):125-49. doi: 10.1007/3-540-44964-7_5. [PMID: 11036693]
  • G Patriarca, C D'Ambrosio, D Schiavino, L M Larocca, E Nucera, A Milani. Clinical usefulness of patch and challenge tests in the diagnosis of cell-mediated allergy to betalactams. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 1999 Sep; 83(3):257-66. doi: 10.1016/s1081-1206(10)62650-6. [PMID: 10507273]
  • P Wallgren, T Segall, A Pedersen Mörner, A Gunnarsson. Experimental infections with Actinobacillus pleuropneumoniae in pigs--II. Comparison of antibiotics for oral strategic treatment. Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B. 1999 May; 46(4):261-9. doi: NULL. [PMID: 10379236]
  • H M Feder, M A Gerber, M F Randolph, P S Stelmach, E L Kaplan. Once-daily therapy for streptococcal pharyngitis with amoxicillin. Pediatrics. 1999 Jan; 103(1):47-51. doi: 10.1542/peds.103.1.47. [PMID: 9917438]
  • I H Choi, Y M Shin, J S Park, M S Lee, E H Han, O H Chai, S Y Im, T Y Ha, H K Lee. Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice. The Journal of experimental medicine. 1998 Nov; 188(9):1587-92. doi: 10.1084/jem.188.9.1587. [PMID: 9802970]
  • H Quiding, H G Arwidsson, E Grahn Håkansson, A Grahnén, S Holm. Saliva-resistant coating of tablets prevents oral release of penicillin: plasma but not saliva equivalence. European journal of clinical pharmacology. 1998 Nov; 54(9-10):749-52. doi: 10.1007/s002280050546. [PMID: 9923579]
  • A Frick, H Möller, E Wirbitzki. Biopharmaceutical characterization of oral immediate release drug products. In vitro/in vivo comparison of phenoxymethylpenicillin potassium, glimepiride and levofloxacin. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 1998 Nov; 46(3):305-11. doi: 10.1016/s0939-6411(98)00041-1. [PMID: 9885303]
  • J S Park, I H Choi, D G Lee, S S Han, T Y Ha, J H Lee, W H Lee, Y M Park, H K Lee. Anti-IL-4 monoclonal antibody prevents antibiotics-induced active fatal anaphylaxis. Journal of immunology (Baltimore, Md. : 1950). 1997 May; 158(10):5002-6. doi: . [PMID: 9144520]
  • I Adamsson, C Edlund, S Sjöstedt, C E Nord. Comparative effects of cefadroxil and phenoxymethylpenicillin on the normal oropharyngeal and intestinal microflora. Infection. 1997 May; 25(3):154-8. doi: 10.1007/bf02113603. [PMID: 9181382]
  • W J Krauwinkel, N J Volkers-Kamermans. Determination of penicillin-V in human plasma by high-performance liquid chromatography and solid-phase extraction. Journal of chromatography. B, Biomedical applications. 1996 Apr; 679(1-2):129-35. doi: 10.1016/0378-4347(95)00560-9. [PMID: 8998551]
  • L Krbkova, G Stanek. Therapy of Lyme borreliosis in children. Infection. 1996 Mar; 24(2):170-3. doi: 10.1007/bf01713333. [PMID: 8740116]
  • T R Paul, A Venter, L C Blaszczak, T R Parr, H Labischinski, T J Beveridge. Localization of penicillin-binding proteins to the splitting system of Staphylococcus aureus septa by using a mercury-penicillin V derivative. Journal of bacteriology. 1995 Jul; 177(13):3631-40. doi: 10.1128/jb.177.13.3631-3640.1995. [PMID: 7541399]
  • J Martin, G Abbott. Serum sickness like illness and antimicrobials in children. The New Zealand medical journal. 1995 Apr; 108(997):123-4. doi: NULL. [PMID: 7739819]
  • P Bolme, M Eriksson, L Paalzow, G Stintzing, G Zerihun, T Woldemariam. Malnutrition and pharmacokinetics of penicillin in Ethiopian children. Pharmacology & toxicology. 1995 Apr; 76(4):259-62. doi: 10.1111/j.1600-0773.1995.tb00140.x. [PMID: 7617556]
  • J G Still, W C Hubbard, J M Poole, C I Sheaffer, S Chartrand, R Jacobs. Comparison of clarithromycin and penicillin VK suspensions in the treatment of children with streptococcal pharyngitis and review of currently available alternative antibiotic therapies. The Pediatric infectious disease journal. 1993 Dec; 12(12 Suppl 3):S134-41. doi: 10.1097/00006454-199312003-00008. [PMID: 8295815]
  • D Harder, W Ehses, P Weller, U Deuss, W Winkelmann. [Pulmonary valve endocarditis and atrial fibrillation]. Deutsche medizinische Wochenschrift (1946). 1993 Jul; 118(26):975-8. doi: 10.1055/s-2008-1059415. [PMID: 8519232]
  • L E Rodewald, M E Pichichero. Compliance with antibiotic therapy: a comparison of deuterium oxide tracer, urine bioassay, bottle weights, and parental reports. The Journal of pediatrics. 1993 Jul; 123(1):143-7. doi: 10.1016/s0022-3476(05)81560-4. [PMID: 8391566]
  • A M Heikkilä, R U Erkkola. The need for adjustment of dosage regimen of penicillin V during pregnancy. Obstetrics and gynecology. 1993 Jun; 81(6):919-21. doi: NULL. [PMID: 8497356]
  • A Stjernquist-Desatnik, P Samuelsson, M Walder. Penetration of penicillin V to tonsillar surface fluid in healthy individuals and in patients with acute tonsillitis. The Journal of laryngology and otology. 1993 Apr; 107(4):309-12. doi: 10.1017/s0022215100122893. [PMID: 8320515]
  • A Nathan, S Zalipsky, S I Ertel, S N Agathos, M L Yarmush, J Kohn. Copolymers of lysine and polyethylene glycol: a new family of functionalized drug carriers. Bioconjugate chemistry. 1993 Jan; 4(1):54-62. doi: 10.1021/bc00019a008. [PMID: 8431513]
  • G D Campbell, S Ramaprasad, K M Olsen, A F Tryka, R A Komoroski, L C Blaszczak, T R Parr. Comparison of the in vivo and in vitro nuclear magnetic resonance detection of trifluoromethyl penicillin V in rats. Journal of pharmaceutical sciences. 1993 Jan; 82(1):48-51. doi: 10.1002/jps.2600820111. [PMID: 8429491]
  • T R Paul, N G Halligan, L C Blaszczak, T R Parr, T J Beveridge. A new mercury-penicillin V derivative as a probe for ultrastructural localization of penicillin-binding proteins in Escherichia coli. Journal of bacteriology. 1992 Jul; 174(14):4689-700. doi: 10.1128/jb.174.14.4689-4700.1992. [PMID: 1624457]
  • J O Boison, G O Korsrud, J D MacNeil, L Keng, M Papich. Determination of penicillin G in bovine plasma by high-performance liquid chromatography after pre-column derivatization. Journal of chromatography. 1992 May; 576(2):315-20. doi: 10.1016/0378-4347(92)80205-5. [PMID: 1400719]
  • T Terasaki, H Nouda, A Tsuji. Selective analysis of mutual displacement effects at the primary binding sites of phenoxymethylpenicillin and cephalothin bindings to human serum albumin. Journal of pharmacobio-dynamics. 1992 Mar; 15(3):91-7. doi: 10.1248/bpb1978.15.91. [PMID: 1625169]
  • W A Moats. High-performance liquid chromatographic determination of penicillin G, penicillin V and cloxacillin in beef and pork tissues. Journal of chromatography. 1992 Feb; 593(1-2):15-20. doi: 10.1016/0021-9673(92)80259-w. [PMID: 1639899]
  • V Thamlikitkul, S Kobwanthanakun, S Pruksachatvuthi, R Lertluknithi. Pharmacokinetics of rheumatic fever prophylaxis regimens. The Journal of international medical research. 1992 Feb; 20(1):20-6. doi: 10.1177/030006059202000103. [PMID: 1568517]
  • M Rank, B Danielsson, J Gram. Implementation of a thermal biosensor in a process environment: on-line monitoring of penicillin V in production-scale fermentations. Biosensors & bioelectronics. 1992; 7(9):631-5. doi: 10.1016/0956-5663(92)85020-b. [PMID: 1292520]
  • A C Sjöblom, J Bruchfeld, B Eriksson, C Jorup-Rönström, K Karkkonen, A S Malmborg, M Lindqvist. Skin concentrations of phenoxymethylpenicillin in patients with erysipelas. Infection. 1992 Jan; 20(1):30-3. doi: 10.1007/bf01704891. [PMID: 1563809]
  • M De Meyere, Y Mervielde, G Verschraegen, M Bogaert. Effect of penicillin on the clinical course of streptococcal pharyngitis in general practice. European journal of clinical pharmacology. 1992; 43(6):581-5. doi: 10.1007/bf02284954. [PMID: 1493837]
  • J S van der Hoeven, C W van den Kieboom. Effects of propicillin on mixed continuous cultures of periodontal bacteria. Antimicrobial agents and chemotherapy. 1991 Sep; 35(9):1717-20. doi: 10.1128/aac.35.9.1717. [PMID: 1952836]
  • L G Zaĭtseva, E I Vasil'eva, E M Gorskaia. [The functional activity of the macrophages in experimental intestinal dysbacteriosis in rats]. Zhurnal mikrobiologii, epidemiologii i immunobiologii. 1991 Aug; ?(8):68-71. doi: . [PMID: 1950291]
  • S J Surtees, M G Stockton, T W Gietzen. Allergy to penicillin: fable or fact?. BMJ (Clinical research ed.). 1991 May; 302(6784):1051-2. doi: 10.1136/bmj.302.6784.1051. [PMID: 1903664]
  • J O Boison, C D Salisbury, W Chan, J D MacNeil. Determination of penicillin G residues in edible animal tissues by liquid chromatography. Journal - Association of Official Analytical Chemists. 1991 May; 74(3):497-501. doi: NULL. [PMID: 1908452]
  • S S Ambedkar, B S Deshpande, V K Sudhakaran, J G Shewale. Beijerinckia indica var. penicillanicum penicillin V acylase: enhanced enzyme production by catabolite repression-resistant mutant and effect of solvents on enzyme activity. Journal of industrial microbiology. 1991 Apr; 7(3):209-14. doi: 10.1007/bf01575885. [PMID: 1367509]
  • M Söderström, J Blomberg, P Christensen, B Hovelius. Erythromycin and phenoxymethylpenicillin (penicillin V) in the treatment of respiratory tract infections as related to microbiological findings and serum C-reactive protein. Scandinavian journal of infectious diseases. 1991; 23(3):347-54. doi: 10.3109/00365549109024322. [PMID: 1909052]
  • O Jetlund, E Thurmann-Nielsen, R A Walstad. Comparison of the serum and tissue concentrations of cefuroxime from cefuroxime axetil and phenoxymethylpenicillin in patients undergoing tonsillectomy. International journal of clinical pharmacology research. 1991; 11(1):1-6. doi: NULL. [PMID: 1908443]
  • P T Mannion, M M Rothburn. Diagnosis of bacterial endocarditis caused by Streptococcus lactis and assisted by immunoblotting of serum antibodies. The Journal of infection. 1990 Nov; 21(3):317-8. doi: 10.1016/0163-4453(90)94149-t. [PMID: 2125626]
  • S R Heckbert, W S Stryker, K L Coltin, J E Manson, R Platt. Serum sickness in children after antibiotic exposure: estimates of occurrence and morbidity in a health maintenance organization population. American journal of epidemiology. 1990 Aug; 132(2):336-42. doi: 10.1093/oxfordjournals.aje.a115663. [PMID: 2115293]
  • I Sjöberg, S Håkansson, S E Holm. Accumulation of penicillin in vaginal fluid. Obstetrics and gynecology. 1990 Jan; 75(1):18-21. doi: NULL. [PMID: 2104967]
  • K Roos, J E Brorson. Concentration of phenoxymethylpenicillin in tonsillar tissue. European journal of clinical pharmacology. 1990; 39(4):417-8. doi: 10.1007/bf00315423. [PMID: 2127570]
  • R Sarel, A Miskin, A Ashkenazi. [Penicillin VK absorption during fasting and after eating]. Harefuah. 1989 Dec; 117(12):430-2. doi: NULL. [PMID: 2516005]
  • B Bauer, V Malerczyk, H J Roethig. Bioavailability of a new liquid formulation of penicillin V (Isocillin syrup) and the influence of ethanol on bioavailability of penicillin V. International journal of clinical pharmacology, therapy, and toxicology. 1989 Dec; 27(12):583-7. doi: NULL. [PMID: 2515160]
  • J K Dunnick, M R Elwell. Toxicity studies of amphetamine sulfate, ampicillin trihydrate, codeine, 8-methoxypsoralen, alpha-methyldopa, penicillin VK and propantheline bromide in rats and mice. Toxicology. 1989 Jun; 56(2):123-36. doi: 10.1016/0300-483x(89)90127-3. [PMID: 2499954]
  • C Bizet, B Pangon, N Moisy, J Bizet, A Bure, P Gehanno. [Comparative study of the penetration of penicillin V, amoxicillin, cefaclor and josamycin in the tonsils]. Pathologie-biologie. 1989 Apr; 37(4):273-5. doi: . [PMID: 2499865]
  • A Leleux, R Snoeck, J Gerain, P Van der Auwera, D Daneau, F Meunier. [Prevention using pefloxacin of infections in cancer patients with granulocytopenia]. Presse medicale (Paris, France : 1983). 1989 Jan; 18(1):21-4. doi: NULL. [PMID: 2521710]
  • E J Vollaard, H A Clasener, A J van Griethuysen, A J Janssen, A H Sanders-Reijmers, N F Muller, P J Huige. Influence of cefaclor, phenethicillin, co-trimoxazole and doxycycline on colonization resistance in healthy volunteers. The Journal of antimicrobial chemotherapy. 1988 Nov; 22(5):747-58. doi: 10.1093/jac/22.5.747. [PMID: 3145269]
  • S Kukolja, W E Wright, J F Quay, J Pfeil-Doyle, S E Draheim, J A Eudaly, R J Johnson, J L Ott, F T Counter, R D Cooper. Oral absorption of cephalosporin antibiotics. 1. Synthesis, biological properties, and oral bioavailability of 7-(arylacetamido)-3-chloro cephalosporins in animals. Journal of medicinal chemistry. 1988 Oct; 31(10):1987-93. doi: 10.1021/jm00118a022. [PMID: 3172134]
  • Z Bounkhala, C Renard, R Baurain, J Marchand-Brynaert, L Ghosez, P M Tulkens. Coupling products of amino acids to penicillin V and cephalothin: synthesis and susceptibility to carboxypeptidases and lysosomal enzymes. Journal of medicinal chemistry. 1988 May; 31(5):976-83. doi: 10.1021/jm00400a015. [PMID: 3129562]
  • I Matheson, M Samseth, R Løberg, A Faegri, A Prentice. Milk transfer of phenoxymethylpenicillin during puerperal mastitis. British journal of clinical pharmacology. 1988 Jan; 25(1):33-40. doi: 10.1111/j.1365-2125.1988.tb03279.x. [PMID: 3130891]