PC(18:0/18:0) (BioDeep_00000029329)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


4-Hydroxy-N,N,N-trimethyl-10-oxo-7-((1-oxooctadecyl)oxy)-3,5,9-trioxa-4-phosphahepta cosan-1-aminium hydroxide, inner salt, 4-oxide

化学式: C44H88NO8P (789.6247218)
中文名称: 1,2-二硬脂酰基-sn-丙三基-3-磷酸胆碱
谱图信息: 最多检出来源 Homo sapiens(blood) 3.27%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
InChI: InChI=1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

描述信息

PC(18:0/18:0) is a phosphatidylcholine (PC or GPCho). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphocholines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PC(18:0/18:0), in particular, consists of two chains of stearic acid at the C-1 and C-2 positions. The stearic acid moieties are derived from animal fats, coco butter and sesame oil. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PCs can be synthesized via three different routes. In one route, choline is activated first by phosphorylation and then by coupling to CDP prior to attachment to phosphatidic acid. PCs can also synthesized by the addition of choline to CDP-activated 1,2-diacylglycerol. A third route to PC synthesis involves the conversion of either PS or PE to PC.
PC(18:0/18:0) is a phosphatidylcholine (PC or GPCho). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphocholines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PC(18:0/18:0), in particular, consists of two chains of stearic acid at the C-1 and C-2 positions. The stearic acid moieties are derived from animal fats, coco butter and sesame oil. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.

同义名列表

25 个代谢物同义名

4-Hydroxy-N,N,N-trimethyl-10-oxo-7-((1-oxooctadecyl)oxy)-3,5,9-trioxa-4-phosphahepta cosan-1-aminium hydroxide, inner salt, 4-oxide; (2-{[(2R)-2,3-bis(octadecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium; 1,2-Dioctadecanoyl-rac-glycero-3-phosphocholine; 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine; 1,2-distearoyl-rac-glycero-3-phosphocholine; 1,2-Distearoyl-sn-glycero-3-phosphocholine; 1,2-Distearoyllecithin, (+-)-isomer; 1,2-Distearoyllecithin, (S)-isomer; 1,2-Distearoyllecithin, (R)-isomer; 1,2-Distearoyl-sn-3-phosphacholine; 1,2-Distearoylphosphatidylcholine; Distearoylglycerophosphocholine; Phosphatidylcholine(18:0/18:0); Distearoyl phosphatidylcholine; Distearoylphosphatidylcholine; Phosphatidylcholine(36:0); 1,2-Distearoyllecithin; GPCho(18:0/18:0); GPC(18:0/18:0); PC(18:0/18:0); PC 18:0/18:0; Gpcho(36:0); PC (18:0)2; PC(36:0); Lecithin



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

14 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(14)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bin Xie, Changchun Hao, Runguang Sun. The impact of fluoxetine and pH values on relaxation of the ternary lipid monolayers. Biochimica et biophysica acta. Biomembranes. 2021 12; 1863(12):183760. doi: 10.1016/j.bbamem.2021.183760. [PMID: 34499884]
  • Juan Jin, Mei Li, Jing Li, Bin Li, Lei Duan, Fang Yang, Ning Gu. Xenon Nanobubbles for the Image-Guided Preemptive Treatment of Acute Ischemic Stroke via Neuroprotection and Microcirculatory Restoration. ACS applied materials & interfaces. 2021 Sep; 13(37):43880-43891. doi: 10.1021/acsami.1c06014. [PMID: 34493044]
  • Thais A Enoki, Joy Wu, Frederick A Heberle, Gerald W Feigenson. Investigation of the domain line tension in asymmetric vesicles prepared via hemifusion. Biochimica et biophysica acta. Biomembranes. 2021 06; 1863(6):183586. doi: 10.1016/j.bbamem.2021.183586. [PMID: 33647248]
  • Uttom Nandi, Ichioma Onyesom, Dennis Douroumis. An in vitro evaluation of antitumor activity of sirolimus-encapsulated liposomes in breast cancer cells. The Journal of pharmacy and pharmacology. 2021 Mar; 73(3):300-309. doi: 10.1093/jpp/rgaa061. [PMID: 33793879]
  • Sagar Kamble, Snehal Patil, Venkata Ramana Murthy Appala. Nano-mechanical characterization of asymmetric DLPC/DSPC supported lipid bilayers. Chemistry and physics of lipids. 2021 01; 234(?):105007. doi: 10.1016/j.chemphyslip.2020.105007. [PMID: 33160952]
  • Shiho Yahata, Mio Hirose, Takayo Ueno, Hiroki Nagumo, Kumiko Sakai-Kato. Effect of Sample Concentration on Nanoparticle Tracking Analysis of Small Extracellular Vesicles and Liposomes Mimicking the Physicochemical Properties of Exosomes. Chemical & pharmaceutical bulletin. 2021; 69(11):1045-1053. doi: 10.1248/cpb.c21-00452. [PMID: 34719585]
  • Galina B Diakova, Zhongmin Du, Alexander L Klibanov. Targeted Ultrasound Contrast Imaging of Tumor Vasculature With Positively Charged Microbubbles. Investigative radiology. 2020 11; 55(11):736-740. doi: 10.1097/rli.0000000000000699. [PMID: 32569011]
  • Yosuke Yanagida, Mio Namba, Tatsuya Fukuta, Hirokazu Yamamoto, Mitsuaki Yanagida, Miki Honda, Naoto Oku, Tomohiro Asai. Release rate is a key variable affecting the therapeutic effectiveness of liposomal fasudil for the treatment of cerebral ischemia/reperfusion injury. Biochemical and biophysical research communications. 2020 10; 531(4):622-627. doi: 10.1016/j.bbrc.2020.07.038. [PMID: 32819716]
  • Yohko F Yano, Hiroki Tada, Etsuo Arakawa, Wolfgang Voegeli, Toshiaki Ina, Tomoya Uruga, Tadashi Matsushita. Periodic Elastic Motion in a Self-Assembled Monolayer under Spontaneous Oscillations of Surface Tension: Molecules in a Scrum Push Back a Marangoni Flow. The journal of physical chemistry letters. 2020 Aug; 11(15):6330-6336. doi: 10.1021/acs.jpclett.0c01205. [PMID: 32663403]
  • H Hashemzadeh, H Javadi, M H Darvishi. Study of Structural stability and formation mechanisms in DSPC and DPSM liposomes: A coarse-grained molecular dynamics simulation. Scientific reports. 2020 02; 10(1):1837. doi: 10.1038/s41598-020-58730-z. [PMID: 32020000]
  • Karin Norling, Valentina Bernasconi, Víctor Agmo Hernández, Nagma Parveen, Katarina Edwards, Nils Y Lycke, Fredrik Höök, Marta Bally. Gel Phase 1,2-Distearoyl-sn-glycero-3-phosphocholine-Based Liposomes Are Superior to Fluid Phase Liposomes at Augmenting Both Antigen Presentation on Major Histocompatibility Complex Class II and Costimulatory Molecule Display by Dendritic Cells in Vitro. ACS infectious diseases. 2019 11; 5(11):1867-1878. doi: 10.1021/acsinfecdis.9b00189. [PMID: 31498993]
  • Jie Liu, Yihan Chen, Guohua Wang, Qiaofeng Jin, Zhenxing Sun, Qing Lv, Jing Wang, Yali Yang, Li Zhang, Mingxing Xie. Improving acute cardiac transplantation rejection therapy using ultrasound-targeted FK506-loaded microbubbles in rats. Biomaterials science. 2019 Sep; 7(9):3729-3740. doi: 10.1039/c9bm00301k. [PMID: 31403142]
  • Victoria Cheng, Dylan R Kimball, Dr John C Conboy. Determination of the Rate-Limiting Step in Fatty Acid Transport. The journal of physical chemistry. B. 2019 08; 123(33):7157-7168. doi: 10.1021/acs.jpcb.9b05162. [PMID: 31334654]
  • Calvin C L Cheung, Wafa T Al-Jamal. Sterically stabilized liposomes production using staggered herringbone micromixer: Effect of lipid composition and PEG-lipid content. International journal of pharmaceutics. 2019 Jul; 566(?):687-696. doi: 10.1016/j.ijpharm.2019.06.033. [PMID: 31212051]
  • Jonathan D Nickels, Micholas Dean Smith, Richard J Alsop, Sebastian Himbert, Ahmad Yahya, Destini Cordner, Piotr Zolnierczuk, Christopher B Stanley, John Katsaras, Xiaolin Cheng, Maikel C Rheinstädter. Lipid Rafts: Buffers of Cell Membrane Physical Properties. The journal of physical chemistry. B. 2019 03; 123(9):2050-2056. doi: 10.1021/acs.jpcb.8b12126. [PMID: 30605612]
  • Nandhini Rajagopal, Flaviyan Jerome Irudayanathan, Shikha Nangia. Palmitoylation of Claudin-5 Proteins Influences Their Lipid Domain Affinity and Tight Junction Assembly at the Blood-Brain Barrier Interface. The journal of physical chemistry. B. 2019 02; 123(5):983-993. doi: 10.1021/acs.jpcb.8b09535. [PMID: 30629442]
  • C Gil, J Dorca-Arévalo, J Blasi. Calcium enhances binding of Clostridium perfringens epsilon toxin to sulfatide. Biochimica et biophysica acta. Biomembranes. 2019 01; 1861(1):161-169. doi: 10.1016/j.bbamem.2018.08.003. [PMID: 30463699]
  • Cory D Sago, Melissa P Lokugamage, Fatima Z Islam, Brandon R Krupczak, Manaka Sato, James E Dahlman. Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution. Journal of the American Chemical Society. 2018 Dec; 140(49):17095-17105. doi: 10.1021/jacs.8b08976. [PMID: 30394729]
  • Jayesh A Kulkarni, Maria M Darjuan, Joanne E Mercer, Sam Chen, Roy van der Meel, Jenifer L Thewalt, Yuen Yi C Tam, Pieter R Cullis. On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA. ACS nano. 2018 05; 12(5):4787-4795. doi: 10.1021/acsnano.8b01516. [PMID: 29614232]
  • Ananda Kafle, Takeshi Misono, Avinash Bhadani, Masaaki Akamatsu, Kenichi Sakai, Chihiro Kaise, Teruhisa Kaneko, Hideki Sakai. Effects of β-Sitosteryl Sulfate on the Phase Behavior and Hydration Properties of Distearoylphosphatidylcholine: a Comparison with Dipalmitoylphosphatidylcholine. Journal of oleo science. 2018 Apr; 67(4):433-443. doi: 10.5650/jos.ess17182. [PMID: 29526873]
  • Remco Hartkamp, Timothy C Moore, Christopher R Iacovella, Michael A Thompson, Pallav A Bulsara, David J Moore, Clare McCabe. Composition Dependence of Water Permeation Across Multicomponent Gel-Phase Bilayers. The journal of physical chemistry. B. 2018 03; 122(12):3113-3123. doi: 10.1021/acs.jpcb.8b00747. [PMID: 29504755]
  • Quentin R Johnson, Barmak Mostofian, Gabriel Fuente Gomez, Jeremy C Smith, Xiaolin Cheng. Effects of carotenoids on lipid bilayers. Physical chemistry chemical physics : PCCP. 2018 Jan; 20(5):3795-3804. doi: 10.1039/c7cp07126d. [PMID: 29349456]
  • Sara Ahlgren, Karin Reijmar, Katarina Edwards. Targeting lipodisks enable selective delivery of anticancer peptides to tumor cells. Nanomedicine : nanotechnology, biology, and medicine. 2017 Oct; 13(7):2325-2328. doi: 10.1016/j.nano.2017.06.020. [PMID: 28712916]
  • Katherine J Black, Andrew T Lock, Lindsay M Thomson, Alexis R Cole, Xiaoqi Tang, Brian D Polizzotti, John N Kheir. Hemodynamic Effects of Lipid-Based Oxygen Microbubbles via Rapid Intravenous Injection in Rodents. Pharmaceutical research. 2017 Oct; 34(10):2156-2162. doi: 10.1007/s11095-017-2222-3. [PMID: 28685297]
  • Mackensie C Smith, Rachael M Crist, Jeffrey D Clogston, Scott E McNeil. Zeta potential: a case study of cationic, anionic, and neutral liposomes. Analytical and bioanalytical chemistry. 2017 Sep; 409(24):5779-5787. doi: 10.1007/s00216-017-0527-z. [PMID: 28762066]
  • Donatella Paolino, Maria Lorena Accolla, Felisa Cilurzo, Maria Chiara Cristiano, Donato Cosco, Francesco Castelli, Maria Grazia Sarpietro, Massimo Fresta, Christian Celia. Interaction between PEG lipid and DSPE/DSPC phospholipids: An insight of PEGylation degree and kinetics of de-PEGylation. Colloids and surfaces. B, Biointerfaces. 2017 Jul; 155(?):266-275. doi: 10.1016/j.colsurfb.2017.04.018. [PMID: 28460301]
  • Wei-Lun Tang, Wei-Hsin Tang, Weihsu Claire Chen, Charles Diako, Carolyn F Ross, Shyh-Dar Li. Development of a Rapidly Dissolvable Oral Pediatric Formulation for Mefloquine Using Liposomes. Molecular pharmaceutics. 2017 06; 14(6):1969-1979. doi: 10.1021/acs.molpharmaceut.7b00077. [PMID: 28460165]
  • Moe Wehbe, Armaan Malhotra, Malathi Anantha, Jeroen Roosendaal, Ada W Y Leung, David Plackett, Katarina Edwards, Roger Gilabert-Oriol, Marcel B Bally. A simple passive equilibration method for loading carboplatin into pre-formed liposomes incubated with ethanol as a temperature dependent permeability enhancer. Journal of controlled release : official journal of the Controlled Release Society. 2017 04; 252(?):50-61. doi: 10.1016/j.jconrel.2017.03.010. [PMID: 28286316]
  • Suvasini Ramaswamy, Nina Tonnu, Kiyoshi Tachikawa, Pattraranee Limphong, Jerel B Vega, Priya P Karmali, Pad Chivukula, Inder M Verma. Systemic delivery of factor IX messenger RNA for protein replacement therapy. Proceedings of the National Academy of Sciences of the United States of America. 2017 03; 114(10):E1941-E1950. doi: 10.1073/pnas.1619653114. [PMID: 28202722]
  • Sijia Wang, Xia Han, Danyang Liu, Mengya Li, Shouhong Xu, Honglai Liu. Melting Behavior of Zipper-Structured Lipopeptides in Lipid Bilayer. Langmuir : the ACS journal of surfaces and colloids. 2017 02; 33(6):1478-1485. doi: 10.1021/acs.langmuir.6b04080. [PMID: 28099806]
  • Mariana Guimarães Sá Correia, Maria L Briuglia, Fabio Niosi, Dimitrios A Lamprou. Microfluidic manufacturing of phospholipid nanoparticles: Stability, encapsulation efficacy, and drug release. International journal of pharmaceutics. 2017 Jan; 516(1-2):91-99. doi: 10.1016/j.ijpharm.2016.11.025. [PMID: 27840162]
  • Mohamed Wehbe, Malathi Anantha, Minghan Shi, Ada Wai-Yin Leung, Wieslawa H Dragowska, Léon Sanche, Marcel B Bally. Development and optimization of an injectable formulation of copper diethyldithiocarbamate, an active anticancer agent. International journal of nanomedicine. 2017; 12(?):4129-4146. doi: 10.2147/ijn.s137347. [PMID: 28615941]
  • Malin Morin Zetterberg, Sara Ahlgren, Víctor Agmo Hernández, Nagma Parveen, Katarina Edwards. Optimization of lipodisk properties by modification of the extent and density of the PEG corona. Journal of colloid and interface science. 2016 Dec; 484(?):86-96. doi: 10.1016/j.jcis.2016.08.067. [PMID: 27592189]
  • Shiying Wang, Elizabeth B Herbst, F William Mauldin, Galina B Diakova, Alexander L Klibanov, John A Hossack. Ultra-Low-Dose Ultrasound Molecular Imaging for the Detection of Angiogenesis in a Mouse Murine Tumor Model: How Little Can We See?. Investigative radiology. 2016 12; 51(12):758-766. doi: 10.1097/rli.0000000000000310. [PMID: 27654582]
  • Laura K Müller, Leonard Kaps, Detlef Schuppan, Alexander Brose, Wenqiang Chai, Karl Fischer, Sophie Müller, Holger Frey, Manfred Schmidt, Kristin Mohr. Physicochemical and Preclinical Evaluation of Spermine-Derived Surfactant Liposomes for in Vitro and in Vivo siRNA-Delivery to Liver Macrophages. Molecular pharmaceutics. 2016 11; 13(11):3636-3647. doi: 10.1021/acs.molpharmaceut.6b00312. [PMID: 27700112]
  • Jianhui Tian, Jonathan Nickels, John Katsaras, Xiaolin Cheng. Behavior of Bilayer Leaflets in Asymmetric Model Membranes: Atomistic Simulation Studies. The journal of physical chemistry. B. 2016 08; 120(33):8438-48. doi: 10.1021/acs.jpcb.6b02148. [PMID: 27121138]
  • Emanuel Schneck, Ernesto Scoppola, Jakub Drnec, Cristian Mocuta, Roberto Felici, Dmitri Novikov, Giovanna Fragneto, Jean Daillant. Atom-scale depth localization of biologically important chemical elements in molecular layers. Proceedings of the National Academy of Sciences of the United States of America. 2016 08; 113(34):9521-6. doi: 10.1073/pnas.1603898113. [PMID: 27503887]
  • Italo Rodrigo Calori, Antonio Claudio Tedesco. Lipid vesicles loading aluminum phthalocyanine chloride: Formulation properties and disaggregation upon intracellular delivery. Journal of photochemistry and photobiology. B, Biology. 2016 Jul; 160(?):240-7. doi: 10.1016/j.jphotobiol.2016.03.050. [PMID: 27130963]
  • Moritz Frewein, Benjamin Kollmitzer, Peter Heftberger, Georg Pabst. Lateral pressure-mediated protein partitioning into liquid-ordered/liquid-disordered domains. Soft matter. 2016 Apr; 12(13):3189-95. doi: 10.1039/c6sm00042h. [PMID: 27003910]
  • Roger Shih, Abraham P Lee. Post-Formation Shrinkage and Stabilization of Microfluidic Bubbles in Lipid Solution. Langmuir : the ACS journal of surfaces and colloids. 2016 Mar; 32(8):1939-46. doi: 10.1021/acs.langmuir.5b03948. [PMID: 26820229]
  • A de Breij, M Riool, P H S Kwakman, L de Boer, R A Cordfunke, J W Drijfhout, O Cohen, N Emanuel, S A J Zaat, P H Nibbering, T F Moriarty. Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145. Journal of controlled release : official journal of the Controlled Release Society. 2016 Jan; 222(?):1-8. doi: 10.1016/j.jconrel.2015.12.003. [PMID: 26658071]
  • A J C Dennison, R A L Jones, R A Staniforth, A J Parnell. Interaction of partially denatured insulin with a DSPC floating lipid bilayer. Soft matter. 2016 Jan; 12(3):824-9. doi: 10.1039/c5sm02502h. [PMID: 26540006]
  • Yenisleidy de Las Mercedes Zulueta Díaz, Milagro Mottola, Raquel V Vico, Natalia Wilke, María Laura Fanani. The Rheological Properties of Lipid Monolayers Modulate the Incorporation of l-Ascorbic Acid Alkyl Esters. Langmuir : the ACS journal of surfaces and colloids. 2016 Jan; 32(2):587-95. doi: 10.1021/acs.langmuir.5b04175. [PMID: 26694518]
  • Abdulrahman K Al Asmari, Zabih Ullah, Mohammad Tariq, Amal Fatani. Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil. Drug design, development and therapy. 2016; 10(?):205-15. doi: 10.2147/dddt.s93937. [PMID: 26834457]
  • Alex K K Leung, Yuen Yi C Tam, Sam Chen, Ismail M Hafez, Pieter R Cullis. Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems. The journal of physical chemistry. B. 2015 Jul; 119(28):8698-706. doi: 10.1021/acs.jpcb.5b02891. [PMID: 26087393]
  • Akshay Sridhar, Bharath Srikanth, Amit Kumar, Ashok Kumar Dasmahapatra. Coarse-grain molecular dynamics study of fullerene transport across a cell membrane. The Journal of chemical physics. 2015 Jul; 143(2):024907. doi: 10.1063/1.4926668. [PMID: 26178127]
  • Rana Ashkar, Michihiro Nagao, Paul D Butler, Andrea C Woodka, Mani K Sen, Tadanori Koga. Tuning membrane thickness fluctuations in model lipid bilayers. Biophysical journal. 2015 Jul; 109(1):106-12. doi: 10.1016/j.bpj.2015.05.033. [PMID: 26153707]
  • M J Alvarez-Figueroa, B C Contreras-Garrido, M A Soto-Arriaza. Use of DMPC and DSPC lipids for verapamil and naproxen permeability studies by PAMPA. Drug development and industrial pharmacy. 2015 Apr; 41(4):658-62. doi: 10.3109/03639045.2014.892954. [PMID: 24568608]
  • Zoltan Beck, Gary R Matyas, Carl R Alving. Detection of liposomal cholesterol and monophosphoryl lipid A by QS-21 saponin and Limulus polyphemus amebocyte lysate. Biochimica et biophysica acta. 2015 Mar; 1848(3):775-80. doi: 10.1016/j.bbamem.2014.12.005. [PMID: 25511587]
  • Elisabeth Kastner, M Jubair Hussain, Vincent W Bramwell, Dennis Christensen, Yvonne Perrie. Correlating liposomal adjuvant characteristics to in-vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein: a multivariate analysis study. The Journal of pharmacy and pharmacology. 2015 Mar; 67(3):450-63. doi: 10.1111/jphp.12390. [PMID: 25677402]
  • Emily M Curtis, Xingqing Xiao, Stavroula Sofou, Carol K Hall. Phase separation behavior of mixed lipid systems at neutral and low pH: coarse-grained simulations with DMD/LIME. Langmuir : the ACS journal of surfaces and colloids. 2015 Jan; 31(3):1086-94. doi: 10.1021/la504082x. [PMID: 25549801]
  • Priyanka A Oroskar, Cynthia J Jameson, Sohail Murad. Surface-functionalized nanoparticle permeation triggers lipid displacement and water and ion leakage. Langmuir : the ACS journal of surfaces and colloids. 2015 Jan; 31(3):1074-85. doi: 10.1021/la503934c. [PMID: 25549137]
  • Ahmad Arouri, Jakub Trojnar, Steffen Schmidt, Anders H Hansen, Jan Mollenhauer, Ole G Mouritsen. Development of a cell-based bioassay for phospholipase A2-triggered liposomal drug release. PloS one. 2015; 10(5):e0125508. doi: 10.1371/journal.pone.0125508. [PMID: 25945937]
  • David G Ackerman, Gerald W Feigenson. Lipid bilayers: clusters, domains and phases. Essays in biochemistry. 2015; 57(?):33-42. doi: 10.1042/bse0570033. [PMID: 25658342]
  • Dawn N Waterhouse, Brent W Sutherland, Nancy Dos Santos, Dana Masin, Maryam Osooly, Dita Strutt, Christina Ostlund, Malathi Anantha, Natashia Harasym, Irina Manisali, Mohamed Wehbe, Marcel B Bally, Murray S Webb. Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities. Investigational new drugs. 2014 Dec; 32(6):1071-82. doi: 10.1007/s10637-014-0138-x. [PMID: 25064374]
  • Stuart Ibsen, Guixin Shi, Carolyn Schutt, Linda Shi, Kyle-David Suico, Michael Benchimol, Viviana Serra, Dmitri Simberg, Michael Berns, Sadik Esener. The behavior of lipid debris left on cell surfaces from microbubble based ultrasound molecular imaging. Ultrasonics. 2014 Dec; 54(8):2090-8. doi: 10.1016/j.ultras.2014.06.020. [PMID: 25059435]
  • Erik B Watkins, Haifei Gao, Andrew J C Dennison, Nathalie Chopin, Bernd Struth, Thomas Arnold, Jean-Claude Florent, Ludger Johannes. Carbohydrate conformation and lipid condensation in monolayers containing glycosphingolipid Gb3: influence of acyl chain structure. Biophysical journal. 2014 Sep; 107(5):1146-1155. doi: 10.1016/j.bpj.2014.07.023. [PMID: 25185550]
  • Kuan-Boone Tan, Leong-Uung Ling, Ralph M Bunte, Wee-Joo Chng, Gigi N C Chiu. Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia. Nanomedicine (London, England). 2014 Aug; 9(11):1665-79. doi: 10.2217/nnm.13.123. [PMID: 24294981]
  • Brian D Polizzotti, Lindsay M Thomson, Daniel W O'Connell, Francis X McGowan, John N Kheir. Optimization and characterization of stable lipid-based, oxygen-filled microbubbles by mixture design. Journal of biomedical materials research. Part B, Applied biomaterials. 2014 Aug; 102(6):1148-56. doi: 10.1002/jbm.b.33096. [PMID: 24425069]
  • Pall Thor Ingvarsson, Ida Svahn Rasmussen, Michelle Viaene, Przemyslaw Jedrzej Irlik, Hanne Mørck Nielsen, Camilla Foged. The surface charge of liposomal adjuvants is decisive for their interactions with the Calu-3 and A549 airway epithelial cell culture models. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2014 Aug; 87(3):480-8. doi: 10.1016/j.ejpb.2014.04.001. [PMID: 24726978]
  • Aniket Magarkar, Vivek Dhawan, Paraskevi Kallinteri, Tapani Viitala, Mohammed Elmowafy, Tomasz Róg, Alex Bunker. Cholesterol level affects surface charge of lipid membranes in saline solution. Scientific reports. 2014 May; 4(?):5005. doi: 10.1038/srep05005. [PMID: 24845659]
  • Aleksandra P Dabkowska, David J Barlow, Luke A Clifton, Arwel V Hughes, John R P Webster, Rebecca J Green, Peter J Quinn, M Jayne Lawrence. Calcium-mediated binding of DNA to 1,2-distearoyl-sn-glycero-3-phosphocholine-containing mixed lipid monolayers. Soft matter. 2014 Mar; 10(11):1685-95. doi: 10.1039/c3sm52747f. [PMID: 24652078]
  • Mohammed Jubair Hussain, Alexander Wilkinson, Vincent W Bramwell, Dennis Christensen, Yvonne Perrie. Th1 immune responses can be modulated by varying dimethyldioctadecylammonium and distearoyl-sn-glycero-3-phosphocholine content in liposomal adjuvants. The Journal of pharmacy and pharmacology. 2014 Mar; 66(3):358-66. doi: 10.1111/jphp.12173. [PMID: 24251796]
  • Anirban Ghosh, Uddhavesh Sonavane, Rajendra Joshi. Multiscale modelling to understand the self-assembly mechanism of human β2-adrenergic receptor in lipid bilayer. Computational biology and chemistry. 2014 Feb; 48(?):29-39. doi: 10.1016/j.compbiolchem.2013.11.002. [PMID: 24291490]
  • Colin Walsh, Kevin Ou, Nathan M Belliveau, Tim J Leaver, Andre W Wild, Jens Huft, Paulo J Lin, Sam Chen, Alex K Leung, Justin B Lee, Carl L Hansen, Robert J Taylor, Euan C Ramsay, Pieter R Cullis. Microfluidic-based manufacture of siRNA-lipid nanoparticles for therapeutic applications. Methods in molecular biology (Clifton, N.J.). 2014; 1141(?):109-20. doi: 10.1007/978-1-4939-0363-4_6. [PMID: 24567134]
  • Krystal L Brown, John C Conboy. Lipid flip-flop in binary membranes composed of phosphatidylserine and phosphatidylcholine. The journal of physical chemistry. B. 2013 Dec; 117(48):15041-50. doi: 10.1021/jp409672q. [PMID: 24200035]
  • M A Soto-Arriaza, C Olivares-Ortega, F H Quina, L F Aguilar, C P Sotomayor. Effect of cholesterol content on the structural and dynamic membrane properties of DMPC/DSPC large unilamellar bilayers. Biochimica et biophysica acta. 2013 Nov; 1828(11):2763-9. doi: 10.1016/j.bbamem.2013.07.031. [PMID: 23954586]
  • Maryam Ghanbari Safari, Saman Hosseinkhani. Lipid composition of cationic nanoliposomes implicate on transfection efficiency. Journal of liposome research. 2013 Sep; 23(3):174-86. doi: 10.3109/08982104.2013.779703. [PMID: 23594237]
  • Tatyana M Konyakhina, Jing Wu, James D Mastroianni, Frederick A Heberle, Gerald W Feigenson. Phase diagram of a 4-component lipid mixture: DSPC/DOPC/POPC/chol. Biochimica et biophysica acta. 2013 Sep; 1828(9):2204-14. doi: 10.1016/j.bbamem.2013.05.020. [PMID: 23747294]
  • Angela C Brown, Steven P Wrenn. Nanoscale phase separation in DSPC-cholesterol systems. Langmuir : the ACS journal of surfaces and colloids. 2013 Aug; 29(31):9832-40. doi: 10.1021/la401249m. [PMID: 23876059]
  • John N Kheir, Brian D Polizzotti, Lindsay M Thomson, Daniel W O'Connell, Katherine J Black, Robert W Lee, James N Wilking, Adam C Graham, David C Bell, Francis X McGowan. Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery. Advanced healthcare materials. 2013 Aug; 2(8):1131-41. doi: 10.1002/adhm.201200350. [PMID: 23471884]
  • Sabina Tatur, Marco Maccarini, Robert Barker, Andrew Nelson, Giovanna Fragneto. Effect of functionalized gold nanoparticles on floating lipid bilayers. Langmuir : the ACS journal of surfaces and colloids. 2013 Jun; 29(22):6606-14. doi: 10.1021/la401074y. [PMID: 23638939]
  • Kanae Ichikawa, Tomohiro Asai, Kosuke Shimizu, Sei Yonezawa, Takeo Urakami, Haruna Miyauchi, Hiroto Kawashima, Tatsuhiro Ishida, Hiroshi Kiwada, Naoto Oku. Suppression of immune response by antigen-modified liposomes encapsulating model agents: a novel strategy for the treatment of allergy. Journal of controlled release : official journal of the Controlled Release Society. 2013 May; 167(3):284-9. doi: 10.1016/j.jconrel.2013.02.002. [PMID: 23419947]
  • Martin Hossann, Tungte Wang, Zulfiya Syunyaeva, Michael Wiggenhorn, Anja Zengerle, Rolf D Issels, Maximilian Reiser, Lars H Lindner, Michael Peller. Non-ionic Gd-based MRI contrast agents are optimal for encapsulation into phosphatidyldiglycerol-based thermosensitive liposomes. Journal of controlled release : official journal of the Controlled Release Society. 2013 Feb; 166(1):22-9. doi: 10.1016/j.jconrel.2012.12.003. [PMID: 23246469]
  • Mette Marie Bruun Nielsen, Adam Cohen Simonsen. Imaging ellipsometry of spin-coated membranes: mapping of multilamellar films, hydrated membranes, and fluid domains. Langmuir : the ACS journal of surfaces and colloids. 2013 Feb; 29(5):1525-32. doi: 10.1021/la3046675. [PMID: 23281595]
  • Jin Liu, Krystal L Brown, John C Conboy. The effect of cholesterol on the intrinsic rate of lipid flip-flop as measured by sum-frequency vibrational spectroscopy. Faraday discussions. 2013; 161(?):45-61; discussion 113. doi: 10.1039/c2fd20083j. [PMID: 23805737]
  • Siddikuzzaman, V M Berlin Grace. Inhibition of metastatic lung cancer in C57BL/6 mice by liposome encapsulated all trans retinoic acid (ATRA). International immunopharmacology. 2012 Dec; 14(4):570-9. doi: 10.1016/j.intimp.2012.09.008. [PMID: 23021983]
  • Yuri Gerelli, Lionel Porcar, Giovanna Fragneto. Lipid rearrangement in DSPC/DMPC bilayers: a neutron reflectometry study. Langmuir : the ACS journal of surfaces and colloids. 2012 Nov; 28(45):15922-8. doi: 10.1021/la303662e. [PMID: 23095050]
  • Shubhadeep Banerjee, Kacoli Sen, Tapan K Pal, Sujoy K Guha. Poly(styrene-co-maleic acid)-based pH-sensitive liposomes mediate cytosolic delivery of drugs for enhanced cancer chemotherapy. International journal of pharmaceutics. 2012 Oct; 436(1-2):786-97. doi: 10.1016/j.ijpharm.2012.07.059. [PMID: 22884831]
  • Sweta Modi, Tian-Xiang Xiang, Bradley D Anderson. Enhanced active liposomal loading of a poorly soluble ionizable drug using supersaturated drug solutions. Journal of controlled release : official journal of the Controlled Release Society. 2012 Sep; 162(2):330-9. doi: 10.1016/j.jconrel.2012.07.001. [PMID: 22800581]
  • Alejandro Perdomo-Ortiz, Julia R Widom, Geoffrey A Lott, Alán Aspuru-Guzik, Andrew H Marcus. Conformation and electronic population transfer in membrane-supported self-assembled porphyrin dimers by 2D fluorescence spectroscopy. The journal of physical chemistry. B. 2012 Sep; 116(35):10757-70. doi: 10.1021/jp305916x. [PMID: 22882118]
  • Hyo-Kyung Han, Hyun-Jae Shin, Dong Hoon Ha. Improved oral bioavailability of alendronate via the mucoadhesive liposomal delivery system. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2012 Aug; 46(5):500-7. doi: 10.1016/j.ejps.2012.04.002. [PMID: 22522117]
  • Anumita Chaudhury, Surajit Das, Ronald F S Lee, Kuan-Boone Tan, Wai-Kiong Ng, Reginald B H Tan, Gigi N C Chiu. Lyophilization of cholesterol-free PEGylated liposomes and its impact on drug loading by passive equilibration. International journal of pharmaceutics. 2012 Jul; 430(1-2):167-75. doi: 10.1016/j.ijpharm.2012.04.036. [PMID: 22537806]
  • Peter J Quinn. The effect of tocopherol on the structure and permeability of phosphatidylcholine liposomes. Journal of controlled release : official journal of the Controlled Release Society. 2012 Jun; 160(2):158-63. doi: 10.1016/j.jconrel.2011.12.029. [PMID: 22233970]
  • Aysegul Aygun, Kathryn Torrey, Ashok Kumar, Larry D Stephenson. Investigation of factors affecting controlled release from photosensitive DMPC and DSPC liposomes. Applied biochemistry and biotechnology. 2012 Jun; 167(4):743-57. doi: 10.1007/s12010-012-9724-6. [PMID: 22592778]
  • Xiaoming Xu, Mansoor A Khan, Diane J Burgess. Predicting hydrophilic drug encapsulation inside unilamellar liposomes. International journal of pharmaceutics. 2012 Feb; 423(2):410-8. doi: 10.1016/j.ijpharm.2011.12.019. [PMID: 22207162]
  • Hiroyuki Nakamura, Noriko Ueda, Hyun Seung Ban, Manabu Ueno, Shoji Tachikawa. Design and synthesis of fluorescence-labeled closo-dodecaborate lipid: its liposome formation and in vivo imaging targeting of tumors for boron neutron capture therapy. Organic & biomolecular chemistry. 2012 Feb; 10(7):1374-80. doi: 10.1039/c1ob06500a. [PMID: 22193924]
  • Saumyabrata Mazumder, Mithun Maji, Nahid Ali. Potentiating effects of MPL on DSPC bearing cationic liposomes promote recombinant GP63 vaccine efficacy: high immunogenicity and protection. PLoS neglected tropical diseases. 2011 Dec; 5(12):e1429. doi: 10.1371/journal.pntd.0001429. [PMID: 22206029]
  • Selver Ahmed, Zhorro Nikolov, Stephanie L Wunder. Effect of curvature on nanoparticle supported lipid bilayers investigated by Raman spectroscopy. The journal of physical chemistry. B. 2011 Nov; 115(45):13181-90. doi: 10.1021/jp205999p. [PMID: 21932795]
  • Mara Canovi, Eleni Markoutsa, Adina N Lazar, Georgios Pampalakis, Carla Clemente, Francesca Re, Silvia Sesana, Massimo Masserini, Mario Salmona, Charles Duyckaerts, Orfeu Flores, Marco Gobbi, Sophia G Antimisiaris. The binding affinity of anti-Aβ1-42 MAb-decorated nanoliposomes to Aβ1-42 peptides in vitro and to amyloid deposits in post-mortem tissue. Biomaterials. 2011 Aug; 32(23):5489-97. doi: 10.1016/j.biomaterials.2011.04.020. [PMID: 21529932]
  • Tatyana M Konyakhina, Shih Lin Goh, Jonathan Amazon, Frederick A Heberle, Jing Wu, Gerald W Feigenson. Control of a nanoscopic-to-macroscopic transition: modulated phases in four-component DSPC/DOPC/POPC/Chol giant unilamellar vesicles. Biophysical journal. 2011 Jul; 101(2):L8-10. doi: 10.1016/j.bpj.2011.06.019. [PMID: 21767476]
  • Kati Vainikka, Karin Reijmar, Gebrenegus Yohannes, Jörgen Samuelsson, Katarina Edwards, Matti Jussila, Marja-Liisa Riekkola. Polyethylene glycol-stabilized lipid disks as model membranes in interaction studies based on electrokinetic capillary chromatography and quartz crystal microbalance. Analytical biochemistry. 2011 Jul; 414(1):117-24. doi: 10.1016/j.ab.2011.03.016. [PMID: 21419750]
  • Ken-ichi Izutsu, Chikako Yomota, Toru Kawanishi. Stabilization of liposomes in frozen solutions through control of osmotic flow and internal solution freezing by trehalose. Journal of pharmaceutical sciences. 2011 Jul; 100(7):2935-44. doi: 10.1002/jps.22518. [PMID: 21328583]
  • Randip Kaur, Jili Chen, Amina Dawoodji, Vincenzo Cerundolo, Yoel R Garcia-Diaz, Justyna Wojno, Liam R Cox, Gurdyal S Besra, Behfar Moghaddam, Yvonne Perrie. Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells. Journal of pharmaceutical sciences. 2011 Jul; 100(7):2724-33. doi: 10.1002/jps.22500. [PMID: 21283989]
  • Leide P Cavalcanti, Ingunn Tho, Oleg Konovalov, Sigrid Fossheim, Martin Brandl. Compressibility study of quaternary phospholipid blend monolayers. Colloids and surfaces. B, Biointerfaces. 2011 Jul; 85(2):153-60. doi: 10.1016/j.colsurfb.2011.02.015. [PMID: 21397464]
  • Kathryn A Smith, John C Conboy. Using micropatterned lipid bilayer arrays to measure the effect of membrane composition on merocyanine 540 binding. Biochimica et biophysica acta. 2011 Jun; 1808(6):1611-7. doi: 10.1016/j.bbamem.2011.02.017. [PMID: 21376014]
  • Sarah E McNeil, Ida Rosenkrands, Else Marie Agger, Peter Andersen, Yvonne Perrie. Subunit vaccines: distearoylphosphatidylcholine-based liposomes entrapping antigen offer a neutral alternative to dimethyldioctadecylammonium-based cationic liposomes as an adjuvant delivery system. Journal of pharmaceutical sciences. 2011 May; 100(5):1856-65. doi: 10.1002/jps.22427. [PMID: 21374619]
  • Ulrik Franzen, Tam T T N Nguyen, Charlotte Vermehren, Bente Gammelgaard, Jesper Ostergaard. Characterization of a liposome-based formulation of oxaliplatin using capillary electrophoresis: encapsulation and leakage. Journal of pharmaceutical and biomedical analysis. 2011 Apr; 55(1):16-22. doi: 10.1016/j.jpba.2010.12.037. [PMID: 21282028]
  • Anshuman Ambike, Véronique Rosilio, Barbara Stella, Sinda Lepêtre-Mouelhi, Patrick Couvreur. Interaction of self-assembled squalenoyl gemcitabine nanoparticles with phospholipid-cholesterol monolayers mimicking a biomembrane. Langmuir : the ACS journal of surfaces and colloids. 2011 Apr; 27(8):4891-9. doi: 10.1021/la200002d. [PMID: 21413743]