globostelletin I|LJRG-82-2 (BioDeep_00000292355)
代谢物信息卡片
globostelletin I|LJRG-82-2
化学式: C27H36O4 (424.2613)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C=CC(=O)O)=CC=CC(C)=C1C(=O)CC2C1(C)CCC1C(C)(C)C(=O)CCC12C
InChI:
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Zhixian Wang, Xiaoling Xu, Yunhuan Zhu, Yuncheng Qian, Yilu Feng, Hongyu Li, Guoheng Hu. Preparation and brain targeting effects study of recombinant human ferritin nanoparticles.
Biochemical and biophysical research communications.
2024 Jun; 712-713(?):149939. doi:
10.1016/j.bbrc.2024.149939. [PMID: 38640729] - Yujie Sun, Jian Zhang. HMOX1 regulates ferroptosis via mic14 and its impact on chemotherapy resistance in small-cell lung cancer.
Anti-cancer drugs.
2024 Jun; 35(5):397-411. doi:
10.1097/cad.0000000000001588. [PMID: 38527419] - Binyu Lu, Shanshan Guo, Jialin Zhao, Xiaoting Wang, Bing Zhou. Adipose knockout of H-ferritin improves energy metabolism in mice.
Molecular metabolism.
2024 Feb; 80(?):101871. doi:
10.1016/j.molmet.2024.101871. [PMID: 38184276] - Wenyu Shi, Jin Wang, Zhaojun Li, Shuning Xu, Jingdong Wang, Liyuan Zhang, Hongying Yang. Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury.
Free radical biology & medicine.
2024 Jan; 213(?):343-358. doi:
10.1016/j.freeradbiomed.2024.01.021. [PMID: 38272326] - Wei Cheng, Yue Zhou, Hange Chen, Qian Wu, Yan Li, Hui Wang, Yan Feng, Yan Wang. The iron matters: Aged microplastics disrupted the iron homeostasis in the liver organoids.
The Science of the total environment.
2023 Oct; ?(?):167529. doi:
10.1016/j.scitotenv.2023.167529. [PMID: 37788777] - Guang Yang, Qi Pan, Yang Lu, Junlong Zhu, Xin Gou. miR-29a-5p modulates ferroptosis by targeting ferritin heavy chain FTH1 in prostate cancer.
Biochemical and biophysical research communications.
2023 04; 652(?):6-13. doi:
10.1016/j.bbrc.2023.02.030. [PMID: 36806086] - Wenqiang Qian, Daozhou Liu, Ying Han, Miao Liu, Bao Liu, Qifeng Ji, Bangle Zhang, Qibing Mei, Siyuan Zhou, Ying Cheng. Cyclosporine A-loaded apoferritin alleviates myocardial ischemia-reperfusion injury by simultaneously blocking ferroptosis and apoptosis of cardiomyocytes.
Acta biomaterialia.
2023 04; 160(?):265-280. doi:
10.1016/j.actbio.2023.02.025. [PMID: 36822483] - Matthias Knödler, Patrick Opdensteinen, Ramya Ambur Sankaranarayanan, Agnieszka Morgenroth, Eva Miriam Buhl, Felix M Mottaghy, Johannes Felix Buyel. Simple plant-based production and purification of the assembled human ferritin heavy chain as a nanocarrier for tumor-targeted drug delivery and bioimaging in cancer therapy.
Biotechnology and bioengineering.
2023 04; 120(4):1038-1054. doi:
10.1002/bit.28312. [PMID: 36539373] - Wenhui Jia, Hailong Tian, Jingwen Jiang, Li Zhou, Lei Li, Maochao Luo, Ning Ding, Edouard C Nice, Canhua Huang, Haiyuan Zhang. Brain-Targeted HFn-Cu-REGO Nanoplatform for Site-Specific Delivery and Manipulation of Autophagy and Cuproptosis in Glioblastoma.
Small (Weinheim an der Bergstrasse, Germany).
2023 01; 19(2):e2205354. doi:
10.1002/smll.202205354. [PMID: 36399643] - Xiaotong Song, Yongxiang Zheng, Yongdong Liu, Huan Meng, Rong Yu, Chun Zhang. Production of Recombinant Human Hybrid Ferritin with Heavy Chain and Light Chain in Escherichia coli and its Characterization.
Current pharmaceutical biotechnology.
2023; 24(2):341-349. doi:
10.2174/1389201023666220517225048. [PMID: 35585819] - Jun Guo, Rong Wang, Fei Min. Ginsenoside Rg1 ameliorates sepsis-induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells.
Journal of leukocyte biology.
2022 11; 112(5):1065-1077. doi:
10.1002/jlb.1a0422-211r. [PMID: 35774015] - Meijie Chen, Xuena Li, Bulin Du, Song Chen, Yaming Li. Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2.
Biochemical pharmacology.
2022 11; 205(?):115255. doi:
10.1016/j.bcp.2022.115255. [PMID: 36210578] - Yijie Wu, Xiuling Zhang, Jianjie Chen, Jinling Cao, Cuiping Feng, Yongju Luo, Yong Lin. Self-recovery study of fluoride-induced ferroptosis in the liver of zebrafish (Danio rerio).
Aquatic toxicology (Amsterdam, Netherlands).
2022 Oct; 251(?):106275. doi:
10.1016/j.aquatox.2022.106275. [PMID: 36007351] - Yanchun Li, Bing Xu, Xueying Ren, Luyang Wang, Yaqing Xu, Yefeng Zhao, Chen Yang, Chen Yuan, Huanjuan Li, Xiangmin Tong, Ying Wang, Jing Du. Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62-Keap1-NRF2 pathway.
Cellular & molecular biology letters.
2022 Sep; 27(1):81. doi:
10.1186/s11658-022-00383-z. [PMID: 36180832] - Oumar Elzenaty, Paola Luciani, Simone Aleandri. A lipidic mesophase with tunable release properties for the local delivery of macromolecules: the apoferritin nanocage, a case study.
Journal of materials chemistry. B.
2022 05; 10(20):3876-3885. doi:
10.1039/d2tb00403h. [PMID: 35470843] - Nana Yang, Qianghua Wang, Biao Ding, Yingying Gong, Yue Wu, Junpei Sun, Xuegu Wang, Lei Liu, Feng Zhang, Danli Du, Xiang Li. Expression profiles and functions of ferroptosis-related genes in the placental tissue samples of early- and late-onset preeclampsia patients.
BMC pregnancy and childbirth.
2022 Jan; 22(1):87. doi:
10.1186/s12884-022-04423-6. [PMID: 35100981] - Li Gong, Qiuyue Yu, Haichao Wang, Chenhaoyi Xu, Yunxiao Dou, Bingjie Mao, Yanxin Zhao. Neurofilament Light Chain (NF-L) Stimulates Lipid Peroxidation to Neuronal Membrane through Microglia-Derived Ferritin Heavy Chain (FTH) Secretion.
Oxidative medicine and cellular longevity.
2022; 2022(?):3938940. doi:
10.1155/2022/3938940. [PMID: 35368870] - Ning-Xia Xiong, Sheng-Wei Luo, Zhuang-Wen Mao, Lan-Fen Fan, Kai-Kun Luo, Shi Wang, Fang-Zhou Hu, Ming Wen, Qing-Feng Liu, Shao-Jun Liu. Ferritin H can counteract inflammatory response in hybrid fish and its parental species after Aeromonas hydrophila infection.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2021 Dec; 250(?):109174. doi:
10.1016/j.cbpc.2021.109174. [PMID: 34461291] - Wataru Otsu, Kodai Ishida, Naoki Chinen, Shinsuke Nakamura, Masamitsu Shimazawa, Hideshi Tsusaki, Hideaki Hara. Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells.
Scientific reports.
2021 09; 11(1):18555. doi:
10.1038/s41598-021-97956-3. [PMID: 34535730] - Abbas Amer Ridha, Soheila Kashanian, Ronak Rafipour, Abbas Hemati Azandaryani, Hossein Zhaleh, Elahe Mahdavian. A promising dual-drug targeted delivery system in cancer therapy: nanocomplexes of folate-apoferritin-conjugated cationic solid lipid nanoparticles.
Pharmaceutical development and technology.
2021 Jul; 26(6):673-681. doi:
10.1080/10837450.2021.1920037. [PMID: 33896342] - Michela Asperti, Sonia Bellini, Elisabetta Grillo, Magdalena Gryzik, Luca Cantamessa, Roberto Ronca, Federica Maccarinelli, Alessandro Salvi, Giuseppina De Petro, Paolo Arosio, Stefania Mitola, Maura Poli. H-ferritin suppression and pronounced mitochondrial respiration make Hepatocellular Carcinoma cells sensitive to RSL3-induced ferroptosis.
Free radical biology & medicine.
2021 06; 169(?):294-303. doi:
10.1016/j.freeradbiomed.2021.04.024. [PMID: 33892112] - Xinrong Li, Wenwen Si, Zhan Li, Ye Tian, Xuelei Liu, Shanyu Ye, Zifeng Huang, Yichun Ji, Caiping Zhao, Xiaoqian Hao, Dongfeng Chen, Meiling Zhu. miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease.
International journal of molecular medicine.
2021 04; 47(4):. doi:
10.3892/ijmm.2021.4894. [PMID: 33649797] - Xuexian Fang, Zhaoxian Cai, Hao Wang, Dan Han, Qi Cheng, Pan Zhang, Feng Gao, Yingying Yu, Zijun Song, Qian Wu, Peng An, Sicong Huang, Jianwei Pan, Hou-Zao Chen, Jinghai Chen, Andreas Linkermann, Junxia Min, Fudi Wang. Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis.
Circulation research.
2020 07; 127(4):486-501. doi:
10.1161/circresaha.120.316509. [PMID: 32349646] - Yan Wang, Meng Tang. PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance.
Environmental pollution (Barking, Essex : 1987).
2019 Nov; 254(Pt A):112937. doi:
10.1016/j.envpol.2019.07.105. [PMID: 31401526] - Demei Meng, Peng Zuo, Huanlu Song, Rui Yang. Influence of Manothermosonication on the Physicochemical and Functional Properties of Ferritin as a Nanocarrier of Iron or Bioactive Compounds.
Journal of agricultural and food chemistry.
2019 Jun; 67(23):6633-6641. doi:
10.1021/acs.jafc.9b01739. [PMID: 31099573] - Berenice Segrestin, José Maria Moreno-Navarrete, Kevin Seyssel, Maud Alligier, Emmanuelle Meugnier, Julie-Anne Nazare, Hubert Vidal, José Manuel Fernandez-Real, Martine Laville. Adipose Tissue Expansion by Overfeeding Healthy Men Alters Iron Gene Expression.
The Journal of clinical endocrinology and metabolism.
2019 03; 104(3):688-696. doi:
10.1210/jc.2018-01169. [PMID: 30260393] - Nilanjan Dey, Asfa Ali, Mohini Kamra, Santanu Bhattacharya. Simultaneous sensing of ferritin and apoferritin proteins using an iron-responsive dye and evaluation of physiological parameters associated with serum iron estimation.
Journal of materials chemistry. B.
2019 02; 7(6):986-993. doi:
10.1039/c8tb01523f. [PMID: 32255103] - Jing Du, Tongtong Wang, Yanchun Li, Yi Zhou, Xin Wang, Xingxing Yu, Xueying Ren, Yihan An, Yi Wu, Weidong Sun, Weimin Fan, Qiaojuan Zhu, Ying Wang, Xiangmin Tong. DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin.
Free radical biology & medicine.
2019 02; 131(?):356-369. doi:
10.1016/j.freeradbiomed.2018.12.011. [PMID: 30557609] - Vivek Venkataramani, Thorsten R Doeppner, Desiree Willkommen, Catherine M Cahill, Yongjuan Xin, Guilin Ye, Yanyan Liu, Adam Southon, Allegra Aron, Ho Yu Au-Yeung, Xudong Huang, Debomoy K Lahiri, Fudi Wang, Ashley I Bush, Gerald G Wulf, Philipp Ströbel, Bernhard Michalke, Jack T Rogers. Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin.
Journal of neurochemistry.
2018 12; 147(6):831-848. doi:
10.1111/jnc.14580. [PMID: 30152072] - Rui Yang, Jing Tian, Desheng Wang, Chris Blanchard, Zhongkai Zhou. Chitosan binding onto the epigallocatechin-loaded ferritin nanocage enhances its transport across Caco-2 cells.
Food & function.
2018 Apr; 9(4):2015-2024. doi:
10.1039/c8fo00097b. [PMID: 29541738] - Shengli Zhang, Jiachen Zang, Hai Chen, Meiliang Li, Chuanshan Xu, Guanghua Zhao. The Size Flexibility of Ferritin Nanocage Opens a New Way to Prepare Nanomaterials.
Small (Weinheim an der Bergstrasse, Germany).
2017 10; 13(37):. doi:
10.1002/smll.201701045. [PMID: 28786527] - Ana M Ferreira, Jonas Grossmann, Claudia Fortes, Tanya Kilminster, Tim Scanlon, John Milton, Johan Greeff, Chris Oldham, Paolo Nanni, André M Almeida. The sheep (Ovis aries) muscle proteome: Decoding the mechanisms of tolerance to Seasonal Weight Loss using label-free proteomics.
Journal of proteomics.
2017 05; 161(?):57-67. doi:
10.1016/j.jprot.2017.03.020. [PMID: 28366878] - Nadia Lobello, Flavia Biamonte, Maria Elena Pisanu, Maria Concetta Faniello, Žiga Jakopin, Emanuela Chiarella, Emilia Dora Giovannone, Rita Mancini, Gennaro Ciliberto, Giovanni Cuda, Francesco Costanzo. Ferritin heavy chain is a negative regulator of ovarian cancer stem cell expansion and epithelial to mesenchymal transition.
Oncotarget.
2016 09; 7(38):62019-62033. doi:
10.18632/oncotarget.11495. [PMID: 27566559] - Sohail Ahmed Otho, Kangkang Chen, Yongdong Zhang, Peng Wang, Zhiqiang Lu. Silkworm ferritin 1 heavy chain homolog is involved in defense against bacterial infection through regulation of haemolymph iron homeostasis.
Developmental and comparative immunology.
2016 Feb; 55(?):152-8. doi:
10.1016/j.dci.2015.10.022. [PMID: 26522340] - Fabiana Zolea, Flavia Biamonte, Patrizio Candeloro, Maddalena Di Sanzo, Anna Cozzi, Anna Di Vito, Barbara Quaresima, Nadia Lobello, Francesca Trecroci, Enzo Di Fabrizio, Sonia Levi, Giovanni Cuda, Francesco Costanzo. H ferritin silencing induces protein misfolding in K562 cells: A Raman analysis.
Free radical biology & medicine.
2015 Dec; 89(?):614-23. doi:
10.1016/j.freeradbiomed.2015.07.161. [PMID: 26454082] - M Hlaváčová, J Gumulec, T Stračina, M Fojtů, M Raudenská, M Masařík, M Nováková, H Paulová. Different doxorubicin formulations affect plasma 4-hydroxy-2-nonenal and gene expression of aldehyde dehydrogenase 3A1 and thioredoxin reductase 2 in rat.
Physiological research.
2015; 64(Suppl 5):S653-60. doi:
10.33549/physiolres.933223. [PMID: 26674287] - W Ziolkowski, D J Flis, M Halon, D M S Vadhana, R A Olek, M Carloni, J Antosiewicz, J J Kaczor, R Gabbianelli. Prolonged swimming promotes cellular oxidative stress and p66Shc phosphorylation, but does not induce oxidative stress in mitochondria in the rat heart.
Free radical research.
2015 Jan; 49(1):7-16. doi:
10.3109/10715762.2014.968147. [PMID: 25287525] - M Halon, J J Kaczor, W Ziolkowski, D J Flis, A Borkowska, U Popowska, W Nyka, M Wozniak, J Antosiewicz. Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutation.
Free radical research.
2014 Nov; 48(11):1363-70. doi:
10.3109/10715762.2014.955484. [PMID: 25175826] - Jong-Hwan Lee, Ji Yun Lee, Jong-Am Song, Kyung-Yeon Han, Doo Sung Lee, Jeewon Lee. A stress-responsive Escherichia coli protein, CysQ is a highly effective solubility enhancer for aggregation-prone heterologous proteins.
Protein expression and purification.
2014 Sep; 101(?):91-8. doi:
10.1016/j.pep.2014.06.006. [PMID: 24945073] - Rui Yang, Senpei Yang, Xiayun Liao, Jianjun Deng, Guanghua Zhao. The interaction of DNA with phytoferritin during iron oxidation.
Food chemistry.
2014 Jun; 153(?):292-7. doi:
10.1016/j.foodchem.2013.12.091. [PMID: 24491733] - Kasim Sader, Martyn Stopps, Lesley J Calder, Peter B Rosenthal. Cryomicroscopy of radiation sensitive specimens on unmodified graphene sheets: reduction of electron-optical effects of charging.
Journal of structural biology.
2013 Sep; 183(3):531-536. doi:
10.1016/j.jsb.2013.04.014. [PMID: 23664842] - Jie Zhao, Meiling Liu, Youyu Zhang, Haitao Li, Yuehe Lin, Shouzhuo Yao. Apoferritin protein nanoparticles dually labeled with aptamer and horseradish peroxidase as a sensing probe for thrombin detection.
Analytica chimica acta.
2013 Jan; 759(?):53-60. doi:
10.1016/j.aca.2012.10.041. [PMID: 23260676] - Yunxia Li, Yusheng He, Qiang Guan, Wuchao Liu, Hongjie Han, Zhiyu Nie. Disrupted iron metabolism and ensuing oxidative stress may mediate cognitive dysfunction induced by chronic cerebral hypoperfusion.
Biological trace element research.
2012 Dec; 150(1-3):242-8. doi:
10.1007/s12011-012-9455-0. [PMID: 22639386] - Xiayun Liao, Chenyan Lv, Xiuqing Zhang, Taro Masuda, Meiliang Li, Guanghua Zhao. A novel strategy of natural plant ferritin to protect DNA from oxidative damage during iron oxidation.
Free radical biology & medicine.
2012 Jul; 53(2):375-82. doi:
10.1016/j.freeradbiomed.2012.05.003. [PMID: 22580341] - Weiming Bu, Renyu Liu, Jasmina C Cheung-Lau, Ivan J Dmochowski, Patrick J Loll, Roderic G Eckenhoff. Ferritin couples iron and fatty acid metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2012 Jun; 26(6):2394-400. doi:
10.1096/fj.11-198853. [PMID: 22362897] - Anja Reinert, Anja Mittag, Tilo Reinert, Attila Tárnok, Thomas Arendt, Markus Morawski. On the quantification of intracellular proteins in multifluorescence-labeled rat brain slices using slide-based cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology.
2011 Jun; 79(6):485-91. doi:
10.1002/cyto.a.21047. [PMID: 21425238] - Lianbing Zhang, Linda Laug, Wolfram Münchgesang, Eckhard Pippel, Ulrich Gösele, Matthias Brandsch, Mato Knez. Reducing stress on cells with apoferritin-encapsulated platinum nanoparticles.
Nano letters.
2010 Jan; 10(1):219-23. doi:
10.1021/nl903313r. [PMID: 20017497] - Ana G Barbeito, Holly J Garringer, Martin A Baraibar, Xiaoying Gao, Miguel Arredondo, Marco T Núñez, Mark A Smith, Bernardino Ghetti, Ruben Vidal. Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene.
Journal of neurochemistry.
2009 May; 109(4):1067-78. doi:
10.1111/j.1471-4159.2009.06028.x. [PMID: 19519778] - Seung H Jung, Lara R DeRuisseau, Andreas N Kavazis, Keith C DeRuisseau. Plantaris muscle of aged rats demonstrates iron accumulation and altered expression of iron regulation proteins.
Experimental physiology.
2008 Mar; 93(3):407-14. doi:
10.1113/expphysiol.2007.039453. [PMID: 17981932] - Fadi Bou-Abdallah, Elissa Carney, N Dennis Chasteen, Paolo Arosio, Arthur J Viescas, Georgia C Papaefthymiou. A comparative Mössbauer study of the mineral cores of human H-chain ferritin employing dioxygen and hydrogen peroxide as iron oxidants.
Biophysical chemistry.
2007 Nov; 130(3):114-21. doi:
10.1016/j.bpc.2007.08.003. [PMID: 17881115] - Louise Toussaint, Luc Bertrand, Louis Hue, Robert R Crichton, Jean-Paul Declercq. High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites.
Journal of molecular biology.
2007 Jan; 365(2):440-52. doi:
10.1016/j.jmb.2006.10.010. [PMID: 17070541] - L Rong, H Komatsu, I Yoshizaki, A Kadowaki, S Yoda. Protein crystallization by using porous glass substrate.
Journal of synchrotron radiation.
2004 Jan; 11(Pt 1):27-9. doi:
10.1107/s0909049503023525. [PMID: 14646126] - M K Jang, M S Choi, Y B Park. Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells.
Biochemical and biophysical research communications.
1999 Nov; 265(2):577-83. doi:
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Cancer research.
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Nature structural biology.
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The Journal of clinical investigation.
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The Journal of biological chemistry.
1992 Sep; 267(25):18148-53. doi:
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Free radical research communications.
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FEBS letters.
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Biological trace element research.
1989 Jul; 21(?):105-10. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
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Lancet (London, England).
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