3-Sialyl Lewis (BioDeep_00000028239)

   

human metabolite Endogenous


代谢物信息卡片


(2S,4S,5R,6R)-2-{[(2R,3R,4S,5S,6R)-2-{[(2R,3R,4R,5R)-5,6-dihydroxy-2-[(1-hydroxyethylidene)amino]-1-oxo-4-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-5-[(1-hydroxyethylidene)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate

化学式: C31H52N2O23 (820.2960722)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC(C(CO)O)C(C(C=O)NC(=O)C)OC2C(C(C(C(O2)CO)O)OC3(CC(C(C(O3)C(C(CO)O)O)NC(=O)C)O)C(=O)O)O)O)O)O
InChI: InChI=1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)54-25(15(42)7-36)24(12(5-34)32-10(2)38)53-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1

描述信息

3-Sialyl Lewis tetrasaccharide, is a tumor-associated carbohydrate antigen. It is used as a tumor marker in colon and pancreatic cancer. When the selectin family of adhesion molecules was described, it was found that 3-Sialyl Lewis, along with sialyl Lewis(x) antigen, is a ligand for E-selectin, responsible for adhesion of several types of human carcinoma cells to endothelium. It has been suggested that such interactions play an important role in the formation of metastases by colon and pancreatic cancer cells. (PMID:12362971) [HMDB]
3-Sialyl Lewis tetrasaccharide, is a tumor-associated carbohydrate antigen. It is used as a tumor marker in colon and pancreatic cancer. When the selectin family of adhesion molecules was described, it was found that 3-Sialyl Lewis, along with sialyl Lewis(x) antigen, is a ligand for E-selectin, responsible for adhesion of several types of human carcinoma cells to endothelium. It has been suggested that such interactions play an important role in the formation of metastases by colon and pancreatic cancer cells. (PMID:12362971).
C307 - Biological Agent > C268 - Antigen > C912 - Tumor Antigen

同义名列表

10 个代谢物同义名

(2S,4S,5R,6R)-2-{[(2R,3R,4S,5S,6R)-2-{[(2R,3R,4R,5R)-5,6-dihydroxy-2-[(1-hydroxyethylidene)amino]-1-oxo-4-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-5-[(1-hydroxyethylidene)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate; (2S,4S,5R,6R)-5-acetamido-2-{[(2R,3R,4S,5S,6R)-2-{[(2R,3R,4R,5R)-2-acetamido-5,6-dihydroxy-1-oxo-4-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid; O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-beta-delta-galactopyranosyl-(1->3)-O-[6-deoxy-alpha-L-galactopyranosyl-(1->4)]-2-(acetylamino)-2-deoxy- D-glucose; O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->3)-O-[6-deoxy-alpha-L-galactopyranosyl-(1->4)]-2-(acetylamino)-2-deoxy- D-glucose; 3-Sialyl lewis a; 3-Sialyl Lewis; sialyl-lewis A; Sialyl lea tri; Sialyl lewis a; SLea



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Tianhong Teng, Han Shi, Yanying Fan, Pengfei Guo, Jin Zhang, Xinyu Qiu, Jianghua Feng, Heguang Huang. Metabolic responses to the occurrence and chemotherapy of pancreatic cancer: biomarker identification and prognosis prediction. Scientific reports. 2024 03; 14(1):6938. doi: 10.1038/s41598-024-56737-4. [PMID: 38521793]
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  • Hai-Ning Liu, Can Yao, Xiao-Fan Wang, Ning-Ping Zhang, Yan-Jie Chen, Dong Pan, Guo-Ping Zhao, Xi-Zhong Shen, Hao Wu, Tao-Tao Liu. Diagnostic and economic value of carcinoembryonic antigen, carbohydrate antigen 19-9, and carbohydrate antigen 72-4 in gastrointestinal cancers. World journal of gastroenterology. 2023 Jan; 29(4):706-730. doi: 10.3748/wjg.v29.i4.706. [PMID: 36742169]
  • Ting Shuang, Yiran Wang, Lanbo Zhao, Kailu Zhang, Panyue Yin, Lin Guo, Wei Jing, Xue Feng, Qiling Li. Extremely high serum CA19-9 level along with elevated D-dimer in assisting detection of ruptured ovarian endometriosis. Annals of medicine. 2022 12; 54(1):1444-1451. doi: 10.1080/07853890.2022.2074534. [PMID: 35733415]
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  • Ece Kartal, Thomas S B Schmidt, Esther Molina-Montes, Sandra Rodríguez-Perales, Jakob Wirbel, Oleksandr M Maistrenko, Wasiu A Akanni, Bilal Alashkar Alhamwe, Renato J Alves, Alfredo Carrato, Hans-Peter Erasmus, Lidia Estudillo, Fabian Finkelmeier, Anthony Fullam, Anna M Glazek, Paulina Gómez-Rubio, Rajna Hercog, Ferris Jung, Stefanie Kandels, Stephan Kersting, Melanie Langheinrich, Mirari Márquez, Xavier Molero, Askarbek Orakov, Thea Van Rossum, Raul Torres-Ruiz, Anja Telzerow, Konrad Zych, Vladimir Benes, Georg Zeller, Jonel Trebicka, Francisco X Real, Nuria Malats, Peer Bork. A faecal microbiota signature with high specificity for pancreatic cancer. Gut. 2022 07; 71(7):1359-1372. doi: 10.1136/gutjnl-2021-324755. [PMID: 35260444]
  • Lu Hong, Liu Xu, Lufei Jin, Kaiwei Xu, Weiwei Tang, Yuchao Zhu, Xuedan Qiu, Jianhua Wang. Exosomal circular RNA hsa_circ_0006220, and hsa_circ_0001666 as biomarkers in the diagnosis of pancreatic cancer. Journal of clinical laboratory analysis. 2022 Jun; 36(6):e24447. doi: 10.1002/jcla.24447. [PMID: 35446993]
  • Kateryna Nesteruk, Iris J M Levink, Esther de Vries, Isis J Visser, Maikel P Peppelenbosch, Djuna L Cahen, Gwenny M Fuhler, Marco J Bruno. Extracellular vesicle-derived microRNAs in pancreatic juice as biomarkers for detection of pancreatic ductal adenocarcinoma. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 2022 Jun; 22(5):626-635. doi: 10.1016/j.pan.2022.04.010. [PMID: 35613957]
  • Shuqiao Yang, Xi Zhan, Jing Wang, Yali Fan, Ruimin Ma, Qiao Ye. Serum Oncomarkers in Patients with MPO-ANCA-Positive Vasculitis: Diagnostic and Prognostic Predictive Values for Interstitial Lung Disease. Lung. 2022 06; 200(3):331-338. doi: 10.1007/s00408-022-00532-3. [PMID: 35426513]
  • Hong Zou, Shu-Han Liu, Rong Yang, Xue-Jing Wu, Ying-Ping Cao, Hui-Fang Huang. Combination of Neutrophil-to-Lymphocyte Ratio and Red Cell Distribution Width With Serum Tumor Markers for the Differential Diagnosis of Breast Cancer and its Association With Pathological Features and Molecular Types. Clinical breast cancer. 2022 06; 22(4):e526-e535. doi: 10.1016/j.clbc.2021.11.014. [PMID: 34963613]
  • Satoshi Matsui, Yusuke Yamamoto, Yukiyasu Okamura, Takaaki Ito, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Katsuhiko Uesaka, Teiichi Sugiura. The Prognostic Relevance of Preoperative CEA and CA19-9 for Ampulla of Vater Carcinoma. Anticancer research. 2022 Jun; 42(6):3169-3176. doi: 10.21873/anticanres.15806. [PMID: 35641260]
  • Andre Lopes, Evandro Sobroza de Mello, Rossana Veronica Mendoza Lopez, Paulo Cesar Leonardi, Ulysses Ribeiro. Prognostic Impact of Pathology, Cytoreduction, and Tumor Markers in Pseudomyxoma Peritonei. The Journal of surgical research. 2022 06; 274(?):68-76. doi: 10.1016/j.jss.2022.01.001. [PMID: 35123285]
  • Mengchen Shi, Yu Tian, Lingyuan He, Jingdan Zhang, Xiangling Yang, Huanliang Liu. Potential roles of serum ATPase and AMPase in predicting diagnosis of colorectal cancer patients. Bioengineered. 2022 06; 13(6):14204-14214. doi: 10.1080/21655979.2022.2084423. [PMID: 35754345]
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  • Zilong Zhang, Yuxin Liang, Deyuan Zhong, Zonglin Dai, Jin Shang, Chunyou Lai, Haibo Zou, Yutong Yao, Tianhang Feng, Xiaolun Huang. Prognostic value of inflammation-immunity-nutrition score in patients with hepatocellular carcinoma treated with anti-PD-1 therapy. Journal of clinical laboratory analysis. 2022 May; 36(5):e24336. doi: 10.1002/jcla.24336. [PMID: 35312116]
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