Sialyl-Lewis X (BioDeep_00000028232)

   

human metabolite Endogenous


代谢物信息卡片


(2S,4S,5R,6R)-2-{[(2S,3R,4S,5S,6R)-2-{[(2R,3R,4R,5R)-1,2-dihydroxy-5-[(1-hydroxyethylidene)amino]-6-oxo-4-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-5-[(1-hydroxyethylidene)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate

化学式: C31H52N2O23 (820.2961)
中文名称: 唾液酸化酶X
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC(C(C=O)NC(=O)C)C(C(CO)O)OC2C(C(C(C(O2)CO)O)OC3(CC(C(C(O3)C(C(CO)O)O)NC(=O)C)O)C(=O)O)O)O)O)O
InChI: InChI=1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)53-24(12(5-34)32-10(2)38)25(15(42)7-36)54-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1

描述信息

Carbohydrate antigen which is accumulated in various human cancer tissues and secreted into the blood stream. The carbohydrate moiety can be further modified with fucose or sialic acid. Monoclonal antibodies have been determined which can discriminate each subgroup of this antigen in the sera of cancer patients. Sialyl SSEA-1 antigen is particularly elevated in the sera of patients with a variety of tumors. [HMDB]
Carbohydrate antigen which is accumulated in various human cancer tissues and secreted into the blood stream. The carbohydrate moiety can be further modified with fucose or sialic acid. Monoclonal antibodies have been determined which can discriminate each subgroup of this antigen in the sera of cancer patients. Sialyl SSEA-1 antigen is particularly elevated in the sera of patients with a variety of tumors.

同义名列表

35 个代谢物同义名

(2S,4S,5R,6R)-2-{[(2S,3R,4S,5S,6R)-2-{[(2R,3R,4R,5R)-1,2-dihydroxy-5-[(1-hydroxyethylidene)amino]-6-oxo-4-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-5-[(1-hydroxyethylidene)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate; (2S,4S,5R,6R)-5-acetamido-2-{[(2S,3R,4S,5S,6R)-2-{[(2R,3R,4R,5R)-5-acetamido-1,2-dihydroxy-6-oxo-4-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid; alpha-NeuNAc-(2>3)-beta-delta-gal-(1>4)(a-L-fuc-[1>3])-delta-glcnac; a-NeuNAc-(2>3)-b-D-gal-(1>4)(a-L-fuc-[1>3])-D-glcnac; 3 alpha-Fucosyl-N-acetyl lactosamine; 3 alpha Fucosyl N acetyl lactosamine; Embryonic antigen-1, stage-specific; Stage specific embryonic antigen 1; Stage-specific embryonic antigen-1; 3-Sialyl-lewis-X tetrasaccharide; Galbeta(1-4)fucalpha(1-3)glcnac; SSEA-1 determinant; SSEA 1 determinant; Antigen, lewis X; X Antigen, lewis; 3-Sialyl-lewis X; X Hapten, lewis; Lewis X antigen; Leu m1 antigens; Leu-m1 antigens; Lewis X hapten; Sialyl lewis-X; Antigens, CD15; Sialyl-Lewis X; Sialyl lex tri; Le(X) antigen; Sialyl lewisx; CD15 Antigens; CD15 Antigen; Sialyl lex; Hapten X; SSEA-1; 3-SLeX; SSEA 1; SLex



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Minhui Guan, Alicia K Olivier, Xiaotong Lu, William Epperson, Xiaojian Zhang, Lei Zhong, Kaitlyn Waters, Nataly Mamaliger, Lei Li, Feng Wen, Yizhi J Tao, Thomas J DeLiberto, Xiu-Feng Wan. The Sialyl Lewis X Glycan Receptor Facilitates Infection of Subtype H7 Avian Influenza A Viruses. Journal of virology. 2022 10; 96(19):e0134422. doi: 10.1128/jvi.01344-22. [PMID: 36125302]
  • Richard Wargodsky, Philip Dela Cruz, John LaFleur, David Yamane, Justin Sungmin Kim, Ivy Benjenk, Eric Heinz, Obinna Ome Irondi, Katherine Farrar, Ian Toma, Tristan Jordan, Jennifer Goldman, Timothy A McCaffrey. RNA Sequencing in COVID-19 patients identifies neutrophil activation biomarkers as a promising diagnostic platform for infections. PloS one. 2022; 17(1):e0261679. doi: 10.1371/journal.pone.0261679. [PMID: 35081105]
  • Georges Tarris, Alexis de Rougemont, Marie-Anaïs Estienney, Julien Journet, Anne-Cécile Lariotte, Damien Aubignat, Jean-Michel Rebibou, Mathilde Funes De La Vega, Mathieu Legendre, Gael Belliot, Laurent Martin. Chronic kidney disease linked to SARS-CoV-2 infection: a case report. BMC nephrology. 2021 08; 22(1):278. doi: 10.1186/s12882-021-02490-z. [PMID: 34376184]
  • Mieke Metzemaekers, Bert Malengier-Devlies, Karen Yu, Sofie Vandendriessche, Jonas Yserbyt, Patrick Matthys, Lien De Somer, Carine Wouters, Paul Proost. Synovial Fluid Neutrophils From Patients With Juvenile Idiopathic Arthritis Display a Hyperactivated Phenotype. Arthritis & rheumatology (Hoboken, N.J.). 2021 05; 73(5):875-884. doi: 10.1002/art.41605. [PMID: 33264510]
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  • Hiroko Ideo, Jumpei Kondo, Taisei Nomura, Norio Nonomura, Masahiro Inoue, Junko Amano. Study of glycosylation of prostate-specific antigen secreted by cancer tissue-originated spheroids reveals new candidates for prostate cancer detection. Scientific reports. 2020 02; 10(1):2708. doi: 10.1038/s41598-020-59622-y. [PMID: 32066783]
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  • Tobias Schmidt, Aurélie Najm, Haider Mussawy, Rolf Burghardt, Nicola Oehler, Veit Krenn, Wolfgang Rüther, Andreas Niemeier. General synovitis score and immunologic synovitis score reflect clinical disease activity in patients with advanced stage rheumatoid arthritis. Scientific reports. 2019 06; 9(1):8448. doi: 10.1038/s41598-019-44895-9. [PMID: 31186464]
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  • Shuichi Kishimoto, Nobuhito Fujitani, Takanori Ohnishi, Hiroki Aoki, Ryosuke Suzuki, Shoji Fukushima. Cisplatin-loaded, Sialyl Lewis X-Modified Liposomes: Drug Release, Biodistribution and Antitumor Efficacy. Anticancer research. 2017 11; 37(11):6055-6061. doi: 10.21873/anticanres.12053. [PMID: 29061785]
  • Márcia Fernandes de Araújo, Renata Margarida Etchebehere, Marcelo Luiz Ribeiro de Melo, Marcela Beghini, Viviane Oliveira Severino, Eliângela de Castro Côbo, Denise Bertulucci Rocha Rodrigues, Sanívia Aparecida de Lima Pereira. Analysis of CD15, CD57 and HIF-1α in biopsies of patients with peri-implantitis. Pathology, research and practice. 2017 Sep; 213(9):1097-1101. doi: 10.1016/j.prp.2017.07.020. [PMID: 28778496]
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  • Faisal Aziz, Wei Gao, Qiu Yan. Fucosyltransferase-4 and Oligosaccharide Lewis Y Antigen as potentially Correlative Biomarkers of Helicobacter pylori CagA Associated Gastric Cancer. Pathology oncology research : POR. 2017 Jan; 23(1):173-179. doi: 10.1007/s12253-016-0122-1. [PMID: 27757838]
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