NSC312620 (BioDeep_00000282317)
代谢物信息卡片
NSC312620
化学式: C28H40O8 (504.2723)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C)C(=O)OC(C(C)(O)C2(O)CCC3(O)C4CC(O)C5(O)CC=CC(=O)C5(C)C4CCC32C)C1
InChI:
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Tingting Li, Si Gao, Yundong Wei, Gang Wu, Yiping Feng, Yanyan Wang, Xudong Jiang, Haixue Kuang, Wei Han. Combined untargeted metabolomics and network pharmacology approaches to reveal the therapeutic role of withanolide B in psoriasis.
Journal of pharmaceutical and biomedical analysis.
2024 Aug; 245(?):116163. doi:
10.1016/j.jpba.2024.116163. [PMID: 38657365] - Tarun Halder, Biswajit Ghosh. Withania somnifera (L.) Dunal: Enhanced production of withanolides and phenolic acids from hairy root culture after application of elicitors.
Journal of biotechnology.
2024 Jun; 388(?):59-71. doi:
10.1016/j.jbiotec.2024.04.010. [PMID: 38636845] - Fu-Rui Wang, Mei-Lin Peng, Qin-Feng Zhu, Ling-Ling Yu, Li-Jie Zhang, Shi-Ying Xu, Qian Wang, Jing Li, Xun He, Shang-Gao Liao, Jun-Li Ao, Guo-Bo Xu. Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Journal of ethnopharmacology.
2024 May; 325(?):117830. doi:
10.1016/j.jep.2024.117830. [PMID: 38301983] - Ke Xiang, Yan Liu, Rui Zhu, Yang Xu, Dejuan Sun, Yueying Yang, Yushu Yan, Bingyou Yang, Hua Li, Lixia Chen. Cytotoxic withanolides from the stems and leaves of Physalis ixocarpa.
Food chemistry.
2024 May; 439(?):138136. doi:
10.1016/j.foodchem.2023.138136. [PMID: 38064840] - Geetanjali Devabattula, Biswajit Panda, Rachana Yadav, Chandraiah Godugu. The Potential Pharmacological Effects of Natural Product Withaferin A in Cancer: Opportunities and Challenges for Clinical Translation.
Planta medica.
2024 May; 90(6):440-453. doi:
10.1055/a-2289-9600. [PMID: 38588695] - Lili Huang, Yingying Wei, Maowei Ni, Hongtao Hu, Luyi Xi, Chen Wang, Zhihui Zhu, Bo Yang, Huajun Zhao. Novel Withanolides from Tubocapsicum anomalum Suppress Triple-Negative Breast Cancer by Triggering Apoptosis and p53-ASCT2-SLC7A11-Mediated Ferroptosis.
Molecules (Basel, Switzerland).
2024 Apr; 29(8):. doi:
10.3390/molecules29081838. [PMID: 38675657] - Xiaoxing Liu, Chunyu Chen, Yingying Lin, Yanhong Liu, Shaochun Cai, Dongcui Li, Li Li, Peigen Xiao, Fan Yi. Withania somnifera root extract inhibits MGO-induced skin fibroblast cells dysfunction via ECM-integrin interaction.
Journal of ethnopharmacology.
2024 Apr; 323(?):117699. doi:
10.1016/j.jep.2023.117699. [PMID: 38185262] - Vidyadhar G Vaidya, Ninad N Naik, Gayatri Ganu, Vijay Parmar, Shubham Jagtap, Ganesh Saste, Ankit Bhatt, Vallabh Mulay, Aboli Girme, Siddharth J Modi, Lal Hingorani. Clinical pharmacokinetic evaluation of Withania somnifera (L.) Dunal root extract in healthy human volunteers: A non-randomized, single dose study utilizing UHPLC-MS/MS analysis.
Journal of ethnopharmacology.
2024 Mar; 322(?):117603. doi:
10.1016/j.jep.2023.117603. [PMID: 38122911] - Mahbobeh Karami, Mohammad Reza Naghavi, Jaber Nasiri, Narjes Farzin, Codruta Ignea. Enhanced production of withaferin A from the hairy root culture of Withania somnifera via synergistic effect of Methyl jasmonate and β-cyclodextrin.
Plant physiology and biochemistry : PPB.
2024 Mar; 208(?):108440. doi:
10.1016/j.plaphy.2024.108440. [PMID: 38412705] - Bhawana Mishra, Shilpi Bansal, Sandhya Tripathi, Smrati Mishra, Ritesh K Yadav, Neelam S Sangwan. Differential regulation of key triterpene synthase gene under abiotic stress in Withania somnifera L. Dunal and its co-relation to sterols and withanolides.
Plant physiology and biochemistry : PPB.
2024 Mar; 208(?):108419. doi:
10.1016/j.plaphy.2024.108419. [PMID: 38377888] - Nisha Yadav, Sandhya Tripathi, Neelam S Sangwan. Phyto-therapeutic potential of Withania somnifera: Molecular mechanism and health implications.
Phytotherapy research : PTR.
2024 Mar; 38(3):1695-1714. doi:
10.1002/ptr.8100. [PMID: 38318763] - Juan Pan, Yan Liu, Xin-Yuan Li, Si-Yi Wang, Jia-Tong Wu, Meng-Meng Li, Wei Guan, Adnan Mohammed Algradi, Hai-Xue Kuang, Bing-You Yang. Cytotoxic withanolides from the leaves of Datura stramonium L.
Chemistry & biodiversity.
2024 Feb; 21(2):e202301655. doi:
10.1002/cbdv.202301655. [PMID: 38084071] - Qiang Zhang, YongKang Yuan, Shijie Cao, Ning Kang, Feng Qiu. Withanolides: Promising candidates for cancer therapy.
Phytotherapy research : PTR.
2024 Feb; 38(2):1104-1158. doi:
10.1002/ptr.8090. [PMID: 38176694] - Jinghan Zhang, Xiao Xu, Yu Zhao, Chunling Ren, Mengzhen Gu, Haili Zhang, Peiye Wu, Yun Wang, Lingyi Kong, Chao Han. Target Separation and Potential Anticancer Activity of Withanolide-Based Glucose Transporter Protein 1 Inhibitors from Physalis angulata var. villosa.
Journal of natural products.
2024 01; 87(1):2-13. doi:
10.1021/acs.jnatprod.3c00613. [PMID: 38117981] - Jian-Fei Zhang, Si-Fang Wu, Ling Zhu, Yu-Xing Cai, Zhan-Peng Yu, Ling-Yi Kong, Jian-Guang Luo. Withanolides from Physalis angulata var. villosa and the Relative Configurational Revision of Some Known Analogs.
Journal of natural products.
2024 01; 87(1):38-49. doi:
10.1021/acs.jnatprod.3c00725. [PMID: 38207331] - Franco Cavaleri, Sukalpa Chattopadhyay, Vrushalee Palsule, Pradip Kumar Kar, Ritam Chatterjee. Study of Drug Targets Associated With Oncogenesis and Cancer Cell Survival and the Therapeutic Activity of Engineered Ashwagandha Extract Having Differential Withanolide Constitutions.
Integrative cancer therapies.
2024 Jan; 23(?):15347354231223499. doi:
10.1177/15347354231223499. [PMID: 38281118] - Nuria Vilaboa, Richard Voellmy. Withaferin A and Celastrol Overwhelm Proteostasis.
International journal of molecular sciences.
2023 Dec; 25(1):. doi:
10.3390/ijms25010367. [PMID: 38203539] - J D Sheng, J Liu, J W Du, Y P Wang. Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2023 Dec; 74(6):. doi:
10.26402/jpp.2023.6.08. [PMID: 38345447] - Peng Wang, Xiao-Meng Yang, Zhan-Xing Hu, Ya-Nan Li, Jue Yang, Xiao-Jiang Hao, Chun-Mao Yuan, Ping Yi. UPLC-Q-Orbitrap-MS/MS-Guided Isolation of Bioactive Withanolides from the Fruits of Physalis angulata.
Journal of agricultural and food chemistry.
2023 Nov; 71(44):16581-16592. doi:
10.1021/acs.jafc.3c04311. [PMID: 37897427] - Monu Dinesh Ojha, Ajay Yadav, Hariprasad P. Analyzing the potential of selected plant extracts and their structurally diverse secondary metabolites for α-glucosidase inhibitory activity: in vitro and in silico approach.
Journal of biomolecular structure & dynamics.
2023 11; 41(19):9523-9538. doi:
10.1080/07391102.2022.2142847. [PMID: 36345773] - Daisuke Nakano, Kenji Ishitsuka, Yurie Deishi, Ryota Tsuchihashi, Junei Kinjo, Toshihiro Nohara, Masafumi Okawa. Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (VIII): six new withanolides from Physalis philadelphica.
Journal of natural medicines.
2023 Sep; 77(4):688-698. doi:
10.1007/s11418-023-01705-x. [PMID: 37202653] - Akira Yano, Sayaka Yuki, Akiko Shiraishi, Mayuka Hakozaki, Yuko Kanno, Ken-Ichi Kimura, Shota Uesugi. Golden berry leaf extract containing withanolides suppresses TNF-α and IL-17 induced IL-6 expression in HeLa Cells.
Bioscience, biotechnology, and biochemistry.
2023 Aug; 87(9):972-980. doi:
10.1093/bbb/zbad070. [PMID: 37279446] - Pawan Kumar, Samudra P Banik, Apurva Goel, Sanjoy Chakraborty, Manashi Bagchi, Debasis Bagchi. A critical assessment of the whole plant-based phytotherapeutics from Withania somnifera(L.) Dunal with respect to safety and efficacy vis-a-vis leaf or root extract-based formulation.
Toxicology mechanisms and methods.
2023 Aug; ?(?):1-25. doi:
10.1080/15376516.2023.2242933. [PMID: 37533233] - Pawan Kumar, Samudra P Banik, Apurva Goel, Sanjoy Chakraborty, Manashi Bagchi, Debasis Bagchi. Revisiting the Multifaceted Therapeutic Potential of Withaferin A (WA), a Novel Steroidal Lactone, W-ferinAmax (Ashwagandha), from Withania Somnifera (L) Dunal.
Journal of the American Nutrition Association.
2023 Jul; ?(?):1-16. doi:
10.1080/27697061.2023.2228863. [PMID: 37410676] - Kibrom Gebreheiwot Bedane, Mekonnen Abebayehu Desta, Peter Spiteller. Withanolides from Discopodium penninervium.
Fitoterapia.
2023 Jun; 167(?):105478. doi:
10.1016/j.fitote.2023.105478. [PMID: 36965582] - Eun-Ryeong Hahm, Su-Hyeong Kim, Shivendra V Singh. Withaferin A inhibits breast cancer-induced osteoclast differentiation.
Molecular carcinogenesis.
2023 Apr; ?(?):. doi:
10.1002/mc.23545. [PMID: 37067392] - Qian-Ran Li, Hui-Jun Liang, Bai-Lin Li, Zhuo-Yi Ao, Yu-Wen Fan, Wei-Jie Zhang, Xin Lian, Jia-Yan Chen, Juan-Juan Hu, Jie Yuan, Jie-Wei Wu. Two new withanolides from the whole plants of Physalis peruviana.
Journal of Asian natural products research.
2023 Apr; 25(4):349-356. doi:
10.1080/10286020.2022.2095263. [PMID: 35796599] - Yu-Hang Tan, Yu-Xing Cai, Min Kong, Ya-Lin Li, Zhan-Peng Yu, Ling-Yi Kong, Jian-Guang Luo. Withanolides from Physalin angulata and Their Inhibitory Effects on Nitric Oxide Production.
Chemistry & biodiversity.
2023 Apr; 20(4):e202300195. doi:
10.1002/cbdv.202300195. [PMID: 36932465] - Rahul Checker, H N Bhilwade, Shivani R Nandha, Raghavendra S Patwardhan, Deepak Sharma, Santosh K Sandur. Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis.
Toxicology and applied pharmacology.
2023 Feb; 461(?):116389. doi:
10.1016/j.taap.2023.116389. [PMID: 36716864] - Vishal Sharma, Somdutt Mujwar, Diksha Sharma, Rina Das, Dinesh Kumar Mehta, Kamal Shah. Computational Design of Plant-Based Antistress Agents Targeting Nociceptin Receptor.
Chemistry & biodiversity.
2023 Feb; 20(2):e202201038. doi:
10.1002/cbdv.202201038. [PMID: 36644820] - Hesham S M Soliman, Eslam M Korany, Elsayed K El-Sayed, Ahmed M Aboelyazed, Haitham A Ibrahim. Nephroprotective effect of Physalis peruviana L. calyx extract and its butanolic fraction against cadmium chloride toxicity in rats and molecular docking of isolated compounds.
BMC complementary medicine and therapies.
2023 Jan; 23(1):21. doi:
10.1186/s12906-023-03845-9. [PMID: 36707799] - Sanjay H Deshpande, Abdullatif Bin Muhsinah, Zabin K Bagewadi, Gireesh M Ankad, Mater H Mahnashi, Deepak A Yaraguppi, Ibrahim Ahmed Shaikh, Aejaz Abdullatif Khan, Harsha V Hegde, Subarna Roy. In Silico Study on the Interactions, Molecular Docking, Dynamics and Simulation of Potential Compounds from Withania somnifera (L.) Dunal Root against Cancer by Targeting KAT6A.
Molecules (Basel, Switzerland).
2023 Jan; 28(3):. doi:
10.3390/molecules28031117. [PMID: 36770785] - Asmaa Mahana, Hala M Hammoda, Asmaa A Khalifa, Samar S Elblehi, Fathallah M Harraz, Eman Shawky. Integrated serum pharmacochemistry and network pharmacology analyses reveal the bioactive metabolites and potential functional mechanism of ground cherry (Physalis pruinosa L.) in treatment of type 2 diabetes mellitus in rats.
Journal of ethnopharmacology.
2023 Jan; 300(?):115750. doi:
10.1016/j.jep.2022.115750. [PMID: 36162547] - Bharathi Nathan, Archana Prabahar, M M Sudheer Mohammed. Network analysis of anti-inflammatory phytochemicals and omics data for Rheumatoid arthritis.
Current computer-aided drug design.
2023 Jan; ?(?):. doi:
10.2174/1573409919666230106125058. [PMID: 36617711] - Krishna B Singh, Eun-Ryeong Hahm, Su-Hyeong Kim, Shivendra V Singh. Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors.
Cancer prevention research (Philadelphia, Pa.).
2023 01; 16(1):5-16. doi:
10.1158/1940-6207.capr-22-0193. [PMID: 36251722] - Pulkit Kumar, Dhaniket Patel. Can Traditional Treatment Such as Ashwagandha Be Beneficial in Treating Depression?.
Alternative therapies in health and medicine.
2023 Jan; 29(1):36-39. doi:
. [PMID: 35139495] - Alessandro Orrù, Giorgio Marchese, Stefania Ruiu. Alkaloids in Withania somnifera (L.) Dunal Root Extract Contribute to Its Anti-Inflammatory Activity.
Pharmacology.
2023; 108(3):301-307. doi:
10.1159/000527656. [PMID: 36754044] - Raj Kumar Chinnadurai, Saravanaraman Ponne, Loganathan Chitra, Rajender Kumar, Palvannan Thayumanavan, Balanehru Subramanian. Pharmacoinformatic approach to identify potential phytochemicals against SARS-CoV-2 spike receptor-binding domain in native and variants of concern.
Molecular diversity.
2022 Dec; ?(?):. doi:
10.1007/s11030-022-10580-9. [PMID: 36547813] - Alisson A Almeida, Betania B Cota, Laís A Rodrigues, Luana L Dutra, Markus Kohlhoff, Gustavo C Bressan, Geraldo C Brandão, João P V Leite. Withalutin, a new cytotoxic withanolide from Athenaea velutina (Sendtn.) D'Arcy.
Natural product research.
2022 Dec; 36(24):6304-6311. doi:
10.1080/14786419.2022.2039135. [PMID: 35156453] - Yue Yang, Fei Zhou, Min Wang, Mukhammadrizo Turanazarov, Xiao-Rong Wang, Changqiang Ke, Sheng Yao, Ligen Lin, Chunping Tang, Yang Ye. Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri.
Molecules (Basel, Switzerland).
2022 Nov; 27(23):. doi:
10.3390/molecules27238197. [PMID: 36500291] - Asmaa Mahana, Hala M Hammoda, Fathalla M Harraz, Eman Shawky. Metabolomics combined to chemometrics reveals the putative α-glucosidase and α-amylase inhibitory metabolites of ground cherry (Physalis pruinosa L.).
Food research international (Ottawa, Ont.).
2022 11; 161(?):111903. doi:
10.1016/j.foodres.2022.111903. [PMID: 36192919] - Késya Amanda Dantas Rocha, Tércio de Freitas Paulo, Alejandro Pedro Ayala, Valéria da Silva Sampaio, Paulo Iury Gomes Nunes, Flávia Almeida Santos, Kirley Marques Canuto, Edilberto Rocha Silveira, Otília Deusdenia Loiola Pessoa. Anti-inflammatory withajardins from the leaves of Athenaea velutina.
Phytochemistry.
2022 Nov; 203(?):113338. doi:
10.1016/j.phytochem.2022.113338. [PMID: 35948140] - Zheyi Yan, Yuanlin Zhang, Chunfang Wang, Yanjie Li, Qiang Su, Jimin Cao, Xiaoming Cao. Withaferin a Attenuates Retinal Ischemia-Reperfusion Injury via Akt-Dependent Inhibition of Oxidative Stress.
Cells.
2022 10; 11(19):. doi:
10.3390/cells11193113. [PMID: 36231074] - Wenhui Liu, Han Zhang, Hongxu Wan, Jiantong Hou, Dongho Lee, Jing Xu, Yuanqiang Guo. Anti-inflammatory withanolides from the aerial parts of Physalis minima.
Phytochemistry.
2022 Oct; 202(?):113301. doi:
10.1016/j.phytochem.2022.113301. [PMID: 35780926] - Helen Holvoet, Dani M Long, Alexander Law, Christine McClure, Jaewoo Choi, Liping Yang, Luke Marney, Burkhard Poeck, Roland Strauss, Jan F Stevens, Claudia S Maier, Amala Soumyanath, Doris Kretzschmar. Withania somnifera Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in Drosophila melanogaster; a Possible Role of Other Compounds besides Withanolides.
Nutrients.
2022 Sep; 14(19):. doi:
10.3390/nu14193923. [PMID: 36235577] - Altevir Rossato Viana, B Godoy Noro, J C Lenz, M Luiza Machado Teixeira, M Bolson Serafin, R Hörner, C Franco, L Maria Fontanari Krause, B Stefanello Vizzotto, B Jalfim Maraschin. Cytotoxic screening and antibacterial activity of Withaferin A.
Journal of toxicology and environmental health. Part A.
2022 08; 85(16):685-698. doi:
10.1080/15287394.2022.2071787. [PMID: 35579288] - Bassam Oudh Aljohny, Yasir Anwar, Shahid Ali Khan. In vitro anticancer and antibacterial potentials of selected medicinal plants and isolation and characterization of a natural compound from Withania coagulans.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2022 Jul; 77(7-8):263-270. doi:
10.1515/znc-2021-0259. [PMID: 34902232] - Hai-Yan Wang, Pian Yu, Xi-Sha Chen, Hui Wei, Shi-Jie Cao, Meng Zhang, Yi Zhang, Yong-Guang Tao, Dong-Sheng Cao, Feng Qiu, Yan Cheng. Identification of HMGCR as the anticancer target of physapubenolide against melanoma cells by in silico target prediction.
Acta pharmacologica Sinica.
2022 Jun; 43(6):1594-1604. doi:
10.1038/s41401-021-00745-x. [PMID: 34588618] - Yashdeep Srivastava, Sandhya Tripathi, Bhawana Mishra, Neelam S Sangwan. Cloning and homologous characterization of geranylgeranyl pyrophosphate synthase (GGPPS) from Withania somnifera revealed alterations in metabolic flux towards gibberellic acid biosynthesis.
Planta.
2022 Jun; 256(1):4. doi:
10.1007/s00425-022-03912-4. [PMID: 35648276] - Jia-Tong Wu, Yan Liu, Si-Yi Wang, Yi-Kai Jiang, Xiao-Mao Li, Anam Naseem, Wei Guan, Juan Pan, Hai-Xue Kuang, Bing-You Yang. Four new withanolides with anti-inflammatory activity from Datura inoxia Mill. leaves.
Steroids.
2022 06; 182(?):109010. doi:
10.1016/j.steroids.2022.109010. [PMID: 35283117] - Jia-Tong Wu, Yan Liu, Yi-Kai Jiang, Si-Yi Wang, Chen-Yu Jiang, Adnan Mohammed Algradi, Juan Pan, Wei Guan, Hai-Xue Kuang, Bing-You Yang. Datinolides E-I, five new withanolides with anti-inflammatory activity from the leaves of Datura inoxia Mill.
Fitoterapia.
2022 Jun; 159(?):105204. doi:
10.1016/j.fitote.2022.105204. [PMID: 35504512] - Fui Fui Lem, Yoong Soon Yong, Saintella Goh, Su Na Chin, Fong Tyng Chee. Withanolides, the hidden gem in Physalis minima: A mini review on their anti-inflammatory, anti-neuroinflammatory and anti-cancer effects.
Food chemistry.
2022 May; 377(?):132002. doi:
10.1016/j.foodchem.2021.132002. [PMID: 35033733] - Bintao Hu, Han Li, Chunping Tang, Chang-Qiang Ke, Meiyu Geng, Sheng Yao, Zuoquan Xie, Yang Ye. Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities.
Journal of agricultural and food chemistry.
2022 May; 70(18):5595-5609. doi:
10.1021/acs.jafc.2c01519. [PMID: 35476903] - Acharya Balkrishna, Siva Kumar Solleti, Hoshiyar Singh, Niti Sharma, Anurag Varshney. Withanolides from Withania somnifera Ameliorate Neutrophil Infiltration in Endotoxin-Induced Peritonitis by Regulating Oxidative Stress and Inflammatory Cytokines.
Planta medica.
2022 May; 88(6):466-478. doi:
10.1055/a-1438-2816. [PMID: 33862643] - Alisson A Almeida, Graziela D A Lima, Marinês Eiterer, Laís A Rodrigues, Juliana A A do Vale, Ana C Zanatta, Gustavo C Bressan, Leandro L de Oliveira, João P V Leite. A Withanolide-rich Fraction of Athenaea velutina Induces Apoptosis and Cell Cycle Arrest in Melanoma B16F10 Cells.
Planta medica.
2022 May; 88(6):429-439. doi:
10.1055/a-1395-9046. [PMID: 33853120] - Yangliu Xia, Mingrui Yan, Ping Wang, Keisuke Hamada, Nana Yan, Haiping Hao, Frank J Gonzalez, Tingting Yan. Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights.
Drug metabolism and disposition: the biological fate of chemicals.
2022 05; 50(5):685-693. doi:
10.1124/dmd.121.000455. [PMID: 34903587] - Richa Shukla, Sonu Pahal, Ayushi Gupta, Princy Choudhary, Krishna Misra, Sangeeta Singh. Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer's and Parkinson's diseases as druggable targets through Withania somnifera bioactives: an in silico study.
Journal of biomolecular structure & dynamics.
2022 May; ?(?):1-19. doi:
10.1080/07391102.2022.2068072. [PMID: 35491707] - Gui-Yang Xia, Shi-Jie Cao, Li-Xia Chen, Feng Qiu. Natural withanolides, an update.
Natural product reports.
2022 04; 39(4):784-813. doi:
10.1039/d1np00055a. [PMID: 34816854] - Jen-Yang Tang, Yuan-Bin Cheng, Ya-Ting Chuang, Kun-Han Yang, Fang-Rong Chang, Wangta Liu, Hsueh-Wei Chang. Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides.
Cells.
2022 03; 11(6):. doi:
10.3390/cells11060961. [PMID: 35326412] - Yang Su, Fan Zhang, Lun Wu, Haixue Kuang, Qiuhong Wang, Genhong Cheng. Total withanolides ameliorates imiquimod-induced psoriasis-like skin inflammation.
Journal of ethnopharmacology.
2022 Mar; 285(?):114895. doi:
10.1016/j.jep.2021.114895. [PMID: 34875348] - Keisuke Hamada, Ping Wang, Yangliu Xia, Nana Yan, Shogo Takahashi, Kristopher W Krausz, Haiping Hao, Tingting Yan, Frank J Gonzalez. Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Feb; 160(?):112807. doi:
10.1016/j.fct.2022.112807. [PMID: 34995708] - Ya-Ming Xu, E M Kithsiri Wijeratne, Manping X Liu, Lijiang Xuan, Wenqiong Wang, A A Leslie Gunatilaka. Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl.
Molecules (Basel, Switzerland).
2022 Jan; 27(3):. doi:
10.3390/molecules27030909. [PMID: 35164184] - Hittanahallikoppal Gajendramurthy Gowtham, Mahadevamurthy Murali, Sudarshana Brijesh Singh, Chandan Shivamallu, Sushma Pradeep, C S Shivakumar, Satish Anandan, Anjana Thampy, Raghu Ram Achar, Ekaterina Silina, Victor Stupin, Joaquín Ortega-Castro, Juan Frau, Norma Flores-Holguín, Kestur Nagaraj Amruthesh, Shiva Prasad Kollur, Daniel Glossman-Mitnik. Phytoconstituents of Withania somnifera unveiled Ashwagandhanolide as a potential drug targeting breast cancer: Investigations through computational, molecular docking and conceptual DFT studies.
PloS one.
2022; 17(10):e0275432. doi:
10.1371/journal.pone.0275432. [PMID: 36201520] - Sartaz Begum, Daniel M Shadrack, Ferister M Joseph, Valence M K Ndensendo. Molecular dynamics simulation of bioactive compounds of Withania somnifera leaf extract as DNA gyrase inhibitor.
Journal of biomolecular structure & dynamics.
2022; 40(19):9279-9286. doi:
10.1080/07391102.2021.1927191. [PMID: 34018468] - Vipul Kumar, Jaspreet Kaur Dhanjal, Priyanshu Bhargava, Ashish Kaul, Jia Wang, Huayue Zhang, Sunil C Kaul, Renu Wadhwa, Durai Sundar. Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells.
Journal of biomolecular structure & dynamics.
2022 01; 40(1):1-13. doi:
10.1080/07391102.2020.1775704. [PMID: 32469279] - Tahira Sultana, Mohammad K Okla, Madiha Ahmed, Nosheen Akhtar, Abdulrahman Al-Hashimi, Hamada Abdelgawad, Ihsan-Ul- Haq. Withaferin A: From Ancient Remedy to Potential Drug Candidate.
Molecules (Basel, Switzerland).
2021 Dec; 26(24):. doi:
10.3390/molecules26247696. [PMID: 34946778] - Sumit K Soni, Rakshapal Singh, Nem K Ngpoore, Abhishek Niranjan, Purnima Singh, Aradhana Mishra, Sudeep Tiwari. Isolation and characterization of endophytic fungi having plant growth promotion traits that biosynthesizes bacosides and withanolides under in vitro conditions.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].
2021 Dec; 52(4):1791-1805. doi:
10.1007/s42770-021-00586-0. [PMID: 34339015] - Muhammad Issa Khan, Maria Maqsood, Raakia Anam Saeed, Amna Alam, Amna Sahar, Marek Kieliszek, Antoni Miecznikowski, Hafiz Shehzad Muzammil, Rana Muhammad Aadil. Phytochemistry, Food Application, and Therapeutic Potential of the Medicinal Plant (Withania coagulans): A Review.
Molecules (Basel, Switzerland).
2021 Nov; 26(22):. doi:
10.3390/molecules26226881. [PMID: 34833974] - Vito A Taddeo, Marvin J Núñez, Manuela Beltrán, Ulises G Castillo, Jenny Menjívar, Ignacio A Jiménez, José Alcamí, Luis M Bedoya, Isabel L Bazzocchi. Withanolide-Type Steroids from Physalis nicandroides Inhibit HIV Transcription.
Journal of natural products.
2021 10; 84(10):2717-2726. doi:
10.1021/acs.jnatprod.1c00637. [PMID: 34549952] - Priya Pathak, Prachi Shukla, Jitendra S Kanshana, Kumaravelu Jagavelu, Neelam S Sangwan, Anil K Dwivedi, Madhu Dikshit. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation.
Journal of ethnopharmacology.
2021 Oct; 278(?):114296. doi:
10.1016/j.jep.2021.114296. [PMID: 34090907] - Jia Wang, Huayue Zhang, Ashish Kaul, Kejuan Li, Didik Priyandoko, Sunil C Kaul, Renu Wadhwa. Effect of Ashwagandha Withanolides on Muscle Cell Differentiation.
Biomolecules.
2021 10; 11(10):. doi:
10.3390/biom11101454. [PMID: 34680087] - Yue Wang, Kai-Lin Yang, Chun-Nian He, Pei-Gen Xiao. [Withania somnifera: a kind of food-medicine plant popular in world in recent years].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Oct; 46(20):5159-5165. doi:
10.19540/j.cnki.cjcmm.20210725.101. [PMID: 34738415] - Luqiong Wang, Shiqing Lu, Liying Wang, Min Xin, Yaoyao Xu, Ge Wang, Daquan Chen, Lixia Chen, Sheng Liu, Feng Zhao. Anti-inflammatory effects of three withanolides isolated from Physalis angulata L. in LPS-activated RAW 264.7 cells through blocking NF-κB signaling pathway.
Journal of ethnopharmacology.
2021 Aug; 276(?):114186. doi:
10.1016/j.jep.2021.114186. [PMID: 33957208] - Hoang Le Tuan Anh, Vinh Le Ba, Thi Thao Do, Van Kiem Phan, Hai Yen Pham Thi, Long Giang Bach, Manh Hung Tran, Phuong Anh Tran Thi, Young Ho Kim. Bioactive compounds from Physalis angulata and their anti-inflammatory and cytotoxic activities.
Journal of Asian natural products research.
2021 Aug; 23(8):809-817. doi:
10.1080/10286020.2020.1825390. [PMID: 33030034] - Jaspreet Kaur Dhanjal, Vipul Kumar, Sukant Garg, Chandru Subramani, Shubhra Agarwal, Jia Wang, Huayue Zhang, Ashish Kaul, Rajkumar Singh Kalra, Sunil C Kaul, Sudhanshu Vrati, Durai Sundar, Renu Wadhwa. Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides.
International journal of biological macromolecules.
2021 Aug; 184(?):297-312. doi:
10.1016/j.ijbiomac.2021.06.015. [PMID: 34118289] - Tripti Joshi, Vipendra Kumar, Elena V Kaznacheyeva, Nihar Ranjan Jana. Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington's Disease.
Molecular neurobiology.
2021 Aug; 58(8):3992-4006. doi:
10.1007/s12035-021-02397-8. [PMID: 33904021] - Tatsunosuke Tomita, Renu Wadhwa, Sunil C Kaul, Ryoji Kurita, Naoshi Kojima, Yoshiaki Onishi. Withanolide Derivative 2,3-Dihydro-3β-methoxy Withaferin-A Modulates the Circadian Clock via Interaction with RAR-Related Orphan Receptor α (RORa).
Journal of natural products.
2021 07; 84(7):1882-1888. doi:
10.1021/acs.jnatprod.0c01276. [PMID: 34152143] - Regan Odongo, Asuman Demiroglu-Zergeroglu, Tunahan Çakır. A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data.
BMC complementary medicine and therapies.
2021 Jun; 21(1):181. doi:
10.1186/s12906-021-03340-z. [PMID: 34193143] - Elisa Bonandi, Mattia Mori, Paola Infante, Irene Basili, Lucia Di Marcotullio, Andrea Calcaterra, Federica Catti, Bruno Botta, Daniele Passarella. Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors.
Chemistry (Weinheim an der Bergstrasse, Germany).
2021 Jun; 27(32):8350-8357. doi:
10.1002/chem.202100315. [PMID: 33811701] - Viet Cuong Le Canh, Vinh Le Ba, Pham Thi Hai Yen, Lien Le Thi, Pham Thi Thuy Hoai, Ton That Huu Dat, Do Thi Thao, Long Giang Bach, Young Ho Kim, Hoang Le Tuan Anh. Identification Of Potential Cytotoxic Inhibitors From Physalis Minima.
Natural product research.
2021 Jun; 35(12):2082-2085. doi:
10.1080/14786419.2019.1650360. [PMID: 31402707] - Tingting Li, Zheng Wei, Haixue Kuang. UPLC-orbitrap-MS-based metabolic profiling of HaCaT cells exposed to withanolides extracted from Datura metel.L: Insights from an untargeted metabolomics.
Journal of pharmaceutical and biomedical analysis.
2021 May; 199(?):113979. doi:
10.1016/j.jpba.2021.113979. [PMID: 33845385] - Emma Maldonado, Teresa Ramírez-Apan, Mahinda Martínez. Cytotoxic withanolides from Datura innoxia.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2021 May; 76(5-6):251-255. doi:
10.1515/znc-2020-0265. [PMID: 33909956] - Kenjiro Kumano, Mazhar A Kanak, Prathab Balaji Saravanan, J P Blanck, Yang Liu, Srividya Vasu, Michael Lawrence, Bashoo Naziruddin. Withaferin A inhibits lymphocyte proliferation, dendritic cell maturation in vitro and prolongs islet allograft survival.
Scientific reports.
2021 05; 11(1):10661. doi:
10.1038/s41598-021-90181-y. [PMID: 34021233] - Ajay G Namdeo, Deepa K Ingawale. Ashwagandha: Advances in plant biotechnological approaches for propagation and production of bioactive compounds.
Journal of ethnopharmacology.
2021 May; 271(?):113709. doi:
10.1016/j.jep.2020.113709. [PMID: 33346029] - Ke Xiang, Chen Li, Ming-Xue Li, Zhuo-Rui Song, Xiao-Xin Ma, De-Juan Sun, Hua Li, Li-Xia Chen. Withanolides isolated from Tubocapsicum anomalum and their antiproliferative activity.
Bioorganic chemistry.
2021 05; 110(?):104809. doi:
10.1016/j.bioorg.2021.104809. [PMID: 33752145] - Sandeep K Singh, Guru R Valicherla, Anil K Bikkasani, Srikanth H Cheruvu, Zakir Hossain, Isha Taneja, Hafsa Ahmad, Kanumuri S R Raju, Neelam S Sangwan, Shio K Singh, Anil K Dwivedi, Mohammad Wahajuddin, Jiaur R Gayen. Elucidation of plasma protein binding, blood partitioning, permeability, CYP phenotyping and CYP inhibition studies of Withanone using validated UPLC method: An active constituent of neuroprotective herb Ashwagandha.
Journal of ethnopharmacology.
2021 Apr; 270(?):113819. doi:
10.1016/j.jep.2021.113819. [PMID: 33460762] - Simona Bungau, Cosmin Mihai Vesa, Areha Abid, Tapan Behl, Delia Mirela Tit, Anamaria Lavinia Purza, Bianca Pasca, Laura Maghiar Todan, Laura Endres. Withaferin A-A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases.
Molecules (Basel, Switzerland).
2021 Apr; 26(9):. doi:
10.3390/molecules26092407. [PMID: 33919088] - Yueying Yang, Ke Xiang, Dejuan Sun, Mengzhu Zheng, Zhuorui Song, Mingxue Li, Xuanbin Wang, Hua Li, Lixia Chen. Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
Bioorganic & medicinal chemistry.
2021 04; 36(?):116095. doi:
10.1016/j.bmc.2021.116095. [PMID: 33735687] - Janine Naß, Sara Abdelfatah, Thomas Efferth. Induction of stress resistance and extension of lifespan in Chaenorhabditis elegans serotonin-receptor knockout strains by withanolide A.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Apr; 84(?):153482. doi:
10.1016/j.phymed.2021.153482. [PMID: 33611213] - Su-Hyeong Kim, Krishna B Singh, Eun-Ryeong Hahm, Shivendra V Singh. The Role of Forkhead Box Q1 Transcription Factor in Anticancer Effects of Withaferin A in Breast Cancer.
Cancer prevention research (Philadelphia, Pa.).
2021 04; 14(4):421-432. doi:
10.1158/1940-6207.capr-20-0590. [PMID: 33509807] - Shreya Dubey, Monika Kallubai, Rajagopal Subramanyam. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives.
International journal of biological macromolecules.
2021 Mar; 173(?):56-65. doi:
10.1016/j.ijbiomac.2021.01.094. [PMID: 33465364] - Liying Wang, Jinpo Gu, Mingyue Zong, Qingran Zhang, Huixiang Li, Danna Li, Xiaofeng Mou, Pan Liu, Yanan Liu, Feng Qiu, Feng Zhao. Anti-inflammatory action of physalin A by blocking the activation of NF-κB signaling pathway.
Journal of ethnopharmacology.
2021 Mar; 267(?):113490. doi:
10.1016/j.jep.2020.113490. [PMID: 33091501] - Zheng Wei, Tingting Li, Yanping Sun, Huilin Su, Yuanning Zeng, Qiuhong Wang, Haixue Kuang. Daturataturin A, a withanolide in Datura metel L., induces HaCaT autophagy through the PI3K-Akt-mTOR signaling pathway.
Phytotherapy research : PTR.
2021 Mar; 35(3):1546-1558. doi:
10.1002/ptr.6921. [PMID: 33560581] - Sachin Ashok Thorat, Poornima Poojari, Arya Kaniyassery, Kodsara Ramachandra Kiran, Kapaettu Satyamoorthy, Krishna Kishore Mahato, Annamalai Muthusamy. Red laser-mediated alterations in seed germination, growth, pigments and withanolide content of Ashwagandha [Withania somnifera (L.) Dunal].
Journal of photochemistry and photobiology. B, Biology.
2021 Mar; 216(?):112144. doi:
10.1016/j.jphotobiol.2021.112144. [PMID: 33556702] - Yangliu Xia, Ping Wang, Nana Yan, Frank J Gonzalez, Tingting Yan. Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3.
Cell death & disease.
2021 02; 12(2):174. doi:
10.1038/s41419-020-03243-w. [PMID: 33574236] - Deepika Tripathi, Krishna Kumar Rai, Shashi Pandey-Rai. Impact of green synthesized WcAgNPs on in-vitro plant regeneration and withanolides production by inducing key biosynthetic genes in Withania coagulans.
Plant cell reports.
2021 Feb; 40(2):283-299. doi:
10.1007/s00299-020-02630-z. [PMID: 33151379] - Harshini Mallipeddi, Anita Thyagarajan, Ravi P Sahu. Implications of Withaferin-A for triple-negative breast cancer chemoprevention.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Feb; 134(?):111124. doi:
10.1016/j.biopha.2020.111124. [PMID: 33434782] - Rajanandh Muhasaparur Ganesan, Dinesh Kumar Settu, Yogeshkumar Murkunde, Chamundeeswari Duraipandian. Pharmacological and pharmacokinetic effect of a polyherbal combination with Withania somnifera (L.) Dunal for the management of anxiety.
Journal of ethnopharmacology.
2021 Jan; 265(?):113337. doi:
10.1016/j.jep.2020.113337. [PMID: 32890709] - Liubov Koval, Nadezhda Zemskaya, Alexander Aliper, Alex Zhavoronkov, Alexey Moskalev. Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster.
Aging.
2021 01; 13(2):1817-1841. doi:
10.18632/aging.202572. [PMID: 33498013]
