3-Mercaptolactate-cysteine disulfide (BioDeep_00000028223)

   

human metabolite Endogenous


代谢物信息卡片


3-{[(2R)-2-amino-2-carboxyethyl]disulphanyl}-2-hydroxypropanoic acid

化学式: C6H11NO5S2 (241.0078636)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C(=O)O)N)SSCC(C(=O)O)O
InChI: InChI=1S/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1

描述信息

3-mercaptolactate-cysteine disulfide is a compound analog of cysteine excreted in the urine of patients affected by Mercaptolactate-cysteine disulfiduria (MCDU, OMIM 249650), the product of disorder of sulfur amino acid metabolism and a reduced activity of the enzyme mercaptopyruvate sulfurtransferase (MST, EC 2.8.1.2). Reduction of protein in the diet, addition of pyridoxine or of neomycin did not affect the urinary excretion of beta-mercaptolactate-cysteine disulfide of a mentally defective patient who was excreting this mixed disulfide. Addition of cysteine to the diet did increase the excretion of this disulfide (PMID: 3888441, 527218, 6945862, 5644041) [HMDB]
3-mercaptolactate-cysteine disulfide is a compound analog of cysteine excreted in the urine of patients affected by Mercaptolactate-cysteine disulfiduria (MCDU, OMIM 249650), the product of disorder of sulfur amino acid metabolism and a reduced activity of the enzyme mercaptopyruvate sulfurtransferase (MST, EC 2.8.1.2). Reduction of protein in the diet, addition of pyridoxine or of neomycin did not affect the urinary excretion of beta-mercaptolactate-cysteine disulfide of a mentally defective patient who was excreting this mixed disulfide. Addition of cysteine to the diet did increase the excretion of this disulfide (PMID: 3888441, 527218, 6945862, 5644041).

同义名列表

12 个代谢物同义名

3-{[(2R)-2-amino-2-carboxyethyl]disulphanyl}-2-hydroxypropanoic acid; 3-{[(2R)-2-amino-2-carboxyethyl]disulfanyl}-2-hydroxypropanoic acid; 3-{[(2R)-2-amino-2-carboxyethyl]disulphanyl}-2-hydroxypropanoate; 3-{[(2R)-2-amino-2-carboxyethyl]disulfanyl}-2-hydroxypropanoate; 3-((2-Carboxy-2-hydroxyethyl)dithio)-L-alanine; 3-Mercaptolactic acid-cysteine disulphide; 3-Mercaptolactic acid-cysteine disulfide; S-(2-Hydroxy-2-carboxyethylthio)cysteine; beta-Mercaptolactate cysteine disulfide; 3-Mercaptolactate-cysteine disulphide; 3-Mercaptolactate-cysteine disulfide; Hcetc



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Wróbel, T Ubuka, W B Yao, T Abe. L-cysteine metabolism in guinea pig and rat tissues. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 1997 Feb; 116(2):223-6. doi: 10.1016/s0305-0491(96)00216-7. [PMID: 9159885]
  • S Yuasa, R Akagi, T Ubuka, N Masuoka, K Yao. Excretion of 3-mercaptolactate-cysteine mixed disulfide, sulfate and taurine in human urine before and after oral administration of sulfur-containing amino acids. Acta medica Okayama. 1990 Jun; 44(3):117-22. doi: 10.18926/amo/30459. [PMID: 2382576]
  • J C Crawhall. A review of the clinical presentation and laboratory findings in two uncommon hereditary disorders of sulfur amino acid metabolism, beta-mercaptolactate cysteine disulfideuria and sulfite oxidase deficiency. Clinical biochemistry. 1985 Jun; 18(3):139-42. doi: 10.1016/s0009-9120(85)80097-7. [PMID: 3888441]
  • H Mikami, Y Hosaki, T Ubuka. Metabolism of L-cysteine in rats fed low and high protein diets. Acta medica Okayama. 1984 Oct; 38(5):415-21. doi: 10.18926/amo/30344. [PMID: 6516897]
  • M Taniguchi, Y Hosaki, T Ubuka. Transaminative metabolism of L-cysteine in guinea pig liver and kidney. Acta medica Okayama. 1984 Aug; 38(4):375-80. doi: 10.18926/amo/30307. [PMID: 6496171]
  • U Hannestad, J Mårtensson, R Sjödahl, B Sörbo. 3-mercaptolactate cysteine disulfiduria: biochemical studies on affected and unaffected members of a family. Biochemical medicine. 1981 Aug; 26(1):106-14. doi: 10.1016/0006-2944(81)90035-1. [PMID: 6945862]