P1,P4-Bis(5'-adenosyl) tetraphosphate (BioDeep_00000028218)
human metabolite Endogenous
代谢物信息卡片
化学式: C20H28N10O19P4 (836.0482658)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)O)O)O)O)N
InChI: InChI=1S/C20H28N10O19P4/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(45-19)1-43-50(35,36)47-52(39,40)49-53(41,42)48-51(37,38)44-2-8-12(32)14(34)20(46-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H2,21,23,25)(H2,22,24,26)
描述信息
P1,P4-Bis(5-adenosyl) tetraphosphate is an intermediate in purine metabolism. P1,P4-Bis(5-adenosyl) tetraphosphate is the first to last step in the synthesis of adenosine 5-triphosphate (ATP) and is converted from adenosine 5-phosphosulfate via the enzyme ATP adenylyltransferase (EC 2.7.7.53). [HMDB]
P1,P4-Bis(5-adenosyl) tetraphosphate is an intermediate in purine metabolism. P1,P4-Bis(5-adenosyl) tetraphosphate is the first to last step in the synthesis of adenosine 5-triphosphate (ATP) and is converted from adenosine 5-phosphosulfate via the enzyme ATP adenylyltransferase (EC 2.7.7.53).
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
同义名列表
16 个代谢物同义名
[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphinic acid; [({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphinate; {[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(({[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxy)phosphinic acid; p(1),p(4)-Bis(5-adenosyl) tetraphosphoric acid; P1,P4-Bis(5-adenosyl) tetraphosphoric acid; Diadenosine 5,5-P(1),P(4)--tetraphosphate; p(1),p(4)-Bis(5-adenosyl) tetraphosphate; P(1), P(4)-Diadenosine-5tetraphosphate; Adenosine(5)tetraphospho(5)adenosine; P1,P4-Bis(5-adenosyl) tetraphosphate; Bis(5-adenosyl)tetraphosphate; bis(5-adenylyl) diphosphate; Diadenosine tetraphosphate; a(5)P4(5)a; AppppA; Ap4a
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jędrzej Dobrogojski, Van Hai Nguyen, Joanna Kowalska, Sławomir Borek, Małgorzata Pietrowska-Borek. The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (Ap4A) in Arabidopsis thaliana.
International journal of molecular sciences.
2023 Nov; 24(23):. doi:
10.3390/ijms242316688. [PMID: 38069010] - Hsing-Mao Chu, Feng-Yuan Chen, Tzu-Ping Ko, Andrew H-J Wang. Binding and catalysis of Humulus lupulus adenylate isopentenyltransferase for the synthesis of isopentenylated diadenosine polyphosphates.
FEBS letters.
2010 Sep; 584(18):4083-8. doi:
10.1016/j.febslet.2010.08.038. [PMID: 20807533] - Kim M Branson, Haydyn D T Mertens, James D Swarbrick, Jamie I Fletcher, Lukasz Kedzierski, Kenwyn R Gayler, Paul R Gooley, Brian J Smith. Discovery of inhibitors of lupin diadenosine 5',5'''-P(1),P(4)-tetraphosphate hydrolase by virtual screening.
Biochemistry.
2009 Aug; 48(32):7614-20. doi:
10.1021/bi900813x. [PMID: 19603790] - D Rüsing, E J Verspohl. Influence of diadenosine tetraphosphate (Ap4A) on lipid metabolism.
Cell biochemistry and function.
2004 Sep; 22(5):333-8. doi:
10.1002/cbf.1111. [PMID: 15338474] - Andrzej Guranowski. Metabolism of diadenosine tetraphosphate (Ap4A) and related nucleotides in plants; review with historical and general perspective.
Frontiers in bioscience : a journal and virtual library.
2004 May; 9(?):1398-411. doi:
10.2741/1338. [PMID: 14977555] - J L Cartwright, P Britton, M F Minnick, A G McLennan. The IalA invasion gene of Bartonella bacilliformis encodes a (de)nucleoside polyphosphate hydrolase of the MutT motif family and has homologs in other invasive bacteria.
Biochemical and biophysical research communications.
1999 Mar; 256(3):474-9. doi:
10.1006/bbrc.1999.0354. [PMID: 10080922] - E R Lazarowski, W C Watt, M J Stutts, R C Boucher, T K Harden. Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate.
British journal of pharmacology.
1995 Sep; 116(1):1619-27. doi:
10.1111/j.1476-5381.1995.tb16382.x. [PMID: 8564228] - R Krauspe, B Parthier, C Wasternack. Synthesis of diadenosine 5',5'''-P1,P4-tetraphosphate by organellar and cytoplasmic phenylalanyl-tRNA synthetases of Euglena gracilis.
FEBS letters.
1988 Aug; 235(1-2):275-7. doi:
10.1016/0014-5793(88)81278-x. [PMID: 3402601] - E F Baril, S A Coughlin, P C Zamecnik. 5',5'''-P1, P4 diadenosine tetraphosphate (Ap4A): a putative initiator of DNA replication.
Cancer investigation.
1985; 3(5):465-71. doi:
10.3109/07357908509039808. [PMID: 2996723] - S Litvak, J Graveline, L Zourgui, P Carvallo, A Solari, H Aoyama, M Castroviejo, L Tarrago-Litvak. Studies on the initiation of DNA synthesis in plant and animal cells.
Advances in experimental medicine and biology.
1984; 179(?):249-62. doi:
10.1007/978-1-4684-8730-5_26. [PMID: 6543092] - H Jakubowski. Synthesis of diadenosine 5',5''-P1,P4-tetraphosphate and related compounds by plant (Lupinus luteus) seryl-tRNA and phenylalanyl-tRNA synthetases.
Acta biochimica Polonica.
1983; 30(1):51-69. doi:
". [PMID: 6553449]