Tetragastrin (BioDeep_00000028153)

   

human metabolite Endogenous


代谢物信息卡片


(3S)-3-[(2S)-2-[(2S)-2-amino-3-(1H-indol-3-yl)propanamido]-4-(methylsulfanyl)butanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid

化学式: C29H36N6O6S (596.2416916)
中文名称: 四肽胃泌素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CSCCC(C(=O)NC(CC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)N
InChI: InChI=1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1

描述信息

Tetragastrin is the C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin. [HMDB]
Tetragastrin is the C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005755 - Gastrins
Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) is the C-terminal tetrapeptide of gastrin. Tetragastrin can stimulate gastric secretion[1]. Tetragastrin is a Cholecystokinin (CCK-4) receptor agonist[2]. Gastric mucosal protection[3].
Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) is the C-terminal tetrapeptide of gastrin. Tetragastrin can stimulate gastric secretion[1]. Tetragastrin is a Cholecystokinin (CCK-4) receptor agonist[2]. Gastric mucosal protection[3].

同义名列表

26 个代谢物同义名

(3S)-3-[(2S)-2-[(2S)-2-amino-3-(1H-indol-3-yl)propanamido]-4-(methylsulfanyl)butanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid; L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide; L-Tryptophyl-L-methionyl-L-aspartylphenyl-alaninamide; Carbobenzoxy-TRP-met-asp-phe-amide; L-TRP-L-Met-L-asp-L-phe-NH(2); Cholecystokinin-tetrapeptide; Cholecystokinin tetrapeptide; Gastrin tetrapeptide amide; Cholecystokinin (30-33); Tetrapeptide, gastrin; TRP-Met-asp-phe-NH(2); GASTRIN TETRAPEPTIDE; 4, Cholecystokinin; Cholecystokinin 4; Cholecystokinin-4; AOC tetragastrin; AOC tetrapeptide; AOC-tetragastrin; AOC-tetrapeptide; Tetragastrin; CCK (30-33); WMDF-NH(2); CCRIS 3246; Gatratet; CCK-4; CKK-4



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Michael Kellner, Peter Zwanzger, Rainer Rupprecht, Daniela Eser, Alexander Yassouridis, Klaus Wiedemann. Copeptin in CCK-4-induced panic in healthy man: Sexual dimorphisms in secretion pattern and panic response, but no correlation of copeptin with panic symptoms. Psychoneuroendocrinology. 2019 12; 110(?):104433. doi: 10.1016/j.psyneuen.2019.104433. [PMID: 31525566]
  • Clémence Cheignon, Emmanuelle Cordeau, Nolween Prache, Sonia Cantel, Jean Martinez, Gilles Subra, Carine Arnaudguilhem, Brice Bouyssiere, Christine Enjalbal. Receptor-Ligand Interaction Measured by Inductively Coupled Plasma Mass Spectrometry and Selenium Labeling. Journal of medicinal chemistry. 2018 11; 61(22):10173-10184. doi: 10.1021/acs.jmedchem.8b01320. [PMID: 30395477]
  • Cüneyt Demiralay, Agorastos Agorastos, Alexander Yassouridis, Holger Jahn, Klaus Wiedemann, Michael Kellner. Copeptin - A potential endocrine surrogate marker of CCK-4-induced panic symptoms?. Psychoneuroendocrinology. 2017 02; 76(?):14-18. doi: 10.1016/j.psyneuen.2016.11.006. [PMID: 27871026]
  • Agorastos Agorastos, Michael Kellner, Oliver Stiedl, Christoph Muhtz, Jos S Becktepe, Klaus Wiedemann, Cüneyt Demiralay. The 5-HTTLPR genotype modulates heart rate variability and its adjustment by pharmacological panic challenge in healthy men. Journal of psychiatric research. 2014 Mar; 50(?):51-8. doi: 10.1016/j.jpsychires.2013.11.013. [PMID: 24342768]
  • Jamie R Doyle, Benjamin N Harwood, Subrahmanian Tarakkad Krishnaji, Vijay M Krishnamurthy, Wei-En Lin, Jean-Philippe Fortin, Krishna Kumar, Alan S Kopin. A two-step strategy to enhance activity of low potency peptides. PloS one. 2014; 9(11):e110502. doi: 10.1371/journal.pone.0110502. [PMID: 25391026]
  • Innar Tõru, Eduard Maron, Mait Raag, Veiko Vasar, David J Nutt, Jakov Shlik. The effect of 6-week treatment with escitalopram on CCK-4 challenge: a placebo-controlled study in CCK-4-sensitive healthy volunteers. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2013 Jul; 23(7):645-52. doi: 10.1016/j.euroneuro.2012.08.011. [PMID: 22939006]
  • Tetsuya Tachibana, Kiyoko Matsuda, Motoko Kawamura, Hiroshi Ueda, Md Sakirul Islam Khan, Mark A Cline. Feeding-suppressive mechanism of sulfated cholecystokinin (26-33) in chicks. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2012 Apr; 161(4):372-8. doi: 10.1016/j.cbpa.2011.12.010. [PMID: 22227312]
  • Hongzhi Ye, Shifei Xia, Lishuang Yu, Xueqin Xu, Chunsong Zheng, Huifeng Xu, Lili Wang, Xianxiang Liu, Zongwei Cai, Guonan Chen. Solid-phase extraction-field-amplified sample injection coupled with CE-ESI-MS for online pre-concentration and quantitative analysis of brain-gut peptides. Electrophoresis. 2011 Oct; 32(20):2823-9. doi: 10.1002/elps.201000591. [PMID: 22009770]
  • E Maron, I Tõru, K Mäemets, S Sepp, V Vasar, J Shlik, A Zharkovsky. CCK-4-induced anxiety but not panic is associated with serum brain-derived neurotrophic factor in healthy subjects. Journal of psychopharmacology (Oxford, England). 2009 Jun; 23(4):460-4. doi: 10.1177/0269881108089600. [PMID: 18562429]
  • Michael Kellner, Christoph Muhtz, Cüneyt Demiralay, Jana Husemann, Wiebke Koelsch, Alexander Yassouridis, Klaus Wiedemann. The selective serotonin re-uptake inhibitor escitalopram modulates the panic response to cholecystokinin tetrapeptide in healthy men depending on 5-HTTLPR genotype. Journal of psychiatric research. 2009 Mar; 43(6):642-8. doi: 10.1016/j.jpsychires.2008.09.001. [PMID: 18930474]
  • Daniela Eser, Gregor Leicht, Thomas Baghai, Oliver Pogarell, Cornelius Schüle, Susanne Karch, Caroline Nothdurfter, Rainer Rupprecht, Christoph Mulert. Impact of loudness dependency of auditory evoked potentials on the panic response to CCK-4. Journal of psychiatric research. 2009 Jan; 43(4):393-400. doi: 10.1016/j.jpsychires.2008.04.010. [PMID: 18534623]
  • Gwendolen E Haley, Francis W Flynn. Tachykinin neurokinin 3 receptor signaling in cholecystokinin-elicited release of oxytocin and vasopressin. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 May; 294(5):R1760-7. doi: 10.1152/ajpregu.00033.2008. [PMID: 18385472]
  • Gene-Jack Wang, Dardo Tomasi, Walter Backus, Ruiliang Wang, Frank Telang, Allan Geliebter, Judith Korner, Angela Bauman, Joanna S Fowler, Panayotis K Thanos, Nora D Volkow. Gastric distention activates satiety circuitry in the human brain. NeuroImage. 2008 Feb; 39(4):1824-31. doi: 10.1016/j.neuroimage.2007.11.008. [PMID: 18155924]
  • Daniela Eser, Cornelius Schüle, Thomas Baghai, Anette Floesser, Axel Krebs-Brown, Michaela Enunwa, Stephan de la Motte, Rolf Engel, Klaus Kucher, Rainer Rupprecht. Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study. Psychopharmacology. 2007 Jul; 192(4):479-87. doi: 10.1007/s00213-007-0738-7. [PMID: 17318504]
  • Peter Zwanzger, Daniela Eser, Nikolas Völkel, Thomas C Baghai, Hans-Jürgen Möller, Rainer Rupprecht, Frank Padberg. Effects of repetitive transcranial magnetic stimulation (rTMS) on panic attacks induced by cholecystokinin-tetrapeptide (CCK-4). The international journal of neuropsychopharmacology. 2007 Apr; 10(2):285-9. doi: 10.1017/s146114570600695x. [PMID: 16817979]
  • Christian Otte, Steffen Moritz, Alexander Yassouridis, Maike Koop, Ana Maria Madrischewski, Klaus Wiedemann, Michael Kellner. Blockade of the mineralocorticoid receptor in healthy men: effects on experimentally induced panic symptoms, stress hormones, and cognition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2007 Jan; 32(1):232-8. doi: 10.1038/sj.npp.1301217. [PMID: 17035932]
  • Andreas Ströhle, Christian Feller, Christian J Strasburger, Andreas Heinz, Fernando Dimeo. Anxiety modulation by the heart? Aerobic exercise and atrial natriuretic peptide. Psychoneuroendocrinology. 2006 Oct; 31(9):1127-30. doi: 10.1016/j.psyneuen.2006.08.003. [PMID: 17010527]
  • Mia H Greisen, Tom G Bolwig, Gitta Wörtwein. Cholecystokinin tetrapeptide effects on HPA axis function and elevated plus maze behaviour in maternally separated and handled rats. Behavioural brain research. 2005 Jun; 161(2):204-12. doi: 10.1016/j.bbr.2005.02.006. [PMID: 15922046]
  • Daniela Eser, Flavia di Michele, Peter Zwanzger, Augusto Pasini, Thomas C Baghai, Cornelius Schüle, Rainer Rupprecht, Elena Romeo. Panic induction with cholecystokinin-tetrapeptide (CCK-4) Increases plasma concentrations of the neuroactive steroid 3alpha, 5alpha tetrahydrodeoxycorticosterone (3alpha, 5alpha-THDOC) in healthy volunteers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2005 Jan; 30(1):192-5. doi: 10.1038/sj.npp.1300572. [PMID: 15467707]
  • G Kronenberg, P Berger, R F Tauber, B Bandelow, V Henkel, I Heuser. Randomized, double-blind study of SR142801 (Osanetant). A novel neurokinin-3 (NK3) receptor antagonist in panic disorder with pre- and posttreatment cholecystokinin tetrapeptide (CCK-4) challenges. Pharmacopsychiatry. 2005 Jan; 38(1):24-9. doi: 10.1055/s-2005-837768. [PMID: 15706463]
  • Koji Yakabi, Harumi Mimura, Hitoshi Iwabuchi, Shoki Ro, Hideo Kamiichi, Seiichi Miura, Takashi Nakamura. Neutrophil-derived hydroxyl radicals mediate interleukin-8-induced increases in tetragastrin-stimulated acid secretion in rats. Digestive diseases and sciences. 2003 Jun; 48(6):1081-7. doi: 10.1023/a:1023708511116. [PMID: 12822866]
  • P Zwanzger, H Jarry, D Eser, F Padberg, T Baghai, C Schule, R Ella, H-J Möller, R Rupprecht. Plasma gamma-amino-butyric acid (GABA) levels in cholecystokinine-tetrapeptide (CCK-4) induced anxiety. Journal of neural transmission (Vienna, Austria : 1996). 2003 Mar; 110(3):313-6. doi: 10.1007/s00702-002-0774-8. [PMID: 12658378]
  • Andreas Ströhle, Elena Romeo, Flavia di Michele, Augusto Pasini, Bettina Hermann, Gisela Gajewsky, Florian Holsboer, Rainer Rupprecht. Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results. Archives of general psychiatry. 2003 Feb; 60(2):161-8. doi: 10.1001/archpsyc.60.2.161. [PMID: 12578433]
  • Alastair Flint, Jacques Bradwejn, Franco Vaccarino, Jolanta Gutkowska, Roberta Palmour, Diana Koszycki. Aging and panicogenic response to cholecystokinin tetrapeptide: an examination of the cholecystokinin system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2002 Oct; 27(4):663-71. doi: 10.1016/s0893-133x(02)00330-5. [PMID: 12377403]
  • Diana Radu, Arne Ahlin, Pär Svanborg, Nils Lindefors. Anxiogenic effects of the CCK(B) agonist pentagastrin in humans and dose-dependent increase in plasma C-peptide levels. Psychopharmacology. 2002 Jun; 161(4):396-403. doi: 10.1007/s00213-002-1044-z. [PMID: 12073167]
  • R A Danilova, O I Rud'ko, T M Korotkova, M F Obukhova, I P Ashmarin. The effects of immunization against cholecystokinin fragment 30-33 in the behavior of white rats. Neuroscience and behavioral physiology. 2002 Mar; 32(2):189-94. doi: 10.1023/a:1013983626780. [PMID: 11942698]
  • P Zwanzger, T C Baghai, C Schuele, A Ströhle, F Padberg, N Kathmann, M Schwarz, H J Möller, R Rupprecht. Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2001 Nov; 25(5):699-703. doi: 10.1016/s0893-133x(01)00266-4. [PMID: 11682253]
  • J M Le Mellédo, J Bradwejn, D Koszycki, F Bellavance, D Bichet. Arginine-vasopressin and oxytocin response to cholecystokinin-tetrapeptide. Peptides. 2001 Aug; 22(8):1349-57. doi: 10.1016/s0196-9781(01)00462-4. [PMID: 11457531]
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  • M Kellner, K Wiedemann, A Yassouridis, R Levengood, L S Guo, F Holsboer, R Yehuda. Behavioral and endocrine response to cholecystokinin tetrapeptide in patients with posttraumatic stress disorder. Biological psychiatry. 2000 Jan; 47(2):107-11. doi: 10.1016/s0006-3223(99)00118-3. [PMID: 10664826]
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  • M Dépôt, S Merani, J Bradwejn, J Mukherjee, J Caillé, J Gutkowska, G Caillé. Effect of oral ondansetron on total cholecystokinin plasma levels following CCK-4 panic challenge procedure in healthy men. Journal of psychiatry & neuroscience : JPN. 1998 Nov; 23(5):298-304. doi: . [PMID: 9846035]
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