Esomeprazole (BioDeep_00000028035)
human metabolite Chemicals and Drugs
代谢物信息卡片
5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazole
化学式: C17H19N3O3S (345.11470640000005)
中文名称: 埃索美拉唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC
InChI: InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)/t24-/m0/s1
描述信息
Esomeprazole is a proton pump inhibitor (brand names Nexium; Esomeprazole is a proton pump inhibitor which reduces gastric acid secretion through inhibition of H+/K+-ATPase in gastric parietal cells. By inhibiting the functioning of this enzyme, the drug prevents formation of gastric acid.; Esopral and Axagon in Italy) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and Zollinger-Ellison syndrome. Esomeprazole is the S-enantiomer of omeprazole (marketed as Losec/Prilosec), and AstraZeneca claims improved efficacy of this single enantiomer product over the racemic mixture of omeprazole (see below).; Esopral and Axagon in Italy) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and Zollinger-Ellison syndrome. Esomeprazole is the S-enantiomer of omeprazole (marketed as Losec/Prilosec), and AstraZeneca claims improved efficacy of this single enantiomer product over the racemic mixture of omeprazole (see below).; Esomeprazole is a proton pump inhibitor (brand names Nexium; Esomeprazole is a proton pump inhibitor (brand names Nexium; Lucen; Esopral and Axagon in Italy) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and Zollinger-Ellison syndrome. Esomeprazole is the S-enantiomer of omeprazole (marketed as Losec/Prilosec), and AstraZeneca claims improved efficacy of this single enantiomer product over the racemic mixture of omeprazole (see below).; Lucen; A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-exchanging ATPase) in the proton pump of gastric parietal cells. [HMDB]
Esomeprazole (brand names Nexium; Lucen; Esopral and Axagon in Italy) is a proton pump inhibitor which reduces gastric acid secretion through the inhibition of H+/K+-ATPase in gastric parietal cells. By inhibiting the functioning of this enzyme, the drug prevents the formation of gastric acid. Esomeprazole is used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD), and Zollinger-Ellison syndrome. Esomeprazole is the S-enantiomer of omeprazole (marketed as Losec/Prilosec), and AstraZeneca claims improved efficacy of this single enantiomer product over the racemic mixture of omeprazole.
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BC - Proton pump inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29723 - Proton Pump Inhibitor
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D004791 - Enzyme Inhibitors > D054328 - Proton Pump Inhibitors
同义名列表
22 个代谢物同义名
5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazole; (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole; AstraZeneca brand OF esomeprazole magnesium; Esomeprazole strontium anhydrous; Strontium, esomeprazole; Esomeprazole potassium; Esomeprazole magnesium; Esomeprazole strontium; Esomeprazole sodium; (S)-(-)-Omeprazole; Inexium paranova; (S)-Esomeprazole; (S)-Omeprazole; (-)-Omeprazole; Esomeprazolum; Esomeprazole; Esomeprazol; Alenia; Esofag; Nexium; Escz
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:50275
- PubChem: 9568614
- HMDB: HMDB0005009
- DrugBank: DB00736
- ChEMBL: CHEMBL1201320
- Wikipedia: Esomeprazole
- MeSH: Esomeprazole
- foodb: FDB023582
- chemspider: 7843323
- CAS: 119141-88-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Qianjun Zhuang, Aijun Liao, Qingling He, Chengxia Liu, Changqing Zheng, Xing Li, Youli Liu, Bangmao Wang, Side Liu, Yan Zhang, Rong Lin, Huixin Chen, Min Deng, Yanping Tang, Chiyi He, Weijie Dai, Haitao Tang, Lei Gong, Liangping Li, Baohong Xu, Changqing Yang, Bingxi Zhou, Dongxing Su, Qinghong Guo, Bin Li, Yongjian Zhou, Xiaoyang Wang, Sujuan Fei, Huili Wu, Sichen Wei, Zhihong Peng, Jianning Wang, Yanqing Li, Hong Wang, Tianwei Deng, Shigang Ding, Fangfang Li, Minhu Chen, Yinglian Xiao. The efficacy and safety of fexuprazan in treating erosive esophagitis: a phase III, randomized, double-blind, multicenter study.
Journal of gastroenterology and hepatology.
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Scientific reports.
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Clinics and research in hepatology and gastroenterology.
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European journal of obstetrics, gynecology, and reproductive biology.
2018 Jun; 225(?):236-242. doi:
10.1016/j.ejogrb.2018.05.004. [PMID: 29758543] - Tayyar Alp Ozkan, Nihat Karakoyunlu, Reyhan Polat, Gülistan Sanem Sarıbaş, Nevzat Can Şener, Seyda Özdemir, Kevser Peker, Dilek Ünal, Can Tuygun. An evaluation of the protective effect of esomeprazole in an experimental model of renal ischemia-reperfusion.
International urology and nephrology.
2018 Feb; 50(2):217-223. doi:
10.1007/s11255-017-1775-8. [PMID: 29280047] - Heba M Eltahir, Maiiada H Nazmy. Esomeprazole ameliorates CCl4 induced liver fibrosis in rats via modulating oxidative stress, inflammatory, fibrogenic and apoptotic markers.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):1356-1365. doi:
10.1016/j.biopha.2017.11.028. [PMID: 29156525] - Hsin Tian, Yanyan Xu, Jiayan Wang, Weiqiang Tian, Jian Sun, Tao Zhang, Qingyun Zhou, Chuxiao Shao. Effects of Plasma Albumin on the Pharmacokinetics of Esomeprazole in ICU Patients.
BioMed research international.
2018; 2018(?):6374374. doi:
10.1155/2018/6374374. [PMID: 30643812] - Jun Nishikawa, Ayumu Hosokawa, Mayo Fuchino, Shunsuke Takatori, Masaya Iwamoto, Yoshiro Kashii, Tadashi Bando, Tetsuro Shimizu, Masami Minemura, Toshiro Sugiyama. [Rhabdomyolysis associated with long-term treatment of esomeprazole].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.
2018 ; 115(3):299-304. doi:
10.11405/nisshoshi.115.299. [PMID: 29526982] - Teppei Okamoto, Shingo Hatakeyama, Shogo Hosogoe, Yoshimi Tanaka, Kengo Imanishi, Toru Takashima, Fumitada Saitoh, Tadashi Suzuki, Chikara Ohyama. Proton pump inhibitor as an independent factor of progression of abdominal aortic calcification in patients on maintenance hemodialysis.
PloS one.
2018; 13(7):e0199160. doi:
10.1371/journal.pone.0199160. [PMID: 29969455] - Ran Liu, Pei Li, Jie Xiao, Yidi Yin, Zheng Sun, Kaishun Bi, Qing Li. A fast, sensitive, and high throughput method for the determination of esomeprazole in dog plasma by UHPLC-MS/MS: Application to formulation development of the compound preparation of esomeprazole.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Nov; 1068-1069(?):352-357. doi:
10.1016/j.jchromb.2017.11.002. [PMID: 29128277] - Xiao Ma, Cheng-Wei Tang, Zhi-Yin Huang, Ming-Guang Zhang, Fang Liu, Chun-Hui Wang, Rui Wang, Huan Tong, Ling Liu. [Effect of Proton Pump Inhibitors on Severe Acute Pancreatitis--a Prospective Randomized Trial].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2017 Nov; 48(6):933-936. doi:
NULL. [PMID: 29260533] - S Yi, H Lee, S B Jang, H M Byun, S H Yoon, J-Y Cho, I-J Jang, K-S Yu. A novel K+ competitive acid blocker, YH4808, sustains inhibition of gastric acid secretion with a faster onset than esomeprazole: randomised clinical study in healthy volunteers.
Alimentary pharmacology & therapeutics.
2017 08; 46(3):337-346. doi:
10.1111/apt.14148. [PMID: 28543183] - S Tommasi, D J Elliot, J A Hulin, B C Lewis, M McEvoy, A A Mangoni. Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance.
Scientific reports.
2017 06; 7(1):2871. doi:
10.1038/s41598-017-03069-1. [PMID: 28588208] - Ward A Heggermont, Gregor Verhoef, Pieter Evenepoel, Ben Sprangers, Evelyn Lerut, Thomas Tousseyn, Kathleen Claes. Clinical case report: a rare cause of acute kidney failure - tissue is the issue.
Acta clinica Belgica.
2017 Jun; 72(3):201-204. doi:
10.1080/17843286.2016.1178967. [PMID: 27253186] - Wael Talaat. Bioanalytical method for the estimation of co-administered esomeprazole, leflunomide and ibuprofen in human plasma and in pharmaceutical dosage forms using micellar liquid chromatography.
Biomedical chromatography : BMC.
2017 May; 31(5):. doi:
10.1002/bmc.3865. [PMID: 27862093] - J-H Hwang, J-W Jeong, G-H Song, T-S Koo, K-W Seo. Pharmacokinetics and Acid Suppressant Efficacy of Esomeprazole after Intravenous, Oral, and Subcutaneous Administration to Healthy Beagle Dogs.
Journal of veterinary internal medicine.
2017 May; 31(3):743-750. doi:
10.1111/jvim.14713. [PMID: 28407418] - Nazar Muhammad Ranjha, Zermina Rashid, Rabia Razzaq, Hina Raza, Muhammad Hanif, Asif Mahmood. DEVELOPMENT AND VALIDATION OF FAST REVERSED-PHASE HPLC METHOD FOR ANALYSIS OF ESOMEPRAZOLE IN RABBIT PLASMA.
Acta poloniae pharmaceutica.
2017 Mar; 74(2):385-391. doi:
NULL. [PMID: 29624243] - Malcolm Boyce, Frans van den Berg, Toni Mitchell, Kate Darwin, Steve Warrington. Randomised trial of the effect of a gastrin/CCK2 receptor antagonist on esomeprazole-induced hypergastrinaemia: evidence against rebound hyperacidity.
European journal of clinical pharmacology.
2017 Feb; 73(2):129-139. doi:
10.1007/s00228-016-2150-x. [PMID: 27796466] - Marcelo F Montenegro, Michaela L Sundqvist, Filip J Larsen, Zhengbing Zhuge, Mattias Carlström, Eddie Weitzberg, Jon O Lundberg. Blood Pressure-Lowering Effect of Orally Ingested Nitrite Is Abolished by a Proton Pump Inhibitor.
Hypertension (Dallas, Tex. : 1979).
2017 01; 69(1):23-31. doi:
10.1161/hypertensionaha.116.08081. [PMID: 27802417] - Tadashi Shimoyama, Daisuke Chinda, Yoshihiko Sawada, Kazuo Komai, Hironobu Chiba, Yoshiharu Saito, Yoshio Sasaki, Masashi Matsuzaka, Shinsaku Fukuda. Randomized Trial Comparing Esomeprazole and Rabeprazole in First-line Eradication Therapy for Helicobacter pylori Infection based on the Serum Levels of Pepsinogens.
Internal medicine (Tokyo, Japan).
2017; 56(13):1621-1627. doi:
10.2169/internalmedicine.56.7823. [PMID: 28674348] - Christoph Castellani, Georg Singer, Karl Kashofer, Andrea Huber-Zeyringer, Christina Flucher, Margarita Kaiser, Holger Till. The Influence of Proton Pump Inhibitors on the Fecal Microbiome of Infants with Gastroesophageal Reflux-A Prospective Longitudinal Interventional Study.
Frontiers in cellular and infection microbiology.
2017; 7(?):444. doi:
10.3389/fcimb.2017.00444. [PMID: 29075620] - Julie Omolola Okiro, Chaudhry Adeel Ebad, Amjad Zaman Khan. Atypical presentation of anti-GBM nephritis in a 90-year-old patient.
BMJ case reports.
2016 Nov; 2016(?):. doi:
10.1136/bcr-2016-217990. [PMID: 27899391] - Jocelyn Zhou, Michelle Quinlan, Kelli Glenn, Hildegard Boss, Franck Picard, Henry Castro, Dalila Sellami. Effect of esomeprazole, a proton pump inhibitor on the pharmacokinetics of sonidegib in healthy volunteers.
British journal of clinical pharmacology.
2016 10; 82(4):1022-9. doi:
10.1111/bcp.13038. [PMID: 27277189] - Dongyang Liu, Hong Yang, Ji Jiang, Péter Nagy, Kai Shen, Jiaming Qian, Pei Hu. Pharmacokinetic and Pharmacodynamic Modeling Analysis of Intravenous Esomeprazole in Healthy Volunteers.
Journal of clinical pharmacology.
2016 07; 56(7):816-26. doi:
10.1002/jcph.733. [PMID: 26970404] - Dae-Hong Jeon, Yire Kim, Min Jeong Kim, Hyun Seop Cho, Eun Jin Bae, Se-Ho Chang, Dong Jun Park. Rhabdomyolysis associated with single-dose intravenous esomeprazole administration: A case report.
Medicine.
2016 Jul; 95(29):e4313. doi:
10.1097/md.0000000000004313. [PMID: 27442680] - Roelof W F van Leeuwen, Robert Peric, Koen G A M Hussaarts, Emma Kienhuis, Nikki S IJzerman, Peter de Bruijn, Cor van der Leest, Henk Codrington, Jeroen S Kloover, Bronno van der Holt, Joachim G Aerts, Teun van Gelder, Ron H J Mathijssen. Influence of the Acidic Beverage Cola on the Absorption of Erlotinib in Patients With Non-Small-Cell Lung Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2016 Apr; 34(12):1309-14. doi:
10.1200/jco.2015.65.2560. [PMID: 26858332] - Tamehachi Namikoshi, Kazuhiro Harada, Hidekazu Hatta, Takehiko Tokura, Yoshiyuki Oshiro, Tetsuichi Nishizaki, Takahiro Obata, Masahiro Mori, Takaaki Fueki, Sohachi Fujimoto, Yoshisuke Haruna, Atsunori Kuwabara, Daisuke Yorimitsu, Chieko Ihoriya, Hiroyuki Kadoya, Seiji Itano, Yasuo Fujimoto, Norio Komai, Tamaki Sasaki, Naoki Kashihara. Prevalence of gastroesophageal reflux disease symptoms and effects of esomeprazole on the quality of life related to reflux and dyspepsia in patients on maintenance hemodialysis.
Clinical and experimental nephrology.
2016 Feb; 20(1):134-42. doi:
10.1007/s10157-015-1130-2. [PMID: 26026991] - Alessandra Rossi, Luca Castrati, Paolo Colombo, Lisa Flammini, Elisabetta Barocelli, Ruggero Bettini, Lisa Elviri. Development and validation of a DESI-HRMS/MS method for the fast profiling of esomeprazole and its metabolites in rat plasma: a pharmacokinetic study.
Drug testing and analysis.
2016 Feb; 8(2):208-13. doi:
10.1002/dta.1805. [PMID: 25922056] - Elisabeth Angermeier, Katrin Domes, Robert Lukowski, Jens Schlossmann, Birgit Rathkolb, Martin Hraběde Angelis, Franz Hofmann. Iron deficiency anemia in cyclic GMP kinase knockout mice.
Haematologica.
2016 Feb; 101(2):e48-51. doi:
10.3324/haematol.2015.137026. [PMID: 26830212] - Saheed Sabiu, Taofeeq Garuba, Taofik Olatunde Sunmonu, AbdulHakeem O Sulyman, Nurain O Ismail. Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata.
Pharmaceutical biology.
2016; 54(1):180-6. doi:
10.3109/13880209.2015.1029050. [PMID: 25815713] - Ayşegül Aksoy Gökmen, Nogay Girginkardeşler, Ali Ahmet Kilimcioğlu, Mümtaz Cem Şirin, Ahmet Özbilgin. [In vitro susceptibility of Trichomonas vaginalis to metronidazole, ornidazole and proton pump inhibitors pantoprazole and esomeprazole].
Mikrobiyoloji bulteni.
2016 Jan; 50(1):133-9. doi:
. [PMID: 27058337] - Shu-Ling Kan, Jing Lu, Jian-Ping Liu, Yi Zhao. Preparation and in vitro/in vivo evaluation of esomeprazole magnesium-modified release pellets.
Drug delivery.
2016; 23(3):866-73. doi:
10.3109/10717544.2014.919545. [PMID: 24892629] - Yoshimasa Saito, Hiroshi Serizawa, Yukako Kato, Masaru Nakano, Masahiko Nakamura, Hidetsugu Saito, Hidekazu Suzuki, Takanori Kanai. First-line eradication for Helicobacter pylori-positive gastritis by esomeprazole-based triple therapy is influenced by CYP2C19 genotype.
World journal of gastroenterology.
2015 Dec; 21(48):13548-54. doi:
10.3748/wjg.v21.i48.13548. [PMID: 26730167] - Yi Qun Yu, Peter James Whorwell, Lin Heng Wang, Jun Xiang Li, Qing Chang, Jie Meng. Cases Report the Cronkhite-Canada Syndrome: Improving the Prognosis.
Medicine.
2015 Dec; 94(52):e2356. doi:
10.1097/md.0000000000002356. [PMID: 26717374] - M L Becker, W P J Franken, F Karapinar, R Verzijl-Zeegers, T Schalekamp, R T M van der Hoeven. Possible drug-drug interaction between high-dose esomeprazole and phenprocoumon.
European journal of clinical pharmacology.
2015 Dec; 71(12):1461-5. doi:
10.1007/s00228-015-1912-1. [PMID: 26400679] - Catherine A Cluver, Susan P Walker, Ben W Mol, Gerard B Theron, David R Hall, Richard Hiscock, N Hannan, S Tong. Double blind, randomised, placebo-controlled trial to evaluate the efficacy of esomeprazole to treat early onset pre-eclampsia (PIE Trial): a study protocol.
BMJ open.
2015 Oct; 5(10):e008211. doi:
10.1136/bmjopen-2015-008211. [PMID: 26510725] - Yuan-Pin Hung, Wen-Chien Ko, Po-Han Chou, Yi-Hsuan Chen, Hsiao-Ju Lin, Ya-Hui Liu, Hung-Wen Tsai, Jen-Chieh Lee, Pei-Jane Tsai. Proton-Pump Inhibitor Exposure Aggravates Clostridium difficile-Associated Colitis: Evidence From a Mouse Model.
The Journal of infectious diseases.
2015 Aug; 212(4):654-63. doi:
10.1093/infdis/jiv184. [PMID: 25805751] - Fathalla Belal, Mohie Sharaf El-Din, Manar M Tolba, Heba Alaa. Enhanced spectrofluorimetric determination of esomeprazole and pantoprazole in dosage forms and spiked human plasma using organized media.
Luminescence : the journal of biological and chemical luminescence.
2015 May; 30(3):343-51. doi:
10.1002/bio.2737. [PMID: 25060291] - Hyun-Gyu Choi, Ji-Young Jeon, Seong-Shin Kwak, Hyunil Kim, Changyun Jin, Yong-Jin Im, Eun-Young Kim, Hye Min Wang, Yunjeong Kim, Sun Young Lee, Min-Gul Kim. Pharmacokinetic comparison study of a combination containing 500 mg of Naproxen and 20 mg of Esomeprazole: a randomized, single-dose, 2-way crossover, open-label study in healthy Korean men.
Clinical therapeutics.
2015 Jan; 37(1):83-93. doi:
10.1016/j.clinthera.2014.11.004. [PMID: 25482305] - YoonJung Choi, HyeKyung Han, Dongseong Shin, Kyoung Soo Lim, Kyung-Sang Yu. Comparison of the pharmacokinetics and tolerability of HCP1004 (a fixed-dose combination of naproxen and esomeprazole strontium) and VIMOVO® (a marketed fixed-dose combination of naproxen and esomeprazole magnesium) in healthy volunteers.
Drug design, development and therapy.
2015; 9(?):4127-35. doi:
10.2147/dddt.s86725. [PMID: 26257511] - Nader N Youssef, Eduardo Tron, Vasundhara Tolia, Jennifer E Hamer-Maansson, Per Lundborg, Marta Illueca. Single-dose pharmacokinetic properties of esomeprazole in children aged 1 - 11 years with endoscopically proven GERD: a randomized, open-label study.
International journal of clinical pharmacology and therapeutics.
2014 Nov; 52(11):965-72. doi:
10.5414/cp201971. [PMID: 25250612] - Congwu Huang, Chuan Cen, Xin Ding, Haiyong Zhang, Lingfei Wu. Effects of calcitriol on bone mineral density in patients treated with esomeprazole.
Pharmaceutical biology.
2014 Oct; 52(10):1341-4. doi:
10.3109/13880209.2014.892141. [PMID: 25046547] - J S Shin, J Y Lee, K H Cho, H L Park, M Kukulka, J-T Wu, D Y Kim, S-H Park. The pharmacokinetics, pharmacodynamics and safety of oral doses of ilaprazole 10, 20 and 40 mg and esomeprazole 40 mg in healthy subjects: a randomised, open-label crossover study.
Alimentary pharmacology & therapeutics.
2014 Sep; 40(5):548-61. doi:
10.1111/apt.12860. [PMID: 25041486] - Samantha Luk, Rabia S Atayee, Joseph D Ma, Brookie M Best. Urinary diazepam metabolite distribution in a chronic pain population.
Journal of analytical toxicology.
2014 Apr; 38(3):135-42. doi:
10.1093/jat/bku001. [PMID: 24500275] - Stephanie A Tse, Rabia S Atayee, Joseph D Ma, Brookie M Best. Factors affecting carisoprodol metabolism in pain patients using urinary excretion data.
Journal of analytical toxicology.
2014 Apr; 38(3):122-8. doi:
10.1093/jat/bku002. [PMID: 24488112] - Francesca Perut, Sofia Avnet, Caterina Fotia, Serena Rubina Baglìo, Manuela Salerno, Shigekuni Hosogi, Katsuyuki Kusuzaki, Nicola Baldini. V-ATPase as an effective therapeutic target for sarcomas.
Experimental cell research.
2014 Jan; 320(1):21-32. doi:
10.1016/j.yexcr.2013.10.011. [PMID: 24416789] - Hong Yang, Jingnan Li, Qian Zhao, Ji Li, Kai Shen, Xiaoou Yang, Ji Jiang, Pei Hu, Jiaming Qian. Pharmacokinetics, pharmacodynamics, and safety of esomeprazole injection/infusion in healthy Chinese volunteers: a five-way crossover study.
Journal of gastroenterology and hepatology.
2013 Dec; 28(12):1823-8. doi:
10.1111/jgh.12305. [PMID: 23800161] - Yohannes T Ghebremariam, Paea LePendu, Jerry C Lee, Daniel A Erlanson, Anna Slaviero, Nigam H Shah, James Leiper, John P Cooke. Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.
Circulation.
2013 Aug; 128(8):845-53. doi:
10.1161/circulationaha.113.003602. [PMID: 23825361] - Shanmugam Gopinath, Ramadass Satiesh Kumar, Madhira Bhawani Shankar, Palanisamy Danabal. Development and validation of a sensitive and high-throughput LC-MS/MS method for the simultaneous determination of esomeprazole and naproxen in human plasma.
Biomedical chromatography : BMC.
2013 Jul; 27(7):894-9. doi:
10.1002/bmc.2878. [PMID: 23483550] - Antoinette R Tan, Darlene G Gibbon, Mark N Stein, Diana Lindquist, Jeffery W Edenfield, Julie C Martin, Charles Gregory, A Benjamin Suttle, Hiroomi Tada, Jeffrey Botbyl, Joseph J Stephenson. Effects of ketoconazole and esomeprazole on the pharmacokinetics of pazopanib in patients with solid tumors.
Cancer chemotherapy and pharmacology.
2013 Jun; 71(6):1635-43. doi:
10.1007/s00280-013-2164-3. [PMID: 23636448] - Lucie Bouchoud, Caroline Fonzo-Christe, Martin Klingmüller, Pascal Bonnabry. Compatibility of intravenous medications with parenteral nutrition: in vitro evaluation.
JPEN. Journal of parenteral and enteral nutrition.
2013 May; 37(3):416-24. doi:
10.1177/0148607112464239. [PMID: 23112277] - Rui-Feng Ding, Yuan-Hu Guo, Wen-Peng Han, Ai-Yu Wang, Li-Ping Xie, Peng-cheng Zhao. [Preventive effects of jinghua weikang capsule on NSAID-induced injury to the mucosa of the small intestine: an experimental research].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2013 Apr; 33(4):522-5. doi:
". [PMID: 23841276] - Dominic-Luc Webb, Tobias Rudholm-Feldreich, Linda Gillberg, Md Abdul Halim, Elvar Theodorsson, Gareth J Sanger, Colin A Campbell, Malcolm Boyce, Erik Näslund, Per M Hellström. The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression.
Naunyn-Schmiedeberg's archives of pharmacology.
2013 Jan; 386(1):41-9. doi:
10.1007/s00210-012-0812-5. [PMID: 23179899] - R Fiocca, L Mastracci, S E Attwood, C Ell, J-P Galmiche, J Hatlebakk, A Bärthel, G Långström, T Lind, L Lundell. Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy: results of a 5-year follow-up in the LOTUS trial.
Alimentary pharmacology & therapeutics.
2012 Nov; 36(10):959-71. doi:
10.1111/apt.12052. [PMID: 22998687] - B Medhi, A Prakash, Rupa Joshi, D S Prasad Byrav. Effect of esomeprazole on pharmacokinetics of phenytoin in rabbits.
Indian journal of physiology and pharmacology.
2012 Oct; 56(4):382-7. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Sep; 40(9):1698-711. doi:
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