Aporphine (BioDeep_00000280170)

   

natural product


代谢物信息卡片


Aporphine

化学式: C17H17N (235.1360922)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCC2=C3C1CC4=CC=CC=C4C3=CC=C2
InChI: InChI=1S/C17H17N/c1-18-10-9-12-6-4-8-15-14-7-3-2-5-13(14)11-16(18)17(12)15/h2-8,16H,9-11H2,1H3

描述信息

An isoquinoline alkaloid that is the N-methyl derivative of 5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline.

同义名列表

1 个代谢物同义名

Aporphine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fanqi Meng, Sixuan Zhang, Jiaxian Su, Butuo Zhu, Xian Pan, Xiaoxiao Qiu, Xinyun Cui, Chunling Wang, Lili Niu, Caili Li, Shanfa Lu. Characterization of two CYP80 enzymes provides insights into aporphine alkaloid skeleton formation in Aristolochia contorta. The Plant journal : for cell and molecular biology. 2024 Jun; 118(5):1439-1454. doi: 10.1111/tpj.16686. [PMID: 38379355]
  • Tran Thi Thu Hien, Vinh Le Ba, Nguyen Quoc Huy, Nguyen Phuong Thao, Seo Young Yang, Le Thi Kim Van. Cytotoxic effects of aporphine alkaloids from the stems and leaves of Stephania dielsiana Y.C.Wu. Natural product research. 2024 Jun; 38(11):1864-1873. doi: 10.1080/14786419.2023.2227911. [PMID: 38739563]
  • Dinesh Kumar Patel, Kanika Patel. Therapeutic Potential and Pharmacological Activities of (+)-Nantenine in Medicine: An Aporphine Class phytocomponent of Nandina domestica Thunberg. Infectious disorders drug targets. 2023 Oct; ?(?):. doi: 10.2174/0118715265244269231010090316. [PMID: 37881077]
  • Yan-Ping Liu, Tong-Wei Wang, Zhen Xie, Yuan Bian, Yun-Yao Liu, Ruo-Qing Guan, Ze-Yu Liu, Lei Qiang, Guang-Ying Chen, Yan-Hui Fu. Artapilosines A and B, Unusual Phenanthrene Derivatives Related to Aporphine Alkaloids from Artabotrys pilosus. Journal of natural products. 2021 12; 84(12):3117-3121. doi: 10.1021/acs.jnatprod.1c00896. [PMID: 34812640]
  • Emmanoel V Costa, Liviane do N Soares, Jamal da Silva Chaar, Valdenizia R Silva, Luciano de S Santos, Hector H F Koolen, Felipe M A da Silva, Josean F Tavares, Gokhan Zengin, Milena B P Soares, Daniel P Bezerra. Benzylated Dihydroflavones and Isoquinoline-Derived Alkaloids from the Bark of Diclinanona calycina (Annonaceae) and Their Cytotoxicities. Molecules (Basel, Switzerland). 2021 Jun; 26(12):. doi: 10.3390/molecules26123714. [PMID: 34207059]
  • Emmanuel Kofi Kumatia, Frederick Ayertey, Regina Appiah-Opong, Godfrey Kyaakyile Bagyour, Kenneth Opare Asare, Valentine Chi Mbatcho, Jonathan Dabo. Intervention of standardized ethanol leaf extract of Annickia polycarpa, (DC.) Setten and Maas ex I.M. Turner. (Annonaceae), in Plasmodium berghei infested mice produced anti-malaria action and normalized gross hematological indices. Journal of ethnopharmacology. 2021 Mar; 267(?):113449. doi: 10.1016/j.jep.2020.113449. [PMID: 33129949]
  • Douglas Costa Gontijo, Maria Fernanda Alves do Nascimento, Geraldo Célio Brandão, Alaíde Braga de Oliveira. Phytochemistry and antiplasmodial activity of Xylopia sericea leaves. Natural product research. 2020 Dec; 34(24):3526-3530. doi: 10.1080/14786419.2019.1577838. [PMID: 30810362]
  • Renzhong Wang, Jie Zhou, Guoru Shi, Yanfei Liu, Dequan Yu. Aporphine and phenanthrene alkaloids with antioxidant activity from the roots of Stephania tetrandra. Fitoterapia. 2020 Jun; 143(?):104551. doi: 10.1016/j.fitote.2020.104551. [PMID: 32173421]
  • Bei Wang, Yin-Jiao Zhao, Yun-Li Zhao, Ya-Ping Liu, Xiao-Nian Li, Hongbin Zhang, Xiao-Dong Luo. Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens. Organic letters. 2020 01; 22(1):257-260. doi: 10.1021/acs.orglett.9b04252. [PMID: 31860319]
  • Qiong Jin, Xin Wei, Xu-Jie Qin, Fei Gao, Pei-Feng Zhu, Hai-Lian Yuan, Guy Sedar Singor Njateng, Zhi Dai, Ya-Ping Liu, Xiao-Dong Luo. Racemic immunosuppressive seco-aporphine derivatives from Thalictrum wangii. Fitoterapia. 2020 Jan; 140(?):104445. doi: 10.1016/j.fitote.2019.104445. [PMID: 31790771]
  • Taghreed A Majrashi, Fazila Zulfiqar, Amar G Chittiboyina, Zulfiqar Ali, Ikhlas A Khan. Isoquinoline alkaloids from Asimina triloba. Natural product research. 2019 Oct; 33(19):2823-2829. doi: 10.1080/14786419.2018.1504045. [PMID: 30453785]
  • Zheng-Meng Jiang, Lan-Jin Wang, Han-Qing Pang, Yong Guo, Ping-Ting Xiao, Chu Chu, Long Guo, E-Hu Liu. Rapid profiling of alkaloid analogues in Sinomenii Caulis by an integrated characterization strategy and quantitative analysis. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):376-385. doi: 10.1016/j.jpba.2019.06.011. [PMID: 31202880]
  • Cai-Feng Ding, Zhi Dai, Hao-Fei Yu, Xu-Dong Zhao, Xiao-Dong Luo. New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum. Chinese journal of natural medicines. 2019 Sep; 17(9):698-706. doi: 10.1016/s1875-5364(19)30084-6. [PMID: 31526505]
  • Chuan-Yen Wei, Shih-Wei Wang, Jin-Wang Ye, Tsong-Long Hwang, Ming-Jen Cheng, Ping-Jyun Sung, Tsung-Hsien Chang, Jih-Jung Chen. New Anti-Inflammatory Aporphine and Lignan Derivatives from the Root Wood of Hernandia nymphaeifolia. Molecules (Basel, Switzerland). 2018 Sep; 23(9):. doi: 10.3390/molecules23092286. [PMID: 30205430]
  • Phuong Mai Le, Vandana Srivastava, Thanh Tam Nguyen, Bruno Pradines, Marylin Madamet, Joel Mosnier, Thi Thuy Trinh, Hoyun Lee. Stephanine from Stephania venosa (Blume) Spreng Showed Effective Antiplasmodial and Anticancer Activities, the Latter by Inducing Apoptosis through the Reverse of Mitotic Exit. Phytotherapy research : PTR. 2017 Sep; 31(9):1357-1368. doi: 10.1002/ptr.5861. [PMID: 28703314]
  • Chhavarath Dary, Sok-Siya Bun, Gaëtan Herbette, Fathi Mabrouki, Hot Bun, Sothea Kim, Florian Jabbour, Sovanmoly Hul, Béatrice Baghdikian, Evelyne Ollivier. Chemical profiling of the tuber of Stephania cambodica Gagnep. (Menispermaceae) and analytical control by UHPLC-DAD. Natural product research. 2017 Apr; 31(7):802-809. doi: 10.1080/14786419.2016.1247077. [PMID: 27976592]
  • Nathalia Luiza Andreazza, Caroline Caramano de Lourenço, Álvaro José Hernandez-Tasco, Maria Lúcia B Pinheiro, Maria Élida Alves Stefanello, Emmanoel Vilaça Costa, Marcos José Salvador. Antimicrobial photodynamic effect of extracts and oxoaporphine alkaloid isomoschatoline from Guatteria blepharophylla. Journal of photochemistry and photobiology. B, Biology. 2016 Jul; 160(?):154-62. doi: 10.1016/j.jphotobiol.2016.04.010. [PMID: 27107335]
  • Jiayong He, Ying Liu, Yun Kang, Ping Yang, Yaqin Wang, Jixian Guo, Jianming Huang. Identification of Alkaloids in Stephania hainanensis by Liquid Chromatography Coupled with Quadrupole Time-of-flight Mass Spectrometry. Phytochemical analysis : PCA. 2016 May; 27(3-4):206-16. doi: 10.1002/pca.2618. [PMID: 27313158]
  • Azeana Zahari, Abdulwali Ablat, Noridayu Omer, Mohd Azlan Nafiah, Yasodha Sivasothy, Jamaludin Mohamad, Mohammad Niyaz Khan, Khalijah Awang. Ultraviolet-visible study on acid-base equilibria of aporphine alkaloids with antiplasmodial and antioxidant activities from Alseodaphne corneri and Dehaasia longipedicellata. Scientific reports. 2016 Feb; 6(?):21517. doi: 10.1038/srep21517. [PMID: 26898753]
  • Shuiying Zhang, Qian Zhang, Qiang Guo, Yunfang Zhao, Xiaoli Gao, Xingyun Chai, Pengfei Tu. Characterization and simultaneous quantification of biological aporphine alkaloids in Litsea cubeba by HPLC with hybrid ion trap time-of-flight mass spectrometry and HPLC with diode array detection. Journal of separation science. 2015 Aug; 38(15):2614-24. doi: 10.1002/jssc.201500286. [PMID: 26011819]
  • Jian-Wei Dong, Le Cai, Yun-Shan Fang, Huai Xiao, Zhen-Jie Li, Zhong-Tao Ding. Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea. Fitoterapia. 2015 Jul; 104(?):102-7. doi: 10.1016/j.fitote.2015.05.019. [PMID: 26028544]
  • Ulrike Grienke, Christina E Mair, Priyanka Saxena, Igor Baburin, Olaf Scheel, Markus Ganzera, Daniela Schuster, Steffen Hering, Judith M Rollinger. Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids from Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements. Journal of agricultural and food chemistry. 2015 Jun; 63(23):5634-9. doi: 10.1021/acs.jafc.5b01901. [PMID: 26035250]
  • N Vachnadze, A Bakuridze, K Bakuridze, A Bozhadze, D Berashvili, V Vachnadze. [Analysis of some species of magnolia introduced to west georgia, on content of aporphine alkaloids and their biological activity]. Georgian medical news. 2015 Apr; ?(241):84-8. doi: . [PMID: 25953946]
  • Yu-Hong Qu, Ming Jiang, Ling-Yan Wang, Yan-Cheng Li, Ya-Nan Wang, Qing-Lan Guo, Yong-Ji Li, Sheng Lin. [Aporphine alkaloids from Litsea greenmaniana]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Jan; 40(1):94-7. doi: . [PMID: 25993795]
  • Chi-Ming Liu, Chiu-Li Kao, Hui-Ming Wu, Wei-Jen Li, Cheng-Tsung Huang, Hsing-Tan Li, Chung-Yi Chen. Antioxidant and anticancer aporphine alkaloids from the leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena. Molecules (Basel, Switzerland). 2014 Nov; 19(11):17829-38. doi: 10.3390/molecules191117829. [PMID: 25372397]
  • Chieh-Hung Huang, Yu-Yi Chan, Ping-Chung Kuo, Yu-Fon Chen, Ren-Jie Chang, Ih-Sheng Chen, Shwu-Jen Wu, Tian-Shung Wu. The constituents of roots and stems of Illigera luzonensis and their anti-platelet aggregation effects. International journal of molecular sciences. 2014 Jul; 15(8):13424-36. doi: 10.3390/ijms150813424. [PMID: 25089876]
  • Rong-Jyh Lin, Mei-Hsuan Wu, Yi-Hsuan Ma, Li-Yu Chung, Chung-Yi Chen, Chuan-Min Yen. Anthelmintic activities of aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana. International journal of molecular sciences. 2014 Feb; 15(3):3624-39. doi: 10.3390/ijms15033624. [PMID: 24583851]
  • Chengjun Ma, Jinjun Wang, Hongmei Chu, Xiaoxiao Zhang, Zhenhua Wang, Honglun Wang, Gang Li. Purification and characterization of aporphine alkaloids from leaves of Nelumbo nucifera Gaertn and their effects on glucose consumption in 3T3-L1 adipocytes. International journal of molecular sciences. 2014 Feb; 15(3):3481-94. doi: 10.3390/ijms15033481. [PMID: 24577311]
  • Sonny Larsson, Nina Rønsted. Reviewing Colchicaceae alkaloids - perspectives of evolution on medicinal chemistry. Current topics in medicinal chemistry. 2014; 14(2):274-89. doi: 10.2174/1568026613666131216110417. [PMID: 24359194]
  • Hamisi M Malebo, Tanja Wenzler, Monical Cal, Sauda M Swaleh, Maurice O Omolo, Ahmed Hassanali, Urs Séquin, Daniel Häussinger, Petur Dalsgaard, Matthias Hamburger, Reto Brun, Isaiah O Ndiege. Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae). BMC complementary and alternative medicine. 2013 Feb; 13(?):48. doi: 10.1186/1472-6882-13-48. [PMID: 23445637]
  • Claire Levrier, Mélodie Balastrier, Karren D Beattie, Anthony R Carroll, Frédéric Martin, Vanida Choomuenwai, Rohan A Davis. Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis. Phytochemistry. 2013 Feb; 86(?):121-6. doi: 10.1016/j.phytochem.2012.09.019. [PMID: 23158725]
  • Yanjuan Liu, Junxi Liu, Duolong Di, Min Li, Yan Fen. Structural and mechanistic bases of the anticancer activity of natural aporphinoid alkaloids. Current topics in medicinal chemistry. 2013; 13(17):2116-26. doi: 10.2174/15680266113139990147. [PMID: 23978138]
  • P L Falé, F Amaral, P J Amorim Madeira, M Sousa Silva, M H Florêncio, F N Frazão, M L M Serralheiro. Acetylcholinesterase inhibition, antioxidant activity and toxicity of Peumus boldus water extracts on HeLa and Caco-2 cell lines. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Aug; 50(8):2656-62. doi: 10.1016/j.fct.2012.04.049. [PMID: 22617353]
  • Maria Francesca Cometa, Stefano Fortuna, Giovanna Palazzino, Maria Teresa Volpe, Elsa Rengifo Salgado, Marcello Nicoletti, Lamberto Tomassini. New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia. Fitoterapia. 2012 Apr; 83(3):476-80. doi: 10.1016/j.fitote.2011.12.015. [PMID: 22230193]
  • Hua Fan, Tong Zheng, Yu Chen, Guang-Zhong Yang. Chemical constituents with free-radical-scavenging activities from the stem of Fissistigma polyanthum. Pharmacognosy magazine. 2012 Apr; 8(30):98-102. doi: 10.4103/0973-1296.96549. [PMID: 22701280]
  • Mamy H Rafamantanana, Benjamin Debrus, Guy E Raoelison, Eric Rozet, Pierre Lebrun, Suzanne Uverg-Ratsimamanga, Philippe Hubert, Joëlle Quetin-Leclercq. Application of design of experiments and design space methodology for the HPLC-UV separation optimization of aporphine alkaloids from leaves of Spirospermum penduliflorum Thouars. Journal of pharmaceutical and biomedical analysis. 2012 Mar; 62(?):23-32. doi: 10.1016/j.jpba.2011.12.028. [PMID: 22310553]
  • Abbas Mollataghi, Emilie Coudiere, A Hamid A Hadi, Mat Ropi Mukhtar, Khalijah Awang, Marc Litaudon, Athar Ata. Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species. Fitoterapia. 2012 Mar; 83(2):298-302. doi: 10.1016/j.fitote.2011.11.009. [PMID: 22119096]
  • Hefen Sun, Helei Hou, Ping Lu, Lixing Zhang, Fangyu Zhao, Chao Ge, Tingpu Wang, Ming Yao, Jinjun Li. Isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/m cell cycle arrest and apoptosis. PloS one. 2012; 7(5):e36808. doi: 10.1371/journal.pone.0036808. [PMID: 22623962]
  • L P S Pimenta, D D Mendonça. Aporphine alkaloids and feruloylamides from the bark of Xylopia benthamii R.E. Fries (Annonaceae). Natural product research. 2012; 26(20):1948-50. doi: 10.1080/14786419.2011.628667. [PMID: 22007762]
  • Ayano Matsushige, Yaichiro Kotake, Katsuyoshi Matsunami, Hideaki Otsuka, Shigeru Ohta, Yoshio Takeda. Annonamine, a new aporphine alkaloid from the leaves of Annona muricata. Chemical & pharmaceutical bulletin. 2012; 60(2):257-9. doi: 10.1248/cpb.60.257. [PMID: 22293487]
  • Jackson Roberto Guedes da Silva Almeida, Edigênia Cavalcante da Cruz Araújo, Luciano Augusto de Araújo Ribeiro, Julianeli Tolentino de Lima, Xirley Pereira Nunes, Ana Sílvia Suassuna Carneiro Lúcio, Maria de Fátima Agra, José Maria Barbosa Filho. Antinociceptive activity of ethanol extract from Duguetia chrysocarpa Maas (Annonaceae). TheScientificWorldJournal. 2012; 2012(?):859210. doi: 10.1100/2012/859210. [PMID: 22645460]
  • Geoffrey E Hawkes, Helene de Wet, Jia Li. Polar compounds isolated from the leaves of Albertisia delagoensis (Menispermaceae). Molecules (Basel, Switzerland). 2011 Nov; 16(11):9153-60. doi: 10.3390/molecules16119153. [PMID: 22048698]
  • Aaishwarya B Deshmukh, Jayvadan K Patel. Aqueous extract of Annona squamosa (L.) ameliorates renal failure induced by 5/6 nephrectomy in rat. Indian journal of pharmacology. 2011 Nov; 43(6):718-21. doi: 10.4103/0253-7613.89834. [PMID: 22144782]
  • Qiaoxia Liu, Shiyi Qiu, Hui Yu, Yanxiong Ke, Yu Jin, Xinmiao Liang. Selective separation of structure-related alkaloids in Rhizoma coptidis with "click" binaphthyl stationary phase and their structural elucidation with liquid chromatography-mass spectrometry. The Analyst. 2011 Oct; 136(20):4357-65. doi: 10.1039/c1an15444c. [PMID: 21881639]
  • Arthit Makarasen, Wandee Sirithana, Samang Mogkhuntod, Nisachon Khunnawutmanotham, Nitirat Chimnoi, Supanna Techasakul. Cytotoxic and antimicrobial activities of aporphine alkaloids isolated from Stephania venosa (Blume) Spreng. Planta medica. 2011 Sep; 77(13):1519-24. doi: 10.1055/s-0030-1270743. [PMID: 21305448]
  • John Alexander Corredor Barinas, Luis Enrique Cuca Suárez. Chemical constituents of Talauma arcabucoana (Magnoliaceae): their brine shrimp lethality and antimicrobial activity. Natural product research. 2011 Sep; 25(16):1497-504. doi: 10.1080/14786410903205146. [PMID: 21347974]
  • Zuo-Fu Guo, Xiao-Bing Wang, Jian-Guang Luo, Jun Luo, Jun-Song Wang, Ling-Yi Kong. A novel aporphine alkaloid from Magnolia officinalis. Fitoterapia. 2011 Jun; 82(4):637-41. doi: 10.1016/j.fitote.2011.01.021. [PMID: 21291961]
  • Helene de Wet, Fanie R van Heerden, Ben-Erik van Wyk. Alkaloidal variation in cissampelos capensis (Menispermaceae). Molecules (Basel, Switzerland). 2011 Apr; 16(4):3001-9. doi: 10.3390/molecules16043001. [PMID: 21475122]
  • Jih-Jung Chen, Hsin-Chih Hung, Ping-Jyun Sung, Ih-Sheng Chen, Wen-Lung Kuo. Aporphine alkaloids and cytotoxic lignans from the roots of Illigera luzonensis. Phytochemistry. 2011 Apr; 72(6):523-32. doi: 10.1016/j.phytochem.2010.12.015. [PMID: 21315382]
  • Jirapast Sichaem, Thanatip Ruksilp, Wisuttaya Worawalai, Pongpan Siripong, Suttira Khumkratok, Santi Tip-pyang. A new dimeric aporphine from the roots of Artabotrys spinosus. Fitoterapia. 2011 Apr; 82(3):422-5. doi: 10.1016/j.fitote.2010.11.025. [PMID: 21130146]
  • Fernanda R Garcez, Ana G Francisca da Silva, Walmir S Garcez, Gabriela Linck, Maria C de Fatima Matos, Evelyn C S Santos, Lyara M M Queiroz. Cytotoxic aporphine alkaloids from Ocotea acutifolia. Planta medica. 2011 Mar; 77(4):383-7. doi: 10.1055/s-0030-1250401. [PMID: 20922653]
  • Rocky Graziose, Thirumurugan Rathinasabapathy, Carmen Lategan, Alexander Poulev, Peter J Smith, Mary Grace, Mary Ann Lila, Ilya Raskin. Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L. Journal of ethnopharmacology. 2011 Jan; 133(1):26-30. doi: 10.1016/j.jep.2010.08.059. [PMID: 20826204]
  • M Iqbal Choudhary, Muhammad Ismail, Zulfiqar Ali, Khozirah Shaari, Nordin H Lajis, Atta-ur-Rahman. Alkaloidal constituents of Tinospora crispa. Natural product communications. 2010 Nov; 5(11):1747-50. doi: ". [PMID: 21213972]
  • Satoshi Fujita, Masayuki Ninomiya, Mai Efdi, Kenji Ohguchi, Yoshinori Nozawa, Mamoru Koketsu. Isolation of chemical constituents from Enicosanthum cupulare (King) Airy-Shaw. Natural product research. 2010 Oct; 24(17):1630-6. doi: 10.1080/14786411003774338. [PMID: 20954090]
  • Ki Hyun Kim, Cheng Jie Piao, Sang Un Choi, Mi Won Son, Kang Ro Lee. New cytotoxic tetrahydroprotoberberine-aporphine dimeric and aporphine alkaloids from Corydalis turtschaninovii. Planta medica. 2010 Oct; 76(15):1732-8. doi: 10.1055/s-0030-1249972. [PMID: 20509105]
  • Juan D Guzman, Antima Gupta, Dimitrios Evangelopoulos, Chandrakala Basavannacharya, Ludy C Pabon, Erika A Plazas, Diego R Muñoz, Wilman A Delgado, Luis E Cuca, Wellman Ribon, Simon Gibbons, Sanjib Bhakta. Anti-tubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis. The Journal of antimicrobial chemotherapy. 2010 Oct; 65(10):2101-7. doi: 10.1093/jac/dkq313. [PMID: 20719764]
  • Sunil K Mishra, A Kumar, A Talukdar. Evaluation of binding property of mucilage from Litsea glutinosa wall. Pharmacognosy research. 2010 Sep; 2(5):289-92. doi: 10.4103/0974-8490.72325. [PMID: 21589753]
  • Maosheng Zhang, Guangyi Liang, Jianping Yu, Weidong Pan. Aporphine alkaloids from the roots of Stephania viridiflavens. Natural product research. 2010 Aug; 24(13):1243-7. doi: 10.1080/14786410903125393. [PMID: 20645211]
  • Asmah Alias, Hazrina Hazni, Faridahanim Mohd Jaafar, Khalijah Awang, Nor Hadiani Ismail. Alkaloids from Fissistigma latifolium (Dunal) Merr. Molecules (Basel, Switzerland). 2010 Jun; 15(7):4583-8. doi: 10.3390/molecules15074583. [PMID: 20657378]
  • Liwei Hu, Wen Xu, Xi Zhang, Juan Su, Xinru Liu, Haiyun Li, Weidong Zhang. In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine. The Journal of pharmacy and pharmacology. 2010 May; 62(5):658-62. doi: 10.1211/jpp.62.05.0015. [PMID: 20609070]
  • Ericsson David Coy Barrera, Luis Enrique Cuca Suárez. In vitro inhibitory activities of Lauraceae aporphine alkaloids. Natural product communications. 2010 Mar; 5(3):383-6. doi: ". [PMID: 20420312]
  • Zhili Liu, Hai Zhang, Na Ye, Jing Zhang, QianQian Wu, Peihua Sun, Linyong Li, Xuechu Zhen, Ao Zhang. Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist. Journal of medicinal chemistry. 2010 Feb; 53(3):1319-28. doi: 10.1021/jm9015763. [PMID: 20041669]
  • Jillian M Hagel, Peter J Facchini. Biochemistry and occurrence of o-demethylation in plant metabolism. Frontiers in physiology. 2010; 1(?):14. doi: 10.3389/fphys.2010.00014. [PMID: 21423357]
  • K V Katkar, A C Suthar, V S Chauhan. The chemistry, pharmacologic, and therapeutic applications of Polyalthia longifolia. Pharmacognosy reviews. 2010 Jan; 4(7):62-8. doi: 10.4103/0973-7847.65329. [PMID: 22228943]
  • Walmir S Garcez, Fernanda R Garcez, Lilliam M G E da Silva, Lidilhone Hamerski. Larvicidal activity against Aedes aegypti of some plants native to the West-Central region of Brazil. Bioresource technology. 2009 Dec; 100(24):6647-50. doi: 10.1016/j.biortech.2009.06.092. [PMID: 19664915]
  • Hee-Kyung Hong, Weon-Jong Yoon, Young Ho Kim, Eun-Sook Yoo, Su-Hyun Jo. Inhibition of the human ether-a-go-go-related gene (HERG) K+ channels by Lindera erythrocarpa. Journal of Korean medical science. 2009 Dec; 24(6):1089-98. doi: 10.3346/jkms.2009.24.6.1089. [PMID: 19949665]
  • Chen Li, Dongho Lee, Tyler N Graf, Sharnelle S Phifer, Yuka Nakanishi, Soedarsono Riswan, Fransisca M Setyowati, Achmad M Saribi, Djaja D Soejarto, Norman R Farnsworth, Joseph O Falkinham, David J Kroll, A Douglas Kinghorn, Mansukh C Wani, Nicholas H Oberlies. Bioactive constituents of the stem bark of Mitrephora glabra. Journal of natural products. 2009 Nov; 72(11):1949-53. doi: 10.1021/np900572g. [PMID: 19874044]
  • Bangning Yu, Carla Cook, Nalini Santanam. The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells. Journal of medicinal food. 2009 Oct; 12(5):1074-83. doi: 10.1089/jmf.2008.0230. [PMID: 19857072]
  • Ziming Lu, Qingjian Zhang, Ruoyun Chen, Dequan Yu. [Aporphine alkaloids from branches and leaves of Polyalthia nemoralis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Sep; 34(18):2343-5. doi: . [PMID: 20030084]
  • Ratsami Lekphrom, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul. Bioactive styryllactones and alkaloid from flowers of Goniothalamus laoticus. Journal of ethnopharmacology. 2009 Aug; 125(1):47-50. doi: 10.1016/j.jep.2009.06.023. [PMID: 19573585]
  • Malcolm S Buchanan, Rohan A Davis, Sandra Duffy, Vicky M Avery, Ronald J Quinn. Antimalarial benzylisoquinoline alkaloid from the rainforest tree Doryphora sassafras. Journal of natural products. 2009 Aug; 72(8):1541-3. doi: 10.1021/np9002564. [PMID: 19637893]
  • Tiah Rachmatiah, Mat Ropi Mukhtar, Mohd Azlan Nafiah, Muhammad Hanafi, Soleh Kosela, Hiroshi Morita, Marc Litaudon, Khalijah Awang, Hanita Omar, A Hamid A Hadi. (+)-N-(2-hydroxypropyl)lindcarpine: a new cytotoxic aporphine isolated from Actinodaphne pruinosa Nees. Molecules (Basel, Switzerland). 2009 Jul; 14(8):2850-6. doi: 10.3390/molecules14082850. [PMID: 19701128]
  • Gao-Xiong Rao, Sen Zhang, Hui-Min Wang, Zhi-Min Li, Suo Gao, Gui-Li Xu. Antifungal alkaloids from the fresh rattan stem of Fibraurea recisa Pierre. Journal of ethnopharmacology. 2009 May; 123(1):1-5. doi: 10.1016/j.jep.2009.02.046. [PMID: 19429331]
  • Sajjad Hussain, Mark Slevin, Nessar Ahmed, David West, Muhammad Iqbal Choudhary, Humera Naz, John Gaffney. Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis. BMC cell biology. 2009 Apr; 10(?):30. doi: 10.1186/1471-2121-10-30. [PMID: 19389252]
  • Jia-Hui Chen, Zhi-Zhi Du, Yue-Mao Shen, Yong-Ping Yang. Aporphine alkaloids from Clematis parviloba and their antifungal activity. Archives of pharmacal research. 2009 Jan; 32(1):3-5. doi: 10.1007/s12272-009-1111-7. [PMID: 19183870]
  • Tran Manh Hung, Minkyun Na, Nguyen Tien Dat, Tran Minh Ngoc, Uijoung Youn, Hong Jin Kim, Byung-Sun Min, Jongpill Lee, Kihwan Bae. Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii. Journal of ethnopharmacology. 2008 Sep; 119(1):74-80. doi: 10.1016/j.jep.2008.05.041. [PMID: 18601993]
  • Wen Lu, Lang Chong He, Xian-Ming Zeng. HPLC method for the pharmacokinetics and tissue distribution of taspine solution and taspine liposome after intravenous administrations to mice. Journal of pharmaceutical and biomedical analysis. 2008 Jan; 46(1):170-6. doi: 10.1016/j.jpba.2007.08.009. [PMID: 17889477]
  • Mat Ropi Mukhtar, A Hamid A Hadi, David Rondeau, Pascal Richomme, Marc Litaudon, M Rais Mustafa, Khalijah Awang. New proaporphines from the bark of Phoebe scortechinii. Natural product research. 2008; 22(11):921-6. doi: 10.1080/14786410701642821. [PMID: 18629705]
  • Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Ratsami Lekphrom. Bioactive constituents of the roots of Polyalthia cerasoides. Journal of natural products. 2007 Sep; 70(9):1536-8. doi: 10.1021/np070293a. [PMID: 17845001]
  • Lucia Rackova, Marek Oblozinsky, Daniela Kostalova, Viktor Kettmann, Lydia Bezakova. Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids. Journal of inflammation (London, England). 2007 Jul; 4(?):15. doi: 10.1186/1476-9255-4-15. [PMID: 17634120]
  • Hilarion Mathouet, Abdelhakim Elomri, Pedro Lameiras, Adam Daïch, Philippe Vérité. An alkaloid, two conjugate sesquiterpenes and a phenylpropanoid from Pachypodanthium confine Engl. and Diels. Phytochemistry. 2007 Jul; 68(13):1813-8. doi: 10.1016/j.phytochem.2007.04.001. [PMID: 17544038]
  • Chun-yan Fu, Wen-qing Yin, Zhong-liu Zhou. [Studies on the aporphine alkaloids from Fissistigma oldhamii (Hemsl.) Merr]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2007 Apr; 30(4):409-12. doi: . [PMID: 17674790]
  • Sloan Ayers, Deborah L Zink, Kenneth Mohn, Joanne Staats Powell, Christine M Brown, Terry Murphy, Robert Brand, Seef Pretorius, Dennis Stevenson, Donald Thompson, Sheo B Singh. Anthelmintic activity of aporphine alkaloids from Cissampelos capensis. Planta medica. 2007 Mar; 73(3):296-7. doi: 10.1055/s-2007-967124. [PMID: 17309014]
  • Ilkay Orhana, Berrin Ozçelik, Taner Karaoğlu, Bilge Sener. Antiviral and antimicrobial profiles of selected isoquinoline alkaloids from Fumaria and Corydalis species. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2007 Jan; 62(1-2):19-26. doi: 10.1515/znc-2007-1-204. [PMID: 17425100]
  • Yun Deng, Tian Jun Tang, Xiang Li, Feng E Wu. A new aporphine alkaloid from Sabia yunnanensis. Natural product research. 2007 Jan; 21(1):28-32. doi: 10.1080/14786410601035340. [PMID: 17365685]
  • Yong Deuk Min, Sang Un Choi, Kang Ro Lee. Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes of Sinomenium acutum. Archives of pharmacal research. 2006 Aug; 29(8):627-32. doi: 10.1007/bf02968246. [PMID: 16964757]
  • Qizhi Zhao, Yimin Zhao, Kejun Wang. Antinociceptive and free radical scavenging activities of alkaloids isolated from Lindera angustifolia Chen. Journal of ethnopharmacology. 2006 Jul; 106(3):408-13. doi: 10.1016/j.jep.2006.01.019. [PMID: 16513307]
  • Qi-Zhi Zhao, Yi-Min Zhao, Ke-Jun Wang. [Alkaloids from the root of Lindera angustifolia]. Yao xue xue bao = Acta pharmaceutica Sinica. 2005 Oct; 40(10):931-4. doi: . [PMID: 16408812]
  • C Stévigny, C Bailly, J Quetin-Leclercq. Cytotoxic and antitumor potentialities of aporphinoid alkaloids. Current medicinal chemistry. Anti-cancer agents. 2005 Mar; 5(2):173-82. doi: 10.2174/1568011053174864. [PMID: 15777224]
  • Yoshiki Kashiwada, Akihiro Aoshima, Yasumasa Ikeshiro, Yuh-Pan Chen, Hiroshi Furukawa, Masataka Itoigawa, Toshihiro Fujioka, Kunihide Mihashi, L Mark Cosentino, Susan L Morris-Natschke, Kuo-Hsiung Lee. Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids. Bioorganic & medicinal chemistry. 2005 Jan; 13(2):443-8. doi: 10.1016/j.bmc.2004.10.020. [PMID: 15598565]
  • Chin-Wei Chiao, Shoei-Sheng Lee, Chin-Chen Wu, Ming-Jai Su. Thaliporphine increases survival rate and attenuates multiple organ injury in LPS-induced endotoxaemia. Naunyn-Schmiedeberg's archives of pharmacology. 2005 Jan; 371(1):34-43. doi: 10.1007/s00210-004-1014-6. [PMID: 15654598]
  • Wei-Luen Chang, Ching-Hu Chung, Yang-Chang Wu, Ming-Jai Su. The vascular and cardioprotective effects of liriodenine in ischemia-reperfusion injury via NO-dependent pathway. Nitric oxide : biology and chemistry. 2004 Dec; 11(4):307-15. doi: 10.1016/j.niox.2004.10.004. [PMID: 15604043]
  • Caroline Stévigny, Marie-Caroline Wautier, Jean-Louis Habib Jiwan, Patrice Chiap, Philippe Hubert, Joëlle Quetin-Leclercq. Development and validation of a high performance liquid chromatographic method for quantitative determination of aporphine alkaloids from different samples of Cassytha filiformis. Planta medica. 2004 Aug; 70(8):764-70. doi: 10.1055/s-2004-827209. [PMID: 15368674]
  • Jesús G Díaz, Juan García Ruiz, Werner Herz. Alkaloids from Delphinium pentagynum. Phytochemistry. 2004 Jul; 65(14):2123-7. doi: 10.1016/j.phytochem.2004.03.017. [PMID: 15279983]
  • Sara Hoet, Caroline Stévigny, Sébastien Block, Frederik Opperdoes, Pierre Colson, Brigitte Baldeyrou, Amélie Lansiaux, Christian Bailly, Joëlle Quetin-Leclercq. Alkaloids from Cassytha filiformis and related aporphines: antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases. Planta medica. 2004 May; 70(5):407-13. doi: 10.1055/s-2004-818967. [PMID: 15124084]
  • Yu-Ming Liu, Jun-Shan Yang, Qing-Hua Liu. A new alkaloid and its artificial derivative with an indazole ring from Nigella glandulifera. Chemical & pharmaceutical bulletin. 2004 Apr; 52(4):454-5. doi: 10.1248/cpb.52.454. [PMID: 15056964]
  • C Xu, Y Zhang, R X Tan. A new oxoaporphine alkaloid from Sinofranchetia chinensis. Fitoterapia. 2004 Mar; 75(2):239-41. doi: 10.1016/j.fitote.2003.12.001. [PMID: 15030935]
  • Francisco Orallo. Acute cardiovascular effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in anaesthetised normotensive rats. Planta medica. 2004 Feb; 70(2):117-26. doi: 10.1055/s-2004-815487. [PMID: 14994188]
  • Caroline Stévigny, Jean-Louis Habib Jiwan, Raoul Rozenberg, Edmond de Hoffmann, Joëlle Quetin-Leclercq. Key fragmentation patterns of aporphine alkaloids by electrospray ionization with multistage mass spectrometry. Rapid communications in mass spectrometry : RCM. 2004; 18(5):523-8. doi: 10.1002/rcm.1343. [PMID: 14978796]