Distigmine (BioDeep_00000279630)

   


代谢物信息卡片


Distigmine

化学式: C22H32N4O4+2 (416.2423432)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(CCCCCCN(C)C(=O)Oc1ccc[n+](C)c1)C(=O)Oc1ccc[n+](C)c1
InChI: InChI=1S/C22H32N4O4/c1-23-13-9-11-19(17-23)29-21(27)25(3)15-7-5-6-8-16-26(4)22(28)30-20-12-10-14-24(2)18-20/h9-14,17-18H,5-8,15-16H2,1-4H3/q+2

描述信息

N - Nervous system > N07 - Other nervous system drugs > N07A - Parasympathomimetics > N07AA - Anticholinesterases
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

Distigmine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kazumasa Kotake, Atsuhito Tone, Satoko Watanabe, Mayumi Senoo, Mitsuhiro Kaneto, Yusuke Imai, Sanae Teshigawara, Yasuhiro Kawakami, Tatsuaki Nakatou. Cholinergic Crisis Owing to Distigmine Bromide Complicated by Hyperosmolar Hyperglycemic State. Internal medicine (Tokyo, Japan). 2021 Jul; 60(14):2251-2254. doi: 10.2169/internalmedicine.6261-20. [PMID: 33583891]
  • Noritoshi Sekido, Takeya Otsuki, Jun Kida, Hiroko Mashimo, Daisuke Wakamatsu, Hiroki Okada, Hidekazu Matsuya. EP2 and EP3 receptors as therapeutic targets for underactive bladder/detrusor underactivity due to diabetic cystopathy in a type 1 diabetic rat model. Lower urinary tract symptoms. 2020 Sep; 12(3):285-291. doi: 10.1111/luts.12317. [PMID: 32410343]
  • Satoru Mitsuboshi, Kazuhiko Nagai, Hideo Okajima. Effect of Patient Age, Dose, and Chronic Kidney Disease on the Risk of Adverse Reactions to Distigmine. Biological & pharmaceutical bulletin. 2020; 43(8):1275-1278. doi: 10.1248/bpb.b20-00216. [PMID: 32741950]
  • Keisuke Obara, Daisuke Chino, Yoshio Tanaka. Distigmine Bromide Produces Sustained Potentiation of Guinea-Pig Urinary Bladder Motility by Inhibiting Cholinesterase Activity. Biological & pharmaceutical bulletin. 2017; 40(6):807-814. doi: 10.1248/bpb.b16-00901. [PMID: 28566624]
  • Takanobu Yamazaki, Ayako Fukata, Yukiko Muraki. Imidafenacin exerts the antidiuretic effect by enhancing vasopressin-related responses in orally water-loaded rats. European journal of pharmacology. 2016 Nov; 791(?):72-77. doi: 10.1016/j.ejphar.2016.08.021. [PMID: 27568834]
  • Kazuki Kobayashi, Hiroshi Sekiguchi, Nobuhiro Sato, Yasuo Hirose. [Bowel obstruction-induced cholinergic crisis with progressive respiratory failure following distigmine bromide treatment]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2016 Mar; 29(1):26-9. doi: NULL. [PMID: 27255021]
  • Satoshi Tatemichi, Kumi Tsuchioka, Saori Yonekubo, Kazuyasu Maruyama, Mamoru Kobayashi. Effects of Silodosin, an α1A-Adrenoceptor Antagonist, and Distigmine, an Acetylcholinesterase Inhibitor, and Their Combined Effects on Impaired Voiding Function in Zucker Diabetic Fatty Rats. Pharmacology. 2015; 95(5-6):285-92. doi: 10.1159/000398811. [PMID: 26023044]
  • Noritoshi Sekido, Jun Kida, Daisuke Wakamatsu, Hiroki Okada, Hidekazu Matsuya. Effects of α1 antagonist and cholinesterase inhibitor on cystometric parameters in lumbar canal stenosis rats with underactive bladder. Urology. 2014 Nov; 84(5):1248.e9-15. doi: 10.1016/j.urology.2014.07.036. [PMID: 25443946]
  • Kimio Sugaya, Katsumi Kadekawa, Tomohiro Onaga, Katsuhiro Ashitomi, Hideki Mukouyama, Kei Nakasone, Hiroichi Shimabukuro, Shuichi Shimabukuro, Yukihide Matayoshi, Sanehiro Hokama, Yuichi Touyama, Saori Nishijima. [Effect of distigmine at 5 mg daily in patients with detrusor underactivity]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology. 2014 Jan; 105(1):10-6. doi: 10.5980/jpnjurol.105.10. [PMID: 24605581]
  • Daisuke Setoguchi, Henry Yatsuki, Tomohito Sadahiro, Masataka Nakamura, Yo Hirayama, Eizo Watanabe, Yoshihisa Tateishi, Shigeto Oda. Effects of a peripheral cholinesterase inhibitor on cytokine production and autonomic nervous activity in a rat model of sepsis. Cytokine. 2012 Feb; 57(2):238-44. doi: 10.1016/j.cyto.2011.11.003. [PMID: 22138106]
  • Kazuko Kariyone, Yoshimi Shimatani, Toshikazu Kurihara, Takehiko Nagao, Yoshika Fujita, Masayoshi Uesugi. [Establishing indicators for diagnosis of cholinergic crisis]. Rinsho byori. The Japanese journal of clinical pathology. 2010 Oct; 58(10):972-8. doi: NULL. [PMID: 21077286]
  • Yoshihiko Ito, Taketsugu Harada, Kasumi Fushimi, Yoshiyuki Kagawa, Hidenobu Oka, Hiroshi Nakazawa, Reiko Homma, Yoshihisa Kato, Shizuo Yamada. Pharmacokinetic and pharmacodynamic analysis of acetylcholinesterase inhibition by distigmine bromide in rats. Drug metabolism and pharmacokinetics. 2010; 25(3):254-61. doi: 10.2133/dmpk.25.254. [PMID: 20610884]
  • Subramanian Vaidyanathan, Paul Mansour, Bakul M Soni, Peter L Hughes, Gurpreet Singh, Tun Oo. Marked hydronephrosis and hydroureter after distigmine therapy in an adult male patient with paraplegia due to spinal cord injury: a case report. Cases journal. 2009 Aug; 2(?):7333. doi: 10.4076/1757-1626-2-7333. [PMID: 19918519]
  • Yoshinori Tanaka, Naoya Masumori, Taiji Tsukamoto, Seiji Furuya, Ryoji Furuya, Hiroshi Ogura. Treatment strategy according to findings on pressure-flow study for women with decreased urinary flow rate. Advances in urology. 2009; ?(?):782985. doi: 10.1155/2009/782985. [PMID: 19841751]
  • Makoto Onodera, Yasuhisa Fujino, Yoshihiro Inoue, Shigeatsu Endo, Yuji Fujita. [Three cases of cholinergic crisis in which serum distigmine bromide concentrations were measured]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2008 Jan; 21(1):75-81. doi: NULL. [PMID: 18277557]
  • Takeshi Saito, Fumiko Satoh, Kozo Tamura, Hiroyuki Otsuka, Shigeaki Inoue, Isotoshi Yamamoto, Sadaki Inokuchi. Screening procedure for the analysis of distigmine bromide in serum by high-performance liquid chromatography-electrospray ionization mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jun; 852(1-2):659-64. doi: 10.1016/j.jchromb.2007.02.004. [PMID: 17331815]
  • Tadatoshi Hashimoto, Hiroshi Nagabukuro, Takayuki Doi. Effects of the selective acetylcholinesterase inhibitor TAK-802 on the voiding behavior and bladder mass increase in rats with partial bladder outlet obstruction. The Journal of urology. 2005 Sep; 174(3):1137-41. doi: 10.1097/01.ju.0000168616.71956.a4. [PMID: 16094081]
  • Masayoshi Tada, Nobuya Fujita, Maiko Umeda, Hiroshi Koike, Hiroko Nagai. [A case of acute distigmine bromide intoxication in the therapeutic dosage for treatment of underactive neurogenic bladder]. No to shinkei = Brain and nerve. 2004 May; 56(5):415-9. doi: NULL. [PMID: 15279199]
  • Tomonori Yamanishi, Kosaku Yasuda, Takao Kamai, Toshihiko Tsujii, Ryuji Sakakibara, Tomoyuki Uchiyama, Ken-ichiro Yoshida. Combination of a cholinergic drug and an alpha-blocker is more effective than monotherapy for the treatment of voiding difficulty in patients with underactive detrusor. International journal of urology : official journal of the Japanese Urological Association. 2004 Feb; 11(2):88-96. doi: 10.1111/j.1442-2042.2004.00753.x. [PMID: 14706012]
  • Shigeki Yamanaka, Ichiro Fujita, Takashi Murota, Mutsushi Kawakita, Tadashi Matsuda. [Cholinergic crisis following administration of distigmine bromide: a case report]. Hinyokika kiyo. Acta urologica Japonica. 2002 Jan; 48(1):21-3. doi: NULL. [PMID: 11868380]
  • T B Vree, J Waitzinger, A Hammermaier, S Radhofer-Welte. Absolute bioavailability, pharmacokinetics, renal and biliary clearance of distigmine after a single oral dose in comparison to i.v. administration of 14C-distigmine-bromide in healthy volunteers. International journal of clinical pharmacology and therapeutics. 1999 Aug; 37(8):393-403. doi: NULL. [PMID: 10475142]
  • M Koga, H Miyata, N Tsuno, K Nakayama, S Ushijima, Y Tanaka, Y Hiraga, N Kobayashi. [Relationship between cholinergic symptoms caused by distigmine and the activities of serum AChE and BChE]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. 1997 Jun; 17(3):143-7. doi: NULL. [PMID: 9278940]