sultiame (BioDeep_00000279102)

   


代谢物信息卡片


Sulthiame

化学式: C10H14N2O4S2 (290.0395)
中文名称: 噻嗪磺胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCS(=O)(=O)N(C1)C2=CC=C(C=C2)S(=O)(=O)N
InChI: InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16)

描述信息

C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
CONFIDENCE Reference Standard (Level 1); HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)

同义名列表

2 个代谢物同义名

Sulthiame; sultiame



数据库引用编号

67 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Katarzyna Madej, Łukasz Paprotny, Dorota Wianowska, Joanna Kasprzyk, Małgorzata Herman, Wojciech Piekoszewski. A fully validated HPLC-UV method for determination of sulthiame in human serum/plasma samples. Biomedical chromatography : BMC. 2021 Mar; 35(3):e5002. doi: 10.1002/bmc.5002. [PMID: 33058183]
  • Kim Dao, Paul Thoueille, Laurent A Decosterd, Thomas Mercier, Monia Guidi, Carine Bardinet, Sébastien Lebon, Eva Choong, Arnaud Castang, Catherine Guittet, Luc-André Granier, Thierry Buclin. Sultiame pharmacokinetic profile in plasma and erythrocytes after single oral doses: A pilot study in healthy volunteers. Pharmacology research & perspectives. 2020 02; 8(1):e00558. doi: 10.1002/prp2.558. [PMID: 31990440]
  • Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Yukiko Mogami, Kazumi Matsuda, Masahiko Nakai, Yoshiyuki Kagawa, Yushi Inoue. Interaction between sulthiame and clobazam: sulthiame inhibits the metabolism of clobazam, possibly via an action on CYP2C19. Epilepsy & behavior : E&B. 2014 May; 34(?):124-6. doi: 10.1016/j.yebeh.2014.03.018. [PMID: 24742983]
  • Mika Hilvo, Anna Maria Salzano, Alessio Innocenti, Markku S Kulomaa, Andrea Scozzafava, Andrea Scaloni, Seppo Parkkila, Claudiu T Supuran. Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. Journal of medicinal chemistry. 2009 Feb; 52(3):646-54. doi: 10.1021/jm801267c. [PMID: 19193158]
  • Tohshin Go. Effect of antiepileptic drug monotherapy on urinary pH in children and young adults. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 2006 Jan; 22(1):56-9. doi: 10.1007/s00381-004-1130-0. [PMID: 15909204]
  • Tohshin Go. Effect of antiepileptic drug polytherapy on crystalluria. Pediatric neurology. 2005 Feb; 32(2):113-5. doi: 10.1016/j.pediatrneurol.2004.09.001. [PMID: 15664771]
  • Theodor W May, Bernhard Rambeck, Uwe Jürgens. Serum concentrations of topiramate in patients with epilepsy: influence of dose, age, and comedication. Therapeutic drug monitoring. 2002 Jun; 24(3):366-74. doi: 10.1097/00007691-200206000-00007. [PMID: 12021627]
  • D Rating, C Wolf, T Bast. Sulthiame as monotherapy in children with benign childhood epilepsy with centrotemporal spikes: a 6-month randomized, double-blind, placebo-controlled study. Sulthiame Study Group. Epilepsia. 2000 Oct; 41(10):1284-8. doi: 10.1111/j.1528-1157.2000.tb04606.x. [PMID: 11051123]
  • D Battino, M Estienne, G Avanzini. Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part II. Phenytoin, carbamazepine, sulthiame, lamotrigine, vigabatrin, oxcarbazepine and felbamate. Clinical pharmacokinetics. 1995 Nov; 29(5):341-69. doi: 10.2165/00003088-199529050-00004. [PMID: 8582119]
  • G J ROCKLEY. ATTEMPTED SUICIDE WITH SULTHIAME. British medical journal. 1965 Sep; 2(5462):632. doi: NULL. [PMID: 14331626]