Dixyrazine (BioDeep_00000279100)

   


代谢物信息卡片


Dixyrazine

化学式: C24H33N3O2S (427.22933580000006)
中文名称: 地西拉嗪
谱图信息: 最多检出来源 Viridiplantae(plant) 50%

分子结构信息

SMILES: CC(CN1CCN(CC1)CCOCCO)CN2C3=CC=CC=C3SC4=CC=CC=C42
InChI: InChI=1S/C24H33N3O2S/c1-20(18-26-12-10-25(11-13-26)14-16-29-17-15-28)19-27-21-6-2-4-8-23(21)30-24-9-5-3-7-22(24)27/h2-9,20,28H,10-19H2,1H3

描述信息

N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AB - Phenothiazines with piperazine structure
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
CONFIDENCE Reference Standard (Level 1); HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu); Flow Injection
CONFIDENCE Reference Standard (Level 1); HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)
HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu); CONFIDENCE Reference Standard (Level 1)

同义名列表

1 个代谢物同义名

Dixyrazine



数据库引用编号

109 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jagdish Gondalia, Björn Fagerberg, Johannes Hulthe, Lars Karlström, Ulf Nilsson, Susanna Waters, Olof Jonsson. Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease. International journal of medical sciences. 2007 Apr; 4(3):124-30. doi: 10.7150/ijms.4.124. [PMID: 17505560]
  • M Oikkonen, J Kärkelä, T Seppälä. CSF concentrations and clinical effects following intravenous dixyrazine premedication. European journal of clinical pharmacology. 1995; 47(5):445-7. doi: 10.1007/bf00196859. [PMID: 7720767]
  • P O Feet, K G Götestam. Increased antipanic efficacy in combined treatment with clomipramine and dixyrazine. Acta psychiatrica Scandinavica. 1994 Apr; 89(4):230-4. doi: 10.1111/j.1600-0447.1994.tb01506.x. [PMID: 7912879]
  • B B Johansson, I Westergren. Pharmacological reduction of brain edema induced by intracarotid infusion of protamine sulphate: a comparison between a free radical scavenger and an AMPA receptor antagonist. Acta neurochirurgica. Supplementum. 1994; 60(?):128-31. doi: 10.1007/978-3-7091-9334-1_34. [PMID: 7976524]
  • I Westergren, B B Johansson. Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate. Acta neurochirurgica. 1991; 113(3-4):171-5. doi: 10.1007/bf01403203. [PMID: 1686824]
  • B Sorbe, C Hallén. Betamethasone-dixyrazine versus betamethasone-metoclopramide as antiemetic treatment of cisplatin-doxorubicin-induced nausea in ovarian carcinoma patients. European journal of gynaecological oncology. 1991; 12(1):31-7. doi: NULL. [PMID: 2050157]
  • P O Feet, S Larsen, P E Lillevold, A Liden, V Holm, O H Robak. Comparison of the serum levels in primary non-agitated depressed out-patients treated with imipramine in combination with placebo, diazepam or dixyrazine. Acta psychiatrica Scandinavica. 1987 Apr; 75(4):435-40. doi: 10.1111/j.1600-0447.1987.tb02812.x. [PMID: 2884811]
  • P O Feet, S Larsen, O H Robak. A double blind study in out-patients with primary non-agitated depression treated with imipramine in combination with placebo, diazepam or dixyrazine. Acta psychiatrica Scandinavica. 1985 Oct; 72(4):334-40. doi: 10.1111/j.1600-0447.1985.tb02618.x. [PMID: 3907277]
  • H Liedholm, A Lidén, L Kroon, A Melander, E Wåhlin-Boll. Pharmacokinetics of dixyrazine: low bioavailability, improved by food intake. Drug-nutrient interactions. 1985; 3(2):87-92. doi: NULL. [PMID: 3987521]
  • O Winsö, B Biber, C Holm, J Martner. Influence of dixyrazine on intestinal and renal vasoconstrictor responses during fentanyl-nitrous oxide anaesthesia. Acta anaesthesiologica Scandinavica. 1983 Dec; 27(6):458-63. doi: 10.1111/j.1399-6576.1983.tb01987.x. [PMID: 6666523]
  • B B Johansson, L M Auer, L E Linder. Phenothiazine-mediated protection of the blood-brain barrier during acute hypertension. Stroke. 1982 Mar; 13(2):220-5. doi: 10.1161/01.str.13.2.220. [PMID: 6121402]
  • A Hulshoff, J H Perrin. Quantitative correlations between albumin binding constants and chromatographic Rm values of phenothiazine derivatives. Journal of medicinal chemistry. 1977 Mar; 20(3):430-9. doi: 10.1021/jm00213a022. [PMID: 576620]