8-Isoprostane (BioDeep_00000027907)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


(1R,2S)-1-Heptyl-2-octylcyclopentane

化学式: C20H40 (280.31298400000003)
中文名称:
谱图信息: 最多检出来源 Danio rerio(blood) 33.33%

分子结构信息

SMILES: CCCCCCCCC1CCCC1CCCCCCC
InChI: InChI=1S/C20H40/c1-3-5-7-9-11-13-16-20-18-14-17-19(20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m1/s1

描述信息

8-isoprostane concentrations are elevated in asthma and increase with the clinical severity and during acute asthma episodes. Isoprostane is formed in the airways of asthmatic patients from peroxidation of poly-unsaturated fatty acids in cell membranes, the effect of reactive oxygen species resulting of the NADPH oxidase of eosinophils, neutrophils and alveolar macrophages, which produces superoxide anion which undergoes dismutation to H2O2. (PMID 16354413). 8-isoprostane is also elevated in Bronchopulmonary dysplasia, which remains an important cause of morbidity and mortality in extremely premature newborn infants receiving intensive care and is the most common contributing factor to severe respiratory morbidity and mortality in early childhood. (PMID 14980283). 8-Isoprostaglandin F(2a) is a marker of oxidative stress in the aqueous humour of patients with exfoliation syndrome (XFS) (PubMed ID 12598453).
8-isoprostane concentrations are elevated in asthma and increase with the clinical severity and during acute asthma episodes. Isoprostane is formed in the airways of asthmatic patients from peroxidation of poly-unsaturated fatty acids in cell membranes, the effect of reactive oxygen species resulting of the NADPH oxidase of eosinophils, neutrophils and alveolar macrophages, which produces superoxide anion which undergoes dismutation to H2O2. (PMID 16354413)

同义名列表

20 个代谢物同义名

(1R,2S)-1-Heptyl-2-octylcyclopentane; Isoprostaglandin F2alpha type-III; 8-Epi-prostaglandin F2alpha; 8-Epiprostaglandin F2alpha; 8-Isoprostaglandin F2alpha; 15-F(2t)-Isoprostane; 8-F(2t)-Isoprostane; 15-F2t-Isoprostane; 8-iso-PGF(2alpha); (8beta)-Prostane; 8-Epi-PGF2 alpha; 8-Epi-PGF2alpha; 8-iso-PGF2alpha; 8-beta-Prostane; (8b)-Prostane; 15-F(2t)-IsoP; 8-Isoprostane; (8Β)-prostane; 8β-prostane; 15-F2t-IsoP



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

46 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Lin Ma, Dongxiao Sun, Guangli Xiu, Philip Lazarus, Anil Vachani, Trevor M Penning, Alexander S Whitehead, Joshua E Muscat. Quantification of Plasma 8-Isoprostane by High-Performance Liquid Chromatography with Tandem Mass Spectrometry in a Case-Control Study of Lung Cancer. International journal of environmental research and public health. 2022 09; 19(19):. doi: 10.3390/ijerph191912488. [PMID: 36231826]
  • Heike Braun, Michael Hauke, Robert Eckenstaler, Markus Petermann, Anne Ripperger, Niklas Kühn, Edzard Schwedhelm, Beatrice Ludwig-Kraus, Frank Bernhard Kraus, Virginie Dubourg, Alma Zernecke, Barbara Schreier, Michael Gekle, Ralf A Benndorf. The F2-isoprostane 8-iso-PGF2α attenuates atherosclerotic lesion formation in Ldlr-deficient mice - Potential role of vascular thromboxane A2 receptors. Free radical biology & medicine. 2022 05; 185(?):36-45. doi: 10.1016/j.freeradbiomed.2022.04.010. [PMID: 35470061]
  • Aliaa Abdelmoniem Bedeir Eita, Azza Mohamed Zaki, Sabah Abdelhady Mahmoud. Serum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trial. BMC oral health. 2021 07; 21(1):343. doi: 10.1186/s12903-021-01711-z. [PMID: 34266435]
  • Victor M Petrone-Garcia, Raquel Lopez-Arellano, Gabriela Rodríguez Patiño, Miriam Aide Castillo Rodríguez, Daniel Hernandez-Patlan, Bruno Solis-Cruz, Xochitl Hernandez-Velasco, Fernando Alba-Hurtado, Christine N Vuong, Inkar Castellanos-Huerta, Guillermo Tellez-Isaias. Curcumin reduces enteric isoprostane 8-iso-PGF2α and prostaglandin GF2α in specific pathogen-free Leghorn chickens challenged with Eimeria maxima. Scientific reports. 2021 06; 11(1):11609. doi: 10.1038/s41598-021-90679-5. [PMID: 34078952]
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  • Farhad Gholami, Jose Antonio, Cassandra Evans, Khadijeh Cheraghi, Leila Rahmani, Fatemeh Amirnezhad. Tomato powder is more effective than lycopene to alleviate exercise-induced lipid peroxidation in well-trained male athletes: randomized, double-blinded cross-over study. Journal of the International Society of Sports Nutrition. 2021 Feb; 18(1):17. doi: 10.1186/s12970-021-00415-7. [PMID: 33639967]
  • Sandra Amalie Dybos, Åge Winje Brustad, Toril Rolfseng, Solveig Kvam, Oddrun Elise Olsen, Jostein Halgunset, Haakon Skogseth. RNA-Integrity and 8-Isoprostane Levels Are Stable in Prostate Tissue Samples Upon Long-Term Storage at -80°C. Biopreservation and biobanking. 2021 Feb; 19(1):2-10. doi: 10.1089/bio.2019.0136. [PMID: 32865438]
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