Resolvin D3 (BioDeep_00000278760)

   


代谢物信息卡片


4S,10,17S-trihydroxy-docosa-5E,7E,9E,12E,14E,19Z-hexaenoic acid

化学式: C22H32O5 (376.225)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 100%

分子结构信息

SMILES: C(=C/[C@@H](C\C=C/C=C/[C@H](C/C=C\CC)O)O)\C=C\C=C/[C@H](CCC(O)=O)O
InChI: InChI=1S/C22H32O5/c1-2-3-7-12-19(23)14-10-6-11-15-20(24)13-8-4-5-9-16-21(25)17-18-22(26)27/h3-11,13-14,16,19-21,23-25H,2,12,15,17-18H2,1H3,(H,26,27)/b5-4+,7-3-,11-6-,13-8+,14-10+,16-9+/t19-,20?,21-/m1/s1

描述信息

A member of the class of resolvins that is (5Z,7E,9E,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 11 and 17 (the 4S,11R,17S-stereoisomer).
CONFIDENCE standard compound; NATIVE_RUN_ID STD_neg_MSMS_1min0210.mzML; PROCESSING averaging of repeated ion fragments at 30.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID STD_neg_MSMS_1min0210.mzML; PROCESSING averaging of repeated ion fragments at 20.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID STD_neg_MSMS_1min0210.mzML; PROCESSING averaging of repeated ion fragments at 10.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0000141.mzML; PROCESSING averaging of repeated ion fragments at 30.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0000141.mzML; PROCESSING averaging of repeated ion fragments at 20.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0000141.mzML; PROCESSING averaging of repeated ion fragments at 10.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0000141.mzML; PROCESSING averaging of repeated ion fragments at 40.0 NCE within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0000141.mzML; PROCESSING averaging of repeated ion fragments at 30.0 NCE within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0000141.mzML; PROCESSING averaging of repeated ion fragments at 20.0 NCE within 5 ppm window [MS, MS:1000575, mean of spectra, ]

同义名列表

5 个代谢物同义名

Resolvin D3; 4S,10,17S-trihydroxy-5E,7E,9E,13Z,15E,19Z-docosahexaenoic acid; FA 22:6;O3; RvD3; 4S,10,17S-trihydroxy-docosa-5E,7E,9E,12E,14E,19Z-hexaenoic acid



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Heeseung Oh, Wonjun Cho, A M Abd El-Aty, Cemil Bayram, Ji Hoon Jeong, Tae Woo Jung. Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK/autophagy-associated attenuation of ER stress. Biochemical pharmacology. 2022 09; 203(?):115203. doi: 10.1016/j.bcp.2022.115203. [PMID: 35948170]
  • Ellen C Keeley, Han J Li, Christopher R Cogle, Eileen M Handberg, C Noel Bairey Merz, Carl J Pepine. Specialized Proresolving Mediators in Symptomatic Women With Coronary Microvascular Dysfunction (from the Women's Ischemia Trial to Reduce Events in Nonobstructive CAD [WARRIOR] Trial). The American journal of cardiology. 2022 01; 162(?):1-5. doi: 10.1016/j.amjcard.2021.09.015. [PMID: 34728061]
  • Fabian Schulte, Abdul Aziz Asbeutah, Peter N Benotti, G Craig Wood, Christopher Still, Bruce R Bistrian, Markus Hardt, Francine K Welty. The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery. Scientific reports. 2020 11; 10(1):20128. doi: 10.1038/s41598-020-75353-6. [PMID: 33208757]
  • Sang Hoon Lee, Raquel Tonello, Sang-Taek Im, Hawon Jeon, Jeongsu Park, Zachary Ford, Steve Davidson, Yong Ho Kim, Chul-Kyu Park, Temugin Berta. Resolvin D3 controls mouse and human TRPV1-positive neurons and preclinical progression of psoriasis. Theranostics. 2020; 10(26):12111-12126. doi: 10.7150/thno.52135. [PMID: 33204332]
  • Patricia R Souza, Mary E Walker, Nicolas J Goulding, Jesmond Dalli, Mauro Perretti, Lucy V Norling. The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections. Frontiers in immunology. 2020; 11(?):573019. doi: 10.3389/fimmu.2020.573019. [PMID: 33133087]
  • Hildur H Arnardottir, Jesmond Dalli, Lucy V Norling, Romain A Colas, Mauro Perretti, Charles N Serhan. Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. Journal of immunology (Baltimore, Md. : 1950). 2016 09; 197(6):2362-8. doi: 10.4049/jimmunol.1502268. [PMID: 27534559]
  • Hildur H Arnardottir, Jesmond Dalli, Romain A Colas, Masakazu Shinohara, Charles N Serhan. Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. Journal of immunology (Baltimore, Md. : 1950). 2014 Oct; 193(8):4235-44. doi: 10.4049/jimmunol.1401313. [PMID: 25217168]
  • Charles N Serhan. Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014 Jun; 510(7503):92-101. doi: 10.1038/nature13479. [PMID: 24899309]
  • Jeremy W Winkler, Jasim Uddin, Charles N Serhan, Nicos A Petasis. Stereocontrolled total synthesis of the potent anti-inflammatory and pro-resolving lipid mediator resolvin D3 and its aspirin-triggered 17R-epimer. Organic letters. 2013 Apr; 15(7):1424-7. doi: 10.1021/ol400484u. [PMID: 23510485]
  • Jesmond Dalli, Jeremy W Winkler, Romain A Colas, Hildur Arnardottir, Chien-Yee C Cheng, Nan Chiang, Nicos A Petasis, Charles N Serhan. Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents. Chemistry & biology. 2013 Feb; 20(2):188-201. doi: 10.1016/j.chembiol.2012.11.010. [PMID: 23438748]