TRICRESYL PHOSPHATE (BioDeep_00000278721)
Industrial Pollutants
代谢物信息卡片
Tris(4-methylphenyl) phosphate
化学式: C21H21O4P (368.1177)
中文名称: 三对甲苯基磷酸酯, 磷酸三甲苯酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC=C(C=C1)OP(=O)(OC2=CC=C(C=C2)C)OC3=CC=C(C=C3)C
InChI: InChI=1S/C21H21O4P/c1-16-4-10-19(11-5-16)23-26(22,24-20-12-6-17(2)7-13-20)25-21-14-8-18(3)9-15-21/h4-15H,1-3H3
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 6529
- ChEMBL: CHEMBL1596847
- MeSH: Tritolyl Phosphates
- CAS: 78-32-0
- PMhub: MS000014633
- CAS: 1330-78-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jing Li, Yi-Jun Wu. Tri-ortho-cresyl phosphate induces hepatic steatosis by mTOR activation and ER stress induction.
Ecotoxicology and environmental safety.
2024 Feb; 271(?):116010. doi:
10.1016/j.ecoenv.2024.116010. [PMID: 38280340] - Dandan Xiang, Qiangwei Wang. PXR-mediated organophorous flame retardant tricresyl phosphate effects on lipid homeostasis.
Chemosphere.
2021 Dec; 284(?):131250. doi:
10.1016/j.chemosphere.2021.131250. [PMID: 34225124] - Helena T Hogberg, Rita de Cássia da Silveira E Sá, Andre Kleensang, Mounir Bouhifd, Ozge Cemiloglu Ulker, Lena Smirnova, Mamta Behl, Alexandra Maertens, Liang Zhao, Thomas Hartung. Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model.
Archives of toxicology.
2021 01; 95(1):207-228. doi:
10.1007/s00204-020-02903-2. [PMID: 33078273] - Samantha Adams, Kimberly Wiersielis, Ali Yasrebi, Kristie Conde, Laura Armstrong, Grace L Guo, Troy A Roepke. Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression.
Reproductive toxicology (Elmsford, N.Y.).
2020 06; 94(?):65-74. doi:
10.1016/j.reprotox.2020.04.001. [PMID: 32360330] - Zhengliang Hao, Zhijie Zhang, Dezhao Lu, Bin Ding, Lin Shu, Quan Zhang, Cui Wang. Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells.
Chemical research in toxicology.
2019 06; 32(6):1250-1258. doi:
10.1021/acs.chemrestox.9b00058. [PMID: 30966736] - Junqi Li, Zheng Dong, Ying Wang, Junsong Bao, Yijun Yan, Jun Jin. Different organophosphate flame retardant and metabolite concentrations in urine from male and female university students in Beijing and an assessment of exposure via indoor dust.
Environmental toxicology and chemistry.
2019 04; 38(4):760-768. doi:
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2018 04; 178(?):322-332. doi:
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2018 03; 162(1):212-224. doi:
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Human & experimental toxicology.
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Toxicology research.
2016 Mar; 5(2):471-481. doi:
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2015 Apr; 50(4):683-92. doi:
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Archives of toxicology.
2015 Feb; 89(2):259-61. doi:
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Archives of toxicology.
2015 Feb; 89(2):263-4. doi:
10.1007/s00204-015-1449-1. [PMID: 25586888] - Lawrence M Schopfer, Patrick Masson, Patricia Lamourette, Stéphanie Simon, Oksana Lockridge. Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome.
Analytical biochemistry.
2014 Sep; 461(?):17-26. doi:
10.1016/j.ab.2014.05.021. [PMID: 24892986] - Ozden Tacal, Lawrence M Schopfer. Healthy F-16 pilots show no evidence of exposure to tri-ortho-cresyl phosphate through the on-board oxygen generating system.
Chemico-biological interactions.
2014 May; 215(?):69-74. doi:
10.1016/j.cbi.2014.03.004. [PMID: 24661946] - Patrick J Morris, Daniel Medina-Cleghorn, Ann Heslin, Sarah M King, Joseph Orr, Melinda M Mulvihill, Ronald M Krauss, Daniel K Nomura. Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia.
ACS chemical biology.
2014 May; 9(5):1097-103. doi:
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Environmental toxicology and chemistry.
2014 Mar; 33(3):573-82. doi:
10.1002/etc.2469. [PMID: 24273086] - Birgit Karin Schindler, Tobias Weiss, Andre Schütze, Stephan Koslitz, Horst Christoph Broding, Jürgen Bünger, Thomas Brüning. Occupational exposure of air crews to tricresyl phosphate isomers and organophosphate flame retardants after fume events.
Archives of toxicology.
2013 Apr; 87(4):645-8. doi:
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Chemosphere.
2012 Aug; 88(10):1119-53. doi:
10.1016/j.chemosphere.2012.03.067. [PMID: 22537891] - Mariya Liyasova, Bin Li, Lawrence M Schopfer, Florian Nachon, Patrick Masson, Clement E Furlong, Oksana Lockridge. Exposure to tri-o-cresyl phosphate detected in jet airplane passengers.
Toxicology and applied pharmacology.
2011 Nov; 256(3):337-47. doi:
10.1016/j.taap.2011.06.016. [PMID: 21723309] - Ellen G Duysen, Oksana Lockridge. Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons.
Toxicology and applied pharmacology.
2011 Sep; 255(2):214-20. doi:
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Toxicology.
2008 Oct; 252(1-3):56-63. doi:
10.1016/j.tox.2008.07.061. [PMID: 18755237] - Hassan A N El-Fawal, Wilfred C McCain. Antibodies to neural proteins in organophosphorus-induced delayed neuropathy (OPIDN) and its amelioration.
Neurotoxicology and teratology.
2008 May; 30(3):161-6. doi:
10.1016/j.ntt.2008.01.005. [PMID: 18353611] - G A Muzardo, R G P Machado, G Honorato de Oliveira. Effects of calcium gluconate and PMSF in the treatment of acute intoxication of chicken by TOCP.
Human & experimental toxicology.
2008 Mar; 27(3):247-52. doi:
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2007 Oct; 35(10):1832-9. doi:
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Toxicology.
2007 Sep; 239(1-2):45-52. doi:
10.1016/j.tox.2007.06.091. [PMID: 17662514] - Georgino Honorato de Oliveira, Vanessa Moreira, Sheila Patricia Ribeiro Goes. Organophosphate induced delayed neuropathy in genetically dissimilar chickens: studies with tri-ortho-cresyl phosphate (TOCP) and trichlorfon.
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2002 Dec; 136(2):143-50. doi:
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2001 Jan; 18(1):13-7. doi:
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Chemosphere.
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1999 Nov; 62(6):48-51. doi:
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Fundamental and applied toxicology : official journal of the Society of Toxicology.
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10.1016/0272-0590(85)90112-5. [PMID: 4092894] - E G Butler, H W Eckerson, B N La Du. Paraoxon hydrolysis vs. covalent binding in the elimination of paraoxon in the rabbit.
Drug metabolism and disposition: the biological fate of chemicals.
1985 Nov; 13(6):640-5. doi:
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Anesthesia and analgesia.
1985 Nov; 64(11):1047-52. doi:
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Toxicology and applied pharmacology.
1985 Jun; 79(1):83-90. doi:
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Bulletin of environmental contamination and toxicology.
1985 Jun; 34(6):780-6. doi:
10.1007/bf01609807. [PMID: 4016286] - H Kurebayashi, A Tanaka, T Yamaha. Metabolism and disposition of the flame retardant plasticizer, tri-p-cresyl phosphate, in the rat.
Toxicology and applied pharmacology.
1985 Mar; 77(3):395-404. doi:
10.1016/0041-008x(85)90179-6. [PMID: 3919466] - A A Nomeir, M B Abou-Donia. Disposition of [14C]tri-o-cresyl phosphate and its metabolites in various tissues of the male cat following a single dermal application.
Drug metabolism and disposition: the biological fate of chemicals.
1984 Nov; 12(6):705-11. doi:
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Journal of toxicology and environmental health.
1984; 14(5-6):773-88. doi:
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Analytical biochemistry.
1983 Dec; 135(2):296-303. doi:
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Toxicology and applied pharmacology.
1983 Mar; 67(3):310-21. doi:
10.1016/0041-008x(83)90314-9. [PMID: 6845361] - R D Wilson, L D Rowe, S L Lovering, D A Witzel. Acute toxicity of tri-ortho-cresyl phosphate in sheep and swine.
American journal of veterinary research.
1982 Nov; 43(11):1954-7. doi:
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JAMA.
1982 Oct; 248(15):1864-7. doi:
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Toxicology and applied pharmacology.
1982 Jun; 64(2):289-305. doi:
10.1016/0041-008x(82)90224-1. [PMID: 7123556] - L P Delbressine, F Seutter-Berlage, E Seutter. Identification or urinary mercapturic acids formed from acrylate, methacrylate and crotonate in the rat.
Xenobiotica; the fate of foreign compounds in biological systems.
1981 Apr; 11(4):241-7. doi:
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The Journal of the Society of Occupational Medicine.
1981 Apr; 31(2):69-75. doi:
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Journal of environmental pathology and toxicology.
1980 Jun; 3(5-6):423-36. doi:
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British journal of industrial medicine.
1979 May; 36(2):153-6. doi:
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Archives of neurology.
1978 Aug; 35(8):530-2. doi:
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Biulleten' eksperimental'noi biologii i meditsiny.
1978 Apr; 85(4):427-9. doi:
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La Medicina del lavoro.
1977 May; 68(3):222-31. doi:
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Archives of environmental contamination and toxicology.
1977; 6(2-3):233-40. doi:
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Journal of toxicology and environmental health.
1976 May; 1(5):777-86. doi:
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Environmental physiology & biochemistry.
1975; 5(6):361-9. doi:
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Folia medica. Folia medica (Naples, Italy).
1962 Apr; 45(?):342-51. doi:
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Indian journal of medical sciences.
1960 Mar; 14(?):183-9. doi:
". [PMID: 14445388]
