Thromboxane (BioDeep_00000027861)
human metabolite Endogenous Chemicals and Drugs
代谢物信息卡片
(2R,3S)-3-heptyl-2-octyl-oxane
化学式: C20H40O (296.307899)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCC1C(CCCO1)CCCCCCC
InChI: InChI=1S/C20H40O/c1-3-5-7-9-11-13-17-20-19(16-14-18-21-20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m0/s1
描述信息
Thromboxane is a member of the family of lipids known as eicosanoids. It is produced in platelets by thromboxane synthetase, which is produced from the endoperoxides by the cyclooxygenase (COX) enzyme from arachidonic acid. -- Wikipedia; Thromboxane is a vasoconstrictor, potent hypertensive agent, and facilitates the clumping of platelets. It is in homeostatic balance in the circulatory system with prostacyclin, a related compound. The widely-used drug aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets. -- WikipediaThromboxanes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways.
Thromboxane is a member of the family of lipids known as eicosanoids. It is produced in platelets by thromboxane synthetase, which is produced from the endoperoxides by the cyclooxygenase (COX) enzyme from arachidonic acid. -- Wikipedia; Thromboxane is a vasoconstrictor, potent hypertensive agent, and facilitates the clumping of platelets. It is in homeostatic balance in the circulatory system with prostacyclin, a related compound. The widely-used drug aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets. -- Wikipedia
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 114873
- HMDB: HMDB0003208
- Wikipedia: Thromboxane
- MeSH: Thromboxanes
- foodb: FDB023124
- chemspider: 102829
- CAS: 66719-58-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hannah J Larsen, Daire Byrne, Tahsin Özpolat, Aastha Chauhan, S Lawrence Bailey, Nicole Rhoads, Franklin Reed, Massiel C Stolla, Reheman Adili, Michael Holinstat, Xiaoyun Fu, Moritz Stolla. Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets.
Arteriosclerosis, thrombosis, and vascular biology.
2023 Aug; ?(?):. doi:
10.1161/atvbaha.123.319021. [PMID: 37650322] - Martin Schoenthaler, Lorenz Waltl, Thomas Hasenoehrl, David Seher, Anna Lutz, Lucia Aulinger, Veronika Temml, Stefanie König, Anita Siller, Doris Elfriede Braun, Ulrike Garscha, Oliver Werz, Daniela Schuster, Harald Schennach, Andreas Koeberle, Barbara Matuszczak. Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility.
Bioorganic chemistry.
2023 Jun; 139(?):106685. doi:
10.1016/j.bioorg.2023.106685. [PMID: 37418786] - Masataka Majima, Kanako Hosono, Yoshiya Ito, Hideki Amano, Yoshinao Nagashima, Yasuhiro Matsuda, Shin-Ichi Watanabe, Hironobu Nishimura. A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 May; 163(?):114831. doi:
10.1016/j.biopha.2023.114831. [PMID: 37150029] - Karsten Schrör, Freek W A Verheugt, Dietmar Trenk. Drug-Drug Interaction between Antiplatelet Therapy and Lipid-Lowering Agents (Statins and PCSK9 Inhibitors).
Thrombosis and haemostasis.
2023 Feb; 123(2):166-176. doi:
10.1055/s-0042-1758654. [PMID: 36522182] - Yuki Nagasaki, Erika Kawai, Saya Maruoka, Miho Osumi, Izumi Tsukayama, Yuki Kawakami, Yoshitaka Takahashi, Yuka Okazaki, Yoshimi Miki, Yoshitaka Taketomi, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto. Lipid profiling reveals the presence of unique lipid mediators in human milk from healthy and mastitic subjects.
Biochemical and biophysical research communications.
2022 11; 630(?):84-91. doi:
10.1016/j.bbrc.2022.09.051. [PMID: 36152349] - Alexander Tamalunas, Amin Wendt, Florian Springer, Victor Vigodski, Anna Ciotkowska, Beata Rutz, Ruixiao Wang, Ru Huang, Yuhan Liu, Heiko Schulz, Stephan Ledderose, Thomas Kolben, Giuseppe Magistro, Christian G Stief, Martin Hennenberg. Permixon®, hexane-extracted Serenoa repens, inhibits human prostate and bladder smooth muscle contraction and exerts growth-related functions in human prostate stromal cells.
Life sciences.
2022 Nov; 308(?):120931. doi:
10.1016/j.lfs.2022.120931. [PMID: 36084760] - Teng Wang, Xi Chen, Haonan Li, Wu Chen, Yifan Xu, Yuan Yao, Hanxiyue Zhang, Yiqun Han, Lina Zhang, Chengli Que, Jicheng Gong, Xinghua Qiu, Tong Zhu. Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation.
Particle and fibre toxicology.
2022 10; 19(1):65. doi:
10.1186/s12989-022-00503-9. [PMID: 36280873] - Lyanne Rodríguez, Andrés Trostchansky, Hermine Vogel, Irene Wood, Iván Palomo, Sergio Wehinger, Eduardo Fuentes. A Comprehensive Literature Review on Cardioprotective Effects of Bioactive Compounds Present in Fruits of Aristotelia chilensis Stuntz (Maqui).
Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196147. [PMID: 36234679] - Robert Wolf, Sophie Grammbauer, Raghavendra Palankar, Céline Tolksdorf, Eileen Moritz, Andreas Böhm, Mahmoud Hasan, Annika Hafkemeyer, Andreas Greinacher, Mladen V Tzvetkov, Bernhard H Rauch, Gabriele Jedlitschky. Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets.
Haematologica.
2022 09; 107(9):2206-2217. doi:
10.3324/haematol.2021.279761. [PMID: 35295075] - Jeffrey J Rade, Bruce A Barton, Ramachandran S Vasan, Shari S Kronsberg, Vanessa Xanthakis, John F Keaney, Naomi M Hamburg, Nikolaos Kakouros, Thomas A Kickler. Association of Thromboxane Generation With Survival in Aspirin Users and Nonusers.
Journal of the American College of Cardiology.
2022 07; 80(3):233-250. doi:
10.1016/j.jacc.2022.04.034. [PMID: 35660296] - Chuan Wang, Lihua Han, Ting Wang, Yuying Wang, Jiping Liu, Bin Wang, Cang-Bao Xu. Cyclosporin A up-regulated thromboxane A2 receptor through activation of MAPK and NF-κB pathways in rat mesenteric artery.
European journal of pharmacology.
2022 Jul; 926(?):175034. doi:
10.1016/j.ejphar.2022.175034. [PMID: 35588871] - V Raparelli, C Nocella, M Proietti, G F Romiti, B Corica, S Bartimoccia, L Stefanini, A Lenzi, N Viceconte, G Tanzilli, V Cammisotto, L Pilote, R Cangemi, S Basili, R Carnevale. Testosterone-to-estradiol ratio and platelet thromboxane release in ischemic heart disease: the EVA project.
Journal of endocrinological investigation.
2022 Jul; 45(7):1367-1377. doi:
10.1007/s40618-022-01771-0. [PMID: 35262860] - Essa Hariri, Nikolaos Kakouros, David A Bunsick, Stuart D Russell, James O Mudd, Katherine Laws, Mikhailia W Lake, Jeffrey J Rade. Nonplatelet thromboxane generation is associated with impaired cardiovascular performance and mortality in heart failure.
American journal of physiology. Heart and circulatory physiology.
2022 07; 323(1):H248-H255. doi:
10.1152/ajpheart.00212.2022. [PMID: 35714178] - Elisa Villa-Martínez, Selma Romina López-Vaquera, Lesvia Karina Alvarado-Coutiño, Ana María Gámez-Méndez, Amelia Ríos, Bruno Escalante. Thromboxane-dependent coronary vasoconstriction in obese mice: Role of peroxynitrite.
Prostaglandins & other lipid mediators.
2022 06; 160(?):106631. doi:
10.1016/j.prostaglandins.2022.106631. [PMID: 35272056] - Heike Braun, Michael Hauke, Robert Eckenstaler, Markus Petermann, Anne Ripperger, Niklas Kühn, Edzard Schwedhelm, Beatrice Ludwig-Kraus, Frank Bernhard Kraus, Virginie Dubourg, Alma Zernecke, Barbara Schreier, Michael Gekle, Ralf A Benndorf. The F2-isoprostane 8-iso-PGF2α attenuates atherosclerotic lesion formation in Ldlr-deficient mice - Potential role of vascular thromboxane A2 receptors.
Free radical biology & medicine.
2022 05; 185(?):36-45. doi:
10.1016/j.freeradbiomed.2022.04.010. [PMID: 35470061] - Alberto Tosetto, Bianca Rocca, Giovanna Petrucci, Silvia Betti, Denise Soldati, Elena Rossi, Andrea Timillero, Viviana Cavalca, Benedetta Porro, Alessandra Iurlo, Daniele Cattaneo, Cristina Bucelli, Alfredo Dragani, Mauro Di Ianni, Paola Ranalli, Francesca Palandri, Nicola Vianelli, Eloise Beggiato, Giuseppe Lanzarone, Marco Ruggeri, Giuseppe Carli, Elena Maria Elli, Stefania Priolo, Maria Luigia Randi, Irene Bertozzi, Giuseppe Gaetano Loscocco, Alessandra Ricco, Giorgina Specchia, Alessandro Maria Vannucchi, Francesco Rodeghiero, Valerio De Stefano, Carlo Patrono. Association of Platelet Thromboxane Inhibition by Low-Dose Aspirin With Platelet Count and Cytoreductive Therapy in Essential Thrombocythemia.
Clinical pharmacology and therapeutics.
2022 04; 111(4):939-949. doi:
10.1002/cpt.2485. [PMID: 34743317] - Robert Eckenstaler, Anne Ripperger, Michael Hauke, Markus Petermann, Sandra A Hemkemeyer, Edzard Schwedhelm, Süleyman Ergün, Maike Frye, Oliver Werz, Andreas Koeberle, Heike Braun, Ralf A Benndorf. A Thromboxane A2 Receptor-Driven COX-2-Dependent Feedback Loop That Affects Endothelial Homeostasis and Angiogenesis.
Arteriosclerosis, thrombosis, and vascular biology.
2022 04; 42(4):444-461. doi:
10.1161/atvbaha.121.317380. [PMID: 35236104] - P-A Regidor, X De La Rosa, F G Santos, J M Rizo, R Gracia Banzo, R S Silva. Acute severe SARS COVID-19 patients produce pro-resolving lipids mediators and eicosanoids.
European review for medical and pharmacological sciences.
2021 Nov; 25(21):6782-6796. doi:
10.26355/eurrev_202111_27123. [PMID: 34787883] - Jiaomei Li, Zhaohong Zheng, Min Liu, Yiping Ren, Yue Ruan, Duo Li. Relationship between the n-3 index, serum metabolites and breast cancer risk.
Food & function.
2021 Sep; 12(17):7741-7748. doi:
10.1039/d1fo01245b. [PMID: 34296713] - Md Abdullah Al Baki, Miltan Chandra Roy, Dong-Hee Lee, David Stanley, Yonggyun Kim. The prostanoids, thromboxanes, mediate hemocytic immunity to bacterial infection in the lepidopteran Spodoptera exigua.
Developmental and comparative immunology.
2021 07; 120(?):104069. doi:
10.1016/j.dci.2021.104069. [PMID: 33737116] - Kehong Zhang, Simona Pace, Paul M Jordan, Lukas K Peltner, Alexander Weber, Dagmar Fischer, Robert K Hofstetter, Xinchun Chen, Oliver Werz. Beneficial Modulation of Lipid Mediator Biosynthesis in Innate Immune Cells by Antirheumatic Tripterygium wilfordii Glycosides.
Biomolecules.
2021 05; 11(5):. doi:
10.3390/biom11050746. [PMID: 34067705] - Zuzana Paduchová, Barbora Katrenčíková, Magdaléna Vaváková, Lucia Laubertová, Zuzana Nagyová, Iveta Garaiova, Zdenka Ďuračková, Jana Trebatická. The Effect of Omega-3 Fatty Acids on Thromboxane, Brain-Derived Neurotrophic Factor, Homocysteine, and Vitamin D in Depressive Children and Adolescents: Randomized Controlled Trial.
Nutrients.
2021 Mar; 13(4):. doi:
10.3390/nu13041095. [PMID: 33801688] - Caroline Honaiser Lescano, Fernando Freitas de Lima, Claudia Andrea Lima Cardoso, Silvia Cristina Heredia Vieira, Fabíola Zakia Mónica, Ivan Pires de Oliveira. Rutin present in Alibertia edulis extract acts on human platelet aggregation through inhibition of cyclooxygenase/thromboxane.
Food & function.
2021 Jan; 12(2):802-814. doi:
10.1039/d0fo02276d. [PMID: 33393955] - Jane A Mitchell, Nicholas S Kirkby, Blerina Ahmetaj-Shala, Paul C Armstrong, Marilena Crescente, Plinio Ferreira, Maria Elisa Lopes Pires, Ricky Vaja, Timothy D Warner. Cyclooxygenases and the cardiovascular system.
Pharmacology & therapeutics.
2021 01; 217(?):107624. doi:
10.1016/j.pharmthera.2020.107624. [PMID: 32640277] - Miriam C Wolters, Julia Schmetzer, Christine V Möser, Lisa Hahnefeld, Carlo Angioni, Dominique Thomas, Nerea Ferreirós, Gerd Geisslinger, Ellen Niederberger. Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers.
Cells.
2020 09; 9(9):. doi:
10.3390/cells9092111. [PMID: 32948055] - Yu Liu, Ye Wang, Pengmei Guo, Qiying Song, Miaomaio Dong, Xiaomin Hou, Mingsheng Zhang. Prostanoids contribute to regulation of inwardly rectifying K+ channels in intrarenal arterial smooth muscle cells.
Life sciences.
2020 Jun; 250(?):117586. doi:
10.1016/j.lfs.2020.117586. [PMID: 32222464] - Bin Liu, Xiangzhong Wu, Ruhui Zeng, Yehu Yin, Tingting Guo, Yineng Xu, Yingzhan Zhang, Jing Leng, Jiahui Ge, Gang Yu, Jinwei Guo, Yingbi Zhou. Prostaglandin E2 sequentially activates E-prostanoid receptor-3 and thromboxane prostanoid receptor to evoke contraction and increase in resistance of the mouse renal vasculature.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 02; 34(2):2568-2578. doi:
10.1096/fj.201901611r. [PMID: 31908041] - Gabriel Dasilva, Isabel Medina. Lipidomic methodologies for biomarkers of chronic inflammation in nutritional research: ω-3 and ω-6 lipid mediators.
Free radical biology & medicine.
2019 11; 144(?):90-109. doi:
10.1016/j.freeradbiomed.2019.03.017. [PMID: 30902758] - Luke Vella, James F Markworth, Michelle M Farnfield, Krishna R Maddipati, Aaron P Russell, David Cameron-Smith. Intramuscular inflammatory and resolving lipid profile responses to an acute bout of resistance exercise in men.
Physiological reports.
2019 08; 7(13):e14108. doi:
10.14814/phy2.14108. [PMID: 31257737] - Federica Di Costanzo, Valeria Di Dato, Adrianna Ianora, Giovanna Romano. Prostaglandins in Marine Organisms: A Review.
Marine drugs.
2019 Jul; 17(7):. doi:
10.3390/md17070428. [PMID: 31340503] - Monique C Suarez-Giron, Isaac Almendros, Jordi Roca-Ferrer, Cesar Picado. Overnight Change in Urinary Prostacyclin and Thromboxane in Obstructive Sleep Apnea.
Archivos de bronconeumologia.
2019 Jun; 55(6):334-336. doi:
10.1016/j.arbres.2018.09.017. [PMID: 30409485] - Cristina Gómez, Carolina Gonzalez-Riano, Coral Barbas, Johan Kolmert, Min Hyung Ryu, Christopher Carlsten, Sven-Erik Dahlén, Craig E Wheelock. Quantitative metabolic profiling of urinary eicosanoids for clinical phenotyping.
Journal of lipid research.
2019 06; 60(6):1164-1173. doi:
10.1194/jlr.d090571. [PMID: 30842246] - Samantha F Moore, Nina R Smith, Thomas A Blair, Tom N Durrant, Ingeborg Hers. Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function.
Scientific reports.
2019 02; 9(1):1468. doi:
10.1038/s41598-018-37012-9. [PMID: 30728366] - M Kolacek, Z Paduchova, M Dvorakova, I Zitnanova, I Cierna, Z Durackova, J Muchova. Effect of natural polyphenols on thromboxane levels in children with Crohn's disease.
Bratislavske lekarske listy.
2019; 120(12):924-928. doi:
10.4149/bll_2019_155. [PMID: 31855052] - Shanzana I Khan, Waled A Shihata, Karen L Andrews, Man K S Lee, Xiao-Lei Moore, Ann-Maree Jefferis, Antony Vinh, Tracey Gaspari, Dragana Dragoljevic, Garry L Jennings, Andrew J Murphy, Jaye P F Chin-Dusting. Effects of high- and low-dose aspirin on adaptive immunity and hypertension in the stroke-prone spontaneously hypertensive rat.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 01; 33(1):1510-1521. doi:
10.1096/fj.201701498rr. [PMID: 30156911] - Paola Simeone, Rossella Liani, Romina Tripaldi, Augusto Di Castelnuovo, Maria Teresa Guagnano, Armando Tartaro, Riccardo C Bonadonna, Virginia Federico, Francesco Cipollone, Agostino Consoli, Francesca Santilli. Thromboxane-Dependent Platelet Activation in Obese Subjects with Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss.
Nutrients.
2018 Dec; 10(12):. doi:
10.3390/nu10121872. [PMID: 30513818] - Shawn F L Hanson, Michael H Terry, Dafne T Moretta, Gordon G Power, Sean M Wilson, Farzana Alam, Fakhrul Ahsan, Arlin B Blood, Paresh C Giri. Inhaled Fasudil Lacks Pulmonary Selectivity in Thromboxane-Induced Acute Pulmonary Hypertension in Newborn Lambs.
Journal of cardiovascular pharmacology and therapeutics.
2018 09; 23(5):472-480. doi:
10.1177/1074248418772814. [PMID: 29756460] - Hanning Liu, Zhengxi Xu, Cheng Sun, Qianlong Chen, Ning Bao, Wen Chen, Zhou Zhou, Xiaoqi Wang, Zhe Zheng. Perioperative urinary thromboxane metabolites and outcome of coronary artery bypass grafting: a nested case-control study.
BMJ open.
2018 08; 8(8):e021219. doi:
10.1136/bmjopen-2017-021219. [PMID: 30166295] - M Leiberich, R Krebber, M Hewetson, J Marais, V Naidoo. A study of the pharmacokinetics and thromboxane inhibitory activity of a single intramuscular dose of carprofen as a means to establish its potential use as an analgesic drug in white rhinoceros.
Journal of veterinary pharmacology and therapeutics.
2018 Aug; 41(4):605-613. doi:
10.1111/jvp.12508. [PMID: 29691872] - Tilo Grosser, Ali Naji, Garret A FitzGerald. Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment.
Circulation research.
2018 02; 122(4):537-539. doi:
10.1161/circresaha.118.312616. [PMID: 29449357] - N McLewee, T Archer, R Wills, A Mackin, J Thomason. Effects of aspirin dose escalation on platelet function and urinary thromboxane and prostacyclin levels in normal dogs.
Journal of veterinary pharmacology and therapeutics.
2018 Feb; 41(1):60-67. doi:
10.1111/jvp.12432. [PMID: 28664658] - Paul A Gurbel, Kevin P Bliden, Junhong Zhu, Emanuel Troullos, Robert Centofanti, Sistine Jarvis, Palak Venkataraman, Udaya S Tantry. Thromboxane inhibition during concurrent therapy with low-dose aspirin and over-the-counter naproxen sodium.
Journal of thrombosis and thrombolysis.
2018 Jan; 45(1):18-26. doi:
10.1007/s11239-017-1593-y. [PMID: 29198079] - Anne Brandolt Larré, Aline Parisotto, Bruna Fagundes Rockenbach, Débora Montenegro Pasin, Cláudia Capellari, Daniele Cristovão Escouto, Bartira Ercília Pinheiro da Costa, Carlos Eduardo Poli-de-Figueiredo. Phosphodiesterases and preeclampsia.
Medical hypotheses.
2017 Oct; 108(?):94-100. doi:
10.1016/j.mehy.2017.08.003. [PMID: 29055408] - A K Rao, M Poncz. Defective acid hydrolase secretion in RUNX1 haplodeficiency: Evidence for a global platelet secretory defect.
Haemophilia : the official journal of the World Federation of Hemophilia.
2017 Sep; 23(5):784-792. doi:
10.1111/hae.13280. [PMID: 28662545] - Opeyemi Abayomi Obilade, Alani Suleimon Akanmu, Fiona Broughton Pipkin, Bosede Bukola Afolabi. Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy.
PloS one.
2017; 12(9):e0184345. doi:
10.1371/journal.pone.0184345. [PMID: 28880908] - Nannan Wang, Xiaoning Zhao, Weihui Wang, Yan Peng, Kaishun Bi, Ronghua Dai. Targeted profiling of arachidonic acid and eicosanoids in rat tissue by UFLC-MS/MS: Application to identify potential markers for rheumatoid arthritis.
Talanta.
2017 Jan; 162(?):479-487. doi:
10.1016/j.talanta.2016.10.065. [PMID: 27837860] - Brittany Heggem-Perry, Stephanie A Smith, Maureen A McMichael, Mauria O'Brien, Anne Saunders, Jason Tarricone. Concentrations of thromboxane metabolites in feline urine.
American journal of veterinary research.
2016 Dec; 77(12):1340-1345. doi:
10.2460/ajvr.77.12.1340. [PMID: 27901385] - W Marlicz, E Wunsch, M Mydlowska, M Milkiewicz, K Serwin, M Mularczyk, P Milkiewicz, J Raszeja-Wyszomirska. The effect of short term treatment with probiotic VSL#3 on various clinical and biochemical parameters in patients with liver cirrhosis.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2016 Dec; 67(6):867-877. doi:
. [PMID: 28195067] - Yoshitaka Yasuda, Guo-Gang Feng, Jiazheng Li, Emi Nakamura, Hisaki Hayashi, Motohiko Sato, Yoshihiro Fujiwara, Hiroyuki Kinoshita. High oxygen modifies vasodilator effect of cysteine via enhanced oxidative stress and thromboxane production in the rat mesenteric artery.
Pflugers Archiv : European journal of physiology.
2016 09; 468(9):1555-64. doi:
10.1007/s00424-016-1857-y. [PMID: 27389323] - Antonio Di Sabatino, Francesca Santilli, Marco Guerci, Paola Simeone, Sandro Ardizzone, Alessandro Massari, Paolo Giuffrida, Romina Tripaldi, Alessandro Malara, Rossella Liani, Evelyn Gurini, Nicola Aronico, Alessandra Balduini, Gino Roberto Corazza, Giovanni Davì. Oxidative stress and thromboxane-dependent platelet activation in inflammatory bowel disease: effects of anti-TNF-α treatment.
Thrombosis and haemostasis.
2016 08; 116(3):486-95. doi:
10.1160/th16-02-0167. [PMID: 27305860] - Eva Tarantino, Patrizia Amadio, Isabella Squellerio, Benedetta Porro, Leonardo Sandrini, Linda Turnu, Viviana Cavalca, Elena Tremoli, Silvia S Barbieri. Role of thromboxane-dependent platelet activation in venous thrombosis: Aspirin effects in mouse model.
Pharmacological research.
2016 05; 107(?):415-425. doi:
10.1016/j.phrs.2016.04.001. [PMID: 27063941] - Arnaud Lubin, Suzy Geerinckx, Steve Bajic, Deirdre Cabooter, Patrick Augustijns, Filip Cuyckens, Rob J Vreeken. Enhanced performance for the analysis of prostaglandins and thromboxanes by liquid chromatography-tandem mass spectrometry using a new atmospheric pressure ionization source.
Journal of chromatography. A.
2016 Apr; 1440(?):260-265. doi:
10.1016/j.chroma.2016.02.055. [PMID: 26948759] - Filip Mejza, Aleksander Kania, Pawel Nastalek, Agata Nizankowska-Jedrzejczyk, Ewa Nizankowska-Mogilnicka. Systemic prostacyclin and thromboxane production in obstructive sleep apnea.
Advances in medical sciences.
2016 Mar; 61(1):154-9. doi:
10.1016/j.advms.2015.12.001. [PMID: 26773760] - A Polzin, L Dannenberg, R Sansone, B Levkau, M Kelm, T Hohlfeld, T Zeus. Antiplatelet effects of aspirin in chronic kidney disease patients.
Journal of thrombosis and haemostasis : JTH.
2016 Feb; 14(2):375-80. doi:
10.1111/jth.13211. [PMID: 26644261] - Francesca Santilli, Paola Simeone, Rossella Liani, Giovanni Davì. Platelets and diabetes mellitus.
Prostaglandins & other lipid mediators.
2015 Jul; 120(?):28-39. doi:
10.1016/j.prostaglandins.2015.05.002. [PMID: 25986598] - Arshid Mir, Summer Frank, Janna Journeycake, Joshua Wolovitis, Kristine Guleserian, Lisa Heistein, Matthew Lemler. Aspirin Resistance in Single-Ventricle Physiology: Aspirin Prophylaxis Is Not Adequate to Inhibit Platelets in the Immediate Postoperative Period.
The Annals of thoracic surgery.
2015 Jun; 99(6):2158-64. doi:
10.1016/j.athoracsur.2015.02.026. [PMID: 25921261] - Adrian Doroszko, Ewa Szahidewicz-Krupska, Agnieszka Janus, Maciej Jakubowski, Aleksandra Turek, Paulina Ilnicka, Andrzej Szuba, Grzegorz Mazur, Arkadiusz Derkacz. Endothelial dysfunction in young healthy men is associated with aspirin resistance.
Vascular pharmacology.
2015 Apr; 67-69(?):30-7. doi:
10.1016/j.vph.2015.02.001. [PMID: 25697550] - Dimitrios Tsikas, Vu Vi Pham, Maria-Theresia Suchy, Marcel A van de Ree, Menno V Huisman, Jürgen C Frölich, Hans M G Princen. No effects of atorvastatin (10 mg/d or 80 mg/d) on nitric oxide, prostacyclin, thromboxane and oxidative stress in type 2 diabetes mellitus patients of the DALI study.
Pharmacological research.
2015 Apr; 94(?):1-8. doi:
10.1016/j.phrs.2015.01.004. [PMID: 25662039] - J Fediuk, A S Sikarwar, P P Lizotte, M Hinton, N Nolette, S Dakshinamurti. Hypoxia increases pulmonary arterial thromboxane receptor internalization independent of receptor sensitization.
Pulmonary pharmacology & therapeutics.
2015 Feb; 30(?):1-10. doi:
10.1016/j.pupt.2014.10.001. [PMID: 25312900] - Yuling Chi, Jean-Francois Jasmin, Yoshinori Seki, Michael P Lisanti, Maureen J Charron, David J Lefer, Victor L Schuster. Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice.
PloS one.
2015; 10(6):e0131735. doi:
10.1371/journal.pone.0131735. [PMID: 26121580] - Dongjuan Yuan, Qiuqiong Zou, Ting Yu, Cuikai Song, Shengfeng Huang, Shangwu Chen, Zhenghua Ren, Anlong Xu. Ancestral genetic complexity of arachidonic acid metabolism in Metazoa.
Biochimica et biophysica acta.
2014 Sep; 1841(9):1272-84. doi:
10.1016/j.bbalip.2014.04.009. [PMID: 24801744] - Nobuaki Tanaka, Hiroaki Yamaguchi, Nariyasu Mano. Transport of eicosapentaenoic acid-derived PGE₃, PGF(3α), and TXB₃ by ABCC4.
PloS one.
2014; 9(10):e109270. doi:
10.1371/journal.pone.0109270. [PMID: 25275481] - W Raphael, L Halbert, G A Contreras, L M Sordillo. Association between polyunsaturated fatty acid-derived oxylipid biosynthesis and leukocyte inflammatory marker expression in periparturient dairy cows.
Journal of dairy science.
2014; 97(6):3615-25. doi:
10.3168/jds.2013-7656. [PMID: 24731638] - Arne Trettin, Anke Böhmer, Maria-Theresia Suchy, Irmelin Probst, Ulrich Staerk, Dirk O Stichtenoth, Jürgen C Frölich, Dimitrios Tsikas. Effects of paracetamol on NOS, COX, and CYP activity and on oxidative stress in healthy male subjects, rat hepatocytes, and recombinant NOS.
Oxidative medicine and cellular longevity.
2014; 2014(?):212576. doi:
10.1155/2014/212576. [PMID: 24799980] - O C Veselkina, N N Petrishchev, L V Vasina, M E Borovitov, A V Seliutin, S V Chepanov, S A Sel'kov. [Influence of new N,N'-substituted piperazines on thrombin-induced platelet activation].
Eksperimental'naia i klinicheskaia farmakologiia.
2014; 77(8):28-33. doi:
. [PMID: 25335388] - Sean-Xavier Neath, John L Jefferies, Jeffrey S Berger, Alan H B Wu, Joseph P McConnell, Jeffrey L Boone, Peter A McCullough, Robert L Jesse, Alan S Maisel. The current and future landscape of urinary thromboxane testing to evaluate atherothrombotic risk.
Reviews in cardiovascular medicine.
2014; 15(2):119-30. doi:
10.3909/ricm0739. [PMID: 25051129] - Francesca Santilli, Natale Vazzana, Pierpaolo Iodice, Stefano Lattanzio, Rossella Liani, Rosa Grazia Bellomo, Gianfranco Lessiani, Francesca Perego, Raoul Saggini, Giovanni Davì. Effects of high-amount-high-intensity exercise on in vivo platelet activation: modulation by lipid peroxidation and AGE/RAGE axis.
Thrombosis and haemostasis.
2013 Dec; 110(6):1232-40. doi:
10.1160/th13-04-0295. [PMID: 24030807] - H J Liu, J W Ma, Z Y Qiao, B Xu. Study of molecular mechanism of Prostaglandin E1 in inhibiting coronary heart disease.
Molecular biology reports.
2013 Dec; 40(12):6701-8. doi:
10.1007/s11033-013-2785-y. [PMID: 24146100] - Gerhard J Johnson, Linda A Leis, Billie C S Slater, Ronald R Bach. Elevated platelet count, C-reactive protein and thromboxane analog-induced platelet aggregation in patients with Gulf War veterans' illnesses: evidence of a chronic inflammatory state?.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2013 Oct; 24(7):736-41. doi:
10.1097/mbc.0b013e328362627f. [PMID: 23751609] - Meagan O'Brien, Emilie Montenont, Liang Hu, Michael A Nardi, Vanessa Valdes, Michael Merolla, Gabrielle Gettenberg, Karen Cavanagh, Judith A Aberg, Nina Bhardwaj, Jeffrey S Berger. Aspirin attenuates platelet activation and immune activation in HIV-1-infected subjects on antiretroviral therapy: a pilot study.
Journal of acquired immune deficiency syndromes (1999).
2013 Jul; 63(3):280-8. doi:
10.1097/qai.0b013e31828a292c. [PMID: 23406976] - Eryn A Shipley, Daniel F Hogan, Nonya N Fiakpui, Aliya N Magee, Henry W Green, Kimberly A Sederquist. In vitro effect of pimobendan on platelet aggregation in dogs.
American journal of veterinary research.
2013 Mar; 74(3):403-7. doi:
10.2460/ajvr.74.3.403. [PMID: 23438115] - Patrizia Ferroni, Silvia Riondino, Natale Vazzana, Nicole Santoro, Fiorella Guadagni, Giovanni Davì. Biomarkers of platelet activation in acute coronary syndromes.
Thrombosis and haemostasis.
2012 Dec; 108(6):1109-23. doi:
10.1160/th12-08-0550. [PMID: 23014768] - J Thomason, K Lunsford, J Stokes, L Pinchuk, R Wills, C Langston, S Pruett, A Mackin. The effects of cyclosporine on platelet function and cyclooxygenase expression in normal dogs.
Journal of veterinary internal medicine.
2012 Nov; 26(6):1389-401. doi:
10.1111/j.1939-1676.2012.01025.x. [PMID: 23106529] - Kjell S Sakariassen, Eti A Femia, Federico M Daray, Gian M Podda, Cristina Razzari, Mariateresa Pugliano, Andrea E Errasti, Arnaldo R Armesto, Wanda Nowak, Pēteris Alberts, Jean-Philippe Meyer, Alexandra S Sorensen, Marco Cattaneo, Rodolfo P Rothlin. EV-077 in vitro inhibits platelet aggregation in type-2 diabetics on aspirin.
Thrombosis research.
2012 Nov; 130(5):746-52. doi:
10.1016/j.thromres.2012.08.309. [PMID: 22959706] - Mathew H Flamm, S L Diamond. Multiscale systems biology and physics of thrombosis under flow.
Annals of biomedical engineering.
2012 Nov; 40(11):2355-64. doi:
10.1007/s10439-012-0557-9. [PMID: 22460075] - Theodor Baars, Petra Kleinbongard, Dirk Böse, Thomas Konorza, Stefan Möhlenkamp, Jörg Hippler, Raimund Erbel, Gerd Heusch. Saphenous vein aorto-coronary graft atherosclerosis in patients with chronic kidney disease: more plaque calcification and necrosis, but less vasoconstrictor potential.
Basic research in cardiology.
2012 Nov; 107(6):303. doi:
10.1007/s00395-012-0303-3. [PMID: 23052640] - J Mo, B Bai, Y Li, J Deng, S Zhang, Y Chen, Y Zeng. Expression of interleukin-18 in a rat model of deep vein thrombosis.
The Journal of cardiovascular surgery.
2012 Oct; 53(5):625-30. doi:
NULL. [PMID: 22318348] - Shi-Hong Wen, Yi Li, Cai Li, Zhi-Qiu Xia, Wei-Feng Liu, Xu-Yu Zhang, Wan-Long Lei, Wen-Qi Huang, Ke-Xuan Liu. Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation.
Shock (Augusta, Ga.).
2012 Oct; 38(4):411-9. doi:
10.1097/shk.0b013e3182662266. [PMID: 22777122] - Sven Francque, Wim Laleman, Len Verbeke, Christophe Van Steenkiste, Christophe Casteleyn, Wilhelmus Kwanten, Christophe Van Dyck, Michiel D'Hondt, Albert Ramon, Wim Vermeulen, Benedicte De Winter, Eric Van Marck, Veerle Van Marck, Paul Pelckmans, Peter Michielsen. Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture.
Laboratory investigation; a journal of technical methods and pathology.
2012 Oct; 92(10):1428-39. doi:
10.1038/labinvest.2012.103. [PMID: 22890552] - Troels Havelund, Boye L Jensen, Pernille J Vinholt, Birte Engvad, Jane Stubbe. Ulcerating and stenosing enteropathy treated with misoprostol: a case report with analysis of prostaglandin metabolism.
European journal of gastroenterology & hepatology.
2012 Oct; 24(10):1238-41. doi:
10.1097/meg.0b013e328356bc95. [PMID: 22786573] - Na Lu, Minxia Zhan, Cong Gao, Guanzhong Wu, Huibing Zhang. I4, a new synthetic sulfonylurea compound, inhibits the action of TXA2 in vivo and in vitro on platelets and aorta vascular smooth muscle.
Thrombosis research.
2012 Oct; 130(4):e209-15. doi:
10.1016/j.thromres.2012.07.022. [PMID: 22909828] - Jiin-Tarng Liou, Chih-Chieh Mao, Fu-Chao Liu, Huan-Tang Lin, Li-Man Hung, Chang-Hui Liao, Yuan-Ji Day. Levobupivacaine differentially suppresses platelet aggregation by modulating calcium release in a dose-dependent manner.
Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists.
2012 Sep; 50(3):112-21. doi:
10.1016/j.aat.2012.07.001. [PMID: 23026170] - Erik Lerkevang Grove. Antiplatelet effect of aspirin in patients with coronary artery disease.
Danish medical journal.
2012 Sep; 59(9):B4506. doi:
NULL. [PMID: 22951204] - Galia Spectre, Claes-Göran Östenson, Nailin Li, Paul Hjemdahl. Postprandial platelet activation is related to postprandial plasma insulin rather than glucose in patients with type 2 diabetes.
Diabetes.
2012 Sep; 61(9):2380-4. doi:
10.2337/db11-1806. [PMID: 22688337] - Paul R J Ames, Joana R Batuca, Ivana J Muncy, Ignacio Garcia De La Torre, Sara Pascoe-Gonzales, K Guyer, E Matsuura, Luis R Lopez. Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus.
Thrombosis research.
2012 Sep; 130(3):350-4. doi:
10.1016/j.thromres.2012.03.025. [PMID: 22521214] - Natale Vazzana, Maria Teresa Guagnano, Chiara Cuccurullo, Elisabetta Ferrante, Stefano Lattanzio, Rossella Liani, Mario Romano, Giovanni Davì. Endogenous secretory RAGE in obese women: association with platelet activation and oxidative stress.
The Journal of clinical endocrinology and metabolism.
2012 Sep; 97(9):E1726-30. doi:
10.1210/jc.2012-1473. [PMID: 22761461] - C Iorio-Morin, P Germain, S Roy, S Génier, P Labrecque, J-L Parent. Thromboxane A2 modulates cisplatin-induced apoptosis through a Siva1-dependent mechanism.
Cell death and differentiation.
2012 Aug; 19(8):1347-57. doi:
10.1038/cdd.2012.11. [PMID: 22343716] - Giovanni Davì, Natale Vazzana, Simona Sestili. Variability in the response to antiplatelet treatment in diabetes mellitus.
Prostaglandins & other lipid mediators.
2012 Aug; 98(3-4):48-55. doi:
10.1016/j.prostaglandins.2012.01.008. [PMID: 22330860] - Hussam Ajamieh, Geoffrey Farrell, Heng Jian Wong, Jun Yu, Eagle Chu, Jeffrey Chen, Narci Teoh. Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation.
Journal of gastroenterology and hepatology.
2012 Aug; 27(8):1353-61. doi:
10.1111/j.1440-1746.2012.07123.x. [PMID: 22432744] - Tomoaki Doi, Haruhiko Tokuda, Rie Matsushima-Nishiwaki, Nguyen The Cuong, Yasunari Kageyama, Yuko Iida, Akira Kondo, Shigeru Akamatsu, Takanobu Otsuka, Hiroki Iida, Osamu Kozawa, Shinji Ogura. Effect of antithrombin III on glycoprotein Ib/IX/V activation in human platelets: suppression of thromboxane A2 generation.
Prostaglandins, leukotrienes, and essential fatty acids.
2012 Aug; 87(2-3):57-62. doi:
10.1016/j.plefa.2012.05.010. [PMID: 22819492] - Shali Xie, Jundong Zhu, Yanqi Zhang, Kai Shi, Yuangang Shi, Xiao Ma. Effects of soya oligosaccharides and soya oligopeptides on lipid metabolism in hyperlipidaemic rats.
The British journal of nutrition.
2012 Aug; 108(4):603-10. doi:
10.1017/s0007114511006015. [PMID: 22082613] - K Mustonen, A Banting, M Raekallio, M Heinonen, O A T Peltoniemi, O Vainio. Dose-response investigation of oral ketoprofen in pigs challenged with Escherichia coli endotoxin.
The Veterinary record.
2012 Jul; 171(3):70. doi:
10.1136/vr.100431. [PMID: 22735989] - Zhihong Tong, Fang Yu, Zhonghua Liu, Haidong Liang. Influence of ShuJinHuoXue tablets on ischemia reperfusion injury of animals' skeletal muscle.
Molecules (Basel, Switzerland).
2012 Jul; 17(7):8494-505. doi:
10.3390/molecules17078494. [PMID: 22801363] - B Rocca, F Santilli, D Pitocco, L Mucci, G Petrucci, E Vitacolonna, S Lattanzio, D Mattoscio, F Zaccardi, R Liani, N Vazzana, A Del Ponte, E Ferrante, F Martini, C Cardillo, R Morosetti, M Mirabella, G Ghirlanda, G Davì, C Patrono. The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes.
Journal of thrombosis and haemostasis : JTH.
2012 Jul; 10(7):1220-30. doi:
10.1111/j.1538-7836.2012.04723.x. [PMID: 22471290] - Maria Barberà-Cremades, Alberto Baroja-Mazo, Ana I Gomez, Francisco Machado, Francesco Di Virgilio, Pablo Pelegrín. P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2012 Jul; 26(7):2951-62. doi:
10.1096/fj.12-205765. [PMID: 22490780] - Giampaolo Niccoli, Simona Giubilato, Andrea Leo, Nicola Cosentino, Francesco Fracassi, Leonardo Cataneo, Italo Porto, Antonio Maria Leone, Francesco Burzotta, Carlo Trani, Luigi Marzio Biasucci, Maria Lucia Narducci, Fabio Maria Pulcinelli, Filippo Crea. Predictors of thromboxane levels in patients with non-ST-elevation acute coronary syndromes on chronic aspirin therapy.
Thrombosis and haemostasis.
2012 Jul; 108(1):133-9. doi:
10.1160/th11-09-0635. [PMID: 22535468] - Abdullah S Shatoor, Hesham Soliman, Fahaid Al-Hashem, Basiouny El- Gamal, Adel Othman, Nadia El-Menshawy. Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino Wistar rats.
Thrombosis research.
2012 Jul; 130(1):75-80. doi:
10.1016/j.thromres.2012.01.001. [PMID: 22261477] - Sanne Bøjet Larsen, Søs Neergaard-Petersen, Erik Lerkevang Grove, Steen Dalby Kristensen, Anne-Mette Hvas. Increased platelet aggregation and serum thromboxane levels in aspirin-treated patients with prior myocardial infarction.
Thrombosis and haemostasis.
2012 Jul; 108(1):140-7. doi:
10.1160/th12-01-0026. [PMID: 22534977] - Matthew Macaluso, Wayne C Drevets, Sheldon H Preskorn. How biomarkers will change psychiatry. Part II: Biomarker selection and potential inflammatory markers of depression.
Journal of psychiatric practice.
2012 Jul; 18(4):281-6. doi:
10.1097/01.pra.0000416018.83709.3e. [PMID: 22805902]