p-Phenetidine (BioDeep_00000278226)

   


代谢物信息卡片


2-Phenoxyethanamine

化学式: C8H11NO (137.0840596)
中文名称: 对氨基苯乙醚
谱图信息: 最多检出来源 Viridiplantae(plant) 1.56%

分子结构信息

SMILES: CCOC1=CC=C(C=C1)N
InChI: InChI=1S/C8H11NO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2,9H2,1H3

描述信息

CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 1025

同义名列表

2 个代谢物同义名

2-Phenoxyethanamine; p-Phenetidine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

33 个相关的代谢反应过程信息。

Reactome(33)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yuki Kobayashi, Tatsuki Fukami, Ryota Higuchi, Miki Nakajima, Tsuyoshi Yokoi. Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia. Biochemical pharmacology. 2012 Nov; 84(9):1196-206. doi: 10.1016/j.bcp.2012.08.015. [PMID: 22940574]
  • C O'Mahony, V L Campbell, M S Al-Khayatt, D J Brull. Rhabdomyolysis with atorvastatin and fusidic acid. Postgraduate medical journal. 2008 Jun; 84(992):325-7. doi: 10.1136/pgmj.2007.064097. [PMID: 18644925]
  • Esko Kankuri, Erkka Solatunturi, Heikki Vapaatalo. Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro. Thrombosis research. 2003 Jun; 110(5-6):299-303. doi: 10.1016/s0049-3848(03)00416-x. [PMID: 14592552]
  • M Sato, F Furukawa, T Kawanishi, K Toyoda, T Imazawa, J Suzuki, M Takahashi. [Twenty-eight-day repeated dose toxicity test of p-phenetidine in F344 rats]. Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences. 1991; ?(109):42-8. doi: NULL. [PMID: 1364403]
  • K Togei, N Sano, T Maeda, M Shibata, H Otsuka. Carcinogenicity of bucetin in (C57BL/6 X C3H)F1 mice. Journal of the National Cancer Institute. 1987 Nov; 79(5):1151-8. doi: NULL. [PMID: 3479641]
  • J A Hinson, J B Mays. Covalent binding of the phenacetin metabolite p-nitrosophenetole to protein. The Journal of pharmacology and experimental therapeutics. 1986 Jul; 238(1):106-12. doi: NULL. [PMID: 3723393]
  • J A Hinson, J B Mays. p-Nitrosophenetole: a reactive intermediate of phenacetin that binds to protein. Advances in experimental medicine and biology. 1986; 197(?):691-6. doi: 10.1007/978-1-4684-5134-4_63. [PMID: 3766288]
  • R Larsson, D Ross, T Berlin, L I Olsson, P Moldéus. Prostaglandin synthase catalyzed metabolic activation of p-phenetidine and acetaminophen by microsomes isolated from rabbit and human kidney. The Journal of pharmacology and experimental therapeutics. 1985 Nov; 235(2):475-80. doi: . [PMID: 3932643]
  • N Nakayama, Y Masuda. Suppression of phenacetin-induced methemoglobinemia by diethyldithiocarbamate and carbon disulfide and its relation to phenacetin metabolism in mice. Journal of pharmacobio-dynamics. 1985 Oct; 8(10):868-76. doi: 10.1248/bpb1978.8.868. [PMID: 3005542]
  • P Moldéus, D Ross, R Larsson. Co-oxidation of xenobiotics. Biochemical Society transactions. 1985 Oct; 13(5):847-50. doi: 10.1042/bst0130847. [PMID: 3934012]
  • K Kigasawa, M Hiiragi, T Hayashi, K Maruyama. [Biopharmaceutical studies of drugs (6). Effect of 2-bromo-isovalerylurea on serum concentrations of O-ethoxybenzamide and N-(beta-hydroxybutyryl)-p-phenetidine in rabbits]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1983 May; 103(5):559-65. doi: . [PMID: 6644546]
  • J Baumann, F von Bruchhausen, G Wurm. Inhibition of prostaglandin synthetases derived from neuronal and glial cells and rat renal medulla by ortho-, meta- and para-substituted aminophenolic compounds. Prostaglandins, leukotrienes, and medicine. 1983 Mar; 10(3):319-29. doi: 10.1016/0262-1746(82)90087-7. [PMID: 6405396]
  • F von Bruchlausen, J Baumann. Inhibitory actions of desacetylation products of phenacetin and paracetamol on prostaglandin synthetases in neuronal and glial cell lines and rat renal medulla. Life sciences. 1982 May; 30(21):1783-91. doi: 10.1016/0024-3205(82)90314-9. [PMID: 6808277]
  • R H Clothier, M Balls, G S Hosty, N J Robertson, S A Horner. Amphibian organ culture in experimental toxicology: the effects of paracetamol and phenacetin on cultured tissues from urodele and anuran amphibians. Toxicology. 1982; 25(1):31-40. doi: 10.1016/0300-483x(82)90082-8. [PMID: 7157388]
  • K Kigasawa, M Hiiragi, T Hayashi. [Biopharmaceutical studies of drugs. III. Serum concentration level of o-ethoxybenzamide and N-(beta-hydroxybutyryl)-p-phenetidine after simultaneous administration to rabbit (author's transl)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1981 Jun; 101(6):556-66. doi: 10.1248/yakushi1947.101.6_556. [PMID: 7310638]
  • W Fischer. [H. U. Zollinger: 25 years of phenacetin abuse]. Schweizerische medizinische Wochenschrift. 1980 Jun; 110(26):1023-4. doi: NULL. [PMID: 7423142]
  • M Cîrstea, G Suhaciu, M Cîrje. Cross immunological reactions between three haptens of the "para" group and 4-aminoantipyrine. Physiologie (Bucarest). 1979 Apr; 16(2):103-8. doi: . [PMID: 117463]
  • U C Dubach. Analgesic nephropathy. Epidemiological studies and pharmacological investigations. Contributions to nephrology. 1979; 16(?):65-9. doi: NULL. [PMID: 467070]
  • R Slechtová, B Chundela. [Finding of analgesic components and their metabolites in doping control]. Soudni lekarstvi. 1977 Aug; 22(3):38-42. doi: NULL. [PMID: 616641]
  • P E Erne, A F Geczy, H Spengler, A L de Weck, U C Dubach. Immunogenicity of p-phenetidine, 2-hydroxy-p-phenetidine and their protein conjugates in guinea pigs, rabbits and man. International archives of allergy and applied immunology. 1977; 53(4):319-28. doi: 10.1159/000231768. [PMID: 856731]
  • M SPACEK. Simultaneous determination of kynurenine and p-phenetidine in human urine. Canadian journal of biochemistry and physiology. 1954 Nov; 32(6):604-9. doi: NULL. [PMID: 13209397]