Miltefosine (BioDeep_00000278115)
代谢物信息卡片
Miltefosine
化学式: C21H46NO4P (407.31642860000005)
中文名称: 米替福新
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C
InChI: InChI=1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01C - Agents against leishmaniasis and trypanosomiasis
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C2188 - Alkylphosphocholine Compound
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
D000970 - Antineoplastic Agents
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity[1][2][3][4]. Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT)[5].
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity[1][2][3][4]. Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT)[5].
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:75283
- KEGGdrug: D02494
- KEGGdrug: D18506
- PubChem: 3599
- Metlin: METLIN43997
- DrugBank: DB09031
- ChEMBL: CHEMBL125
- CAS: 58066-85-6
- CAS: 89367-17-9
- PMhub: MS000013559
- medchemexpress: HY-13685
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Asmaa F Ibrahim, Sahar M Selim, Dalia A Shafey, Dina M Sweed, Shaimaa A Farag, Marwa A Gouda. Appraisal of Chitosan-Coated Lipid Nano-Combination with Miltefosine and Albendazole in the Treatment of Murine Trichinellosis: Experimental Study with Evaluation of Immunological and Immunohistochemical Parameters.
Acta parasitologica.
2024 Mar; 69(1):929-950. doi:
10.1007/s11686-024-00799-x. [PMID: 38489009] - Jun Li, Nasir Tajuddeen, Doris Feineis, Virima Mudogo, Marcel Kaiser, Ean-Jeong Seo, Thomas Efferth, Gerhard Bringmann. Jozibrevine D from Ancistrocladus ileboensis, the fifth alkaloid in a series of six possible atropo-diastereomeric naphthylisoquinoline dimers, showing antiparasitic and antileukemic activities.
Bioorganic & medicinal chemistry letters.
2023 Apr; 86(?):129258. doi:
10.1016/j.bmcl.2023.129258. [PMID: 36972793] - Fernanda V Cabral, Michela Cerone, Saydulla Persheyev, Cheng Lian, Ifor D W Samuel, Martha S Ribeiro, Terry K Smith. New insights in photodynamic inactivation of Leishmania amazonensis: A focus on lipidomics and resistance.
PloS one.
2023; 18(9):e0289492. doi:
10.1371/journal.pone.0289492. [PMID: 37713373] - Juliana B T Carnielli, Anuja Dave, Audrey Romano, Sarah Forrester, Pedro R de Faria, Renata Monti-Rocha, Carlos H N Costa, Reynaldo Dietze, Ian A Graham, Jeremy C Mottram. 3'Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosine.
EBioMedicine.
2022 Dec; 86(?):104378. doi:
10.1016/j.ebiom.2022.104378. [PMID: 36462405] - Janaína de Pina Carvalho, Sarah Nascimento Silva, Mariana Lourenço Freire, Líndicy Leidicy Alves, Carolina Senra Alves de Souza, Gláucia Cota. The cure rate after different treatments for mucosal leishmaniasis in the Americas: A systematic review.
PLoS neglected tropical diseases.
2022 11; 16(11):e0010931. doi:
10.1371/journal.pntd.0010931. [PMID: 36395328] - Lais Alonso, Laryssa Ketelyn Lima Pimenta, André Kipnis, Antonio Alonso. Mycobacterium abscessus cell wall and plasma membrane characterization by EPR spectroscopy and effects of amphotericin B, miltefosine and nerolidol.
Biochimica et biophysica acta. Biomembranes.
2022 05; 1864(5):183872. doi:
10.1016/j.bbamem.2022.183872. [PMID: 35085568] - Lívia Mendes Carvalho, Miriã Rodrigues Gusmão, Ana Flávia Pereira Costa, Rory Cristiane Fortes de Brito, Rodrigo Dian de Oliveira Aguiar-Soares, Jamille Mirelle de Oliveira Cardoso, Alexandre Barbosa Reis, Cláudia Martins Carneiro, Bruno Mendes Roatt. Immunochemotherapy for visceral leishmaniasis: combinatorial action of Miltefosine plus LBSapMPL vaccine improves adaptative Th1 immune response with control of splenic parasitism in experimental hamster model.
Parasitology.
2022 03; 149(3):371-379. doi:
10.1017/s0031182021001906. [PMID: 35264268] - Olga Lucía Fernández, Mariana Rosales-Chilama, Natali Quintero, Bruno L Travi, Dawn M Wetzel, María Adelaida Gómez, Nancy Gore Saravia. Potency and Preclinical Evidence of Synergy of Oral Azole Drugs and Miltefosine in an Ex Vivo Model of Leishmania (Viannia) panamensis Infection.
Antimicrobial agents and chemotherapy.
2022 01; 66(1):e0142521. doi:
10.1128/aac.01425-21. [PMID: 34694879] - Nabila A El-Sheridy, Riham M El-Moslemany, Alyaa A Ramadan, Maged W Helmy, Labiba K El-Khordagui. Enhancing the in vitro and in vivo activity of itraconazole against breast cancer using miltefosine-modified lipid nanocapsules.
Drug delivery.
2021 Dec; 28(1):906-919. doi:
10.1080/10717544.2021.1917728. [PMID: 33960245] - So-Yeon Park, Jee-Heun Kim, Jang-Hyun Choi, Choong-Jae Lee, Won-Jae Lee, Sehoon Park, Zee-Yong Park, Jeong-Heum Baek, Jeong-Seok Nam. Lipid raft-disrupting miltefosine preferentially induces the death of colorectal cancer stem-like cells.
Clinical and translational medicine.
2021 11; 11(11):e552. doi:
10.1002/ctm2.552. [PMID: 34841679] - Alexander Rysin, Michael Paal, Wouter J M Lokerse, Barbara Wedmann, Martin Hossann, Michael Vogeser, Gerhard Winter, Lars H Lindner. Evaluation of release and pharmacokinetics of hexadecylphosphocholine (miltefosine) in phosphatidyldiglycerol-based thermosensitive liposomes.
Biochimica et biophysica acta. Biomembranes.
2021 11; 1863(11):183698. doi:
10.1016/j.bbamem.2021.183698. [PMID: 34283999] - Fernando Almeida-Souza, Verônica Diniz da Silva, Noemi Nosomi Taniwaki, Daiana de Jesus Hardoim, Ailésio Rocha Mendonça Filho, Wendel Fragoso de Freitas Moreira, Camilla Djenne Buarque, Kátia da Silva Calabrese, Ana Lucia Abreu-Silva. Nitric Oxide Induction in Peritoneal Macrophages by a 1,2,3-Triazole Derivative Improves Its Efficacy upon Leishmania amazonensis In Vitro Infection.
Journal of medicinal chemistry.
2021 09; 64(17):12691-12704. doi:
10.1021/acs.jmedchem.1c00725. [PMID: 34427442] - Lais Alonso, Sebastião Antônio Mendanha, Rodrigo Saar Gomes, Miriam Leandro Dorta, Antonio Alonso. Comparative EPR spectroscopy analysis of amphotericin B and miltefosine interactions with Leishmania, erythrocyte and macrophage membranes.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Aug; 163(?):105859. doi:
10.1016/j.ejps.2021.105859. [PMID: 33894283] - Dimitri Bulté, Lieselotte Van Bockstal, Laura Dirkx, Magali Van den Kerkhof, Carl De Trez, Jean-Pierre Timmermans, Sarah Hendrickx, Louis Maes, Guy Caljon. Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition.
PLoS neglected tropical diseases.
2021 07; 15(7):e0009622. doi:
10.1371/journal.pntd.0009622. [PMID: 34292975] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Thaís Amanda de Lima Nunes, Lellis Henrique Costa, Julyanne Maria Saraiva De Sousa, Vanessa Maria Rodrigues De Souza, Raiza Raianne Luz Rodrigues, Maria da Conceição Albuquerque Val, Anna Carolina Toledo da Cunha Pereira, Gustavo Portela Ferreira, Marcos Vinícius Da Silva, João Marcos Antônio Rodrigues Da Costa, Leiz Maria Costa Véras, Roseane Costa Diniz, Klinger Antonio da Franca Rodrigues. Eugenia piauhiensis Vellaff. essential oil and γ-elemene its major constituent exhibit antileishmanial activity, promoting cell membrane damage and in vitro immunomodulation.
Chemico-biological interactions.
2021 Apr; 339(?):109429. doi:
10.1016/j.cbi.2021.109429. [PMID: 33713644] - Blaise Kimbadi Lombe, Doris Feineis, Virima Mudogo, Marcel Kaiser, Gerhard Bringmann. Spirombandakamine A3 and Cyclombandakamines A8 and A9, Polycyclic Naphthylisoquinoline Dimers, with Antiprotozoal Activity, from a Congolese Ancistrocladus Plant.
Journal of natural products.
2021 04; 84(4):1335-1344. doi:
10.1021/acs.jnatprod.1c00063. [PMID: 33843232] - Jaime A Soto, María Isabel Méndez, Jonathan D Berman. Case Report: COVID-19 Misdiagnosed as a Drug Reaction to Miltefosine.
The American journal of tropical medicine and hygiene.
2021 Mar; 104(5):1659-1660. doi:
10.4269/ajtmh.20-1510. [PMID: 33705346] - Andrew A Voak, Andy Harris, Jose Miguel Coteron-Lopez, Iñigo Angulo-Barturen, Santiago Ferrer-Bazaga, Simon L Croft, Karin Seifert. Pharmacokinetic / pharmacodynamic relationships of liposomal amphotericin B and miltefosine in experimental visceral leishmaniasis.
PLoS neglected tropical diseases.
2021 03; 15(3):e0009013. doi:
10.1371/journal.pntd.0009013. [PMID: 33651812] - Sauman Singh-Phulgenda, Prabin Dahal, Roland Ngu, Brittany J Maguire, Alice Hawryszkiewycz, Sumayyah Rashan, Matthew Brack, Christine M Halleux, Fabiana Alves, Kasia Stepniewska, Piero L Olliaro, Philippe J Guerin. Serious adverse events following treatment of visceral leishmaniasis: A systematic review and meta-analysis.
PLoS neglected tropical diseases.
2021 03; 15(3):e0009302. doi:
10.1371/journal.pntd.0009302. [PMID: 33780461] - Humberto E Ortega, Vitor B Lourenzon, Marc G Chevrette, Leonardo L G Ferreira, René F Ramos Alvarenga, Weilan G P Melo, Tiago Venâncio, Cameron R Currie, Adriano D Andricopulo, Tim S Bugni, Mônica T Pupo. Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311.
Bioorganic & medicinal chemistry.
2021 02; 32(?):116016. doi:
10.1016/j.bmc.2021.116016. [PMID: 33493972] - Anam Sajjad Khan, Fakhar Ud Din, Zakir Ali, Maryam Bibi, Fatima Zahid, Alam Zeb, Mujeeb-Ur-Rehman, Gul Majid Khan. Development, in vitro and in vivo evaluation of miltefosine loaded nanostructured lipid carriers for the treatment of Cutaneous Leishmaniasis.
International journal of pharmaceutics.
2021 Jan; 593(?):120109. doi:
10.1016/j.ijpharm.2020.120109. [PMID: 33253802] - Guo Yu, Zakir Ali, Anam Sajjad Khan, Kalim Ullah, Humzah Jamshaid, Alam Zeb, Muhammad Imran, Sadia Sarwar, Han-Gon Choi, Fakhar Ud Din. Preparation, Pharmacokinetics, and Antitumor Potential of Miltefosine-Loaded Nanostructured Lipid Carriers.
International journal of nanomedicine.
2021; 16(?):3255-3273. doi:
10.2147/ijn.s299443. [PMID: 34012260] - Renata Mondêgo-Oliveira, Joicy Cortez de Sá Sousa, Carla Junqueira Moragas-Tellis, Paulo Victor Ramos de Souza, Maria do Socorro Dos Santos Chagas, Maria Dutra Behrens, Daiana de Jesús Hardoim, Noemi Nosomi Taniwaki, Thaize Quiroga Chometon, Alvaro Luiz Bertho, Kátia da Silva Calabrese, Fernando Almeida-Souza, Ana Lucia Abreu-Silva. Vernonia brasiliana (L.) Druce induces ultrastructural changes and apoptosis-like death of Leishmania infantum promastigotes.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jan; 133(?):111025. doi:
10.1016/j.biopha.2020.111025. [PMID: 33254018] - Rodrigo Rollin-Pinheiro, Yuri de Castro Almeida, Victor Pereira Rochetti, Mariana Ingrid Dutra da Silva Xisto, Luana Pereira Borba-Santos, Sonia Rozental, Eliana Barreto-Bergter. Miltefosine Against Scedosporium and Lomentospora Species: Antifungal Activity and Its Effects on Fungal Cells.
Frontiers in cellular and infection microbiology.
2021; 11(?):698662. doi:
10.3389/fcimb.2021.698662. [PMID: 34368017] - Maha M Eissa, Mervat Z El-Azzouni, Labiba K El-Khordagui, Amany Abdel Bary, Riham M El-Moslemany, Sara A Abdel Salam. Evaluation of prophylactic efficacy and safety of praziquantel-miltefosine nanocombination in experimental Schistosomiasis mansoni.
Acta tropica.
2020 Dec; 212(?):105714. doi:
10.1016/j.actatropica.2020.105714. [PMID: 32950482] - Semra Palić, Anke E Kip, Jos H Beijnen, Jane Mbui, Ahmed Musa, Alexandra Solomos, Monique Wasunna, Joseph Olobo, Fabiana Alves, Thomas P C Dorlo. Characterizing the non-linear pharmacokinetics of miltefosine in paediatric visceral leishmaniasis patients from Eastern Africa.
The Journal of antimicrobial chemotherapy.
2020 11; 75(11):3260-3268. doi:
10.1093/jac/dkaa314. [PMID: 32780098] - Ikrame Zeouk, Ines Sifaoui, Atteneri López-Arencibia, María Reyes-Batlle, Carlos J Bethencourt-Estrella, Isabel L Bazzocchi, Khadija Bekhti, Jacob Lorenzo-Morales, Ignacio A Jiménez, José E Piñero. Sesquiterpenoids and flavonoids from Inula viscosa induce programmed cell death in kinetoplastids.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Oct; 130(?):110518. doi:
10.1016/j.biopha.2020.110518. [PMID: 32674017] - Yenisleidy de Las Mercedes Zulueta Díaz, Ernesto Esteban Ambroggio, María Laura Fanani. Miltefosine inhibits the membrane remodeling caused by phospholipase action by changing membrane physical properties.
Biochimica et biophysica acta. Biomembranes.
2020 10; 1862(10):183407. doi:
10.1016/j.bbamem.2020.183407. [PMID: 32628918] - Cyril Fersing, Clotilde Boudot, Caroline Castera-Ducros, Emilie Pinault, Sébastien Hutter, Romain Paoli-Lombardo, Nicolas Primas, Julien Pedron, Line Seguy, Sandra Bourgeade-Delmas, Alix Sournia-Saquet, Jean-Luc Stigliani, Jean-Yves Brossas, Luc Paris, Alexis Valentin, Susan Wyllie, Alan H Fairlamb, Élisa Boutet-Robinet, Sophie Corvaisier, Marc Since, Aurélie Malzert-Fréon, Alexandre Destere, Dominique Mazier, Pascal Rathelot, Bertrand Courtioux, Nadine Azas, Pierre Verhaeghe, Patrice Vanelle. 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
European journal of medicinal chemistry.
2020 Sep; 202(?):112558. doi:
10.1016/j.ejmech.2020.112558. [PMID: 32652409] - Maha M Eissa, Mervat Z El-Azzouni, Labiba K El-Khordagui, Amany Abdel Bary, Riham M El-Moslemany, Sara A Abdel Salam. Single oral fixed-dose praziquantel-miltefosine nanocombination for effective control of experimental schistosomiasis mansoni.
Parasites & vectors.
2020 Sep; 13(1):474. doi:
10.1186/s13071-020-04346-1. [PMID: 32933556] - Shabi Parvez, Ganesh Yadagiri, Mallikarjuna Rao Gedda, Aakriti Singh, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath. Modified solid lipid nanoparticles encapsulated with Amphotericin B and Paromomycin: an effective oral combination against experimental murine visceral leishmaniasis.
Scientific reports.
2020 07; 10(1):12243. doi:
10.1038/s41598-020-69276-5. [PMID: 32699361] - Christa Buechler, Charalampos Aslanidis. Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 05; 1865(5):158658. doi:
10.1016/j.bbalip.2020.158658. [PMID: 32058031] - Marguerite L Monogue, Durward Watson, Julie S Alexander, Dominick Cavuoti, Laura M Doyle, Michael Zhuo Wang, Bonnie C Prokesch. Minimal Cerebrospinal Fluid Concentration of Miltefosine despite Therapeutic Plasma Levels during the Treatment of Amebic Encephalitis.
Antimicrobial agents and chemotherapy.
2019 12; 64(1):. doi:
10.1128/aac.01127-19. [PMID: 31685474] - José Ignacio Manzano, Eduardo J Cueto-Díaz, Ana Isabel Olías-Molero, Ana Perea, Tomás Herraiz, Juan J Torrado, José María Alunda, Francisco Gamarro, Christophe Dardonville. Discovery and Pharmacological Studies of 4-Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis.
Journal of medicinal chemistry.
2019 12; 62(23):10664-10675. doi:
10.1021/acs.jmedchem.9b00998. [PMID: 31702921] - Arijit Bhattacharya, Philippe Leprohon, Sophia Bigot, Prasad Kottayil Padmanabhan, Angana Mukherjee, Gaétan Roy, Hélène Gingras, Anais Mestdagh, Barbara Papadopoulou, Marc Ouellette. Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania.
Nature communications.
2019 12; 10(1):5627. doi:
10.1038/s41467-019-13344-6. [PMID: 31819054] - Luciana Maria Ribeiro Antinarelli, Raissa Soares Meinel, Eduardo Antonio Ferraz Coelho, Adilson David da Silva, Elaine Soares Coimbra. Resveratrol analogues present effective antileishmanial activity against promastigotes and amastigotes from distinct Leishmania species by multitarget action in the parasites.
The Journal of pharmacy and pharmacology.
2019 Dec; 71(12):1854-1863. doi:
10.1111/jphp.13177. [PMID: 31595530] - Juliana R Brito, Luiz Felipe D Passero, Adriana Bezerra-Souza, Márcia D Laurenti, Paulete Romoff, Henrique Barbosa, Edgard A Ferreira, João Henrique G Lago. Antileishmanial activity and ultrastructural changes of related tetrahydrofuran dineolignans isolated from Saururus cernuus L. (Saururaceae).
The Journal of pharmacy and pharmacology.
2019 Dec; 71(12):1871-1878. doi:
10.1111/jphp.13171. [PMID: 31595517] - Dieudonné Tshitenge Tshitenge, Torsten Bruhn, Doris Feineis, David Schmidt, Virima Mudogo, Marcel Kaiser, Reto Brun, Frank Würthner, Suresh Awale, Gerhard Bringmann. Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells.
Journal of natural products.
2019 11; 82(11):3150-3164. doi:
10.1021/acs.jnatprod.9b00755. [PMID: 31630523] - Shaimaa Fayez, Jun Li, Doris Feineis, Laurent Aké Assi, Marcel Kaiser, Reto Brun, Mohamed A Anany, Harald Wajant, Gerhard Bringmann. A Near-Complete Series of Four Atropisomeric Jozimine A2-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from Ancistrocladus abbreviatus.
Journal of natural products.
2019 11; 82(11):3033-3046. doi:
10.1021/acs.jnatprod.9b00589. [PMID: 31642313] - Pragya Chandrakar, Naresh Gunaganti, Naveen Parmar, Ashok Kumar, Sandeep Kumar Singh, Mamunur Rashid, M Wahajuddin, Kalyan Mitra, Tadigopula Narender, Susanta Kar. β-Amino acid derivatives as mitochondrial complex III inhibitors of L. donovani: A promising chemotype targeting visceral leishmaniasis.
European journal of medicinal chemistry.
2019 Nov; 182(?):111632. doi:
10.1016/j.ejmech.2019.111632. [PMID: 31499363] - Elena M Sánchez-Fernández, Ma Isabel García-Moreno, Ana I Arroba, Manuel Aguilar-Diosdado, José M Padrón, Raquel García-Hernández, Francisco Gamarro, Santos Fustero, José-Emilio Sánchez-Aparicio, Laura Masgrau, José Manuel García Fernández, Carmen Ortiz Mellet. Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies.
European journal of medicinal chemistry.
2019 Nov; 182(?):111604. doi:
10.1016/j.ejmech.2019.111604. [PMID: 31425910] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Lais Alonso, Éder Jeferson Souza Cardoso, Rodrigo Saar Gomes, Sebastião Antônio Mendanha, Miriam Leandro Dorta, Antonio Alonso. Antileishmanial and cytotoxic activities of ionic surfactants compared to those of miltefosine.
Colloids and surfaces. B, Biointerfaces.
2019 Nov; 183(?):110421. doi:
10.1016/j.colsurfb.2019.110421. [PMID: 31401463] - Jerald J Nair, Johannes van Staden. Antiprotozoal alkaloid principles of the plant family Amaryllidaceae.
Bioorganic & medicinal chemistry letters.
2019 10; 29(20):126642. doi:
10.1016/j.bmcl.2019.126642. [PMID: 31515186] - José Ignacio Manzano, Jelena Konstantinović, Diletta Scaccabarozzi, Ana Perea, Aleksandar Pavić, Loredana Cavicchini, Nicoletta Basilico, Francisco Gamarro, Bogdan A Šolaja. 4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania.
European journal of medicinal chemistry.
2019 Oct; 180(?):28-40. doi:
10.1016/j.ejmech.2019.07.010. [PMID: 31299585] - Jessica Rodriguez-Duran, Andrea Pinto-Martinez, Cecilia Castillo, Gustavo Benaim. Identification and electrophysiological properties of a sphingosine-dependent plasma membrane Ca2+ channel in Trypanosoma cruzi.
The FEBS journal.
2019 10; 286(19):3909-3925. doi:
10.1111/febs.14947. [PMID: 31162791] - Veselina Uzunova, Rumiana Tzoneva, Tihomira Stoyanova, Roumen Pankov, Ralica Skrobanska, Georgi Georgiev, Liliana Maslenkova, Zlatan Tsonchev, Albena Momchilova. Dimethylsphingosine and miltefosine induce apoptosis in lung adenocarcinoma A549 cells in a synergistic manner.
Chemico-biological interactions.
2019 Sep; 310(?):108731. doi:
10.1016/j.cbi.2019.108731. [PMID: 31265827] - Sara Botschuijver, Sophie A van Diest, Isabelle A M van Thiel, Rafael S Saia, Anne S Strik, Zhumei Yu, Daniele Maria-Ferreira, Olaf Welting, Daniel Keszthelyi, Gary Jennings, Sigrid E M Heinsbroek, Ronald P Oude Elferink, Frank H J Schuren, Wouter J de Jonge, René M van den Wijngaard. Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms.
Scientific reports.
2019 08; 9(1):12530. doi:
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Antimicrobial agents and chemotherapy.
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Frontiers in cellular and infection microbiology.
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Molecules (Basel, Switzerland).
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Infectious diseases of poverty.
2018 Aug; 7(1):80. doi:
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Antimicrobial agents and chemotherapy.
2018 08; 62(8):. doi:
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The Journal of antimicrobial chemotherapy.
2018 08; 73(8):2104-2111. doi:
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Journal of natural products.
2018 06; 81(6):1384-1390. doi:
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Experimental parasitology.
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Experimental parasitology.
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Frontiers in cellular and infection microbiology.
2018; 8(?):181. doi:
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Antimicrobial agents and chemotherapy.
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International journal of biological macromolecules.
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Cellular microbiology.
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Journal of natural products.
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European journal of medicinal chemistry.
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Biochimica et biophysica acta. Biomembranes.
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BMC infectious diseases.
2017 07; 17(1):478. doi:
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Bioorganic & medicinal chemistry.
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Journal of natural products.
2017 04; 80(4):1007-1014. doi:
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The American journal of tropical medicine and hygiene.
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Analytical and bioanalytical chemistry.
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Transplant infectious disease : an official journal of the Transplantation Society.
2017 Apr; 19(2):. doi:
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Antimicrobial agents and chemotherapy.
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Journal of natural products.
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Journal of pharmaceutical and biomedical analysis.
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Transplant infectious disease : an official journal of the Transplantation Society.
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Biochimica et biophysica acta. Biomembranes.
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Parasitology international.
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PLoS neglected tropical diseases.
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Experimental parasitology.
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International journal of antimicrobial agents.
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Biophysical chemistry.
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Journal of natural products.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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International journal of pharmaceutics.
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Acta tropica.
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