Milciclib (BioDeep_00000277887)

   


代谢物信息卡片


PHA-848125

化学式: C25H32N8O (460.26989419999995)
中文名称: PHA-848125
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C
InChI: InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29)

描述信息

C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C2185 - Cyclin-Dependent Kinase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent

同义名列表

2 个代谢物同义名

PHA-848125; Milciclib



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Clara Albanese, Rachele Alzani, Nadia Amboldi, Nilla Avanzi, Dario Ballinari, Maria Gabriella Brasca, Claudio Festuccia, Francesco Fiorentini, Giuseppe Locatelli, Wilma Pastori, Veronica Patton, Fulvia Roletto, Francesco Colotta, Arturo Galvani, Antonella Isacchi, Jurgen Moll, Enrico Pesenti, Ciro Mercurio, Marina Ciomei. Dual targeting of CDK and tropomyosin receptor kinase families by the oral inhibitor PHA-848125, an agent with broad-spectrum antitumor efficacy. Molecular cancer therapeutics. 2010 Aug; 9(8):2243-54. doi: 10.1158/1535-7163.mct-10-0190. [PMID: 20682657]
  • Simona Caporali, Ester Alvino, Giuseppe Starace, Marina Ciomei, Maria Gabriella Brasca, Lauretta Levati, Alberto Garbin, Daniele Castiglia, Claudia Covaciu, Enzo Bonmassar, Stefania D'Atri. The cyclin-dependent kinase inhibitor PHA-848125 suppresses the in vitro growth of human melanomas sensitive or resistant to temozolomide, and shows synergistic effects in combination with this triazene compound. Pharmacological research. 2010 May; 61(5):437-48. doi: 10.1016/j.phrs.2009.12.009. [PMID: 20026273]
  • J Z Scott, O A Kletzky, P F Brenner, D R Mishell. Comparison of the effects of contraceptive steroid formulations containing two doses of estrogen on pituitary function. Fertility and sterility. 1978 Aug; 30(2):141-5. doi: 10.1016/s0015-0282(16)43451-5. [PMID: 98356]
  • S Melethil, W D Conway. Urinary excretion of probenecid and its metabolites in humans as a function of dose. Journal of pharmaceutical sciences. 1976 Jun; 65(6):861-5. doi: 10.1002/jps.2600650615. [PMID: 6781]