Hematein (BioDeep_00000277566)

   

natural product


代谢物信息卡片


3,4,6a,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-9-one

化学式: C16H12O6 (300.06338519999997)
中文名称: 氧化苏木精, 海尔丹, 苏木红, 苏木因, 天然黑1, 氧化苏木红, 氧化苏木素
谱图信息: 最多检出来源 Viridiplantae(plant) 2.41%

分子结构信息

SMILES: C1C2=CC(=C(C=C2C3=C4C=CC(=O)C(=C4OCC31O)O)O)O
InChI: InChI=1S/C16H12O6/c17-10-2-1-8-13-9-4-12(19)11(18)3-7(9)5-16(13,21)6-22-15(8)14(10)20/h1-4,18-21H,5-6H2

描述信息

Hematein is an organic heterotetracyclic compound that is -6a,7-dihydrobenzo[b]indeno[1,2-d]pyran-9-one carrying four hydroxy substituents at positions 3, 4, 6a and 10. It has a role as a histological dye. It is an enol, an organic heterotetracyclic compound, a member of phenols, a member of quinomethanes and a tertiary alcohol.
Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].

同义名列表

1 个代谢物同义名

HEMATEIN



相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Silvia Biggi, Michael Pancher, Claudia Stincardini, Silvia Luotti, Tania Massignan, Andrea Dalle Vedove, Andrea Astolfi, Pamela Gatto, Graziano Lolli, Maria Letizia Barreca, Valentina Bonetto, Valentina Adami, Emiliano Biasini. Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface. Journal of neurochemistry. 2020 01; 152(1):136-150. doi: 10.1111/jnc.14805. [PMID: 31264722]
  • Bi Chen, Ming Ma, Xiaoli Su. An amperometric penicillin biosensor with enhanced sensitivity based on co-immobilization of carbon nanotubes, hematein, and beta-lactamase on glassy carbon electrode. Analytica chimica acta. 2010 Jul; 674(1):89-95. doi: 10.1016/j.aca.2010.06.014. [PMID: 20638504]
  • Jae-Hoon Choi, Tae-Sook Jeong, Dae-Yong Kim, Young-Myeong Kim, Hee-Jun Na, Ki-Hwan Nam, Sae-Bom Lee, Hyoung-Chin Kim, Sei Ryang Oh, Yang-Kyu Choi, Song-Hae Bok, Goo Taeg Oh. Hematein inhibits atherosclerosis by inhibition of reactive oxygen generation and NF-kappaB-dependent inflammatory mediators in hyperlipidemic mice. Journal of cardiovascular pharmacology. 2003 Aug; 42(2):287-95. doi: 10.1097/00005344-200308000-00019. [PMID: 12883334]
  • G T Oh, J H Choi, J J Hong, D Y Kim, S B Lee, J R Kim, C H Lee, B H Hyun, S R Oh, S H Bok, T S Jeong. Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression. Atherosclerosis. 2001 Nov; 159(1):17-26. doi: 10.1016/s0021-9150(01)00464-6. [PMID: 11689202]
  • H Puchtler, S N Meloan, F S Waldrop. Application of current chemical concepts to metal-hematein and -brazilein stains. Histochemistry. 1986; 85(5):353-64. doi: 10.1007/bf00982665. [PMID: 2430916]
  • N J LANE. VISUALIZATION OF SITES OF PHOSPHATASE ACTIVITIES BY MEANS OF MORDANTED HAEMATEIN. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1965 Mar; 13(?):235-8. doi: 10.1177/13.3.235. [PMID: 14327696]