Norepinephrine sulfate (BioDeep_00000027753)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


{4-[(1R)-2-amino-1-hydroxyethyl]-2-hydroxyphenyl}oxidanesulphonic acid

化学式: C8H11NO6S (249.0307066)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 9.8%

分子结构信息

SMILES: C1=CC(=C(C=C1C(CN)O)O)OS(=O)(=O)O
InChI: InChI=1S/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1

描述信息

Plasma norepinephrine sulfate increases after sympathetic nervous system activation by an exhausting incremental exercise test and remain elevated up to 2 h after exercise. (PMID: 8330610). Human platelets contribute to the formation of plasma norepinephrine sulfate by norepinephrine uptake, intraplatelet sulfoconjugation and release of norepinephrine sulfate. (PMID: 7968241). Higher concentrations of norepinephrine sulfate in portal venous than arterial plasma indicate substantial production of norepinephrine by mesenteric organs. (PMID: 8627312). Intravenously infused norepinephrine is sulfoconjugated in humans, indicating that a major part of NE is sulfoconjugated in blood or at sites easily accessible from blood. (PMID: 12020748).
Plasma norepinephrine sulfate increases after sympathetic nervous system activation by an exhausting incremental exercise test and remain elevated up to 2 h after exercise. (PMID: 8330610)

同义名列表

15 个代谢物同义名

{4-[(1R)-2-amino-1-hydroxyethyl]-2-hydroxyphenyl}oxidanesulphonic acid; {4-[(1R)-2-amino-1-hydroxyethyl]-2-hydroxyphenyl}oxidanesulfonic acid; {4-[(1R)-2-amino-1-hydroxyethyl]-2-hydroxyphenyl}oxidanesulphonate; {4-[(1R)-2-amino-1-hydroxyethyl]-2-hydroxyphenyl}oxidanesulfonate; Norepinephrine sulphuric acid; Noradrenaline sulfoconjugate; Norepinephrine sulfuric acid; Norepinephrine-3-O-sulphate; Norepinephrine-3-O-sulfate; Norepinephrine-O-sulphate; Norepinephrine-O-sulfate; Norepinephrine sulphate; Noradrenaline sulphate; Norepinephrine sulfate; Noradrenaline sulfate



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • P P Freestone, M Lyte, C P Neal, A F Maggs, R D Haigh, P H Williams. The mammalian neuroendocrine hormone norepinephrine supplies iron for bacterial growth in the presence of transferrin or lactoferrin. Journal of bacteriology. 2000 Nov; 182(21):6091-8. doi: 10.1128/jb.182.21.6091-6098.2000. [PMID: 11029429]
  • G Strobel, M Neureither, P Bärtsch. Effect of acute mild hypoxia during exercise on plasma free and sulphoconjugated catecholamines. European journal of applied physiology and occupational physiology. 1996; 73(1-2):82-7. doi: 10.1007/bf00262813. [PMID: 8861673]
  • K Mielke, G Strobel. The potential of intact human platelets for sulfoconjugation of norepinephrine in vitro. Life sciences. 1994; 55(21):1657-63. doi: 10.1016/0024-3205(94)00333-5. [PMID: 7968241]
  • B A Faraj, V M Camp, D C Davis, M Kutner, G A Cotsonis, T Holloway. Elevated concentrations of dopamine sulfate in plasma of cocaine abusers. Biochemical pharmacology. 1993 Oct; 46(8):1453-7. doi: 10.1016/0006-2952(93)90111-9. [PMID: 8240395]
  • G Strobel, V Hack, R Kinscherf, H Weicker. Sustained noradrenaline sulphate response in long-distance runners and untrained subjects up to 2 h after exhausting exercise. European journal of applied physiology and occupational physiology. 1993; 66(5):421-6. doi: 10.1007/bf00599615. [PMID: 8330610]
  • D Ratge, K P Kohse, U Steegmüller, H Wisser. Distribution of free and conjugated catecholamines between plasma, platelets and erythrocytes: different effects of intravenous and oral catecholamine administrations. The Journal of pharmacology and experimental therapeutics. 1991 Apr; 257(1):232-8. doi: NULL. [PMID: 2019988]
  • G Strobel, H Weicker. Catecholamine sulfates as internal standards in HPLC determinations of sulfoconjugated catecholamines in plasma and urine. Clinical chemistry. 1991 Feb; 37(2):196-9. doi: 10.1093/clinchem/37.2.196. [PMID: 1993323]
  • J L Cuche, P Brochier, N Klioua, M F Poirier, H Cuche, M Benmiloud, H Loo, M Safar. Conjugated catecholamines in human plasma: where are they coming from?. The Journal of laboratory and clinical medicine. 1990 Nov; 116(5):681-6. doi: NULL. [PMID: 2230539]
  • M S Sothmann, J Blaney, T Woulfe, S Donahue-Fuhrman, K Lefever, A B Gustafson, V S Murthy. Plasma free and sulfoconjugated catecholamines during sustained exercise. Journal of applied physiology (Bethesda, Md. : 1985). 1990 Feb; 68(2):452-6. doi: 10.1152/jappl.1990.68.2.452. [PMID: 2318755]
  • I Eichler, H G Eichler, M Rotter, P A Kyrle, S Gasic, A Korn. Plasma concentrations of free and sulfoconjugated dopamine, epinephrine, and norepinephrine in healthy infants and children. Klinische Wochenschrift. 1989 Jul; 67(13):672-5. doi: 10.1007/bf01718028. [PMID: 2755031]
  • B Fruhstorfer, M G Pritsch, M B Pritsch, H W Clement, W Wesemann. Effects of daytime noise load on the sleep-wake cycle and endocrine patterns in man. III. 24 hours secretion of free and sulfate conjugated catecholamines. The International journal of neuroscience. 1988 Nov; 43(1-2):53-62. doi: 10.3109/00207458808985779. [PMID: 3215733]
  • E Werle, G Michel, T Lenz, H Kather, B Schneider, H Weicker. Restricted alpha- and beta-adrenoceptor affinity of sulfoconjugated catecholamines in human mononuclear leukocytes, platelets, and fat cells and reduction of the postreceptor mechanisms. International journal of sports medicine. 1988 Aug; 9 Suppl 2(?):S93-102. doi: 10.1055/s-2008-1025623. [PMID: 2846457]
  • H Weicker. Determination of free and sulfoconjugated catecholamines in plasma and urine by high-performance liquid chromatography. International journal of sports medicine. 1988 Aug; 9 Suppl 2(?):S68-74. doi: 10.1055/s-2008-1025619. [PMID: 3182165]
  • M S Sothmann, A B Gustafson, M Chandler. Plasma free and sulfoconjugated catecholamine responses to varying exercise intensity. Journal of applied physiology (Bethesda, Md. : 1985). 1987 Aug; 63(2):654-8. doi: 10.1152/jappl.1987.63.2.654. [PMID: 3654425]
  • G M Tyce, J M Messick, T L Yaksh, D E Byer, D R Danielson, D K Rorie. Amine sulfate formation in the central nervous system. Federation proceedings. 1986 Jul; 45(8):2247-53. doi: NULL. [PMID: 3459671]
  • H Tanaka, J Cléroux, J de Champlain, J R Ducharme, R Collu. Persistent effects of a marathon run on the pituitary-testicular axis. Journal of endocrinological investigation. 1986 Apr; 9(2):97-101. doi: 10.1007/bf03348075. [PMID: 2940291]
  • N T Buu, J Duhaime, O Kuchel. Effects of L-DOPA on the concentrations of free and sulfoconjugated catecholamines in plasma, cerebrospinal fluid, urine, and central and peripheral nervous system tissues of the rat. Journal of neurochemistry. 1985 Mar; 44(3):787-92. doi: 10.1111/j.1471-4159.1985.tb12884.x. [PMID: 3838339]
  • O Kuchel, C Hausser, N T Buu, S Tenneson. CSF sulfoconjugated catecholamines in man: their relationship with plasma catecholamines. Journal of neural transmission. 1985; 62(1-2):91-7. doi: 10.1007/bf01260418. [PMID: 3839521]
  • O Kuchel, N T Buu. Circadian variations of free and sulfoconjugated catecholamines in normal subjects. Endocrine research. 1985; 11(1-2):17-25. doi: 10.3109/07435808509035421. [PMID: 3840083]
  • N Alexander, S Yoneda, N D Vlachakis, R F Maronde. Role of conjugation and red blood cells for inactivation of circulating catecholamines. The American journal of physiology. 1984 Jul; 247(1 Pt 2):R203-7. doi: 10.1152/ajpregu.1984.247.1.r203. [PMID: 6547571]
  • L Davidson, R Vandongen, L J Beilin, P D Arkwright. Free and sulfate-conjugated catecholamines during exercise in man. The Journal of clinical endocrinology and metabolism. 1984 Mar; 58(3):415-8. doi: 10.1210/jcem-58-3-415. [PMID: 6546389]
  • M A Elchisak. Determination of dopamine-O-sulfate and norepinephrine-O-sulfate isomers and serotonin-O-sulfate by high-performance liquid chromatography using dual-electrode electrochemical detection. Journal of chromatography. 1983 Jul; 264(1):119-27. doi: 10.1016/s0021-9673(01)95011-3. [PMID: 6688426]
  • L J Beilin, J Deacon, C A Michael, R Vandongen, C M Lalor, A E Barden, L Davidson, I Rouse. Diurnal rhythms of blood pressure, plasma renin activity, angiotensin II and catecholamines in normotensive and hypertensive pregnancies. Clinical and experimental hypertension. Part B, Hypertension in pregnancy. 1983; 2(2):271-93. doi: 10.3109/10641958309006086. [PMID: 6347445]
  • J Claustre, P Serusclat, L Peyrin. Glucuronide and sulfate catecholamine conjugates in rat and human plasma. Journal of neural transmission. 1983; 56(4):265-78. doi: 10.1007/bf01243495. [PMID: 6688268]
  • J L Cuche, J Prinseau, G Ruget, F Selz, J L Tual, A Baglin, J Guedon, D Fritel. Plasma free and sulfoconjugated catecholamines in healthy men. European heart journal. 1982 Oct; 3 Suppl C(?):3-8. doi: 10.1093/eurheartj/3.suppl_c.3. [PMID: 6897383]
  • D A Joyce, L J Beilin, R Vandongen, L Davidson. Plasma free and sulfate conjugated catecholamine levels during acute physiological stimulation in man. Life sciences. 1982 Feb; 30(5):447-54. doi: 10.1016/0024-3205(82)90461-1. [PMID: 6895925]