Cornuside (BioDeep_00000277069)
natural product PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C24H30O14 (542.163548)
中文名称: 山茱萸新苷
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 16.13%
分子结构信息
SMILES: C=CC1C(OC2OC(CO)C(O)C(O)C2O)OC=C(C(=O)OC)C1CCOC(=O)c1cc(O)c(O)c(O)c1
InChI: InChI=1S/C24H30O14/c1-3-11-12(4-5-35-21(32)10-6-14(26)17(28)15(27)7-10)13(22(33)34-2)9-36-23(11)38-24-20(31)19(30)18(29)16(8-25)37-24/h3,6-7,9,11-12,16,18-20,23-31H,1,4-5,8H2,2H3/t11-,12+,16-,18-,19+,20-,23+,24+/m1/s1
描述信息
Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases[1].
Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases[1].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 11228694
- ChEMBL: CHEMBL4872792
- CAS: 131189-57-6
- MoNA: CCMSLIB00000850541
- MoNA: CCMSLIB00000852867
- MoNA: CCMSLIB00000850538
- PMhub: MS000011986
- medchemexpress: HY-N0631
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chao Yan, Zhihao Liu, Waner Xie, Ting Zhang, Jiyao Zhang, Guodong Li, Xiaoyan Xu, Lei Ye, Jianwei Gong. Cornuside protects against ischemic stroke in rats by suppressing the IL-17F/TRAF6/NF-κB pathway via the brain-gut axis.
Experimental neurology.
2023 Dec; 373(?):114672. doi:
10.1016/j.expneurol.2023.114672. [PMID: 38169196] - Lin Wang, Fenglian Yan, Junfeng Zhang, Yucai Xiao, Changying Wang, Yuanbo Zhu, Chunxia Li, Zhihong Liu, Wenbo Li, Chengduo Wang, Jie Liu, Hui Zhang, Huabao Xiong, Dongmei Shi. Cornuside improves murine autoimmune hepatitis through inhibition of inflammatory responses.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Nov; 120(?):155077. doi:
10.1016/j.phymed.2023.155077. [PMID: 37716032] - Lei Yu, Ruomei Che, Weiku Zhang, Jiekun Xu, Wenwen Lian, Jun He, Shuxin Tu, Xue Bai, Xiaoli He. Cornuside, by regulating the AGEs-RAGE-IκBα-ERK1/2 signaling pathway, ameliorates cognitive impairment associated with brain aging.
Phytotherapy research : PTR.
2023 Jun; 37(6):2419-2436. doi:
10.1002/ptr.7765. [PMID: 36781177] - Jun-Zhuo Shi, Xiao-Ming Zheng, Yun-Feng Zhou, Lu-Yao Yun, Dong-Mei Luo, Jiao-Jiao Hao, Peng-Fei Liu, Wei-Ku Zhang, Jie-Kun Xu, Yi Yan, Xin-Mei Xie, Yang-Yang He, Xiao-Bin Pang. Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes.
Nutrients.
2022 Aug; 14(15):. doi:
10.3390/nu14153179. [PMID: 35956355] - Ze-Xing Wang, Wen-Wen Lian, Jun He, Xiao-Li He, Yu-Ming Wang, Chen-Hao Pan, Mei Li, Wei-Ku Zhang, Lian-Qi Liu, Jie-Kun Xu. Cornuside ameliorates cognitive impairments in scopolamine induced AD mice: Involvement of neurotransmitter and oxidative stress.
Journal of ethnopharmacology.
2022 Jul; 293(?):115252. doi:
10.1016/j.jep.2022.115252. [PMID: 35405255] - Rongbo Zhang, Jin Liu, Bin Xu, You Wu, Shunli Liang, Qiang Yuan. Cornuside alleviates experimental autoimmune encephalomyelitis by inhibiting Th17 cell infiltration into the central nervous system.
Journal of Zhejiang University. Science. B.
2021 May; 22(5):421-430. doi:
10.1631/jzus.b2000771. [PMID: 33973423] - Xian-Sheng Ye, Jun He, Yung-Chi Cheng, Lei Zhang, Hao-Yi Qiao, Xue-Ge Pan, Jia Zhang, Shu-Na Liu, Wei-Ku Zhang, Jie-Kun Xu. Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis.
Journal of natural products.
2017 12; 80(12):3103-3111. doi:
10.1021/acs.jnatprod.6b01127. [PMID: 29140705] - Himanshu Kumar Bhakta, Chan Hum Park, Takako Yokozawa, Takashi Tanaka, Hyun Ah Jung, Jae Sue Choi. Potential anti-cholinesterase and β-site amyloid precursor protein cleaving enzyme 1 inhibitory activities of cornuside and gallotannins from Cornus officinalis fruits.
Archives of pharmacal research.
2017 Jul; 40(7):836-853. doi:
10.1007/s12272-017-0924-z. [PMID: 28589255] - Filiz Tubaş, Sedat Per, Abdulkadir Taşdemir, Ayşe Kaçar Bayram, Mehmet Yıldırım, Aydın Uzun, Recep Saraymen, Hakan Gümüş, Ferhan Elmalı, Hüseyin Per. Effects of Cornus mas L. and Morus rubra L. extracts on penicillin-induced epileptiform activity: an electrophysiological and biochemical study.
Acta neurobiologiae experimentalis.
2017; 77(1):45-56. doi:
10.21307/ane-2017-035. [PMID: 28379215] - Wang-Lin Jiang, Shu-Min Zhang, Xue-Xi Tang, Hong-Zhan Liu. Protective roles of cornuside in acute myocardial ischemia and reperfusion injury in rats.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Feb; 18(4):266-71. doi:
10.1016/j.phymed.2010.07.009. [PMID: 20739159] - Shun Zong Song, Yun Ho Choi, Guang Yu Jin, Guang Zhao Li, Guang Hai Yan. Protective effect of cornuside against carbon tetrachloride-induced acute hepatic injury.
Bioscience, biotechnology, and biochemistry.
2011; 75(4):656-61. doi:
10.1271/bbb.100739. [PMID: 21512227] - Wang-Lin Jiang, Xi-Guang Chen, Hai-Bo Zhu, Jing-Wei Tian. Effect of cornuside on experimental sepsis.
Planta medica.
2009 May; 75(6):614-9. doi:
10.1055/s-0029-1185383. [PMID: 19263342]