Paromomycin sulfate (BioDeep_00000277023)
natural product Chemicals and Drugs
代谢物信息卡片
Paromomycin sulfate
化学式: C23H47N5O18S (713.2636682)
中文名称: 巴龙霉素硫酸盐
谱图信息:
最多检出来源 Escherichia coli(natural_products) 50%
分子结构信息
SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
InChI: /m1./s1
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis?by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections[1][2][3].
同义名列表
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:7935
- KEGGdrug: D00868
- PubChem: 441375
- PubChem: 5458443
- ChEMBL: CHEMBL2206196
- MeSH: Paromomycin
- CAS: 7205-49-4
- CAS: 1263-89-4
- MoNA: VF-NPL-QEHF011262
- MoNA: VF-NPL-QEHF011261
- MoNA: VF-NPL-QEHF011260
- MoNA: VF-NPL-QEHF011259
- MoNA: VF-NPL-QEHF011258
- MoNA: VF-NPL-QEHF011257
- MoNA: VF-NPL-QEHF011256
- MoNA: VF-NPL-QEHF011255
- MoNA: VF-NPL-QEHF011254
- MoNA: VF-NPL-QEHF011253
- MoNA: VF-NPL-QEHF011252
- MoNA: VF-NPL-QEHF011251
- MoNA: VF-NPL-QEHF011250
- MoNA: VF-NPL-QEHF011249
- MoNA: VF-NPL-QEHF011248
- PMhub: MS000011869
- medchemexpress: HY-B0956
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mingxiao Liu, Di Zhang, Dongqiang Wang, Xiaodong Wu, Ying Zhang, Jigang Yin, Guan Zhu. Cost-effective In vivo and In vitro Mouse Models for Evaluating Anti-Cryptosporidial Drug Efficacy: Assessing Vorinostat, Docetaxel and Baicalein.
The Journal of infectious diseases.
2023 Jul; ?(?):. doi:
10.1093/infdis/jiad243. [PMID: 37418629] - Yiğit Kaçar, Ahmet Tarık Baykal, Levent Aydin, Hasan Batmaz. Evaluation of the efficacy of cow colostrum in the treatment and its effect on serum proteomes in calves with cryptosporidiosis.
Veterinary immunology and immunopathology.
2022 Jun; 248(?):110429. doi:
10.1016/j.vetimm.2022.110429. [PMID: 35500421] - Shipra Gupta, Layne Smith, Adriana Diakiw. Amebiasis and Amebic Liver Abscess in Children.
Pediatric clinics of North America.
2022 02; 69(1):79-97. doi:
10.1016/j.pcl.2021.08.003. [PMID: 34794678] - Luka Verrest, Monique Wasunna, Gilbert Kokwaro, Rashid Aman, Ahmed M Musa, Eltahir A G Khalil, Mahmoud Mudawi, Brima M Younis, Asrat Hailu, Zewdu Hurissa, Workagegnehu Hailu, Samson Tesfaye, Eyasu Makonnen, Yalemtsehay Mekonnen, Alwin D R Huitema, Jos H Beijnen, Smita A Kshirsagar, Jaya Chakravarty, Madhukar Rai, Shyam Sundar, Fabiana Alves, Thomas P C Dorlo. Geographical Variability in Paromomycin Pharmacokinetics Does Not Explain Efficacy Differences between Eastern African and Indian Visceral Leishmaniasis Patients.
Clinical pharmacokinetics.
2021 11; 60(11):1463-1473. doi:
10.1007/s40262-021-01036-8. [PMID: 34105063] - Aschalew Tamiru, Rezika Mohammed, Saba Atnafu, Girmay Medhin, Asrat Hailu. Efficacy and safety of a combined treatment of sodium stibogluconate at 20mg/kg/day with upper maximum daily dose limit of 850mg and Paromomycin 15mg/kg/day in HIV negative visceral leishmaniasis patients. A retrospective study, northwest Ethiopia.
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2008 Aug; 38(2):399-418. doi:
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2008 May; 127(5):489-93. doi:
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The New England journal of medicine.
2007 Jun; 356(25):2571-81. doi:
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Plant cell reports.
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Hepato-gastroenterology.
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