Suberylglycine (BioDeep_00000027673)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


7-[(Carboxymethyl)-C-hydroxycarbonimidoyl]heptanoate

化学式: C10H17NO5 (231.11066720000002)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 2.33%

分子结构信息

SMILES: C(CCCC(=O)O)CCC(=O)NCC(=O)O
InChI: InChI=1S/C10H17NO5/c12-8(11-7-10(15)16)5-3-1-2-4-6-9(13)14/h1-7H2,(H,11,12)(H,13,14)(H,15,16)

描述信息

Suberylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycineSuberylglycine is a dicarboxylic acid. It is formed by glycine-N-acylase catalyzed conjugation (PMID 947635). It can be used for the diagnosis of hereditary medium-chain acyl-CoA dehydrogenase deficiency (PMID 2775902). Suberylglycine is found to be associated with propionic acidemia, which is an inborn error of metabolism.
Suberylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:

同义名列表

5 个代谢物同义名

7-[(Carboxymethyl)-C-hydroxycarbonimidoyl]heptanoate; 7-[(carboxymethyl)carbamoyl]heptanoic acid; 7-(carboxymethylcarbamoyl)heptanoic acid; Suberylglycine; Suberylglycin



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bei Yan, Yao Liu, Aixin Shi, Zhihong Wang, Jiye Aa, Xiaoping Huang, Yi Liu. Investigation of the Antifatigue Effects of Korean Ginseng on Professional Athletes by Gas Chromatography-Time-of-Flight-Mass Spectrometry-Based Metabolomics. Journal of AOAC International. 2018 May; 101(3):701-707. doi: 10.5740/jaoacint.17-0220. [PMID: 28927488]
  • S Albers, H L Levy, M Irons, A W Strauss, D Marsden. Compound heterozygosity in four asymptomatic siblings with medium-chain acyl-CoA dehydrogenase deficiency. Journal of inherited metabolic disease. 2001 Jun; 24(3):417-8. doi: 10.1023/a:1010533408635. [PMID: 11486912]
  • M Kimura, S Yamaguchi. Screening for fatty acid beta oxidation disorders. Acylglycine analysis by electron impact ionization gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 1999 Aug; 731(1):105-10. doi: 10.1016/s0378-4347(99)00208-x. [PMID: 10491995]
  • M J Bennett, P M Coates, D E Hale, D S Millington, R J Pollitt, P Rinaldo, C R Roe, K Tanaka. Analysis of abnormal urinary metabolites in the newborn period in medium-chain acyl-CoA dehydrogenase deficiency. Journal of inherited metabolic disease. 1990; 13(5):707-15. doi: 10.1007/bf01799572. [PMID: 2246856]
  • P Rinaldo, J J O'Shea, R D Welch, K Tanaka. Stable isotope dilution analysis of n-hexanoylglycine, 3-phenylpropionylglycine and suberylglycine in human urine using chemical ionization gas chromatography/mass spectrometry selected ion monitoring. Biomedical & environmental mass spectrometry. 1989 Jul; 18(7):471-7. doi: 10.1002/bms.1200180705. [PMID: 2775902]
  • P Rinaldo, J J O'Shea, P M Coates, D E Hale, C A Stanley, K Tanaka. Medium-chain acyl-CoA dehydrogenase deficiency. Diagnosis by stable-isotope dilution measurement of urinary n-hexanoylglycine and 3-phenylpropionylglycine. The New England journal of medicine. 1988 Nov; 319(20):1308-13. doi: 10.1056/nejm198811173192003. [PMID: 3054550]
  • N Gregersen, R Lauritzen, K Rasmussen. Suberylglycine excretion in the urine from a patient with dicarboxylic aciduria. Clinica chimica acta; international journal of clinical chemistry. 1976 Aug; 70(3):417-25. doi: 10.1016/0009-8981(76)90355-7. [PMID: 947635]