Ethyl eburnamenine-14-carboxylate (BioDeep_00000276348)
代谢物信息卡片
ethyl (41R,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
化学式: C22H26N2O2 (350.1994176)
中文名称: 长春西汀杂质G
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(=C2)C(=O)OCC
InChI: InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3
描述信息
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
D020011 - Protective Agents
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:91571
- PubChem: 5673
- ChEMBL: CHEMBL1367774
- CAS: 77549-94-1
- PMhub: MS000010246
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhang-Chao Dong, Yang Shi, Liang-Liang Zheng, You-Ping Tian, Jian Yang, Ying Wei, Ying Zhou, Bo-Wen Pan. Synthesis and Activity Evaluation of Vinpocetine-Derived Indole Alkaloids.
Molecules (Basel, Switzerland).
2023 Dec; 29(1):. doi:
10.3390/molecules29010014. [PMID: 38202595] - Sumaia Abdulbari Ahmed Ali Hard, H N Shivakumar, Moqbel Ali Moqbel Redhwan. Development and optimization of in-situ gel containing chitosan nanoparticles for possible nose-to-brain delivery of vinpocetine.
International journal of biological macromolecules.
2023 Oct; ?(?):127217. doi:
10.1016/j.ijbiomac.2023.127217. [PMID: 37793522] - Hayder M Al-Kuraishy, Athanasios Alexiou, Marios Papadakis, Omnya Elhussieny, Hebatallah M Saad, Gaber El-Saber Batiha. New insights on the potential effect of vinpocetine in Parkinson's disease: one of the neglected warden and baffling topics.
Metabolic brain disease.
2023 08; 38(6):1831-1840. doi:
10.1007/s11011-023-01254-y. [PMID: 37335452] - Archana Bharti Sonkar, Pranesh Kumar, Anand Kumar, Anurag Kumar Gautam, Abhishek Verma, Amita Singh, Umesh Kumar, Dinesh Kumar, Tarun Mahata, Bolay Bhattacharya, Amit K Keshari, Biswanath Maity, Sudipta Saha. Vinpocetine mitigates DMH-induce pre-neoplastic colon damage in rats through inhibition of pro-inflammatory cytokines.
International immunopharmacology.
2023 May; 119(?):110236. doi:
10.1016/j.intimp.2023.110236. [PMID: 37148772] - Hibah M Aldawsari, Shaimaa M Badr-Eldin, Nourah Y Assiri, Nabil A Alhakamy, Anna Privitera, Filippo Caraci, Giuseppe Caruso. Surface-tailoring of emulsomes for boosting brain delivery of vinpocetine via intranasal route: in vitro optimization and in vivo pharmacokinetic assessment.
Drug delivery.
2022 Aug; 29(1):2671-2684. doi:
10.1080/10717544.2022.2110996. [PMID: 35975309] - Amany A Azouz, Fatema Hersi, Fares E M Ali, Asmaa M M Hussein Elkelawy, Hany A Omar. Renoprotective effect of vinpocetine against ischemia/reperfusion injury: Modulation of NADPH oxidase/Nrf2, IKKβ/NF-κB p65, and cleaved caspase-3 expressions.
Journal of biochemical and molecular toxicology.
2022 Jul; 36(7):e23046. doi:
10.1002/jbt.23046. [PMID: 35315168] - Azza A Ali, Mona M Kamal, Mona G Khalil, Shimaa A Ali, Hemat A Elariny, Amany Bekhit, Ahmed Wahid. Behavioral, Biochemical and Histopathological effects of Standardised Pomegranate extract with Vinpocetine, Propolis or Cocoa in a rat model of Parkinson's disease.
Experimental aging research.
2022 Mar; 48(2):191-210. doi:
10.1080/0361073x.2021.1959823. [PMID: 34384037] - Hyun Sik Kang, Jin Yong Song, Jong Heon Kim, Tae Il Park, Won Seok Choi, Ji -Yun Lee. Effects of vinpocetine on atopic dermatitis after administration via three different routes in HR-1 hairless mice.
Die Pharmazie.
2022 01; 77(1):9-13. doi:
10.1691/ph.2022.1941. [PMID: 35045919] - Nasr Y Khalil, Ahmed H Bakheit, Hamad M Alkahtani, Turki Al-Muhanna. Vinpocetine (A comprehensive profile).
Profiles of drug substances, excipients, and related methodology.
2022; 47(?):1-54. doi:
10.1016/bs.podrm.2021.10.001. [PMID: 35396012] - Shermineh Moini-Nodeh, Mahban Rahimifard, Maryam Baeeri, Mahshid Hodjat, Hamed Haghi-Aminjan, Mohammad Abdollahi. Vinpocetine Effect on the Juncture of Diabetes and Aging: An in-vitro study.
Drug research.
2021 Oct; 71(8):438-447. doi:
10.1055/a-1381-6625. [PMID: 34255319] - Walaa Wadie, Nermeen S Abdel-Razek, Hesham A Salem. Phosphodiesterase (1, 3 & 5) inhibitors attenuate diclofenac-induced acute kidney toxicity in rats.
Life sciences.
2021 Jul; 277(?):119506. doi:
10.1016/j.lfs.2021.119506. [PMID: 33865881] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Esma Yıldırım, Gulay Sezer. Clinical plasma concentration of vinpocetine does not affect osteogenic differentiation of mesenchymal stem cells.
Pharmacological reports : PR.
2021 Feb; 73(1):202-210. doi:
10.1007/s43440-020-00153-8. [PMID: 32865810] - Won Seok Choi, Hyun Sik Kang, Hong Jo Kim, Wang Tae Lee, Uy Dong Sohn, Ji-Yun Lee. Vinpocetine alleviates lung inflammation via macrophage inflammatory protein-1β inhibition in an ovalbumin-induced allergic asthma model.
PloS one.
2021; 16(4):e0251012. doi:
10.1371/journal.pone.0251012. [PMID: 33914833] - Walaa Yehia Abdelzaher, Sabreen Mahmoud Ahmed, Nermeen N Welson, Najat Marraiki, Gaber El-Saber Batiha, Maha Yehia Kamel. Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jan; 133(?):110976. doi:
10.1016/j.biopha.2020.110976. [PMID: 33202281] - Ping Zhang, Yungang Cao, Songfang Chen, Liang Shao. Combination of Vinpocetine and Dexamethasone Alleviates Cognitive Impairment in Nasopharyngeal Carcinoma Patients following Radiation Injury.
Pharmacology.
2021; 106(1-2):37-44. doi:
10.1159/000506777. [PMID: 32294652] - I N Samartsev, S A Zhivolupov, J S Butakova, M S Parshin. [The open observational study of aceclofenac and vinpocetine effectiveness and tolerability in treatment of patients with chronic cerebrovascular disease after COVID-19 (AQUA study)].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2021; 121(11):s1-s8. doi:
10.17116/jnevro2021121111s1. [PMID: 34968019] - Noha Nafee, Abd El Rahman Ameen, Osama Y Abdallah. Patient-Friendly, Olfactory-Targeted, Stimuli-Responsive Hydrogels for Cerebral Degenerative Disorders Ensured > 400\% Brain Targeting Efficiency in Rats.
AAPS PharmSciTech.
2020 Nov; 22(1):6. doi:
10.1208/s12249-020-01872-0. [PMID: 33222021] - Sally A Habib, Rehab S Abdelrahman, Mona Abdel Rahim, Ghada M Suddek. Anti-apoptotic effect of vinpocetine on cisplatin-induced hepatotoxicity in mice: The role of Annexin-V, Caspase-3, and Bax.
Journal of biochemical and molecular toxicology.
2020 Oct; 34(10):e22555. doi:
10.1002/jbt.22555. [PMID: 32578916] - Qun Ma, Rui Luo, Huimin Zhang, Manman Dai, Luyu Bai, Qingsong Fei, Fang Lei, Ning He. Design, Characterization, and Application of a pH-Triggered In Situ Gel for Ocular Delivery of Vinpocetine.
AAPS PharmSciTech.
2020 Sep; 21(7):253. doi:
10.1208/s12249-020-01791-0. [PMID: 32888086] - Ahsas Goyal, Debapriya Garabadu. Vinpocetine facilitates the anti-amnesic activity of estrogen-receptor alpha agonist in bilateral ovariectomy-challenged animals.
Behavioural brain research.
2020 09; 393(?):112789. doi:
10.1016/j.bbr.2020.112789. [PMID: 32593544] - Wenjing Song, Weinan Yin, Liang Ding, Yang Gao, JingJing Xu, Yan Yang, Xin He, Pengju Gong, Lei Wei, Wenli Chen, Jingwei Zhang. Vinpocetine reduces cisplatin-induced acute kidney injury through inhibition of NF-κB pathway and activation of Nrf2/ARE pathway in rats.
International urology and nephrology.
2020 Jul; 52(7):1389-1401. doi:
10.1007/s11255-020-02485-z. [PMID: 32418008] - Qun Ma, Manman Dai, Huimin Zhang, Luyu Bai, Ning He. Effect of different doses of borneol on the pharmacokinetics of vinpocetine in rat plasma and brain after intraocular administration.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 May; 50(5):580-587. doi:
10.1080/00498254.2019.1658139. [PMID: 31424307] - Jiaxin Zhou, Wenfang Zhang, Jiali Pang, Xiaoting Wang, Zijie Zheng, Yuanxin Li, Fan Yang, Wei Yang. Optimized preparation of vinpocetine micelles and in vivo evaluation of its pharmacokinetics in rats.
Pharmaceutical development and technology.
2020 Apr; 25(4):464-471. doi:
10.1080/10837450.2019.1709501. [PMID: 31910066] - Meipeng Zhu, Hui Liu, Kai Sun, Jian Liu, Yan Mou, Dahu Qi, Chuankun Zhou, Maihaiti Abudunaibi, Bahebieergan Tasiken, Jianwen Li, Hao Cheng, Hui Huang. Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Mar; 123(?):109769. doi:
10.1016/j.biopha.2019.109769. [PMID: 31846839] - Bo-Wen Pan, Yang Shi, Wen-Chao Li, Qing Wang, Meng Pan, Qiong Wu, Hong-Zheng Fu. Synthesis and biological evaluation of Vinpocetine derivatives.
Bioorganic & medicinal chemistry letters.
2020 01; 30(2):126472. doi:
10.1016/j.bmcl.2019.05.052. [PMID: 31859156] - Jelena Ristic, Marko Folic, Katarina Radonjic, Milenko I Rosic, Sergey Bolevich, Omarov Israpil Alisultanovich, Nevena Draginic, Marijana Andjic, Jovana Jeremic, Isidora Milosavljevic, Vladimir Zivkovic, Vladimir Jakovljevic. Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats.
Oxidative medicine and cellular longevity.
2020; 2020(?):6361703. doi:
10.1155/2020/6361703. [PMID: 32104536] - Santoshi Billakota, J Michael Andresen, Bryant C Gay, Gregory R Stewart, Nikolai B Fedorov, Aaron C Gerlach, Orrin Devinsky. Personalized medicine: Vinpocetine to reverse effects of GABRB3 mutation.
Epilepsia.
2019 12; 60(12):2459-2465. doi:
10.1111/epi.16394. [PMID: 31755996] - Azza A Ali, Dina M Abo El-Ella, Soad Z El-Emam, Amal S Shahat, Rehab M El-Sayed. Physical & mental activities enhance the neuroprotective effect of vinpocetine & coenzyme Q10 combination against Alzheimer & bone remodeling in rats.
Life sciences.
2019 Jul; 229(?):21-35. doi:
10.1016/j.lfs.2019.05.006. [PMID: 31063734] - Maha Nasr, Sara A Wahdan. Neuroprotective effects of novel nanosystems simultaneously loaded with vinpocetine and piracetam after intranasal administration.
Life sciences.
2019 Jun; 226(?):117-129. doi:
10.1016/j.lfs.2019.04.014. [PMID: 30981765] - Nam-Jun Kim, Jung-Hwan Baek, JinAh Lee, HyeNa Kim, Jun-Kyu Song, Kyung-Hee Chun. A PDE1 inhibitor reduces adipogenesis in mice via regulation of lipolysis and adipogenic cell signaling.
Experimental & molecular medicine.
2019 01; 51(1):1-15. doi:
10.1038/s12276-018-0198-7. [PMID: 30635550] - Zhang Ping, Wu Xiaomu, Xie Xufang, Shao Liang. Vinpocetine regulates levels of circulating TLRs in Parkinson's disease patients.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2019 Jan; 40(1):113-120. doi:
10.1007/s10072-018-3592-y. [PMID: 30315378] - Tarek A Ahmed, Khalid M El-Say, Osama Aa Ahmed, Bader M Aljaeid. Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel.
International journal of nanomedicine.
2019; 14(?):5555-5567. doi:
10.2147/ijn.s213086. [PMID: 31413562] - Hebatalla I Ahmed, Somaia A Abdel-Sattar, Heba S Zaky. Vinpocetine halts ketamine-induced schizophrenia-like deficits in rats: impact on BDNF and GSK-3β/β-catenin pathway.
Naunyn-Schmiedeberg's archives of pharmacology.
2018 12; 391(12):1327-1338. doi:
10.1007/s00210-018-1552-y. [PMID: 30083945] - Cheng-Hwang Perng, Yue-Cune Chang, Ruu-Fen Tzang. The treatment of cognitive dysfunction in dementia: a multiple treatments meta-analysis.
Psychopharmacology.
2018 05; 235(5):1571-1580. doi:
10.1007/s00213-018-4867-y. [PMID: 29502274] - Suramya Waidyanatha, Heather Toy, Natalie South, Seth Gibbs, Esra Mutlu, Brian Burback, Barry S McIntyre, Natasha Catlin. Systemic exposure of vinpocetine in pregnant Sprague Dawley rats following repeated oral exposure: An investigation of fetal transfer.
Toxicology and applied pharmacology.
2018 01; 338(?):83-92. doi:
10.1016/j.taap.2017.11.011. [PMID: 29155086] - Walaa Wadie, Dalia M El-Tanbouly. Vinpocetine mitigates proteinuria and podocytes injury in a rat model of diabetic nephropathy.
European journal of pharmacology.
2017 Nov; 814(?):187-195. doi:
10.1016/j.ejphar.2017.08.027. [PMID: 28843828] - Mengqi Liu, Shiming Zhang, Shuxia Cui, Fen Chen, Lianqun Jia, Shu Wang, Xiumei Gai, Pingfei Li, Feifei Yang, Weisan Pan, Xinggang Yang. Preparation and evaluation of Vinpocetine self-emulsifying pH gradient release pellets.
Drug delivery.
2017 Nov; 24(1):1598-1604. doi:
10.1080/10717544.2017.1388453. [PMID: 29043863] - Jiaojiao Ding, Yujiao Sun, Jinfeng Li, Huimin Wang, Shirui Mao. Enhanced blood-brain barrier transport of vinpocetine by oral delivery of mixed micelles in combination with a message guider.
Journal of drug targeting.
2017 Jul; 25(6):532-540. doi:
10.1080/1061186x.2017.1289541. [PMID: 28151022] - Victor Fattori, Sergio M Borghi, Carla F S Guazelli, Andressa C Giroldo, Jefferson Crespigio, Allan J C Bussmann, Letícia Coelho-Silva, Natasha G Ludwig, Tânia L Mazzuco, Rubia Casagrande, Waldiceu A Verri. Vinpocetine reduces diclofenac-induced acute kidney injury through inhibition of oxidative stress, apoptosis, cytokine production, and NF-κB activation in mice.
Pharmacological research.
2017 Jun; 120(?):10-22. doi:
10.1016/j.phrs.2016.12.039. [PMID: 28315429] - Mei-Ping Wu, Yi-Shuai Zhang, Xiangbin Xu, Qian Zhou, Jian-Dong Li, Chen Yan. Vinpocetine Attenuates Pathological Cardiac Remodeling by Inhibiting Cardiac Hypertrophy and Fibrosis.
Cardiovascular drugs and therapy.
2017 Apr; 31(2):157-166. doi:
10.1007/s10557-017-6719-0. [PMID: 28321644] - Xungang Feng, Yuzhong Wang, Yanlei Hao, Qun Ma, Jun Dai, Zhibo Liang, Yantao Liu, Xiangyuan Li, Yan Song, Chuanping Si. Vinpocetine Inhibited the CpG Oligodeoxynucleotide-induced Immune Response in Plasmacytoid Dendritic Cells.
Immunological investigations.
2017 Apr; 46(3):263-273. doi:
10.1080/08820139.2016.1248561. [PMID: 27967259] - Saylav Bora, Mumin Alper Erdogan, Güliz Armagan, Elvin Sevgili, Taner Dagcı. Vinpocetine and Vasoactive Intestinal Peptide Attenuate Manganese-Induced Toxicity in NE-4C Cells.
Biological trace element research.
2016 Dec; 174(2):410-418. doi:
10.1007/s12011-016-0742-z. [PMID: 27206668] - Samuel Golob, Miranda Perry, Matteo Lusi, Michele R Chierotti, Iztok Grabnar, Lucia Lassiani, Dario Voinovich, Michael J Zaworotko. Improving Biopharmaceutical Properties of Vinpocetine Through Cocrystallization.
Journal of pharmaceutical sciences.
2016 12; 105(12):3626-3633. doi:
10.1016/j.xphs.2016.09.017. [PMID: 27789032] - Weiwei Zhang, Yining Huang, Ying Li, Liming Tan, Jianfei Nao, Hongtao Hu, Jingyu Zhang, Chen Li, Yuenan Kong, Yulin Song. Efficacy and Safety of Vinpocetine as Part of Treatment for Acute Cerebral Infarction: A Randomized, Open-Label, Controlled, Multicenter CAVIN (Chinese Assessment for Vinpocetine in Neurology) Trial.
Clinical drug investigation.
2016 Sep; 36(9):697-704. doi:
10.1007/s40261-016-0415-x. [PMID: 27283947] - Ron Bonner, Gérard Hopfgartner. SWATH acquisition mode for drug metabolism and metabolomics investigations.
Bioanalysis.
2016 Aug; 8(16):1735-50. doi:
10.4155/bio-2016-0141. [PMID: 27460983] - F Ghayomi, M Navaei-Nigjeh, M Baeeri, M A Rezvanfar, M Abdollahi. A mechanistic approach for modulation of chlorpyrifos-induced toxicity in human lymphocytes by melatonin, coenzyme Q10, and vinpocetine.
Human & experimental toxicology.
2016 Aug; 35(8):839-50. doi:
10.1177/0960327115607945. [PMID: 26519479] - Patrizzia Mastromatteo-Alberga, Fabiola Placeres-Uray, Marcelo A Alfonzo-González, Ramona Gonzalez de Alfonzo, Itala Lippo de Becemberg, Marcelo J Alfonzo. A novel PDE1A coupled to M2AChR at plasma membranes from bovine tracheal smooth muscle.
Journal of receptor and signal transduction research.
2016; 36(3):278-87. doi:
10.3109/10799893.2015.1101136. [PMID: 26513204] - Congcong Lin, Fen Chen, Tiantian Ye, Lina Zhang, Wenji Zhang, Dandan Liu, Wei Xiong, Xinggang Yang, Weisan Pan. A novel oral delivery system consisting in 'drug-in cyclodextrin-in nanostructured lipid carriers' for poorly water-soluble drug: vinpocetine.
International journal of pharmaceutics.
2014 Apr; 465(1-2):90-6. doi:
10.1016/j.ijpharm.2014.02.013. [PMID: 24530388] - Hayder M Alkuraishy, Ali I Al-Gareeb, Ali K Albuhadilly. Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders—a randomized controlled clinical study.
BioMed research international.
2014; 2014(?):324307. doi:
10.1155/2014/324307. [PMID: 25548768] - Hala Fahmy Zaki, Rania Mohsen Abdelsalam. Vinpocetine protects liver against ischemia-reperfusion injury.
Canadian journal of physiology and pharmacology.
2013 Dec; 91(12):1064-70. doi:
10.1139/cjpp-2013-0097. [PMID: 24289077] - Yujun Cai, Jian-Dong Li, Chen Yan. Vinpocetine attenuates lipid accumulation and atherosclerosis formation.
Biochemical and biophysical research communications.
2013 May; 434(3):439-43. doi:
10.1016/j.bbrc.2013.03.092. [PMID: 23583194] - Jianhui Zhuang, Wenhui Peng, Hailing Li, Yuyan Lu, Ke Wang, Fan Fan, Shuang Li, Yawei Xu. Inhibitory effects of vinpocetine on the progression of atherosclerosis are mediated by Akt/NF-κB dependent mechanisms in apoE-/- mice.
PloS one.
2013; 8(12):e82509. doi:
10.1371/journal.pone.0082509. [PMID: 24349299] - Nieves Herrera-Mundo, María Sitges. Vinpocetine and α-tocopherol prevent the increase in DA and oxidative stress induced by 3-NPA in striatum isolated nerve endings.
Journal of neurochemistry.
2013 Jan; 124(2):233-40. doi:
10.1111/jnc.12082. [PMID: 23121080] - Omar M E Abdel-Salam, Yasser A Khadrawy, Neveen A Salem, Amany A Sleem. Oxidative stress in a model of toxic demyelination in rat brain: the effect of piracetam and vinpocetine.
Neurochemical research.
2011 Jun; 36(6):1062-72. doi:
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Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc.
2011 Mar; 38(2):137-42. doi:
NULL. [PMID: 21510273] - Alexei V Muravyov, Svetlana V Bulaeva, Irina A Tikhomirova, Andrey V Zamishlayev, Ekaterina V Uzikova, Mikhail Ju Miloradov. Macro- and microrheological parameters of blood in patients with cerebral and peripheral atherosclerosis: the molecular change mechanisms after pentoxifylline treatment.
Clinical hemorheology and microcirculation.
2011; 49(1-4):431-9. doi:
10.3233/ch-2011-1493. [PMID: 22214714] - Hui-Min Xia, Li-Na Su, Jian-Wei Guo, Guang-Ming Liu, Zhi-Qing Pang, Xin-Guo Jiang, Jun Chen. Determination of vinpocetine and its primary metabolite, apovincaminic acid, in rat plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Jul; 878(22):1959-66. doi:
10.1016/j.jchromb.2010.05.029. [PMID: 20561830] - Chun-Yang Zhuang, Ning Li, Mi Wang, Xiao-Ning Zhang, Wei-San Pan, Jun-Jie Peng, Yu-Sheng Pan, Xin Tang. Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability.
International journal of pharmaceutics.
2010 Jul; 394(1-2):179-85. doi:
10.1016/j.ijpharm.2010.05.005. [PMID: 20471464] - Hongtao Xu, Ling He, Shufang Nie, Jin Guan, Xiaoning Zhang, Xinggang Yang, Weisan Pan. Optimized preparation of vinpocetine proliposomes by a novel method and in vivo evaluation of its pharmacokinetics in New Zealand rabbits.
Journal of controlled release : official journal of the Controlled Release Society.
2009 Nov; 140(1):61-8. doi:
10.1016/j.jconrel.2009.07.014. [PMID: 19651165] - A A Vishnevskiĭ, I G Korotkevich, Ch O Zhaparalieva. [Membrane and functional effects of vinpocetine and tocopherol in rats with experimental cerebral ischemia].
Biomeditsinskaia khimiia.
2009 Sep; 55(5):635-42. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2009 Mar; 16(2-3):111-7. doi:
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