2-amino-3,4,5,6-tetrahydroxyhexanal (BioDeep_00000276206)

   

BioNovoGene_Lab2019


代谢物信息卡片


(2S,3R,4S,5R)-2-AMINO-3,4,5,6-TETRAHYDROXYHEXANAL

化学式: C6H13NO5 (179.0794)
中文名称: D-甘露糖胺, 2-氨基-3,4,5,6-四羟基己醛
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C(C(C(C=O)N)O)O)O)O
InChI: InChI=1S/C6H13NO5/c7-3(1-8)5(11)6(12)4(10)2-9/h1,3-6,9-12H,2,7H2

描述信息

同义名列表

5 个代谢物同义名

(2S,3R,4S,5R)-2-AMINO-3,4,5,6-TETRAHYDROXYHEXANAL; 2-amino-3,4,5,6-tetrahydroxyhexanal; D-Mannosamine; D-Mannosamine; 2-Amino-3,4,5,6-tetrahydroxyhexanal



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yuqiao Zeng, Yiyu He, Li Wang, Hao Xu, Qianwen Zhang, Yanjun Wang, Jianhua Zhang, Likun Wang. Dihydroquercetin improves experimental acute liver failure by targeting ferroptosis and mitochondria-mediated apoptosis through the SIRT1/p53 axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155533. doi: 10.1016/j.phymed.2024.155533. [PMID: 38552433]
  • Wesam H Abdulaal, Ulfat M Omar, Mustafa Zeyadi, Dina S El-Agamy, Nabil A Alhakamy, Sabrin R M Ibrahim, Naif A R Almalki, Hani Z Asfour, Mohammed W Al-Rabia, Gamal A Mohamed, Mahmoud Elshal. Modulation of the crosstalk between Keap1/Nrf2/HO-1 and NF-κB signaling pathways by Tomatidine protects against inflammation/oxidative stress-driven fulminant hepatic failure in mice. International immunopharmacology. 2024 Mar; 130(?):111732. doi: 10.1016/j.intimp.2024.111732. [PMID: 38402834]
  • Xiangming Wang, Menghui Zhao, Chengguo Ju, Hui Gao, Wei Wang. Protective Mechanisms of Juncus effusus and Carbonized Juncus effusus against D-Galactosamine-Induced Acute Liver Injury in Mice. Chemical & pharmaceutical bulletin. 2024 Mar; 72(3):280-285. doi: 10.1248/cpb.c23-00578. [PMID: 38325836]
  • Yameng Zhu, Yuqi Fan, Xiunan Cao, Shujie Wei, Mengmeng Zhang, Yanxu Chang, Huizi Ouyang, Jun He. Pharmacokinetic-pharmacodynamic (PK/PD) modeling to study the hepatoprotective effect of Perilla Folium on the acute hepatic injury rats. Journal of ethnopharmacology. 2023 Sep; 313(?):116589. doi: 10.1016/j.jep.2023.116589. [PMID: 37142149]
  • X Zong, Q Ding, X Liu, Q Liu, S Song, X Yan, Y Zhang. Preventive Effect of 6-shogaol on D-galactosamine Induced Hepatotoxicity Through NF-?B/MAPK Signaling Pathway in Rats. Physiological research. 2023 Aug; 72(4):445-454. doi: . [PMID: 37795887]
  • Yi-Chan Liu, Samwel Mchele Limbu, Jin-Gang Wang, Mai Wang, Li-Qiao Chen, Fang Qiao, Yuan Luo, Mei-Ling Zhang, Zhen-Yu Du. Dietary docosahexaenoic acid reduces fat deposition and alleviates liver damage induced by D-galactosamine and lipopolysaccharides in Nile tilapia (Oreochromis niloticus). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023 Jun; 268(?):109603. doi: 10.1016/j.cbpc.2023.109603. [PMID: 36906246]
  • Yusuke Sakamoto, Naoki Inoue, Yusuke Nakanishi, Kiyofumi Ninomiya, Masayuki Yoshikawa, Osamu Muraoka, Yoshiaki Manse, Toshio Morikawa. Hepatoprotective Principles from the Rhizomes of Picrorhiza kurroa. Biological & pharmaceutical bulletin. 2023; 46(6):848-855. doi: 10.1248/bpb.b23-00167. [PMID: 37258151]
  • Nuerbiye Aobulikasimu, Dan Zheng, Peipei Guan, Lixiao Xu, Bo Liu, Minglei Li, Xueshi Huang, Li Han. The Anti-inflammatory Effects of Isoflavonoids from Radix Astragali in Hepatoprotective Potential against LPS/D-gal-induced Acute Liver Injury. Planta medica. 2022 Dec; ?(?):. doi: 10.1055/a-1953-0369. [PMID: 36509104]
  • Samrat Rakshit, Nisha Sahu, Satendra Kumar Nirala, Monika Bhadauria. Protective activity of purpurin against d-galactosamine and lipopolysaccharide-induced hepatorenal injury by upregulation of heme oxygenase-1 in the RBC degradation cycle. Journal of biochemical and molecular toxicology. 2022 Oct; 36(10):e23168. doi: 10.1002/jbt.23168. [PMID: 35838105]
  • Dileknur Topaloglu, Ismet Burcu Turkyilmaz, Refiye Yanardag. Gastroprotective effect of vitamin U in D-galactosamine-induced hepatotoxicity. Journal of biochemical and molecular toxicology. 2022 Sep; 36(9):e23124. doi: 10.1002/jbt.23124. [PMID: 35670011]
  • Yanfang Yu, Yuhuan Chen, Xuping Shi, Chuan Ye, Junwen Wang, Jinzhi Huang, Bing Zhang, Zeyuan Deng. Hepatoprotective effects of different mulberry leaf extracts against acute liver injury in rats by alleviating oxidative stress and inflammatory response. Food & function. 2022 Aug; 13(16):8593-8604. doi: 10.1039/d2fo00282e. [PMID: 35894215]
  • Seerat Mehdi, Fiaz-Ud-Din Ahmad, Arslan Hussain Lodhi, Umair Khurshid, Ahmed Awais Khalid, Sheikh Safeena Sidiq, Liaqat Hussain, Mirza Shaharyar Baig. Protective Effects of p-CA Against Acute Liver Damage Induced by LPS/D-GalN in Wistar Albino Rats. Drug design, development and therapy. 2022; 16(?):3327-3342. doi: 10.2147/dddt.s380324. [PMID: 36199629]
  • Shuhui Liu, Ruiying Yin, Ziwei Yang, Feili Wei, Jianhua Hu. The effects of rhein on D-GalN/LPS-induced acute liver injury in mice: Results from gut microbiome-metabolomics and host transcriptome analysis. Frontiers in immunology. 2022; 13(?):971409. doi: 10.3389/fimmu.2022.971409. [PMID: 36389730]
  • Sha Huang, Yuhua Wang, Shuwen Xie, Yuqi Lai, Chan Mo, Ting Zeng, Shanshan Kuang, Guanghui Deng, Chuying Zhou, Yuyao Chen, Shaohui Huang, Lei Gao, Zhiping Lv. Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis. Cellular and molecular gastroenterology and hepatology. 2022; 13(6):1649-1672. doi: 10.1016/j.jcmgh.2022.02.009. [PMID: 35202887]
  • Woojae Hong, Jeon Hwang-Bo, Hyelin Jeon, Minsung Ko, Joongyeon Choi, Yong-Joon Jeong, Jae-Hyun Park, Inhye Kim, Tae-Woo Kim, Hyunggun Kim, Se-Chan Kang. A Comparative Study of the Hepatoprotective Effect of Centella asiatica Extract (CA-HE50) on Lipopolysaccharide/d-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice. Nutrients. 2021 Nov; 13(11):. doi: 10.3390/nu13114090. [PMID: 34836346]
  • Yun Hee Jeong, Youn-Hwan Hwang, Tae In Kim, You-Chang Oh, Jin Yeul Ma. Forsythia Fruit Prevents Fulminant Hepatitis in Mice and Ameliorates Inflammation in Murine Macrophages. Nutrients. 2021 Aug; 13(8):. doi: 10.3390/nu13082901. [PMID: 34445058]
  • Chui-Yoke Chin, Jinshi Zhao, Anna C Llewellyn, Igor Golovliov, Anders Sjöstedt, Pei Zhou, David S Weiss. Francisella FlmX broadly affects lipopolysaccharide modification and virulence. Cell reports. 2021 06; 35(11):109247. doi: 10.1016/j.celrep.2021.109247. [PMID: 34133919]
  • Sawsan M El-Sonbaty, Fatma S M Moawed, Mustafa M M Elbakry. Amphora algae with low-level ionizing radiation exposure ameliorate D-galactosamine-induced inflammatory impairment in rat kidney. Environmental toxicology. 2021 Apr; 36(4):451-459. doi: 10.1002/tox.23050. [PMID: 33107697]
  • Sha Huang, Chan Mo, Ting Zeng, Yuqi Lai, Chuying Zhou, Shunwen Xie, Limei Chen, Yuhua Wang, Yuyao Chen, Shaohui Huang, Lei Gao, Zhiping Lv. Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway. Aging. 2021 03; 13(5):6592-6605. doi: 10.18632/aging.202409. [PMID: 33707345]
  • Hongyan Li, Tianrong Lei, Jianghua Zhang, Yuhui Yan, Nan Wang, Cheng Song, Chang Li, Mingyu Sun, Jinyu Li, Yuxin Guo, Jingxian Yang, Tingguo Kang. Longan (Dimocarpus longan Lour.) Aril ameliorates cognitive impairment in AD mice induced by combination of D-gal/AlCl3 and an irregular diet via RAS/MEK/ERK signaling pathway. Journal of ethnopharmacology. 2021 Mar; 267(?):113612. doi: 10.1016/j.jep.2020.113612. [PMID: 33249246]
  • Hua Nie, Bo Qiu, Qi-Xuan Yang, Ying Zhao, Xiao-Min Liu, Ying-Ting Zhang, Fu-Lin Liao, Sheng-Yuan Zhang. Effect of gal/GalNAc regioisomerism in galactosylated liposomes on asialoglycoprotein receptor-mediated hepatocyte-selective targeting in vivo. Journal of liposome research. 2021 Mar; 31(1):79-89. doi: 10.1080/08982104.2019.1682606. [PMID: 31691619]
  • Yangliu Xia, Ping Wang, Nana Yan, Frank J Gonzalez, Tingting Yan. Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3. Cell death & disease. 2021 02; 12(2):174. doi: 10.1038/s41419-020-03243-w. [PMID: 33574236]
  • Samrat Rakshit, Piyush Shukla, Anjani Verma, Satendra Kumar Nirala, Monika Bhadauria. Protective role of rutin against combined exposure to lipopolysaccharide and D-galactosamine-induced dysfunctions in liver, kidney, and brain: Hematological, biochemical, and histological evidences. Journal of food biochemistry. 2021 02; 45(2):e13605. doi: 10.1111/jfbc.13605. [PMID: 33433008]
  • Ruidong Li, Wenchang Yang, Yuping Yin, Peng Zhang, Yaxin Wang, Kaixiong Tao. Protective Role of 4-Octyl Itaconate in Murine LPS/D-GalN-Induced Acute Liver Failure via Inhibiting Inflammation, Oxidative Stress, and Apoptosis. Oxidative medicine and cellular longevity. 2021; 2021(?):9932099. doi: 10.1155/2021/9932099. [PMID: 34457120]
  • Daniel Gaudet, Ewa Karwatowska-Prokopczuk, Seth J Baum, Eunju Hurh, Joyce Kingsbury, Victoria J Bartlett, Amparo L Figueroa, Philip Piscitelli, Walter Singleton, Joseph L Witztum, Richard S Geary, Sotirios Tsimikas, Louis St L O'Dea. Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia. European heart journal. 2020 10; 41(40):3936-3945. doi: 10.1093/eurheartj/ehaa689. [PMID: 32860031]
  • So Ra Kim, Eun Jung Park, Theodomir Dusabimana, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Kye Man Cho, Hwajin Kim, Sang Won Park. Platycodon grandiflorus Fermented Extracts Attenuate Endotoxin-Induced Acute Liver Injury in Mice. Nutrients. 2020 Sep; 12(9):. doi: 10.3390/nu12092802. [PMID: 32933130]
  • Erli Zhang, Jingbo Huang, Kun Wang, Qinlei Yu, Chao Zhu, Hua Ren. Pterostilbene Protects Against Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure by Upregulating the Nrf2 Pathway and Inhibiting NF-κB, MAPK, and NLRP3 Inflammasome Activation. Journal of medicinal food. 2020 Sep; 23(9):952-960. doi: 10.1089/jmf.2019.4647. [PMID: 32701014]
  • Jinxia Li, Qiuyun Zhang, Lianyin Gao, Yuqiong Du, Yu Chen. Efficacy of decoction from Jieduan Niwan formula on rat model of acute-on-chronic liver failure induced by porcine serum. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2020 08; 40(4):602-612. doi: 10.19852/j.cnki.jtcm.2020.04.009. [PMID: 32744027]
  • Jilan A Nazeam, Hala M El-Hefnawy, Abdel-Naser B Singab. Structural Elucidation of Immunomodulators, Acetylated Heteroglycan and Galactosamine, Isolated from Aloe arborescens Leaves. Journal of medicinal food. 2020 Aug; 23(8):895-901. doi: 10.1089/jmf.2019.0229. [PMID: 31976801]
  • Yong Yook Lee, Sung-Won Kim, Soo-Hyun Youn, Sun Hee Hyun, Jong-Su Kyung, Gyo In, Chae-Kyu Park, Hye Ryeon Jung, Seung Ju Moon, Min Jeung Kang, Eugene C Yi, Chang-Kyun Han. Biological Effects of Korean Red Ginseng Polysaccharides in Aged Rat Using Global Proteomic Approach. Molecules (Basel, Switzerland). 2020 Jul; 25(13):. doi: 10.3390/molecules25133019. [PMID: 32630349]
  • Yusuke Sato, Yoshiyuki Kinami, Kazuki Hashiba, Hideyoshi Harashima. Different kinetics for the hepatic uptake of lipid nanoparticles between the apolipoprotein E/low density lipoprotein receptor and the N-acetyl-d-galactosamine/asialoglycoprotein receptor pathway. Journal of controlled release : official journal of the Controlled Release Society. 2020 06; 322(?):217-226. doi: 10.1016/j.jconrel.2020.03.006. [PMID: 32145269]
  • Xianwen Peng, Yongqiang Yang, Li Tang, Jingyuan Wan, Jie Dai, Longjiang Li, Jiayi Huang, Yi Shen, Ling Lin, Xianqiong Gong, Li Zhang. Therapeutic benefits of apocynin in mice with lipopolysaccharide/D-galactosamine-induced acute liver injury via suppression of the late stage pro-apoptotic AMPK/JNK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 May; 125(?):110020. doi: 10.1016/j.biopha.2020.110020. [PMID: 32106375]
  • Mirca Marini, Alessia Tani, Mirko Manetti, Eleonora Sgambati. Characterization and distribution of sialic acids in human testicular seminoma. Acta histochemica. 2020 Apr; 122(3):151532. doi: 10.1016/j.acthis.2020.151532. [PMID: 32143917]
  • Li Hao, Ming-Wei Liu, Song-Tao Gu, Xue Huang, Hong Deng, Xu Wang. Sedum sarmentosum Bunge extract ameliorates lipopolysaccharide- and D-galactosamine-induced acute liver injury by attenuating the hedgehog signaling pathway via regulation of miR-124 expression. BMC complementary medicine and therapies. 2020 Mar; 20(1):88. doi: 10.1186/s12906-020-2873-1. [PMID: 32178661]
  • Zheng Li, Haihua Feng, Lu Han, Lu Ding, Bingyu Shen, Ye Tian, Lilei Zhao, Meiyu Jin, Qi Wang, Haiyan Qin, Jiaqi Cheng, Guowen Liu. Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d-galactosamine induced acute liver injury. Journal of cellular and molecular medicine. 2020 03; 24(5):3022-3033. doi: 10.1111/jcmm.14935. [PMID: 31989756]
  • Hui-Zheng Fu, Yuan-Yu Ma, Shuang-Cheng Ma, Zhi-Qiang Zhou, Yue-Hua Luo. Two new iridoid glycosides from Callicarpa nudiflora. Journal of Asian natural products research. 2020 Mar; 22(3):264-270. doi: 10.1080/10286020.2018.1557636. [PMID: 30590951]
  • Baolong Liu, Yizhu Lu, Xingyi Chen, Philma Glora Muthuraj, Xingzhi Li, Mahesh Pattabiraman, Janos Zempleni, Stephen D Kachman, Sathish Kumar Natarajan, Jiujiu Yu. Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice. Nutrients. 2020 Feb; 12(2):. doi: 10.3390/nu12020477. [PMID: 32069862]
  • Gary J Haderski, Bojidar M Kandar, Craig M Brackett, Ilia M Toshkov, Christopher P Johnson, Geraldine M Paszkiewicz, Venkatesh Natarajan, Anatoli S Gleiberman, Andrei V Gudkov, Lyudmila G Burdelya. TLR5 agonist entolimod reduces the adverse toxicity of TNF while preserving its antitumor effects. PloS one. 2020; 15(2):e0227940. doi: 10.1371/journal.pone.0227940. [PMID: 32027657]
  • Samrat Rakshit, Satendra K Nirala, Monika Bhadauria. Gallic Acid Protects from Acute Multiorgan Injury Induced by Lipopolysaccharide and D-galactosamine. Current pharmaceutical biotechnology. 2020; 21(14):1489-1504. doi: 10.2174/1389201021666200615165732. [PMID: 32538720]
  • Laura Gauthier, Mathieu Varache, Anne-Claude Couffin, Colette Lebrun, Pascale Delangle, Christelle Gateau, Isabelle Texier. Quantification of Surface GalNAc Ligands Decorating Nanostructured Lipid Carriers by UPLC-ELSD. International journal of molecular sciences. 2019 Nov; 20(22):. doi: 10.3390/ijms20225669. [PMID: 31726778]
  • Yan Li, Yongmei Zeng, Quanfang Huang, Shujuan Wen, Yuanyuan Wei, Ya Chen, Xiaolin Zhang, Facheng Bai, Zhongpeng Lu, Jinbin Wei, Xing Lin. Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Nov; 119(?):109435. doi: 10.1016/j.biopha.2019.109435. [PMID: 31520915]
  • Xiang Song, Pan Shang, Zhenwei Sun, Mingzi Lu, Guoxing You, Shaoduo Yan, Gan Chen, Hong Zhou. Therapeutic effect of yttrium oxide nanoparticles for the treatment of fulminant hepatic failure. Nanomedicine (London, England). 2019 10; 14(19):2519-2533. doi: 10.2217/nnm-2019-0154. [PMID: 31317822]
  • Yang Li, Chenxi Guang, Na Zhao, Xinchi Feng, Feng Qiu. LC-MS/MS Method for Simultaneous Determination of Linarin and Its Metabolites in Rat Plasma and Liver Tissue Samples: Application to Pharmacokinetic and Liver Tissue Distribution Study After Oral Administration of Linarin. Molecules (Basel, Switzerland). 2019 Sep; 24(18):. doi: 10.3390/molecules24183342. [PMID: 31540332]
  • Pallerla Praneetha, Vanapatla Swaroopa Rani, Vatsavaya Satyanarayana Raju, Yellu Narasimha Reddy, Bobbala Ravi Kumar. Hepatoprotective studies on methanolic extract of caryopses of Echinochloa colona Link. Pakistan journal of pharmaceutical sciences. 2019 Sep; 32(5):1949-1956. doi: NULL. [PMID: 31813857]
  • Cong Zhang, Fangxin Hu, Han Zhang, Shihong Chen, Ruo Yuan. An electrochemiluminescence biosensor for the detection of soybean agglutinin based on carboxylated graphitic carbon nitride as luminophore. Analytical and bioanalytical chemistry. 2019 Sep; 411(23):6049-6056. doi: 10.1007/s00216-019-01986-w. [PMID: 31280477]
  • Xiao Wang, Chao Han, Jiaojiao Qin, Yuanyuan Wei, Xufeng Qian, Yongzhan Bao, Wanyu Shi. Pretreatment with Salvia miltiorrhiza Polysaccharides Protects from Lipopolysaccharides/d-Galactosamine-Induced Liver Injury in Mice Through Inhibiting TLR4/MyD88 Signaling Pathway. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2019 08; 39(8):495-505. doi: 10.1089/jir.2018.0137. [PMID: 31074668]
  • Cuiyun Zou, Minglei Xu, Leling Chen, Qingying Liu, Yuanyuan Zhou, Zhenzhu Sun, Huaqun Ye, Ningning Su, Chaoxia Ye, Anli Wang. Xiaochaihu Decoction reduces hepatic steatosis and improves D-GalN/LPS-induced liver injury in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀). Fish & shellfish immunology. 2019 Aug; 91(?):293-305. doi: 10.1016/j.fsi.2019.05.025. [PMID: 31100441]
  • Yi Li, Nian Wang, Yongfang Jiang. Geraniol protects against lipopolysaccharide and D-galactosamine-induced fulminant hepatic failure by activating PPARγ. Microbial pathogenesis. 2019 Mar; 128(?):7-12. doi: 10.1016/j.micpath.2018.11.054. [PMID: 30550845]
  • Danmei Tian, Fangfang Wang, Menglong Duan, Lingyun Cao, Youwei Zhang, Xinsheng Yao, Jinshan Tang. Coumarin Analogues from the Citrus grandis (L.) Osbeck and Their Hepatoprotective Activity. Journal of agricultural and food chemistry. 2019 Feb; 67(7):1937-1947. doi: 10.1021/acs.jafc.8b06489. [PMID: 30689373]
  • Hua Qiu, Dewen Mao, Nong Tang, Fuli Long, Rongzhen Zhang, Minggang Wang, Qinglan Shi, Jiahuan Li, Qin Jiang, Yueqiao Chen, Xiufeng Wang. The underlying mechanisms of Jie-Du-Hua-Yu granule for protecting rat liver failure. Drug design, development and therapy. 2019; 13(?):589-600. doi: 10.2147/dddt.s180969. [PMID: 30809090]
  • Tong-Gang Liu, Kai-Hui Sha, Li-Guo Zhang, Xian-Xian Liu, Fang Yang, Jin-Ying Cheng. Protective effects of alpinetin on lipopolysaccharide/d-Galactosamine-induced liver injury through inhibiting inflammatory and oxidative responses. Microbial pathogenesis. 2019 Jan; 126(?):239-244. doi: 10.1016/j.micpath.2018.11.007. [PMID: 30414839]
  • Yuanjun Shen, Cesar A Lau-Cam. Taurine Enhances the Protective Actions of Fish Oil Against D-Galactosamine-Induced Metabolic Changes and Hepatic Lipid Accumulation and Injury in the Rat. Advances in experimental medicine and biology. 2019; 1155(?):71-85. doi: 10.1007/978-981-13-8023-5_7. [PMID: 31468387]
  • Cuiyun Zou, Xiaohong Tan, Huaqun Ye, Zhenzhu Sun, Shu Chen, Qingying Liu, Minglei Xu, Chaoxia Ye, Anli Wang. The hepatoprotective effects of Radix Bupleuri extracts against D-galactosamine/lipopolysaccharide induced liver injury in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀). Fish & shellfish immunology. 2018 Dec; 83(?):8-17. doi: 10.1016/j.fsi.2018.08.047. [PMID: 30145200]
  • Yong Tian, Yao Li, Fuhua Li, Qi Zhi, Fuxiang Li, Yu Tang, Yaxuan Yang, Ran Yin, Jian Ming. Protective effects of Coreopsis tinctoria flowers phenolic extract against D-galactosamine/lipopolysaccharide -induced acute liver injury by up-regulation of Nrf2, PPARα, and PPARγ. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Nov; 121(?):404-412. doi: 10.1016/j.fct.2018.09.026. [PMID: 30236599]
  • Yingjiao Wang, Dandan Wang, Jianhua Zhang, Dan Liu, Zihao Wang, Dali Meng. Isoquinolines from Corydalis tomentella from Tibet, China, possess hepatoprotective activities. Phytochemistry. 2018 Nov; 155(?):93-99. doi: 10.1016/j.phytochem.2018.07.010. [PMID: 30081273]
  • Jinhyung Bae, Young Sil Min, Yoonjin Nam, Hyun Seok Lee, Uy Dong Sohn. Humulus japonicus Extracts Protect Against Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Rats. Journal of medicinal food. 2018 Oct; 21(10):1009-1015. doi: 10.1089/jmf.2018.4178. [PMID: 30334699]
  • Shulong Jiang, Mengying Li, Ying Hu, Zhenhai Zhang, Huixia Lv. Multifunctional self-assembled micelles of galactosamine-hyaluronic acid-vitamin E succinate for targeting delivery of norcantharidin to hepatic carcinoma. Carbohydrate polymers. 2018 Oct; 197(?):194-203. doi: 10.1016/j.carbpol.2018.05.090. [PMID: 30007605]
  • Haixue Kuang, Zhenqiu Tang, Xinguo Wang, Bingyou Yang, Zhibin Wang, Qiuhong Wang. Chemical constituents from Sambucus williamsii Hance fruits and hepatoprotective effects in mouse hepatocytes. Natural product research. 2018 Sep; 32(17):2008-2016. doi: 10.1080/14786419.2017.1361948. [PMID: 28783968]
  • Xiaofang Zhao, Hong Zhou, Ying Cheng, Wenjing Yu, Guosong Luo, Chunyan Duan, Fuli Yao, Bin Xiao, Chunhong Feng, Xianming Xia, Mei Wei, Yong Wang, Jing Li, Rongyang Dai. Reduction in activating transcription factor 4 promotes carbon tetrachloride and lipopolysaccharide/D‑galactosamine‑mediated liver injury in mice. Molecular medicine reports. 2018 Aug; 18(2):1718-1725. doi: 10.3892/mmr.2018.9080. [PMID: 29845243]
  • Weidong Wang, Yanguo Zhang, Haijun Li, Yan Zhao, Enbo Cai, Hongyan Zhu, Pingya Li, Jinping Liu. Protective Effects of Sesquiterpenoids from the Root of Panax ginseng on Fulminant Liver Injury Induced by Lipopolysaccharide/d-Galactosamine. Journal of agricultural and food chemistry. 2018 Jul; 66(29):7758-7763. doi: 10.1021/acs.jafc.8b02627. [PMID: 29974747]
  • Mansour Sobeh, Mona F Mahmoud, Rehab A Hasan, Mohamed A O Abdelfattah, Omar M Sabry, Mosad A Ghareeb, Assem M El-Shazly, Michael Wink. Tannin-rich extracts from Lannea stuhlmannii and Lannea humilis (Anacardiaceae) exhibit hepatoprotective activities in vivo via enhancement of the anti-apoptotic protein Bcl-2. Scientific reports. 2018 06; 8(1):9343. doi: 10.1038/s41598-018-27452-8. [PMID: 29921841]
  • Jian-Jian Hu, Hui Wang, Chen-Wei Pan, Meng-Xiang Lin. Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation. Microbial pathogenesis. 2018 Jun; 119(?):86-92. doi: 10.1016/j.micpath.2018.03.053. [PMID: 29604422]
  • Amjad M Husaini, Kyoko Morimoto, Balakumaran Chandrasekar, Steven Kelly, Farnusch Kaschani, Daniel Palmero, Jianbing Jiang, Markus Kaiser, Oussama Ahrazem, Hermen S Overkleeft, Renier A L van der Hoorn. Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants. Plant physiology. 2018 05; 177(1):24-37. doi: 10.1104/pp.18.00250. [PMID: 29555787]
  • Yi-Ran Wang, Shi-Yan Yang, Guang-Xia Chen, Ping Wei. Barbaloin loaded polydopamine-polylactide-TPGS (PLA-TPGS) nanoparticles against gastric cancer as a targeted drug delivery system: Studies in vitro and in vivo. Biochemical and biophysical research communications. 2018 04; 499(1):8-16. doi: 10.1016/j.bbrc.2018.03.069. [PMID: 29534962]
  • Jia-Bo Wang, He-Rong Cui, Rui-Lin Wang, Cong-En Zhang, Ming Niu, Zhao-Fang Bai, Gen-Hua Xu, Peng-Yan Li, Wen-Yan Jiang, Jing-Jing Han, Xiao Ma, Guang-Ming Cai, Rui-Sheng Li, Li-Ping Zhang, Xiao-He Xiao. A systems pharmacology-oriented discovery of a new therapeutic use of the TCM formula Liuweiwuling for liver failure. Scientific reports. 2018 04; 8(1):5645. doi: 10.1038/s41598-018-21515-6. [PMID: 29618826]
  • Ya-Nan Jia, Hai-Peng Lu, Ya-Lin Peng, Bao-Shun Zhang, Xiao-Bao Gong, Jun Su, You Zhou, Min-Hui Pan, Li Xu. Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. International immunopharmacology. 2018 Mar; 56(?):105-112. doi: 10.1016/j.intimp.2018.01.014. [PMID: 29414639]
  • Mansour Sobeh, Mona F Mahmoud, Mohamed A O Abdelfattah, Haroan Cheng, Assem M El-Shazly, Michael Wink. A proanthocyanidin-rich extract from Cassia abbreviata exhibits antioxidant and hepatoprotective activities in vivo. Journal of ethnopharmacology. 2018 Mar; 213(?):38-47. doi: 10.1016/j.jep.2017.11.007. [PMID: 29126990]
  • Jie Wang, Hui-Zheng Fu, Yue-Hua Luo, Yuan-Yu Ma, Bo Huang, Shuang-Cheng Ma. Two new iridoid glycosides from the leaves of Callicarpa nudiflora. Journal of Asian natural products research. 2018 Mar; 20(3):242-248. doi: 10.1080/10286020.2017.1323884. [PMID: 28537085]
  • Lulu Xu, Xia Zheng, Yinhang Wang, Qilin Fan, Miao Zhang, Ruiyan Li, Junmei Ye, Xiaojun Wu, Wenfeng Zhao, Yubin Zhang. Berberine protects acute liver failure in mice through inhibiting inflammation and mitochondria-dependent apoptosis. European journal of pharmacology. 2018 Jan; 819(?):161-168. doi: 10.1016/j.ejphar.2017.11.013. [PMID: 29191769]
  • YiMin Zhang, Li Shao, Ning Zhou, JianZhou Li, Yu Chen, Juan Lu, Jie Wang, ErMei Chen, ZhongYang Xie, LanJuan Li. Transcriptome Analysis of Porcine PBMCs Reveals the Immune Cascade Response and Gene Ontology Terms Related to Cell Death and Fibrosis in the Progression of Liver Failure. Canadian journal of gastroenterology & hepatology. 2018; 2018(?):2101906. doi: 10.1155/2018/2101906. [PMID: 29850453]
  • Stefano Benini, Mirco Toccafondi, Martin Rejzek, Francesco Musiani, Ben A Wagstaff, Jochen Wuerges, Michele Cianci, Robert A Field. Glucose-1-phosphate uridylyltransferase from Erwinia amylovora: Activity, structure and substrate specificity. Biochimica et biophysica acta. Proteins and proteomics. 2017 Nov; 1865(11 Pt A):1348-1357. doi: 10.1016/j.bbapap.2017.08.015. [PMID: 28844747]
  • Lin Dong, Lei Yin, Hongfeng Quan, Yuankui Chu, Jincai Lu. Hepatoprotective Effects of Kaempferol-3-O-α-l-Arabinopyranosyl-7-O-α-l-Rhamnopyranoside on d-Galactosamine and Lipopolysaccharide Caused Hepatic Failure in Mice. Molecules (Basel, Switzerland). 2017 Oct; 22(10):. doi: 10.3390/molecules22101755. [PMID: 29057809]
  • Mansour Sobeh, Mona F Mahmoud, Mohamed A O Abdelfattah, Hesham A El-Beshbishy, Assem M El-Shazly, Michael Wink. Hepatoprotective and hypoglycemic effects of a tannin rich extract from Ximenia americana var. caffra root. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017 Sep; 33(?):36-42. doi: 10.1016/j.phymed.2017.07.003. [PMID: 28887918]
  • Mansour Sobeh, Mona F Mahmoud, Rehab A Hasan, Haroan Cheng, Assem M El-Shazly, Michael Wink. Senna singueana: Antioxidant, Hepatoprotective, Antiapoptotic Properties and Phytochemical Profiling of a Methanol Bark Extract. Molecules (Basel, Switzerland). 2017 Sep; 22(9):. doi: 10.3390/molecules22091502. [PMID: 28885586]
  • Xiao-Li Wan, Yuan-Fu Lu, Shang-Fu Xu, Qin Wu, Jie Liu. Oeanolic acid protects against the hepatotoxicity of D-galactosame plus endotoxin in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Sep; 93(?):1040-1046. doi: 10.1016/j.biopha.2017.07.045. [PMID: 28738497]
  • Sheik Abdulazeez Sheriff, Shaikhussain Shaik Ibrahim, Thiruvengadam Devaki, Sandipan Chakraborty, Subhash Agarwal, Horacio Pérez-Sánchez. Lycopene Prevents Mitochondrial Dysfunction during d-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Albino Rats. Journal of proteome research. 2017 09; 16(9):3190-3199. doi: 10.1021/acs.jproteome.7b00176. [PMID: 28758404]
  • Yi-Lian Xie, Jin-Guo Chu, Xiao-Min Jian, Jin-Zhong Dong, Li-Ping Wang, Guo-Xiang Li, Nai-Bin Yang. Curcumin attenuates lipopolysaccharide/d-galactosamine-induced acute liver injury by activating Nrf2 nuclear translocation and inhibiting NF-kB activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jul; 91(?):70-77. doi: 10.1016/j.biopha.2017.04.070. [PMID: 28448872]
  • Suxia Bao, Qiang Zhao, Jianming Zheng, Ning Li, Chong Huang, Mingquan Chen, Qi Cheng, Mengqi Zhu, Kangkang Yu, Chenghai Liu, Guangfeng Shi. Interleukin-23 mediates the pathogenesis of LPS/GalN-induced liver injury in mice. International immunopharmacology. 2017 May; 46(?):97-104. doi: 10.1016/j.intimp.2017.03.001. [PMID: 28282579]
  • Xiangying Zhang, Jianbo Ding, Chunyan Gou, Tao Wen, Li Li, Xiaojun Wang, Huasheng Yang, Dan Liu, Jinli Lou, Dexi Chen, Feng Ren, Xiuhui Li. Qingchangligan formula attenuates the inflammatory response to protect the liver from acute failure induced by d-galactosamine/lipopolysaccharide in mice. Journal of ethnopharmacology. 2017 Apr; 201(?):108-116. doi: 10.1016/j.jep.2016.11.007. [PMID: 27833028]
  • Pappithi Ramesh Babu, Cherukupalle Bhuvaneswar, Gandham Sandeep, Chintha Venkata Ramaiah, Wudayagiri Rajendra. Hepatoprotective role of Ricinus communis leaf extract against d-galactosamine induced acute hepatitis in albino rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Apr; 88(?):658-666. doi: 10.1016/j.biopha.2017.01.073. [PMID: 28152474]
  • Xinru Yin, Xia Gong, Li Zhang, Rong Jiang, Ge Kuang, Bin Wang, Xinyu Chen, Jingyuan Wan. Glycyrrhetinic acid attenuates lipopolysaccharide-induced fulminant hepatic failure in d-galactosamine-sensitized mice by up-regulating expression of interleukin-1 receptor-associated kinase-M. Toxicology and applied pharmacology. 2017 04; 320(?):8-16. doi: 10.1016/j.taap.2017.02.011. [PMID: 28213090]
  • Jie Ma, Chuang-Jun Li, Jing-Zhi Yang, Yan Li, Xiu-Qi Bao, Nai-Hong Chen, Dong-Ming Zhang. Three new coumarin glycosides from the stems of Hydrangea paniculata. Journal of Asian natural products research. 2017 Apr; 19(4):320-326. doi: 10.1080/10286020.2017.1305958. [PMID: 28367637]
  • Jun Zhao, Shilei Zhang, Shuping You, Tao Liu, Fang Xu, Tengfei Ji, Zhengyi Gu. Hepatoprotective Effects of Nicotiflorin from Nymphaea candida against Concanavalin A-Induced and D-Galactosamine-Induced Liver Injury in Mice. International journal of molecular sciences. 2017 Mar; 18(3):. doi: 10.3390/ijms18030587. [PMID: 28282879]
  • Kai Hu, Xianqiong Gong, Qing Ai, Ling Lin, Jie Dai, Lu Cai, Rong Jiang, Pu Ge, Li Zhang. Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis. Cell death & disease. 2017 03; 8(3):e2637. doi: 10.1038/cddis.2017.62. [PMID: 28252653]
  • Kiyofumi Ninomiya, Saowanee Chaipech, Yusuke Kunikata, Ryohei Yagi, Yutana Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa. Quantitative Determination of Stilbenoids and Dihydroisocoumarins in Shorea roxburghii and Evaluation of Their Hepatoprotective Activity. International journal of molecular sciences. 2017 Feb; 18(2):. doi: 10.3390/ijms18020451. [PMID: 28230758]
  • Lu Chen, Bingyu Xiang, Xiaojun Wang, Charlie Xiang. Exosomes derived from human menstrual blood-derived stem cells alleviate fulminant hepatic failure. Stem cell research & therapy. 2017 01; 8(1):9. doi: 10.1186/s13287-016-0453-6. [PMID: 28115012]
  • Qinge Ma, Rongrui Wei, Zhiqiang Wang, Wenmin Liu, Zhipei Sang, Yaping Li, Hongchun Huang. Bioactive alkaloids from the aerial parts of Houttuynia cordata. Journal of ethnopharmacology. 2017 Jan; 195(?):166-172. doi: 10.1016/j.jep.2016.11.013. [PMID: 27840258]
  • Jin Li, Liping Zhong, Haibo Zhu, Fengzhong Wang. The Protective Effect of Cordycepin on D-Galactosamine/Lipopolysaccharide-Induced Acute Liver Injury. Mediators of inflammation. 2017; 2017(?):3946706. doi: 10.1155/2017/3946706. [PMID: 28522898]
  • Ajaz Ahmad Ganai, Ishfaq Ahmad Ganaie, Nishika Verma, Humaira Farooqi. Regression of fibrosis/cirrhosis by Glycine propionyl-l-carnitine treatment in d-Galactosamine induced chronic liver damage. Chemico-biological interactions. 2016 Dec; 260(?):117-128. doi: 10.1016/j.cbi.2016.11.008. [PMID: 27836788]
  • Young-Su Yi, Jae Youl Cho, Daewon Kim. Cerbera manghas methanol extract exerts anti-inflammatory activity by targeting c-Jun N-terminal kinase in the AP-1 pathway. Journal of ethnopharmacology. 2016 Dec; 193(?):387-396. doi: 10.1016/j.jep.2016.08.033. [PMID: 27562319]
  • Mohammad Raish, Ajaz Ahmad, Khalid M Alkharfy, Syed Rizwan Ahamad, Kazi Mohsin, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea, Mushtaq Ahmad Ansari. Hepatoprotective activity of Lepidium sativum seeds against D-galactosamine/lipopolysaccharide induced hepatotoxicity in animal model. BMC complementary and alternative medicine. 2016 Dec; 16(1):501. doi: 10.1186/s12906-016-1483-4. [PMID: 27912738]
  • Hong-Min Xia, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Yan Li, Li Li, Dong-Ming Zhang. Hepatoprotective pyranocoumarins from the stems of Clausena emarginata. Phytochemistry. 2016 Oct; 130(?):238-43. doi: 10.1016/j.phytochem.2016.05.010. [PMID: 27289140]
  • Thangaiyan Radhiga, Arjunan Sundaresan, Periyasamy Viswanathan, Kodukkur Viswanathan Pugalendi. Effect of protocatechuic acid on lipid profile and DNA damage in D-galactosamine-induced hepatotoxic rats. Journal of basic and clinical physiology and pharmacology. 2016 Sep; 27(5):505-14. doi: 10.1515/jbcpp-2015-0135. [PMID: 27226100]
  • Guo Ai, Zheng-Ming Huang, Qing-Chuan Liu, Yan-Quan Han, Xi Chen. The protective effect of total phenolics from Oenanthe Javanica on acute liver failure induced by D-galactosamine. Journal of ethnopharmacology. 2016 Jun; 186(?):53-60. doi: 10.1016/j.jep.2016.03.024. [PMID: 26976768]
  • Jian-Xing Luo, Yang Zhang, Xiao-Yu Hu, Guo Chen, Xi-Yun Liu, Hong-Ming Nie, Jing-Li Liu, Da-Chao Wen. Aqueous extract from Aconitum carmichaelii Debeaux reduces liver injury in rats via regulation of HMGB1/TLR4/NF-ΚB/caspase-3 and PCNA signaling pathways. Journal of ethnopharmacology. 2016 May; 183(?):187-192. doi: 10.1016/j.jep.2016.01.020. [PMID: 26806574]
  • Jie Kang, Ting Zhang, Li Li, Hua Sun, Ding-Ding Wang, Ruo-Yun Chen. Hepatoprotective diterpenoids from the roots of Salvia grandifolia. Journal of Asian natural products research. 2016 May; 18(5):504-8. doi: 10.1080/10286020.2015.1130705. [PMID: 27086714]
  • Jeong-Wook Choi, In-Hye Kim, Young-Min Kim, Min-Kyeong Lee, Taek-Jeong Nam. Pyropia yezoensis glycoprotein regulates antioxidant status and prevents hepatotoxicity in a rat model of D-galactosamine/lipopolysaccharide-induced acute liver failure. Molecular medicine reports. 2016 Apr; 13(4):3110-4. doi: 10.3892/mmr.2016.4932. [PMID: 26935645]
  • Zhiying Gao, Jishun Zhang, Libo Li, Longqing Shen, Qingyi Li, Yu Zou, Xiaohui Du, Zhibo Zhao. Heat shock proteins 27 and 70 contribute to the protection of Schisandrin B against d-galactosamine-induced liver injury in mice. Canadian journal of physiology and pharmacology. 2016 Apr; 94(4):373-8. doi: 10.1139/cjpp-2015-0419. [PMID: 26666831]
  • Yan-Gai Wang, Qin-Ge Ma, Jin Tian, Jin Ren, Ai-Guo Wang, Teng-Fei Ji, Jian-Bo Yang, Ya-Lun Su. Hepatoprotective triterpenes from the gum resin of Boswellia carterii. Fitoterapia. 2016 Mar; 109(?):266-73. doi: 10.1016/j.fitote.2015.12.018. [PMID: 26739386]