3-Methoxy-4-hydroxyphenylglycol glucuronide (BioDeep_00000027589)
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C15H20O10 (360.105642)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 52.63%
分子结构信息
SMILES: COC1=C(C=CC(=C1)C(CO)O)OC2C(C(C(C(O2)C(=O)O)O)O)O
InChI: InChI=1S/C15H20O10/c1-23-9-4-6(7(17)5-16)2-3-8(9)24-15-12(20)10(18)11(19)13(25-15)14(21)22/h2-4,7,10-13,15-20H,5H2,1H3,(H,21,22)/t7?,10-,11-,12+,13-,15+/m0/s1
描述信息
3-Methoxy-4-hydroxyphenylglycol (HMPG) glucuronide is the main form of HMPG in human urine. HMPG is a major metabolite of norepinephrine that is found in urine and cerebrospinal fluid (CSF). It has been determined that 25-50\\% of it is derived from brain norepinephrine. The conjugated form is reported to be derived mainly from the metabolism of systemic norepinephrine. (PMID 528605) [HMDB]
3-Methoxy-4-hydroxyphenylglycol (HMPG) glucuronide is the main form of HMPG in human urine. HMPG is a major metabolite of norepinephrine that is found in urine and cerebrospinal fluid (CSF). It has been determined that 25-50\\% of it is derived from brain norepinephrine. The conjugated form is reported to be derived mainly from the metabolism of systemic norepinephrine. (PMID 528605).
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:89405
- PubChem: 22833525
- HMDB: HMDB0000496
- foodb: FDB022075
- chemspider: 17215958
- CAS: 52002-41-2
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- K Yoshino, K Takahashi, T Shirai, A Nishigaki, Y Araki, M Kitao. Changes in plasma catecholamines and pulsatile patterns of gonadotropin release in subjects with a normal ovulatory cycle and with polycystic ovary syndrome.
International journal of fertility.
1990 Jan; 35(1):34-9. doi:
NULL. [PMID: 1968442] - W E Müller, K Bauer, W Rost, J G Filser, M Fischer, W F Gattaz. Urinary MHPG-sulfate and urinary MHPG-glucuronide, two possible markers of the central or peripheral norepinephrine metabolism in man. The effect of alprazolam treatment.
Pharmacopsychiatry.
1988 Nov; 21(6):371-3. doi:
10.1055/s-2007-1017013. [PMID: 3244770] - J G Filser, J Spira, M Fischer, W F Gattaz, W E Müller. The evaluation of 4-hydroxy-3-methoxyphenylglycol sulfate as a possible marker of central norepinephrine turnover. Studies in healthy volunteers and depressed patients.
Journal of psychiatric research.
1988; 22(3):171-81. doi:
10.1016/0022-3956(88)90003-9. [PMID: 2852249] - L Peyrin, J M Pequignot, G Chauplannaz, B Laurent, J Moindrot, G Aimard. [Selective study of sulfate and glucuronide conjugates of urinary MHPG in nervous depression. Peripheral and central influences].
L'Encephale.
1985 Jan; 11(1):19-24. doi:
. [PMID: 3996286] - L Peyrin, J M Pequignot, G Chauplannaz, B Laurent, G Aimard. Sulfate and glucuronide conjugates of 3-methoxy-4-hydroxyphenylglycol (MHPG) in urine of depressed patients: central and peripheral influences.
Journal of neural transmission.
1985; 63(3-4):255-69. doi:
10.1007/bf01252030. [PMID: 4067598] - R A Lobo, D Shoupe, S Roy, W Paul. Central and peripheral metabolites of norepinephrine and dopamine in postmenopausal women.
American journal of obstetrics and gynecology.
1984 Jul; 149(5):548-52. doi:
10.1016/0002-9378(84)90034-6. [PMID: 6742025] - L Peyrin, J M Pequignot. Free and conjugated 3-methoxy-4-hydroxyphenylglycol in human urine: peripheral origin of glucuronide.
Psychopharmacology.
1983; 79(1):16-20. doi:
10.1007/bf00433009. [PMID: 6403958]