cis-4-Hydroxycyclohexylacetic acid (BioDeep_00000027580)

   

human metabolite Endogenous


代谢物信息卡片


cis-4-Hydroxycyclohexylacetic acid

化学式: C8H14O3 (158.0943)
中文名称: 2-(4-羟基环己基)乙酸 (顺反混合物)
谱图信息: 最多检出来源 Homo sapiens(feces) 95.26%

分子结构信息

SMILES: C1CC(CCC1CC(=O)O)O
InChI: InChI=1S/C8H14O3/c9-7-3-1-6(2-4-7)5-8(10)11/h6-7,9H,1-5H2,(H,10,11)

描述信息

cis-4-Hydroxycyclohexylacetic acid is a tyrosine metabolite that has been found in the urine of a patient with a defect of 4-hydroxyphenylpyruvate dioxygenase (or HPPD) (EC 1.13.11.27), an inborn error of metabolism (PMIDs 701419, 719903) also called hawkinsinuria. 4-Hydroxyphenylpyruvate dioxygenase participates in the tyrosine catabolic pathway by catalyzing the conversion of 4-hydroxyphenylpyruvate to homogentisate (Hager et al., 1957). The mechanism of action of 4-hydroxyphenylpyruvate dioxygenase involves a decarboxylation step and an oxidation step, followed by a rearrangement step to form homogentisic acid (Tomoeda et al., 2000). Awata et al. (1994) determined that the HPD gene contains 14 exons. Analysis of the 5-prime flanking sequence of the gene suggested that expression of the gene is regulated by hepatocyte-specific and liver-enriched transcription factors, as well as by hormones (OMIM: 609695). cis-4-Hydroxycyclohexylacetic acid has also been found to be a microbial metabolite (PMID: 20615997).
Cis-4-hydroxycyclohexylacetic acid is a tyrosine metabolite that has been found in the urine of a patient with a defect of 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27), an inborn error of metabolism. (PMIDs 701419, 719903)

同义名列表

7 个代谢物同义名

cis-4-Hydroxycyclohexylacetic acid; 2-(4-hydroxycyclohexyl)acetic acid; 4-Hydroxy-cyclohexylessigsaeure; 2-(4-Hydroxycyclohexyl)acetate; cis-4-Hydroxycyclohexylacetate; 4-hydroxycyclohexylacetic acid; 4-Hydroxycyclohexylacetate



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • M Borden, J Holm, J Leslie, L Sweetman, W L Nyhan, L Fleisher, H Nadler, D Lewis, C R Scott. Hawkinsinuria in two families. American journal of medical genetics. 1992 Sep; 44(1):52-6. doi: 10.1002/ajmg.1320440113. [PMID: 1519651]
  • B Wilcken, J W Hammond, N Howard, T Bohane, C Hocart, B Halpern. Hawkinsinuria: a dominantly inherited defect of tyrosine metabolism with severe effects in infancy. The New England journal of medicine. 1981 Oct; 305(15):865-8. doi: 10.1056/nejm198110083051505. [PMID: 7278885]
  • A Niederwieser, S K Wadman, D M Danks. Excretion of cis- and trans-4-hydroxycyclohexylacetic acid in addition to hawkinsin in a family with a postulated defect of 4-hydroxyphenylpyruvate dioxygenase. Clinica chimica acta; international journal of clinical chemistry. 1978 Dec; 90(2):195-200. doi: 10.1016/0009-8981(78)90522-3. [PMID: 719903]