Tibolone (BioDeep_00000275661)
natural product
代谢物信息卡片
17α-hydroxy-7α-methyl-19-norpregn-5(10)-en-20-yn-3-one
化学式: C21H28O2 (312.2089)
中文名称: 替勃龙
谱图信息:
最多检出来源 Viridiplantae(plant) 83.52%
分子结构信息
SMILES: C#CC1(O)CCC2C3C(C)CC4=C(CCC(=O)C4)C3CCC21C
InChI: InChI=1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D020847 - Estrogen Receptor Modulators
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D000726 - Androgen Antagonists
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03C - Estrogens
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D045930 - Anabolic Agents
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:32223
- KEGGdrug: D01639
- PubChem: 444008
- Metlin: METLIN2847
- DrugBank: DB09070
- ChEMBL: CHEMBL2103774
- CAS: 5630-53-5
- MoNA: FiehnHILIC002363
- MoNA: CCMSLIB00000079085
- PMhub: MS000008649
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Cuiming Li, Min Wei, Linling Mo, Periyannan Velu, Kousalya Prabahar, Mihnea-Alexandru Găman, Mei Chen. The effect of tibolone treatment on apolipoproteins and lipoprotein (a) concentrations in postmenopausal women: A meta-analysis of randomized controlled trials.
European journal of obstetrics, gynecology, and reproductive biology.
2023 Oct; 292(?):8-16. doi:
10.1016/j.ejogrb.2023.10.020. [PMID: 37948929] - Changyu Lv, Wencui Zhang, Xia Tan, Xianping Shang, Mihnea-Alexandru Găman, Hany Salem, Ahmed Abu-Zaid, Xiaohong Wang. The effect of tibolone treatment on lipid profile in women: A systematic review and dose-response meta-analysis of randomized controlled trials.
Pharmacological research.
2021 07; 169(?):105612. doi:
10.1016/j.phrs.2021.105612. [PMID: 33865986] - Payal Trupti Kotecha, Ian F Godsland, David Crook, John C Stevenson. Effects of tibolone or continuous combined oestradiol and norethisterone acetate on lipids, high-density lipoprotein subfractions and apolipoproteins in postmenopausal women in a two-year, randomized, double-blind, placebo-controlled trial.
Clinical endocrinology.
2020 04; 92(4):303-311. doi:
10.1111/cen.14155. [PMID: 31925799] - Norma Angélica Estrada Cruz, Julio César Almanza Pérez, Ángeles Fortis Barrera, Juan Manuel Gallardo, Leticia Manuel Apolinar, Julia Jeanett Segura Uribe, Sandra Orozco Suárez, Angélica Coyoy Salgado, Christian Guerra Araiza. Acute Administration of Tibolone Prevents Oxidative Stress in Ovariectomized Rats Fed High-Fat-and-Fructose Diet.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2019 Jun; 127(6):396-404. doi:
10.1055/a-0659-9928. [PMID: 30107623] - Päivi Rahkola-Soisalo, Hanna Savolainen-Peltonen, Mika Gissler, Fabian Hoti, Pia Vattulainen, Olavi Ylikorkala, Tomi S Mikkola. Increased risk for stress urinary incontinence in women with postmenopausal hormone therapy.
International urogynecology journal.
2019 Feb; 30(2):251-256. doi:
10.1007/s00192-018-3682-7. [PMID: 29946829] - Anette L Eilertsen, Anders E A Dahm, Else Høibraaten, Cathrine M Lofthus, Marie-Christine Mowinckel, Per M Sandset. Relationship between sex hormone binding globulin and blood coagulation in women on postmenopausal hormone treatment.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2019 Jan; 30(1):17-23. doi:
10.1097/mbc.0000000000000784. [PMID: 30507711] - Oscar Hidalgo-Lanussa, Marco Ávila-Rodriguez, Eliana Baez-Jurado, Jairo Zamudio, Valentina Echeverria, Luis Miguel Garcia-Segura, George E Barreto. Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta.
Molecular neurobiology.
2018 Jul; 55(7):5462-5477. doi:
10.1007/s12035-017-0777-y. [PMID: 28948468] - Małgorzata Bała, Amirhossein Sahebkar, Sorin Ursoniu, Maria-Corina Serban, Anetta Undas, Dimitri P Mikhailidis, Gregory Y H Lip, Jacek Rysz, Maciej Banach. Effects of tibolone on fibrinogen and antithrombin III: A systematic review and meta-analysis of controlled trials.
Pharmacological research.
2017 Oct; 124(?):64-73. doi:
10.1016/j.phrs.2017.07.024. [PMID: 28760491] - Cristiana Vitale, Caterina Mammi, Marco Gambacciani, Novella Russo, Ilaria Spoletini, Massimo Fini, Maurizio Volterrani, Giuseppe M C Rosano. Effect of hormone replacement therapy with the anti-mineralocorticoid progestin Drospirenone compared to tibolone on endothelial function and central haemodynamics in post-menopausal women.
International journal of cardiology.
2017 Jan; 227(?):217-221. doi:
10.1016/j.ijcard.2016.11.149. [PMID: 27843051] - Rodolfo Pinto-Almazán, Julia J Segura-Uribe, Eunice D Farfán-García, Christian Guerra-Araiza. Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches.
BioMed research international.
2017; 2017(?):8630764. doi:
10.1155/2017/8630764. [PMID: 28191467] - V Beltrán-Campos, A Díaz-Ruiz, E Padilla-Gómez, H Aguilar Zavala, C Ríos, S Díaz Cintra. Effect of tibolone on dendritic spine density in the rat hippocampus.
Neurologia (Barcelona, Spain).
2015 Sep; 30(7):401-6. doi:
10.1016/j.nrl.2014.03.002. [PMID: 24704246] - Kazuhiko Kotani, Amirhossein Sahebkar, Corina Serban, Florina Andrica, Peter P Toth, Steven R Jones, Karam Kostner, Michael J Blaha, Seth Martin, Jacek Rysz, Stephen Glasser, Kausik K Ray, Gerald F Watts, Dimitri P Mikhailidis, Maciej Banach. Tibolone decreases Lipoprotein(a) levels in postmenopausal women: A systematic review and meta-analysis of 12 studies with 1009 patients.
Atherosclerosis.
2015 Sep; 242(1):87-96. doi:
10.1016/j.atherosclerosis.2015.06.056. [PMID: 26186655] - Jiao Cheng, Zhenyu Zhang. [Clinical and metabolic effects of drospirenone-estradiol versus tibolone in postmenopausal women:a comparative study].
Zhonghua yi xue za zhi.
2015 Jun; 95(23):1815-8. doi:
". [PMID: 26712397] - Ji-Ming Chen, Hong-Yan Gao, Yi Ding, Xia Yuan, Qing Wang, Qin Li, Guo-Hua Jiang. Efficacy and safety investigation of Kuntai capsule for the add-back therapy of gonadotropin releasing hormone agonist administration to endometriosis patients: a randomized, double-blind, blank- and tibolone-controlled study.
Chinese medical journal.
2015 Feb; 128(4):427-32. doi:
10.4103/0366-6999.151057. [PMID: 25673440] - Sudhindra M Bhattacharya, Mainak Ghosh. Changes in serum calcium and vitamin D₃ levels after tibolone treatment and their correlations with health-related quality of life.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
2015 Feb; 128(2):174-6. doi:
10.1016/j.ijgo.2014.08.010. [PMID: 25482436] - Stephanie Maxine Ross. Efficacy of a standardized isopropanolic black cohosh (Actaea racemosa) extract in treatment of uterine fibroids in comparison with tibolone among patients with menopausal symptoms.
Holistic nursing practice.
2014 Nov; 28(6):386-91. doi:
10.1097/hnp.0000000000000055. [PMID: 25314113] - Jiming Chen, Hongyan Gao, Qin Li, Jing Cong, Jie Wu, Dahua Pu, Guohua Jiang. Efficacy and safety of remifemin on peri-menopausal symptoms induced by post-operative GnRH-a therapy for endometriosis: a randomized study versus tibolone.
Medical science monitor : international medical journal of experimental and clinical research.
2014 Oct; 20(?):1950-7. doi:
10.12659/msm.891353. [PMID: 25321621] - Rodolfo Pinto-Almazán, Selva Rivas-Arancibia, Eunice D Farfán-García, Erika Rodríguez-Martínez, Christian Guerra-Araiza. Neuroprotective effects of tibolone against oxidative stress induced by ozone exposure.
Revista de neurologia.
2014 May; 58(10):441-8. doi:
". [PMID: 24819940] - P-Y Yang, C-C Tang, Y-C Chang, S-Y Huang, S-P Hsieh, S-S Fan, H-P Lee, S-C Lin, W-F Chen, Z-H Wen, Y-H Jean. Effects of tibolone on osteoarthritis in ovariectomized rats: association with nociceptive pain behaviour.
European journal of pain (London, England).
2014 May; 18(5):680-90. doi:
10.1002/j.1532-2149.2013.00406.x. [PMID: 24151039] - Fabiana Fernandes de Santana e Silva Cardoso, Isabela Costa César, Iram Moreira Mundim, Leonardo de Souza Teixeira, Enikson Pontes da Silva, Ricardo Rodrigues Bonfim, Sandro Antônio Gomes, Denys Pires Ferreira, Aderimar Rogério Batista Lopes, Helifas Duarte Pascoal, Weidson Carlo de Souza, Gerson Antônio Pianetti. Determination of 3-α-hydroxytibolone in human plasma by LC-MS/MS: application for a pharmacokinetic study after administration of a tibolone formulation.
Biomedical chromatography : BMC.
2013 Nov; 27(11):1457-62. doi:
10.1002/bmc.2943. [PMID: 23813413] - Levent Akman, Hamza Duygu, Fuat Akercan, Murat Ulukus, Filiz Ozerkan, Mustafa Akin. The effects of different hormone treatment on endothelial function in healthy postmenopausal women.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2013 Sep; 29(9):867-72. doi:
10.3109/09513590.2013.813471. [PMID: 23875965] - Eduardo Hideo Gilglioni, Lilian Brites Campos, Monique Cristine Oliveira, Rosângela Fernandes Garcia, Célia Regina Ambiel, Ana Julia dos Reis Buzzo, Emy Luzia Ishii-Iwamoto, Clairce Luzia Salgueiro-Pagadigorria. Beneficial effects of tibolone on blood pressure and liver redox status in ovariectomized rats with renovascular hypertension.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2013 May; 68(5):510-20. doi:
10.1093/gerona/gls210. [PMID: 23089337] - Cho-Ming Loi, Dennis A Smith, Deepak Dalvie. Which metabolites circulate?.
Drug metabolism and disposition: the biological fate of chemicals.
2013 May; 41(5):933-51. doi:
10.1124/dmd.112.050278. [PMID: 23454828] - Teun M Post, Stephan Schmidt, Lambertus A Peletier, Rik de Greef, Thomas Kerbusch, Meindert Danhof. Application of a mechanism-based disease systems model for osteoporosis to clinical data.
Journal of pharmacokinetics and pharmacodynamics.
2013 Apr; 40(2):143-56. doi:
10.1007/s10928-012-9294-9. [PMID: 23315144] - I Lambrinoudaki, M Karaflou, G Kaparos, A Alexandrou, M Creatsa, L Aravantinos, A Augoulea, E Kouskouni. Effect of tibolone and raloxifene on serum markers of apoptosis in postmenopausal women.
Climacteric : the journal of the International Menopause Society.
2013 Apr; 16(2):258-64. doi:
10.3109/13697137.2012.668251. [PMID: 22642937] - Nik Manassiev, Ian F Godsland, Anthony J Proudler, Malcolm I Whitehead, John C Stevenson. Effects of tibolone or continuous combined oestradiol/norethisterone acetate on glucose and insulin metabolism.
Clinical endocrinology.
2013 Feb; 78(2):297-302. doi:
10.1111/j.1365-2265.2012.04491.x. [PMID: 22775481] - A Traianos, D Vavilis, A Makedos, A Karkanaki, K Ravanos, N Prapas, B C Tarlatzis. Effect of short-term tibolone treatment on risk markers for cardiovascular disease in healthy postmenopausal women: a randomized controlled study.
Clinical and experimental obstetrics & gynecology.
2013; 40(4):542-5. doi:
NULL. [PMID: 24597251] - Ana Raquel Santos de Medeiros, Aline Zandonadi Lamas, Izabela Facco Caliman, Polyana L Meireles Dalpiaz, Luciana Barbosa Firmes, Gláucia Rodrigues de Abreu, Margareth Ribeiro Moysés, Elenice Moreira Lemos, Adelina Martha dos Reis, Nazaré Souza Bissoli. Tibolone has anti-inflammatory effects in estrogen-deficient female rats on the natriuretic peptide system and TNF-alpha.
Regulatory peptides.
2012 Nov; 179(1-3):55-60. doi:
10.1016/j.regpep.2012.08.015. [PMID: 22975659] - Anders E A Dahm, Anette L Eilertsen, Jelle Goeman, Ole Kristoffer Olstad, Reidun Ovstebø, Peter Kierulf, Marie-Christine Mowinckel, Grethe Skretting, Per Morten Sandset. A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women.
Thrombosis research.
2012 Jul; 130(1):45-51. doi:
10.1016/j.thromres.2011.12.009. [PMID: 22217510] - Maria Morais-Socorro, Maciel Alvaro Cavalcanti, Rand Martins, Paulo Neto Francisco, Adriana Rezende, George Azevedo, Maria Almeida. Safety and efficacy of tibolone and menopausal transition: a randomized, double-blind placebo-controlled trial.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2012 Jun; 28(6):483-7. doi:
10.3109/09513590.2011.634937. [PMID: 22132809] - Anna-Clara E Spetz Holm, Jessica Frisk, Mats L Hammar. Acupuncture as treatment of hot flashes and the possible role of calcitonin gene-related Peptide.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):579321. doi:
10.1155/2012/579321. [PMID: 22110545] - Laure Carcaillon, Carmen Blanco, Cristina Alonso-Bouzón, Ana Alfaro-Acha, Francisco-José Garcia-García, Leocadio Rodriguez-Mañas. Sex differences in the association between serum levels of testosterone and frailty in an elderly population: the Toledo Study for Healthy Aging.
PloS one.
2012; 7(3):e32401. doi:
10.1371/journal.pone.0032401. [PMID: 22403651] - E Lundström, A L Hirschberg, G Söderqvist. Digitized assessment of mammographic breast density--effects of continuous combined hormone therapy, tibolone and black cohosh compared to placebo.
Maturitas.
2011 Dec; 70(4):361-4. doi:
10.1016/j.maturitas.2011.08.009. [PMID: 21958943] - Abdullah Foraih Al-Anazi, Viquar Fatima Qureshi, Khalida Javaid, Shoeb Qureshi. Preventive effects of phytoestrogens against postmenopausal osteoporosis as compared to the available therapeutic choices: An overview.
Journal of natural science, biology, and medicine.
2011 Jul; 2(2):154-63. doi:
10.4103/0976-9668.92322. [PMID: 22346228] - Marit Waaseth, Karina S Olsen, Charlotta Rylander, Eiliv Lund, Vanessa Dumeaux. Sex hormones and gene expression signatures in peripheral blood from postmenopausal women - the NOWAC postgenome study.
BMC medical genomics.
2011 Mar; 4(?):29. doi:
10.1186/1755-8794-4-29. [PMID: 21453500] - Cristina Vassalle, Ettore Cicinelli, Stefano Lello, Antonella Mercuri, Debora Battaglia, Silvia Maffei. Effects of menopause and tibolone on different cardiovascular biomarkers in healthy women.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2011 Mar; 27(3):163-9. doi:
10.3109/09513590.2010.488770. [PMID: 20500110] - Eva L Ribom, Peter Svensson, Steve van Os, Marita Larsson, Tord Naessen. Low-dose tibolone (1.25 mg/d) does not affect muscle strength in older women.
Menopause (New York, N.Y.).
2011 Feb; 18(2):194-7. doi:
10.1097/gme.0b013e3181e9d833. [PMID: 20689464] - Giovanni Gaeta, Simona Lanero, Silvia Barra, Nunzia Silvestri, Vittoria Cuomo, Crescenzo Materazzi, Giancarlo Vitagliano. Sex hormones and lipoprotein(a) concentration.
Expert opinion on investigational drugs.
2011 Feb; 20(2):221-38. doi:
10.1517/13543784.2011.548804. [PMID: 21204723] - Klaus G Parhofer. Lipoprotein(a): medical treatment options for an elusive molecule.
Current pharmaceutical design.
2011; 17(9):871-6. doi:
10.2174/138161211795428777. [PMID: 21476974] - Jue Zhou, Fan Qu, Xisheng Sang, Xiaotong Wang, Rui Nan. Acupuncture and auricular acupressure in relieving menopausal hot flashes of bilaterally ovariectomized chinese women: a randomized controlled trial.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):713274. doi:
10.1093/ecam/nep001. [PMID: 19189989] - Børge G Nordestgaard, M John Chapman, Kausik Ray, Jan Borén, Felicita Andreotti, Gerald F Watts, Henry Ginsberg, Pierre Amarenco, Alberico Catapano, Olivier S Descamps, Edward Fisher, Petri T Kovanen, Jan Albert Kuivenhoven, Philippe Lesnik, Luis Masana, Zeljko Reiner, Marja-Riitta Taskinen, Lale Tokgözoglu, Anne Tybjærg-Hansen. Lipoprotein(a) as a cardiovascular risk factor: current status.
European heart journal.
2010 Dec; 31(23):2844-53. doi:
10.1093/eurheartj/ehq386. [PMID: 20965889] - Ronald C Hamdy. Zoledronic acid: clinical utility and patient considerations in osteoporosis and low bone mass.
Drug design, development and therapy.
2010 Nov; 4(?):321-35. doi:
10.2147/dddt.s6287. [PMID: 21151620] - I Lambrinoudaki, M Karaflou, G Kaparos, O Grigoriou, A Alexandrou, C Panoulis, E Logothetis, M Creatsa, G Christodoulakos, E Kouskouni. The effect of hormone therapy and tibolone on serum CD40L and ADAM-8 in healthy post-menopausal women.
Journal of endocrinological investigation.
2010 Nov; 33(10):720-4. doi:
10.1007/bf03346677. [PMID: 20436265] - B G A Stuckey, P H R Barrett, J M Wagner, R A Hampton, D C Chan, S J Brown, G F Watts. The effect of fenofibrate on HDL cholesterol and HDL particle concentration in postmenopausal women on tibolone therapy.
Clinical endocrinology.
2010 Oct; 73(4):497-501. doi:
10.1111/j.1365-2265.2010.03839.x. [PMID: 20560981] - Carolyn J Clark, Carmel M Hawley, David W Mudge. Probable tacrolimus toxicity from tibolone co-administration in a woman: a case report.
Journal of medical case reports.
2010 Aug; 4(?):276. doi:
10.1186/1752-1947-4-276. [PMID: 20718999] - M A Karsdal, I Byrjalsen, A C Bay-Jensen, K Henriksen, B J Riis, C Christiansen. Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis--the effect of sex, Kellgren-Lawrence (KL) score, body mass index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation.
BMC musculoskeletal disorders.
2010 Jun; 11(?):125. doi:
10.1186/1471-2474-11-125. [PMID: 20565725] - Leif Wide, Tord Naessén, Karin Eriksson. Effects of 17beta-oestradiol and norethisterone acetate on sulfonation and sialylation of gonadotrophins in post-menopausal women.
Upsala journal of medical sciences.
2010 May; 115(2):97-106. doi:
10.3109/03009730903573253. [PMID: 20141368] - Helene Nara Henriques, Natérsia Rosa Câmara, Ana Carolina Bergmann de Carvalho, José Augusto Soares Pantaleão, Maria Angélica Guzmán-Silva. [Effect of high doses of tibolone in body weight and lipid profile of ovariectomized rats].
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia.
2010 Feb; 32(2):88-93. doi:
10.1590/s0100-72032010000200007. [PMID: 20305947] - Vishal R Tandon, Annil Mahajan, Sudhaa Sharma, Anil Sharma. Prevalence of cardiovascular risk factors in postmenopausal women: A rural study.
Journal of mid-life health.
2010 Jan; 1(1):26-9. doi:
10.4103/0976-7800.66993. [PMID: 21799635] - Wen-pei Bai, Shu-yu Wang, Jian-li Liu, Li Geng, Li-na Hu, Zhong-lan Zhang, Shu-ling Chen, Shu-rong Zheng. [Efficacy and safety of remifemin compared to tibolone for controlling of perimenopausal symptoms].
Zhonghua fu chan ke za zhi.
2009 Aug; 44(8):597-600. doi:
". [PMID: 20003788] - M Widschwendter, H Lichtenberg-Frate, G Hasenbrink, S Schwarzer, A Dawnay, A Lam, U Menon, S Apostolidou, E Raum, C Stegmaier, I J Jacobs, H Brenner. Serum oestrogen receptor alpha and beta bioactivity are independently associated with breast cancer: a proof of principle study.
British journal of cancer.
2009 Jul; 101(1):160-5. doi:
10.1038/sj.bjc.6605106. [PMID: 19491898] - Gertraud Maskarinec, Jana S Steude, Adrian A Franke, Robert V Cooney. Inflammatory markers in a 2-year soy intervention among premenopausal women.
Journal of inflammation (London, England).
2009 Apr; 6(?):9. doi:
10.1186/1476-9255-6-9. [PMID: 19348684] - St Zervoudis, G Iatrakis, P Peitsidis, P Tsikouras, G Galazios, V Liberis, I Navrozoglou, Iuliana Ceauşu, C Badiu. Tibolone vaginal versus per os administration in the management of post-menopausal symptoms.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi.
2009 Apr; 113(2):471-7. doi:
NULL. [PMID: 21491823] - Yaprak Engin-Ustün, Yusuf Ustün, Ilgin Türkçüoğlu, M Mutlu Meydanli, Ayşe Kafkasli, Gülay Yetkin. Short-term effect of tibolone on C-reactive protein in hypertensive postmenopausal women.
Archives of gynecology and obstetrics.
2009 Mar; 279(3):305-9. doi:
10.1007/s00404-008-0712-6. [PMID: 18584186] - K Sezer Ozer, M Erenus, T Yoldemir. The impact of tibolone and hormone therapy on serum C-reactive protein, tumor necrosis factor-alpha and hepatocyte growth factor in postmenopausal women.
Climacteric : the journal of the International Menopause Society.
2009 Feb; 12(1):66-71. doi:
10.1080/13697130802479580. [PMID: 19012050] - Emine Nihan Dedeoğlu, Mithat Erenus, Pinar Yörük. Effects of hormone therapy and tibolone on body composition and serum leptin levels in postmenopausal women.
Fertility and sterility.
2009 Feb; 91(2):425-31. doi:
10.1016/j.fertnstert.2007.11.061. [PMID: 18249383] - Tord Naessen, Birgitta Lindmark, Hans Christian Larsen, Steve van Os, Marita Larsson. Tibolone low dose (1.25 mg/d) therapy and postural balance in elderly women.
Maturitas.
2009 Jan; 62(1):72-5. doi:
10.1016/j.maturitas.2008.11.004. [PMID: 19097714] - Angelo A Izzo, Edzard Ernst. Interactions between herbal medicines and prescribed drugs: an updated systematic review.
Drugs.
2009; 69(13):1777-98. doi:
10.2165/11317010-000000000-00000. [PMID: 19719333] - Keon W Kang, Yoon G Kim. Bioequivalence studies of tibolone in premenopausal women and effects on expression of the tibolone-metabolizing enzyme AKR1C (aldo-keto reductase) family caused by estradiol.
Journal of clinical pharmacology.
2008 Dec; 48(12):1430-7. doi:
10.1177/0091270008323262. [PMID: 18832293] - M A Karsdal, I Byrjalsen, D J Leeming, C Christiansen. Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation.
BMC musculoskeletal disorders.
2008 Nov; 9(?):153. doi:
10.1186/1471-2474-9-153. [PMID: 19019210] - R B de Aguiar, O E Dickel, R W Cunha, J M Monserrat, D M Barros, P E Martinez. Estradiol valerate and tibolone: effects upon brain oxidative stress and blood biochemistry during aging in female rats.
Biogerontology.
2008 Oct; 9(5):285-98. doi:
10.1007/s10522-008-9137-7. [PMID: 18386154] - P D Delmas, S R Davis, J Hensen, S Adami, S van Os, E A Nijland. Effects of tibolone and raloxifene on bone mineral density in osteopenic postmenopausal women.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2008 Aug; 19(8):1153-60. doi:
10.1007/s00198-007-0545-3. [PMID: 18256777] - Doris Auer, Michael Hubalek, Martina Fleischer, Julia Roessler, Guenter Daxenbichler. The growth-promoting action of individual women's sera on mammary carcinoma cells.
Anticancer research.
2008 Jul; 28(4B):2213-7. doi:
NULL. [PMID: 18751397] - Susan E Appt, Riina Törmälä, Adrian A Franke, Tomi S Mikkola, Matti J Tikkanen, Olavi Ylikorkala, Thomas B Clarkson. Soy-tibolone combination - effect on lipids in postmenopausal monkeys and women.
Maturitas.
2008 Jul; 60(3-4):216-22. doi:
10.1016/j.maturitas.2008.06.003. [PMID: 18687539] - Martin Petzel, David Stejskal, Libor Jedelsky, Lenka Kadalova, Kristian Safarcik. The influence of estradiole and tibolone administration on leptin levels in women with surgically induced menopause.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
2008 Jun; 152(1):101-5. doi:
10.5507/bp.2008.016. [PMID: 18795083] - Petra Stute, Martin Götte, Ludwig Kiesel. Differential effect of hormone therapy on E1S-sulfatase activity in non-malignant and cancerous breast cells in vitro.
Breast cancer research and treatment.
2008 Apr; 108(3):363-74. doi:
10.1007/s10549-007-9615-7. [PMID: 17546497] - G E Christodoulakos, I V Lambrinoudaki, M G Creatsa, E V Economou, Z Siasou, C P Panoulis, I Kalligerou, C Papadias. Circulating levels of atherogenesis-associated adipocytokines and apoptotic markers are differentially influenced by hormone therapy, tibolone and raloxifene in healthy postmenopausal women.
Climacteric : the journal of the International Menopause Society.
2008 Apr; 11(2):155-65. doi:
10.1080/13697130801954484. [PMID: 18365858] - Irene V Lambrinoudaki, George E Christodoulakos, Emmanuel V Economou, Sofia A Vlachou, Constantinos P Panoulis, Andreas P Alexandrou, Evangelia E Kouskouni, George C Creatsas. Circulating leptin and ghrelin are differentially influenced by estrogen/progestin therapy and raloxifene.
Maturitas.
2008 Jan; 59(1):62-71. doi:
10.1016/j.maturitas.2007.10.003. [PMID: 18164562] - Marit Waaseth, Kjersti Bakken, Vanessa Dumeaux, Karina S Olsen, Charlotta Rylander, Yngve Figenschau, Eiliv Lund. Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer postgenome cohort - a cross-sectional analysis.
BMC women's health.
2008 Jan; 8(?):1. doi:
10.1186/1472-6874-8-1. [PMID: 18194511] - D Bruce, A Frick, J Rymer, J Robinson, O Ylikorkala. A comparison of hormone therapies on the urinary excretion of prostacyclin and thromboxane A2.
Climacteric : the journal of the International Menopause Society.
2008; 11(6):447-53. doi:
10.1080/13697130802387619. [PMID: 18821092] - S O Skouby, J J Sidelmann, L Nilas, J Gram, J Jespersen. The effect of continuous combined conjugated equine estrogen plus medroxyprogesterone acetate and tibolone on cardiovascular metabolic risk factors.
Climacteric : the journal of the International Menopause Society.
2008; 11(6):489-97. doi:
10.1080/13697130802455150. [PMID: 18991076] - C Tamer Erel, Altay Gezer, Levent M Sentürk, Asli Somunkiran, Semih Kaleli, Hakan Seyisoglu. Effect of different hormonal therapies on thyroid function in surgical menopause: short-term results.
The Journal of reproductive medicine.
2007 Dec; 52(12):1079-84. doi:
NULL. [PMID: 18210897] - M Bayram, G Ozer, H Kalender, N Kabakci, U Kisa, Y Ozkan. The effects of raloxifene and tibolone on homocysteine and vascular histopathological changes.
Clinical and experimental medicine.
2007 Dec; 7(4):149-53. doi:
10.1007/s10238-007-0139-6. [PMID: 18188527] - N C Keramaris, G E Christodoulakos, I V Lambrinoudaki, A Dalamanga, A P Alexandrou, J Bramis, E Bastounis, G C Creatsas. The differential effect of estrogen, estrogen-progestin and tibolone on coagulation inhibitors in postmenopausal women.
Climacteric : the journal of the International Menopause Society.
2007 Oct; 10(5):400-7. doi:
10.1080/13697130701624773. [PMID: 17852143] - Wenpei Bai, Hans-Heinrich Henneicke-von Zepelin, Shuyu Wang, Shurong Zheng, Jianli Liu, Zhonglan Zhang, Li Geng, Lina Hu, Chunfeng Jiao, Eckehard Liske. Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone.
Maturitas.
2007 Sep; 58(1):31-41. doi:
10.1016/j.maturitas.2007.04.009. [PMID: 17587516] - Sebastian Mirkin, David F Archer. Effects of tibolone and its metabolites on Angiopoietin-1, Tie-2 and tumor necrosis factor-alpha mRNA in Ishikawa cells. Implication for tibolone's effects on the endometrium.
Maturitas.
2007 Aug; 57(4):338-46. doi:
10.1016/j.maturitas.2007.03.002. [PMID: 17478063] - Marianne S Andresen, Anette L Eilertsen, Ulrich Abildgaard, Per Morten Sandset. Hormone therapy and raloxifene reduce the coagulation inhibitor potential.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2007 Jul; 18(5):455-60. doi:
10.1097/mbc.0b013e32813a2de7. [PMID: 17581320] - V N Zorina, E M Predeina, R M Zorina, V G Levchenko, L G Bazhenova, N A Zorin. [The level of pregnancy-associated alpha2-glycoprotein and the hormonal background during different options of hormonal replacement therapy in the menopausal syndrome].
Klinicheskaia laboratornaia diagnostika.
2007 Jul; ?(7):24-7. doi:
NULL. [PMID: 17802803] - George E Christodoulakos, Irene V Lambrinoudaki, Emmanuel V Economou, Constantinos Papadias, Nikolaos Vitoratos, Constantinos P Panoulis, Evangelia E Kouskouni, Sofia A Vlachou, George C Creatsas. Circulating chemoattractants RANTES, negatively related to endogenous androgens, and MCP-1 are differentially suppressed by hormone therapy and raloxifene.
Atherosclerosis.
2007 Jul; 193(1):142-50. doi:
10.1016/j.atherosclerosis.2006.05.045. [PMID: 16842799] - H A M Verheul, C J Timmer, M L P S van Iersel, L P C Delbressine, H J Kloosterboer. Pharmacokinetic parameters of tibolone and metabolites in plasma, urine, feces, and bile from ovariectomized cynomolgus monkeys after a single dose or multiple doses of tibolone.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Jul; 35(7):1112-8. doi:
10.1124/dmd.106.014159. [PMID: 17420282] - H A M Verheul, M L P S van Iersel, L P C Delbressine, H J Kloosterboer. Selective tissue distribution of tibolone metabolites in mature ovariectomized female cynomolgus monkeys after multiple doses of tibolone.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Jul; 35(7):1105-11. doi:
10.1124/dmd.106.014118. [PMID: 17420283] - Anette L Eilertsen, Sigurd Liestøl, Marie-Christine Mowinckel, H C Hemker, Per-Morten Sandset. Differential impact of conventional and low-dose oral hormone therapy (HT), tibolone and raloxifene on functionality of the activated protein C system.
Thrombosis and haemostasis.
2007 Jun; 97(6):938-43. doi:
. [PMID: 17549295] - Melloney J Dröge, Freddy Oostebring, Ep Oosting, Herman A M Verheul, Helenius J Kloosterboer. 7alpha-Methyl-ethinyl estradiol is not a metabolite of tibolone but a chemical stress artifact.
Menopause (New York, N.Y.).
2007 May; 14(3 Pt 1):474-80. doi:
10.1097/01.gme.0000247015.63877.d4. [PMID: 17237734] - Aygul Demirol, Suleyman Guven, Emine Seda Guvendag Guven, Serafettin Kirazli, Timur Gurgan, Ali Ayhan. Comparison of the effects of tibolone and estrogen therapy on hemostasis in surgical menopause: a randomized, double-blind, placebo-controlled study.
Fertility and sterility.
2007 Apr; 87(4):842-8. doi:
10.1016/j.fertnstert.2006.08.090. [PMID: 17222829] - Herman A M Verheul, Leen J Blok, Curt W Burger, Payman Hanifi-Moghaddam, Helenius J Kloosterboer. Levels of tibolone and estradiol and their nonsulfated and sulfated metabolites in serum, myometrium, and vagina of postmenopausal women following treatment for 21 days with tibolone, estradiol, or estradiol plus medroxyprogestrone acetate.
Reproductive sciences (Thousand Oaks, Calif.).
2007 Feb; 14(2):160-8. doi:
10.1177/1933719106298684. [PMID: 17636227] - Helenius J Kloosterboer, Lars Löfgren, Eva von Schoulz, Bo von Schoultz, Herman A M Verheul. Estrogen and tibolone metabolite levels in blood and breast tissue of postmenopausal women recently diagnosed with early-stage breast cancer and treated with tibolone or placebo for 14 days.
Reproductive sciences (Thousand Oaks, Calif.).
2007 Feb; 14(2):151-9. doi:
10.1177/1933719106298679. [PMID: 17636226] - Somdat Mahabir, David Baer, Laura L Johnson, Mark Roth, William Campbell, Beverly Clevidence, Philip R Taylor. Body Mass Index, percent body fat, and regional body fat distribution in relation to leptin concentrations in healthy, non-smoking postmenopausal women in a feeding study.
Nutrition journal.
2007 Jan; 6(?):3. doi:
10.1186/1475-2891-6-3. [PMID: 17229323] - Marcelino Hernandez-Valencia, Arturo Zarate, Angelica Sandoval, Miriam Ruiz, Carlos Timossi, Dante Amato, Lourdes Basurto. Conjugated estrogens and tibolone modify the gonadotrophin glycosylation pattern in postmenopausal women.
Gynecologic and obstetric investigation.
2007; 63(1):22-7. doi:
10.1159/000094673. [PMID: 16864983] - Joëlle Desreux, Helenius Kloosterboer, Agnès Noël, Francis Frankenne, Madeleine Lemaire, Monique Putman, Jean-Michel Foidart. Effects of tibolone on sulfatase pathway of estrogens metabolism and on growth of MCF-7 human breast tumors implanted in ovariectomized nude mice.
Gynecologic and obstetric investigation.
2007; 63(1):31-8. doi:
10.1159/000094917. [PMID: 16899995] - Ali Riza Odabasi, Hasan Yuksel, Samet Kafkas, Selda Demircan, Aslihan Karul, Didem Kozaci, Kutsi Koseoglu, Ergun Onur. Effects of tibolone on abdominal subcutaneous fat, serum leptin levels, and anthropometric indices: a 6-month, prospective, randomized, placebo-controlled, double-blind study.
Advances in therapy.
2006 Nov; 23(6):926-37. doi:
10.1007/bf02850215. [PMID: 17276962] - Ettore Cicinelli, Giuseppe Ranieri, Silvia Maffei, Giuseppe Colafiglio, Roberto Ria, Marina Bellavia, Matteo M Schonauer. Long-term effects of tibolone on circulating levels of vascular cell adhesion molecules and E-selectin in postmenopausal women.
Fertility and sterility.
2006 Oct; 86(4):899-904. doi:
10.1016/j.fertnstert.2006.03.041. [PMID: 16963035] - Junghyun Son, Ju-Yeon Moon, Seol-A Kim, Young-Dae Cho, Jong-Dae Kim, Dong-Hyun Kim, Man Ho Choi. Improved detectability in pharmacokinetic study of tibolone by gas chromatography-high resolution mass spectrometry with selected ion monitoring.
Talanta.
2006 Aug; 70(1):37-42. doi:
10.1016/j.talanta.2006.02.003. [PMID: 18970725] - K C Lewandowski, J Komorowski, D P Mikhalidis, M Bienkiewicz, B K Tan, C J O'Callaghan, A Lewinski, G Prelevic, H S Randeva. Effects of hormone replacement therapy type and route of administration on plasma matrix metalloproteinases and their tissue inhibitors in postmenopausal women.
The Journal of clinical endocrinology and metabolism.
2006 Aug; 91(8):3123-30. doi:
10.1210/jc.2005-2789. [PMID: 16705077] - Giovanni A Tommaselli, Costantino Di Carlo, Attilio Di Spiezio Sardo, Giuseppe Bifulco, Domenico Cirillo, Maurizio Guida, Rachele Capasso, Carmine Nappi. Serum leptin levels and body composition in postmenopausal women treated with tibolone and raloxifene.
Menopause (New York, N.Y.).
2006 Jul; 13(4):660-8. doi:
10.1097/01.gme.0000227335.27996.d8. [PMID: 16837888] - Levent Yasar, Ali Süha Sönmez, Nurhan Utku, Jane Ozcan, Ziya Cebi, Kadir Savan, Necdet Sut, Fehmi Yazicioğlu. Effect of misoprostol on bone mineral density in women with postmenopausal osteoporosis.
Prostaglandins & other lipid mediators.
2006 May; 79(3-4):199-205. doi:
10.1016/j.prostaglandins.2005.12.001. [PMID: 16647634] - Katarina Jeremić, Gordana Lazović, Ivan Tulić, Miroslava Gojnić, Jelena Stojnić, Jelena Jeremić. [Effects of tibolone on the risk factors for cardiovascular diseases in postmenopausal women].
Vojnosanitetski pregled.
2006 Apr; 63(4):387-91. doi:
10.2298/vsp0604387j. [PMID: 16683408] - Pervin Vural, Mukaddes Canbaz, Cemil Akgul. Effects of menopause and postmenopausal tibolone treatment on plasma TNFalpha, IL-4, IL-10, IL-12 cytokine pattern and some bone turnover markers.
Pharmacological research.
2006 Apr; 53(4):367-71. doi:
10.1016/j.phrs.2006.01.005. [PMID: 16503406] - S Shah, R J Bell, S R Davis. Homocysteine, estrogen and cognitive decline.
Climacteric : the journal of the International Menopause Society.
2006 Apr; 9(2):77-87. doi:
10.1080/13697130600641282. [PMID: 16698655] - George E Christodoulakos, Irene V Lambrinoudaki, Emmanuel V Economou, Constantinos Papadias, Constantinos P Panoulis, Evangelia E Kouskouni, Sofia A Vlachou, George C Creatsas. Differential effect of hormone therapy and tibolone on lipids, lipoproteins, and the atherogenic index of plasma.
Journal of cardiovascular pharmacology.
2006 Apr; 47(4):542-8. doi:
10.1097/01.fjc.0000211747.16573.d5. [PMID: 16680067]
