2-Oxothiazolidine-4-carboxylic acid (BioDeep_00000275650)
代谢物信息卡片
化学式: C4H5NO3S (146.99901400000002)
中文名称:
谱图信息:
最多检出来源 Mentha canadensis(plant) 50%
分子结构信息
SMILES: C1C(NC(=O)S1)C(=O)O
InChI: InChI=1S/C4H5NO3S/c6-3(7)2-1-9-4(8)5-2/h2H,1H2,(H,5,8)(H,6,7)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Daniela Giustarini, Federico Galvagni, Isabella Dalle Donne, Aldo Milzani, Filiberto Maria Severi, Annalisa Santucci, Ranieri Rossi. N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs.
Free radical biology & medicine.
2018 10; 126(?):202-209. doi:
10.1016/j.freeradbiomed.2018.08.013
. [PMID: 30114478] - Gergana Deevska, Manjula Sunkara, Claudia Karakashian, Benjamin Peppers, Andrew J Morris, Mariana N Nikolova-Karakashian. Effect of procysteine on aging-associated changes in hepatic GSH and SMase: evidence for transcriptional regulation of smpd3.
Journal of lipid research.
2014 Oct; 55(10):2041-52. doi:
10.1194/jlr.m048223
. [PMID: 25047167] - María José Clemente-Moreno, Pedro Díaz-Vivancos, Manuel Rubio, Nieves Fernández-García, José A Hernández. Chloroplast protection in plum pox virus-infected peach plants by L-2-oxo-4-thiazolidine-carboxylic acid treatments: effect in the proteome.
Plant, cell & environment.
2013 Mar; 36(3):640-54. doi:
10.1111/pce.12003
. [PMID: 22913613] - María José Clemente-Moreno, Pedro Díaz-Vivancos, Abel Piqueras, José Antonio Hernández. Plant growth stimulation in Prunus species plantlets by BTH or OTC treatments under in vitro conditions.
Journal of plant physiology.
2012 Jul; 169(11):1074-83. doi:
10.1016/j.jplph.2012.03.012
. [PMID: 22595304] - In Hee Kim, Dae-Ghon Kim, Peipei Hao, Yunpeng Wang, Seong Hun Kim, Sang Wook Kim, Seung Ok Lee, Soo Teik Lee. Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats.
BMB reports.
2012 Jun; 45(6):348-53. doi:
10.5483/bmbrep.2012.45.6.276
. [PMID: 22732220] - John E Casida. The greening of pesticide-environment interactions: some personal observations.
Environmental health perspectives.
2012 Apr; 120(4):487-93. doi:
10.1289/ehp.1104405
. [PMID: 22472325] - Xian Fan, Pratibha C Joshi, Michael Koval, David M Guidot. Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats.
Alcoholism, clinical and experimental research.
2011 Oct; 35(10):1866-75. doi:
10.1111/j.1530-0277.2011.01531.x
. [PMID: 21569054] - Nikola Hadzi-Petrushev, Nikola Jankulovski, Kiril Hristov, Mitko Mladenov. L-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent redox changes in rat's blood plasma.
The journal of physiological sciences : JPS.
2011 Sep; 61(5):437-42. doi:
10.1007/s12576-011-0165-8
. [PMID: 21786149] - M J Clemente-Moreno, P Díaz-Vivancos, G Barba-Espín, J A Hernández. Benzothiadiazole and l-2-oxothiazolidine-4-carboxylic acid reduce the severity of Sharka symptoms in pea leaves: effect on antioxidative metabolism at the subcellular level.
Plant biology (Stuttgart, Germany).
2010 Jan; 12(1):88-97. doi:
10.1111/j.1438-8677.2009.00204.x
. [PMID: 20653891] - Abderrahim Nemmar, Suhail Al-Salam, Subramanian Dhanasekaran, Manjusha Sudhadevi, Badreldin H Ali. Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid.
Toxicology.
2009 Sep; 263(2-3):84-92. doi:
10.1016/j.tox.2009.06.017
. [PMID: 19560508] - Nghi Phung, Natasha Pera, Geoffrey Farrell, Isabelle Leclercq, Jing Yun Hou, Jacob George. Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis.
International journal of molecular medicine.
2009 Aug; 24(2):171-80. doi:
10.3892/ijmm_00000220
. [PMID: 19578790] - Anna B Ohlsson, Tommy Landberg, Torkel Berglund, Maria Greger. Increased metal tolerance in Salix by nicotinamide and nicotinic acid.
Plant physiology and biochemistry : PPB.
2008 Jul; 46(7):655-664. doi:
10.1016/j.plaphy.2008.04.004
. [PMID: 18524611] - Erik R Kline, Dean J Kleinhenz, Bill Liang, Sergey Dikalov, David M Guidot, C Michael Hart, Dean P Jones, Roy L Sutliff. Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.
American journal of physiology. Heart and circulatory physiology.
2008 Jun; 294(6):H2792-804. doi:
10.1152/ajpheart.91447.2007
. [PMID: 18456725] - Nikolaos Patsoukis, Christos D Georgiou. Differentiation of Sclerotinia minor depends on thiol redox state and oxidative stress.
Canadian journal of microbiology.
2008 Jan; 54(1):28-36. doi:
10.1139/w07-108
. [PMID: 18388969] - Jorge L Zurita, Angeles Jos, Ana del Peso, Manuel Salguero, Ana M Cameán, Miguel López-Artíguez, Guillermo Repetto. Toxicological assessment of indium nitrate on aquatic organisms and investigation of the effects on the PLHC-1 fish cell line.
The Science of the total environment.
2007 Nov; 387(1-3):155-65. doi:
10.1016/j.scitotenv.2007.07.057
. [PMID: 17804041] - B H Ali, M S Al Moundhri, M Tag Eldin, A Nemmar, M O Tanira. The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats.
Fundamental & clinical pharmacology.
2007 Oct; 21(5):547-53. doi:
10.1111/j.1472-8206.2007.00495.x
. [PMID: 17868208] - Jorge L Zurita, Angeles Jos, Ana del Peso, Manuel Salguero, Miguel López-Artíguez, Guillermo Repetto. Ecotoxicological effects of the antioxidant additive propyl gallate in five aquatic systems.
Water research.
2007 Jun; 41(12):2599-611. doi:
10.1016/j.watres.2007.02.003
. [PMID: 17382989] - Yung-Chuan Ho, Yu-Chao Chang. Effects of a bacterial lipid byproduct on human pulp fibroblasts in vitro.
Journal of endodontics.
2007 Apr; 33(4):437-41. doi:
10.1016/j.joen.2006.12.022
. [PMID: 17368334] - B Zechmann, G Zellnig, A Urbanek-Krajnc, M Müller. Artificial elevation of glutathione affects symptom development in ZYMV-infected Cucurbita pepo L. plants.
Archives of virology.
2007; 152(4):747-62. doi:
10.1007/s00705-006-0880-2
. [PMID: 17143780] - Sik Lee, Sang-Ok Moon, Won Kim, Mi Jeong Sung, Duk Hoon Kim, Kyung Pyo Kang, Yong Bum Jang, Jung Eun Lee, Kyu Yun Jang, Sang Yong Lee, Sung Kwang Park. Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2006 Aug; 21(8):2085-95. doi:
10.1093/ndt/gfl209
. [PMID: 16705027] - Kyung Sun Lee, Hee Sun Park, Seoung Ju Park, So Ri Kim, Kyung Hoon Min, Sun Mi Jin, Liangchang Li, Yong Chul Lee. An antioxidant modulates expression of receptor activator of NF-kappaB in asthma.
Experimental & molecular medicine.
2006 Jun; 38(3):217-29. doi:
10.1038/emm.2006.27
. [PMID: 16819280] - Kyung Sun Lee, Hee Sun Park, Seoung Ju Park, So Ri Kim, Kyung Hoon Min, Sun Mi Jin, Kwang-Hyun Park, Uh-Hyun Kim, Chan Young Kim, Yong Chul Lee. A prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, regulates vascular permeability by reducing vascular endothelial growth factor expression in asthma.
Molecular pharmacology.
2005 Nov; 68(5):1281-90. doi:
10.1124/mol.105.016055
. [PMID: 16103046] - Eugene Elmore, Shazia Siddiqui, Meena Navidi, Vernon E Steele, J Leslie Redpath. Correlation of in vitro chemopreventive efficacy data from the human epidermal cell assay with animal efficacy data and clinical trial plasma levels.
Journal of cellular biochemistry.
2005 Jun; 95(3):571-88. doi:
10.1002/jcb.20426
. [PMID: 15786488] - Tohru Watanabe, Koji Abe, Hirokazu Ishikawa, Yasuteru Iijima. Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery.
Biological & pharmaceutical bulletin.
2004 Mar; 27(3):288-94. doi:
10.1248/bpb.27.288
. [PMID: 14993790] - Katarzyna Winiarska, Jakub Drozak, Michał Wegrzynowicz, Adam K Jagielski, Jadwiga Bryła. Relationship between gluconeogenesis and glutathione redox state in rabbit kidney-cortex tubules.
Metabolism: clinical and experimental.
2003 Jun; 52(6):739-46. doi:
10.1016/s0026-0495(03)00035-0
. [PMID: 12800101] - Halil Ozgüç, Rifat Tokyay, Nevzat Kahveci, Zehra Serdar, Esma Surmen Gur, Ender Korfali. Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (Pringle maneuver) under hypovolemic conditions.
World journal of surgery.
2003 Apr; 27(4):448-54. doi:
10.1007/s00268-002-6551-x
. [PMID: 12658491] - Daune L Crankshaw, Lorelle I Berkeley, Jonathan F Cohen, Frances N Shirota, Herbert T Nagasawa. Double-prodrugs of L-cysteine: differential protection against acetaminophen-induced hepatotoxicity in mice.
Journal of biochemical and molecular toxicology.
2002; 16(5):235-44. doi:
10.1002/jbt.10044
. [PMID: 12439865] - R P Holmes, D G Assimos, D M Wilson, D S Milliner. (L)-2-oxothiazolidine-4-carboxylate in the treatment of primary hyperoxaluria type 1.
BJU international.
2001 Dec; 88(9):858-62. doi:
10.1046/j.1464-4096.2001.02439.x
. [PMID: 11851603] - Y Iimuro, B U Bradford, S Yamashina, I Rusyn, M Nakagami, N Enomoto, H Kono, W Frey, D Forman, D Brenner, R G Thurman. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat.
Hepatology (Baltimore, Md.).
2000 Feb; 31(2):391-8. doi:
10.1002/hep.510310219
. [PMID: 10655262] - G Gullner, I Tóbiás, J Fodor, T Kömives. Elevation of glutathione level and activation of glutathione-related enzymes affect virus infection in tobacco.
Free radical research.
1999 Dec; 31 Suppl(?):S155-61. doi:
10.1080/10715769900301451
. [PMID: 10694054] - J Oiry, J Y Puy, P Mialocq, P Clayette, P Fretier, P Jaccard, N Dereuddre-Bosquet, D Dormont, J L Imbach. Synthesis and in vitro anti-HIV activity in human monocyte-derived macrophages of 2-oxothiazolidine-4(R)-carboxylic acid derivatives.
Journal of medicinal chemistry.
1999 Nov; 42(23):4733-40. doi:
10.1021/jm980289j
. [PMID: 10579837] - A Breborowicz, J Wisniewska, J B Moberly, D G Oreopoulos. l-2-oxothiazolidine-4-carboxylic acid modulates function of peritoneal mesothelial cells in vitro.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1999 Oct; 34(4):663-8. doi:
10.1016/s0272-6386(99)70391-4
. [PMID: 10516347] - L R Pena, D B Hill, C J McClain. Treatment with glutathione precursor decreases cytokine activity.
JPEN. Journal of parenteral and enteral nutrition.
1999 Jan; 23(1):1-6. doi:
10.1177/014860719902300101
. [PMID: 9888410] - P K Rudra, H E Krokan. Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid sensitive- and resistant human tumor cells.
Anticancer research.
1999 Jan; 19(1A):461-9. doi:
"
. [PMID: 10226583] - B Y Poon, C M Goddard, C D Leaf, J A Russell, K R Walley. L-2-Oxothiazolidine-4-carboxylic acid prevents endotoxin-induced cardiac dysfunction.
American journal of respiratory and critical care medicine.
1998 Oct; 158(4):1109-13. doi:
10.1164/ajrccm.158.4.9702043
. [PMID: 9769268] - P R Gwilt, L E Radick, X Y Li, J J Whalen, C D Leaf. Pharmacokinetics of 2-oxothiazolidine-4-carboxylate, a cysteine prodrug, and cysteine.
Journal of clinical pharmacology.
1998 Oct; 38(10):945-50. doi:
10.1002/j.1552-4604.1998.tb04391.x
. [PMID: 9807976] - J B Moberly, J Logan, P R Borum, K O Story, L E Webb, S V Jassal, L Mupas, H Rodela, G A Alghamdi, J E Moran, M Wolfson, L Martis, D G Oreopoulos. Elevation of whole-blood glutathione in peritoneal dialysis patients by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug (Procysteine).
Journal of the American Society of Nephrology : JASN.
1998 Jun; 9(6):1093-9. doi:
10.1681/asn.v961093
. [PMID: 9621294] - P W Baker, A M Rofe, R Bais. The effect of (L)-cysteine and (L)-2-oxothiazolidine-4-carboxylic acid (OTZ) on urinary oxalate excretion: studies using a hyperoxaluric rat model.
The Journal of urology.
1998 Jun; 159(6):2177-81. doi:
NULL
. [PMID: 9598565] - M Liu, J C Pelling, J Ju, E Chu, D E Brash. Antioxidant action via p53-mediated apoptosis.
Cancer research.
1998 Apr; 58(8):1723-9. doi:
"
. [PMID: 9563490] - P Barditch-Crovo, D Noe, G Skowron, M Lederman, R C Kalayjian, P Borum, R Buier, W B Rowe, D Goldberg, P Lietman. A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus.
Journal of clinical pharmacology.
1998 Apr; 38(4):357-63. doi:
10.1002/j.1552-4604.1998.tb04435.x
. [PMID: 9590463] - J A Vita, B Frei, M Holbrook, N Gokce, C Leaf, J F Keaney. L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease.
The Journal of clinical investigation.
1998 Mar; 101(6):1408-14. doi:
10.1172/jci1155
. [PMID: 9502783] - M Rosenblat, M Aviram. Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: in vitro and in vivo studies.
Free radical biology & medicine.
1998 Jan; 24(2):305-17. doi:
10.1016/s0891-5849(97)00231-1
. [PMID: 9433906] - X Chen, R L Schecter, O W Griffith, M A Hayward, L C Alpert, G Batist. Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1998 Jan; 4(1):131-8. doi:
NULL
. [PMID: 9516961] - K S Srivenugopal, F Ali-Osman. Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues.
Cancer letters.
1997 Jul; 117(1):105-11. doi:
10.1016/s0304-3835(97)00210-3
. [PMID: 9233839] - R P Holmes, D G Assimos, C D Leaf, J J Whalen. The effects of (L)-2-oxothiazolidine-4-carboxylate on urinary oxalate excretion.
The Journal of urology.
1997 Jul; 158(1):34-7. doi:
10.1097/00005392-199707000-00008
. [PMID: 9186317] - R Lüthen, J H Grendell, D Häussinger, C Niederau. Beneficial effects of L-2-oxothiazolidine-4-carboxylate on cerulein pancreatitis in mice.
Gastroenterology.
1997 May; 112(5):1681-91. doi:
10.1016/s0016-5085(97)70051-9
. [PMID: 9136848] - A M Kalergis, C B López, M I Becker, M I Díaz, J Sein, J A Garbarino, A E De Ioannes. Modulation of fatty acid oxidation alters contact hypersensitivity to urushiols: role of aliphatic chain beta-oxidation in processing and activation of urushiols.
The Journal of investigative dermatology.
1997 Jan; 108(1):57-61. doi:
10.1111/1523-1747.ep12285632
. [PMID: 8980288] - J P Fawcett, B Schiller, R Jiang, J Moran, R J Walker. Supplementation with L-2-oxothiazolidine-4-carboxylic acid, a cysteine precursor, does not protect against lipid peroxidation in puromycin aminonucleoside-induced nephropathy.
Experimental nephrology.
1996 Jul; 4(4):248-52. doi:
NULL
. [PMID: 8864728] - D M Rose, S N Hochwald, L E Harrison, M Burt. Selective glutathione repletion with oral oxothiazolidine carboxylate (OTZ) in the radiated tumor-bearing rat.
The Journal of surgical research.
1996 May; 62(2):224-8. doi:
10.1006/jsre.1996.0199
. [PMID: 8632643] - S Baruchel, T Wang, R Farah, M Jamali, G Batist. In vivo selective modulation of tissue glutathione in a rat mammary carcinoma model.
Biochemical pharmacology.
1995 Oct; 50(9):1505-8. doi:
10.1016/0006-2952(95)02063-2
. [PMID: 7503802] - M G Sousadias, T K Smith. Toxicity and growth-promoting potential of spermine when fed to chicks.
Journal of animal science.
1995 Aug; 73(8):2375-81. doi:
10.2527/1995.7382375x
. [PMID: 8567475] - A Jain, D C Madsen, P A Auld, W W Frayer, M K Schwartz, A Meister, J Mårtensson. L-2-oxothiazolidine-4-carboxylate, a cysteine precursor, stimulates growth and normalizes tissue glutathione concentrations in rats fed a sulfur amino acid-deficient diet.
The Journal of nutrition.
1995 Apr; 125(4):851-6. doi:
10.1093/jn/125.4.851
. [PMID: 7722686] - H H Bohets, M N Van Thielen, I Van der Biest, G F Van Landeghem, P C D'Haese, E J Nouwen, M E De Broe, P J Dierickx. Cytotoxicity of mercury compounds in LLC-PK1, MDCK and human proximal tubular cells.
Kidney international.
1995 Feb; 47(2):395-403. doi:
10.1038/ki.1995.52
. [PMID: 7723229] - P W Baker, R Bais, A M Rofe. The efficacy of (L)-2-oxothiazolidine-4-carboxylate (OTC) and (L)-cysteine in reducing urinary oxalate excretion.
The Journal of urology.
1994 Dec; 152(6 Pt 1):2139-46. doi:
10.1016/s0022-5347(17)32339-x
. [PMID: 7966703] - B A Neuschwander-Tetri, M Barnidge, C G Janney. Cerulein-induced pancreatic cysteine depletion: prevention does not diminish acute pancreatitis in the mouse.
Gastroenterology.
1994 Sep; 107(3):824-30. doi:
10.1016/0016-5085(94)90133-3
. [PMID: 8076769] - L E Webb, M Gechman, K Story. Determination of L-2-oxothiazolidine-4-carboxylic acid (Procysteine) in human plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications.
1994 Apr; 654(2):257-62. doi:
10.1016/0378-4347(94)00021-2
. [PMID: 8044286] - E F Zimmerman, R B Potturi, E Resnick, J E Fisher. Role of oxygen free radicals in cocaine-induced vascular disruption in mice.
Teratology.
1994 Mar; 49(3):192-201. doi:
10.1002/tera.1420490315
. [PMID: 8059426] - S Boesgaard, J Aldershvile, H E Poulsen, S Loft, M E Anderson, A Meister. Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels.
Circulation research.
1994 Jan; 74(1):115-20. doi:
10.1161/01.res.74.1.115
. [PMID: 8261584] - D Gerard-Monnier, S Fougeat, J F Gourvest, J Chaudiére. Partial prevention of glutathione depletion in rats following acute intoxication with diethylmaleate.
Clinical physiology and biochemistry.
1993; 10(1):36-42. doi:
NULL
. [PMID: 8339521] - M Jurima-Romet, H S Huang. Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione.
Biochemical pharmacology.
1992 Nov; 44(9):1803-10. doi:
10.1016/0006-2952(92)90075-t
. [PMID: 1449535] - C G Taylor, P F Bauman, B Sikorski, T M Bray. Elevation of lung glutathione by oral supplementation of L-2-oxothiazolidine-4-carboxylate protects against oxygen toxicity in protein-energy malnourished rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
1992 Sep; 6(12):3101-7. doi:
10.1096/fasebj.6.12.1521740
. [PMID: 1521740] - H Ochi, I Morita, S Murota. Roles of glutathione and glutathione peroxidase in the protection against endothelial cell injury induced by 15-hydroperoxyeicosatetraenoic acid.
Archives of biochemistry and biophysics.
1992 May; 294(2):407-11. doi:
10.1016/0003-9861(92)90704-z
. [PMID: 1314541] - R M Coloso, L L Hirschberger, M H Stipanuk. Uptake and metabolism of L-2-oxo-[35S]thiazolidine-4-carboxylate by rat cells is slower than that of L-[35S]cysteine or L-[35S]methionine.
The Journal of nutrition.
1991 Sep; 121(9):1341-8. doi:
10.1093/jn/121.9.1341
. [PMID: 1880612] - V Ravindranath, M R Boyd. Effect of modulators of glutathione synthesis on the hepatotoxicity of 2-methylfuran.
Biochemical pharmacology.
1991 May; 41(9):1311-8. doi:
10.1016/0006-2952(91)90102-b
. [PMID: 2018563] - P Porta, S Aebi, K Summer, B H Lauterburg. L-2-oxothiazolidine-4-carboxylic acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human.
The Journal of pharmacology and experimental therapeutics.
1991 Apr; 257(1):331-4. doi:
NULL
. [PMID: 2019996] - T Taguchi, R Akagi, T Ubuka. Tissue contents and urinary excretion of taurine after administration of L-cysteine and L-2-oxothiazolidine-4-carboxylate to rats.
Acta medica Okayama.
1990 Jun; 44(3):123-8. doi:
10.18926/amo/30456
. [PMID: 2382577] - M E Anderson, M Underwood, R J Bridges, A Meister. Glutathione metabolism at the blood-cerebrospinal fluid barrier.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
1989 Nov; 3(13):2527-31. doi:
10.1096/fasebj.3.13.2572501
. [PMID: 2572501] - R Goyal, R Tardif, J Brodeur. Influence of a cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid, on the urinary elimination of mercapturic acids of ethylene oxide, dibromoethane, and acrylonitrile: a dose-effect study.
Canadian journal of physiology and pharmacology.
1989 Mar; 67(3):207-12. doi:
10.1139/y89-035
. [PMID: 2663124] - S K Duddy, M T Hsia. Alteration of precocene II-induced hepatotoxicity by modulation of hepatic glutathione levels.
Chemico-biological interactions.
1989; 71(2-3):187-99. doi:
10.1016/0009-2797(89)90034-3
. [PMID: 2598296] - M T Moslen, R F Whitehead, A E Ferguson, M F Kanz. Protection by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug, against 1,1-dichloroethylene hepatotoxicity in rats is associated with decreases in toxin metabolism and cytochrome P-450.
The Journal of pharmacology and experimental therapeutics.
1989 Jan; 248(1):157-63. doi:
NULL
. [PMID: 2913268] - M T Moslen, B L Harper, D Roy. Effects of a cysteine precursor, L-2-oxothiazolidine-carboxylate, nutritional status, and sex on tissue glutathione and hepatic GSH-utilizing enzymes of CD-1 mice.
Research communications in chemical pathology and pharmacology.
1988 Jul; 61(1):49-63. doi:
NULL
. [PMID: 3175343] - R K Fidelus. The generation of oxygen radicals: a positive signal for lymphocyte activation.
Cellular immunology.
1988 Apr; 113(1):175-82. doi:
10.1016/0008-8749(88)90015-9
. [PMID: 3365770] - R Goyal, J Brodeur. Effect of a cysteine prodrug (L-2-oxothiazolidine-4-carboxylic acid) on the metabolism and toxicity of bromobenzene: a repeated exposure study.
Journal of toxicology and environmental health.
1987; 21(3):325-40. doi:
10.1080/15287398709531022
. [PMID: 3586063] - H Nishina, J Ohta, T Ubuka. Effect of L-2-oxothiazolidine-4-carboxylate administration on glutathione and cysteine concentrations in guinea pig liver and kidney.
Physiological chemistry and physics and medical NMR.
1987; 19(1):9-13. doi:
NULL
. [PMID: 3615644] - A Meister, M E Anderson, O Hwang. Intracellular cysteine and glutathione delivery systems.
Journal of the American College of Nutrition.
1986; 5(2):137-51. doi:
10.1080/07315724.1986.10720121
. [PMID: 3722629] - M B Bailie, J H Smith, J F Newton, J B Hook. Mechanism of chloroform nephrotoxicity. IV. Phenobarbital potentiation of in vitro chloroform metabolism and toxicity in rabbit kidneys.
Toxicology and applied pharmacology.
1984 Jun; 74(2):285-92. doi:
10.1016/0041-008x(84)90153-4
. [PMID: 6740677] - L R Pohl, J W George, H Satoh. Strain and sex differences in chloroform-induced nephrotoxicity. Different rates of metabolism of chloroform to phosgene by the mouse kidney.
Drug metabolism and disposition: the biological fate of chemicals.
1984 May; 12(3):304-8. doi:
NULL
. [PMID: 6145557] - J M Williamson, A Meister. Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate.
Proceedings of the National Academy of Sciences of the United States of America.
1981 Feb; 78(2):936-9. doi:
10.1073/pnas.78.2.936
. [PMID: 6940159]