Zacopride (BioDeep_00000275641)

   


代谢物信息卡片


(±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamidehydrochloride

化学式: C15H20ClN3O2 (309.124397)
中文名称: 查可必利
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: ClC1=CC(C(O)=NC2CN3CCC2CC3)=C(OC)C=C1N
InChI: InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)

描述信息

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents

同义名列表

2 个代谢物同义名

(±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamidehydrochloride; Zacopride



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Qinghua Liu, Jiaxing Sun, Lijun Zhang, Yanwu Xu, Bowei Wu, Jimin Cao. The Agonist of Inward Rectifier Potassium Channel (IK1) Attenuates Rat Reperfusion Arrhythmias Linked to CaMKII Signaling. International heart journal. 2021; 62(6):1348-1357. doi: 10.1536/ihj.21-379. [PMID: 34853227]
  • Cheng-Fang Liu, Qing-Hua Liu, En-Li Liu, Xu-Wen Zhai, Li Zhang, Tian-E Luo, Wei-Fang Zhang, Qi-Long Feng, Xiang-Li Cui, Zhi-Qing Zhao, Ji-Min Cao, Bo-Wei Wu. Activation of IK1 channel by zacopride attenuates left ventricular remodeling in rats with myocardial infarction. Journal of cardiovascular pharmacology. 2014 Oct; 64(4):345-56. doi: 10.1097/fjc.0000000000000127. [PMID: 25286360]
  • Li Zhang, Qinghua Liu, Chengfang Liu, Xuwen Zhai, Qilong Feng, Ruiling Xu, Xiangli Cui, Zhiqing Zhao, Jimin Cao, Bowei Wu. Zacopride selectively activates the Kir2.1 channel via a PKA signaling pathway in rat cardiomyocytes. Science China. Life sciences. 2013 Sep; 56(9):788-96. doi: 10.1007/s11427-013-4531-z. [PMID: 23929001]
  • Paolo Magnani, Anita Conforti, Elisabetta Zanolin, Marta Marzotto, Paolo Bellavite. Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice. Psychopharmacology. 2010 Jul; 210(4):533-45. doi: 10.1007/s00213-010-1855-2. [PMID: 20401745]
  • Hyun Chul Lim, Young Gyun Kim, Jung Hyun Lim, Hee Sun Kim, Hyojin Park. Effect of itopride hydrochloride on the ileal and colonic motility in guinea pig in vitro. Yonsei medical journal. 2008 Jun; 49(3):472-8. doi: 10.3349/ymj.2008.49.3.472. [PMID: 18581598]
  • Hans H Maurer. Role of gas chromatography-mass spectrometry with negative ion chemical ionization in clinical and forensic toxicology, doping control, and biomonitoring. Therapeutic drug monitoring. 2002 Apr; 24(2):247-54. doi: 10.1097/00007691-200204000-00007. [PMID: 11897971]
  • E Doucet, M C Miquel, A Nosjean, D Vergé, M Hamon, M B Emerit. Immunolabeling of the rat central nervous system with antibodies partially selective of the short form of the 5-HT3 receptor. Neuroscience. 2000; 95(3):881-92. doi: 10.1016/s0306-4522(99)00494-7. [PMID: 10670455]
  • E Doucet, M Hamon, M B Emerit. Immunolabelling of the rat intestinal tract with antibodies specific to the long form of the 5-hydroxytryptamine3 receptor. Neuroscience. 1998 Dec; 87(3):691-707. doi: 10.1016/s0306-4522(98)00184-5. [PMID: 9758234]
  • J Ge, J M Barnes, P Towers, N M Barnes. Distribution of S(-)-zacopride-insensitive [125I]R(+)-zacopride binding sites in the rat brain and peripheral tissues. European journal of pharmacology. 1997 Aug; 332(3):307-12. doi: 10.1016/s0014-2999(97)01091-1. [PMID: 9300265]
  • J Ge, P Towers, A C Patel, N M Barnes. [125I]S(-)-zacopride labels a novel 5-hydroxytryptamine sensitive recognition site in rat duodenum and ileum. European journal of pharmacology. 1996 Apr; 300(1-2):113-7. doi: 10.1016/0014-2999(95)00854-3. [PMID: 8741175]
  • H Lefebvre, V Contesse, C Delarue, J M Kuhn, H Vaudry, L M Wolf. Lack of effect of the serotonin4 receptor agonist zacopride on ACTH secretion in normal men. European journal of clinical pharmacology. 1996; 51(1):49-51. doi: 10.1007/s002280050159. [PMID: 8880051]
  • J Girault, D Longueville, L Ntzanis, S Couffin, J B Fourtillan. Quantitative measurement of zacopride in human plasma and urine by combined gas chromatography/negative ion chemical ionization mass spectrometry. Biological mass spectrometry. 1994 Sep; 23(9):572-80. doi: 10.1002/bms.1200230907. [PMID: 7948050]
  • H Lefebvre, V Contesse, C Delarue, C Soubrane, A Legrand, J M Kuhn, L M Wolf, H Vaudry. Effect of the serotonin-4 receptor agonist zacopride on aldosterone secretion from the human adrenal cortex: in vivo and in vitro studies. The Journal of clinical endocrinology and metabolism. 1993 Dec; 77(6):1662-6. doi: 10.1210/jcem.77.6.8263156. [PMID: 8263156]
  • F J Kidd, J C Levy, M Nielsen, M Hamon, H Gozlan. Characterisation of the non-5-HT3 high-affinity 'R' binding site for (R)-zacopride in brain and other tissues. European journal of pharmacology. 1993 Sep; 247(1):45-56. doi: 10.1016/0922-4106(93)90136-w. [PMID: 8258360]
  • L Oosterbosch, M von der Ohe, M A Valdovinos, L J Kost, S F Phillips, M Camilleri. Effects of serotonin on rat ileocolonic transit and fluid transfer in vivo: possible mechanisms of action. Gut. 1993 Jun; 34(6):794-8. doi: 10.1136/gut.34.6.794. [PMID: 8100206]
  • J C Gordon, D S Barefoot, N S Sarbin, L M Pinkus. [3H]zacopride binding to 5-hydroxytryptamine3 sites on partially purified rabbit enteric neuronal membranes. The Journal of pharmacology and experimental therapeutics. 1989 Dec; 251(3):962-8. doi: NULL. [PMID: 2600824]