vesamicol (BioDeep_00000275638)

   


代谢物信息卡片


vesamicol

化学式: C17H25NO (259.1936)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 95.33%

分子结构信息

SMILES: C1CCC(C(C1)N2CCC(CC2)C3=CC=CC=C3)O
InChI: InChI=1S/C17H25NO/c19-17-9-5-4-8-16(17)18-12-10-15(11-13-18)14-6-2-1-3-7-14/h1-3,6-7,15-17,19H,4-5,8-13H2/t16-,17-/m1/s1

描述信息

D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
(-)-Vesamicol (AH5183) is an inhibitor of acetylcholine transport into synaptic vesicles, with the IC50 of 75 nM[1]. (-)-Vesamicol can be used for release and recycling of synaptic vesicles study[1].
(-)-Vesamicol (AH5183) is an inhibitor of acetylcholine transport into synaptic vesicles, with the IC50 of 75 nM[1]. (-)-Vesamicol can be used for release and recycling of synaptic vesicles study[1].

同义名列表

3 个代谢物同义名

vesamicol; AH5183; (-)-Vesamicol



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Zhude Tu, Xiang Zhang, Hongjun Jin, Xuyi Yue, Prashanth K Padakanti, Lihai Yu, Hui Liu, Hubert P Flores, Kota Kaneshige, Stanley M Parsons, Joel S Perlmutter. Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter. Bioorganic & medicinal chemistry. 2015 Aug; 23(15):4699-4709. doi: 10.1016/j.bmc.2015.05.058. [PMID: 26138195]
  • Kazuma Ogawa, Kazuhiro Shiba, Nasima Akhter, Mitsuyoshi Yoshimoto, Kohshin Washiyama, Seigo Kinuya, Keiichi Kawai, Hirofumi Mori. Evaluation of radioiodinated vesamicol analogs for sigma receptor imaging in tumor and radionuclide receptor therapy. Cancer science. 2009 Nov; 100(11):2188-92. doi: 10.1111/j.1349-7006.2009.01279.x. [PMID: 19659515]
  • Dietlind Sorger, Matthias Scheunemann, Udo Grossmann, Steffen Fischer, Johnny Vercouille, Achim Hiller, Barbara Wenzel, Ali Roghani, Reinhard Schliebs, Peter Brust, Osama Sabri, Jörg Steinbach. A new 18F-labeled fluoroacetylmorpholino derivative of vesamicol for neuroimaging of the vesicular acetylcholine transporter. Nuclear medicine and biology. 2008 Feb; 35(2):185-95. doi: 10.1016/j.nucmedbio.2007.10.004. [PMID: 18312828]
  • Wen-Kung Lee, Shung-Te Kao, I-Min Liu, Juei-Tang Cheng. Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats. Clinical and experimental pharmacology & physiology. 2006 Jan; 33(1-2):27-32. doi: 10.1111/j.1440-1681.2006.04319.x. [PMID: 16445695]
  • Mohamed M Hefnawy, Hassan Y Aboul-Enein. A validated LC method for the determination of vesamicol enantiomers in human plasma using vancomycin chiral stationary phase and solid phase extraction. Journal of pharmaceutical and biomedical analysis. 2004 May; 35(3):535-43. doi: 10.1016/j.jpba.2004.01.017. [PMID: 15137978]
  • Meng Zhou, James T Stewart. Enantioseparation of vesamicol in human serum by capillary electrophoresis with solid phase extraction and sulfated-beta-cyclodextrin. Journal of pharmaceutical and biomedical analysis. 2002 Oct; 30(3):443-9. doi: 10.1016/s0731-7085(02)00219-4. [PMID: 12367668]
  • Shorong-Shii Liou, I-Min Liu, Jen-Hao Hsu, Yang-Chang Wu, Sheng-Fa Hsu, Juei-Tang Chen. Release of acetylcholine by Die-Huang-Wan to enhance insulin secretion for lowering plasma glucose in Wistar rats. Autonomic neuroscience : basic & clinical. 2002 Sep; 100(1-2):21-6. doi: 10.1016/s1566-0702(02)00138-8. [PMID: 12422956]
  • M Israël, B Lesbats, M Tomasi, S Ohkuma. Enhanced acetylcholine release from cells that have more 15-kDa proteolipid in their membrane, a constituent V-ATPase, and mediatophore. Journal of neurochemistry. 1998 Aug; 71(2):630-5. doi: 10.1046/j.1471-4159.1998.71020630.x. [PMID: 9681453]
  • S M Efange, A P Kamath, A B Khare, M P Kung, R H Mach, S M Parsons. N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. Journal of medicinal chemistry. 1997 Nov; 40(24):3905-14. doi: 10.1021/jm970326r. [PMID: 9397171]
  • T Sakamoto, A Tanaka, Y Nakahara. Hair analysis for drugs of abuse XII. Determination of PCP and its major metabolites, PCHP and PPC, in rat hair after administration of PCP. Journal of analytical toxicology. 1996 Mar; 20(2):124-30. doi: 10.1093/jat/20.2.124. [PMID: 8868405]
  • M R Marien, J W Richard, C Allaire, C A Altar. Suppression of in vivo neostriatal acetylcholine release by vesamicol: evidence for a functional role of vesamicol receptors in brain. Journal of neurochemistry. 1991 Dec; 57(6):1878-83. doi: 10.1111/j.1471-4159.1991.tb06398.x. [PMID: 1658227]
  • D H Otero, F Wilbekin, E M Meyer. Effects of 4-(2-hydroxyethyl)-1-piperazine-ethanesulfonic acid (AH5183) on rat cortical synaptosome choline uptake, acetylcholine storage and release. Brain research. 1985 Dec; 359(1-2):208-14. doi: 10.1016/0006-8993(85)91430-1. [PMID: 4075144]