Tranilast (trans-) (BioDeep_00000275633)
代谢物信息卡片
Tranilast (trans-)
化学式: C18H17NO5 (327.1107)
中文名称:
谱图信息:
最多检出来源 Astragalus membranaceus(plant) 100%
分子结构信息
SMILES: COc1ccc(C=CC(=O)Nc2ccccc2C(=O)O)cc1OC
InChI:
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Yi Lin, Zhongjie Sun. Antiaging gene Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 β-cells.
Endocrinology.
2012 Jul; 153(7):3029-39. doi:
10.1210/en.2012-1091. [PMID: 22597535] - Eman Said, Shehta A Said, Wagdi F Elkashef, Nariman M Gameil, Elsayed M Ammar. Tranilast ameliorates impaired hepatic functions in Schistosoma mansoni-infected mice.
Inflammopharmacology.
2012 Apr; 20(2):77-87. doi:
10.1007/s10787-011-0117-1. [PMID: 22278738] - Tadafumi Tamura. Olopatadine ophthalmic solution suppresses substance P release in the conjunctivitis models.
Asia Pacific allergy.
2012 Apr; 2(2):115-21. doi:
10.5415/apallergy.2012.2.2.115. [PMID: 22701861] - Yasuhiko Tomino. Mechanisms and interventions in peritoneal fibrosis.
Clinical and experimental nephrology.
2012 Feb; 16(1):109-14. doi:
10.1007/s10157-011-0533-y. [PMID: 21935614] - Michael A Shi, Guo-Ping Shi. Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans.
Frontiers in immunology.
2012; 3(?):7. doi:
10.3389/fimmu.2012.00007. [PMID: 22566893] - Qing-Feng Sun, Ji-Guang Ding, Ji-Fang Sheng, Man-Hua Zhu, Jun-Jie Li, Zi-Ke Sheng, Xiao-Feng Tang. Novel action of 3,4-DAA ameliorating acute liver allograft injury.
Cell biochemistry and function.
2011 Dec; 29(8):673-8. doi:
10.1002/cbf.1805. [PMID: 21932299] - Anne Hertenstein, Theresa Schumacher, Ulrike Litzenburger, Christiane A Opitz, Christine S Falk, Tito Serafini, Wolfgang Wick, Michael Platten. Suppression of human CD4+ T cell activation by 3,4-dimethoxycinnamonyl-anthranilic acid (tranilast) is mediated by CXCL9 and CXCL10.
Biochemical pharmacology.
2011 Sep; 82(6):632-41. doi:
10.1016/j.bcp.2011.06.013. [PMID: 21703247] - Y Tao, L Hu, S Li, Q Liu, X Wu, D Li, P Fu, D Wei, Z Luo. Tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor β/Smad pathways.
Transplantation proceedings.
2011 Jun; 43(5):1985-8. doi:
10.1016/j.transproceed.2011.01.160. [PMID: 21693312] - Aymerick Eudes, Edward E K Baidoo, Fan Yang, Helcio Burd, Masood Z Hadi, F William Collins, Jay D Keasling, Dominique Loqué. Production of tranilast [N-(3',4'-dimethoxycinnamoyl)-anthranilic acid] and its analogs in yeast Saccharomyces cerevisiae.
Applied microbiology and biotechnology.
2011 Feb; 89(4):989-1000. doi:
10.1007/s00253-010-2939-y. [PMID: 20972784] - Sih Min Tan, Yuan Zhang, Alison J Cox, Darren J Kelly, Weier Qi. Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Jan; 26(1):100-10. doi:
10.1093/ndt/gfq355. [PMID: 20573806] - Kyota Aoyagi, Mica Ohara-Imaizumi, Chiyono Nishiwaki, Yoko Nakamichi, Shinya Nagamatsu. Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells.
The Biochemical journal.
2010 Dec; 432(2):375-86. doi:
10.1042/bj20100864. [PMID: 20854263] - C-F Xu, B H Reck, Z Xue, L Huang, K L Baker, M Chen, E P Chen, H E Ellens, V E Mooser, L R Cardon, C F Spraggs, L Pandite. Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.
British journal of cancer.
2010 Apr; 102(9):1371-7. doi:
10.1038/sj.bjc.6605653. [PMID: 20389299] - Rie Ono, Yoto Kagawa, Yuji Takahashi, Masaki Akagi, Chiaki Kamei. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on scratching behavior in mice.
International immunopharmacology.
2010 Mar; 10(3):304-7. doi:
10.1016/j.intimp.2009.11.015. [PMID: 19969104] - Wen-Hsiang Su, Ming-Huei Cheng, Wen-Ling Lee, Tsung-Shan Tsou, Wen-Hsun Chang, Chien-Sheng Chen, Peng-Hui Wang. Nonsteroidal anti-inflammatory drugs for wounds: pain relief or excessive scar formation?.
Mediators of inflammation.
2010; 2010(?):413238. doi:
10.1155/2010/413238. [PMID: 20671960] - Yayoi Saegusa, Chiharu Sadakane, Junichi Koseki, Yoshihiro Hasegawa, Shoichiro Shindo, Hirobumi Maruyama, Yoshio Kase, Shuichi Takeda, Hiroshi Takeda, Tomohisa Hattori. Effect of TJN-331 on anti-Thy1 nephritis in rats via inhibition of transforming growth factor-β1 production.
Biological & pharmaceutical bulletin.
2010; 33(10):1710-5. doi:
10.1248/bpb.33.1710. [PMID: 20930380] - Tomoki Kaneyama, Satoshi Kobayashi, Daiju Aoyagi, Takashi Ehara. Tranilast modulates fibrosis, epithelial-mesenchymal transition and peritubular capillary injury in unilateral ureteral obstruction rats.
Pathology.
2010; 42(6):564-73. doi:
10.3109/00313025.2010.508784. [PMID: 20854076] - Steven C Zammit, Alison J Cox, Renae M Gow, Yuan Zhang, Richard E Gilbert, Henry Krum, Darren J Kelly, Spencer J Williams. Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates.
Bioorganic & medicinal chemistry letters.
2009 Dec; 19(24):7003-6. doi:
10.1016/j.bmcl.2009.09.120. [PMID: 19879136] - Y Tao, L Hu, S Li, Y Bai, Q Liu, Y Jin, D Wei, Z Luo. Tranilast attenuates chronic cyclosporine nephrotoxicity in rats.
Transplantation proceedings.
2009 Dec; 41(10):4373-5. doi:
10.1016/j.transproceed.2009.09.073. [PMID: 20005402] - Ashwani K Khanna. Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis.
Journal of biomedical science.
2009 Jul; 16(?):66. doi:
10.1186/1423-0127-16-66. [PMID: 19604372] - Eswari Vilayur, David C H Harris. Emerging therapies for chronic kidney disease: what is their role?.
Nature reviews. Nephrology.
2009 Jul; 5(7):375-83. doi:
10.1038/nrneph.2009.76. [PMID: 19455178] - Samia Yazid, Egle Solito, Helen Christian, Simon McArthur, Nicolas Goulding, Roderick Flower. Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.
Biochemical pharmacology.
2009 Jun; 77(12):1814-26. doi:
10.1016/j.bcp.2009.03.010. [PMID: 19428336] - Etsuko Hisanaga, Masahiro Nagasawa, Kohjiro Ueki, Rohit N Kulkarni, Masatomo Mori, Itaru Kojima. Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells.
Diabetes.
2009 Jan; 58(1):174-84. doi:
10.2337/db08-0862. [PMID: 18984736] - Shuhei Kawahara, Yasuaki Hata, Takeshi Kita, Ryoichi Arita, Muneki Miura, Shintaro Nakao, Yasutaka Mochizuki, Hiroshi Enaida, Tadahisa Kagimoto, Yoshinobu Goto, Ali Hafezi-Moghadam, Tatsuro Ishibashi. Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins.
Diabetes.
2008 Oct; 57(10):2784-93. doi:
10.2337/db08-0302. [PMID: 18599521] - Ye Tao, Xin Wu, Dan-dan Li, Qi-feng Liu, Hong Bo, Xue-rong Wang. [Experimental study in renal protective effect of tranilast on rats with adriamycin nephropathy].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2008 Jan; 39(1):76-9. doi:
NULL. [PMID: 18390206] - Masahito Onoda, Shigeko Inokuma, Zenro Ikezawa. [Adverse effects of chemical mediator release inhibitors].
Nihon rinsho. Japanese journal of clinical medicine.
2007 Oct; 65 Suppl 8(?):259-66. doi:
NULL. [PMID: 18074547] - J J Inglis, G Criado, M Andrews, M Feldmann, R O Williams, M L Selley. The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.
Rheumatology (Oxford, England).
2007 Sep; 46(9):1428-32. doi:
10.1093/rheumatology/kem160. [PMID: 17644821] - Qihe Xu, Jill T Norman, Shashi Shrivastav, Javier Lucio-Cazana, Jeffrey B Kopp. In vitro models of TGF-beta-induced fibrosis suitable for high-throughput screening of antifibrotic agents.
American journal of physiology. Renal physiology.
2007 Aug; 293(2):F631-40. doi:
10.1152/ajprenal.00379.2006. [PMID: 17494090] - Ying Li, Fu-You Liu, You-Ming Peng, Jun Li, Jun Chen. Mast cell, a promising therapeutic target in tubulointerstitial fibrosis.
Medical hypotheses.
2007; 69(1):99-103. doi:
10.1016/j.mehy.2006.10.059. [PMID: 17257770] - Jun Soma, Kozo Sato, Harutaka Saito, Yoshinori Tsuchiya. Effect of tranilast in early-stage diabetic nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2006 Oct; 21(10):2795-9. doi:
10.1093/ndt/gfl325. [PMID: 16820373] - D J Kelly, Y Zhang, A J Cox, R E Gilbert. Combination therapy with tranilast and angiotensin-converting enzyme inhibition provides additional renoprotection in the remnant kidney model.
Kidney international.
2006 Jun; 69(11):1954-60. doi:
10.1038/sj.ki.5000376. [PMID: 16557218] - Bo Tang, Hui-Ling Liang, Li-Li Tong, Ping Li. Synthesis of ethylenediamine linked beta-cyclodextrin dimer and its analytical application for tranilast determination by spectrofluorimetry.
Bioorganic & medicinal chemistry.
2006 Jun; 14(11):3947-52. doi:
10.1016/j.bmc.2006.01.049. [PMID: 16564175] - Qing-Yong Zhang, Jun-Bo Ge, Jun-Zhu Chen, Jian-Hua Zhu, Liang-Hui Zhang, Chu-Pak Lau, Hung-Fat Tse. Mast cell contributes to cardiomyocyte apoptosis after coronary microembolization.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
2006 May; 54(5):515-23. doi:
10.1369/jhc.5a6804.2005. [PMID: 16344327] - Giorgio Cavallini. Male idiopathic oligoasthenoteratozoospermia.
Asian journal of andrology.
2006 Mar; 8(2):143-57. doi:
10.1111/j.1745-7262.2006.00123.x. [PMID: 16491265] - W Qi, X Chen, S Twigg, T S Polhill, R E Gilbert, C A Pollock. Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells.
Kidney international.
2006 Mar; 69(6):989-95. doi:
10.1038/sj.ki.5000189. [PMID: 16528248] - Jing Lan, Jian Wang, Dan Wu, Yingwu Wang, J Paul Fawcett, Jingkai Gu. Liquid chromatographic/tandem mass spectrometric method for the quantitation of tranilast in human plasma.
Rapid communications in mass spectrometry : RCM.
2006; 20(22):3309-12. doi:
10.1002/rcm.2741. [PMID: 17044126] - Hiroshi Akahori, Tsuguhito Ota, Muneyoshi Torita, Hitoshi Ando, Shuichi Kaneko, Toshinari Takamura. Tranilast prevents the progression of experimental diabetic nephropathy through suppression of enhanced extracellular matrix gene expression.
The Journal of pharmacology and experimental therapeutics.
2005 Aug; 314(2):514-21. doi:
10.1124/jpet.105.084772. [PMID: 15857946] - Jennifer Martin, Darren J Kelly, Sally A Mifsud, Yuan Zhang, Alison J Cox, Fiona See, Henry Krum, Jennifer Wilkinson-Berka, Richard E Gilbert. Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta.
Cardiovascular research.
2005 Feb; 65(3):694-701. doi:
10.1016/j.cardiores.2004.10.041. [PMID: 15664396] - Masaki Mizuno, Hwa-Jin Chung, Ikuro Maruyama, Tadato Tani. Inhibitory effects of bezoar bovis on intimal formation and vascular smooth muscle cell proliferation in rat.
The American journal of Chinese medicine.
2005; 33(3):439-47. doi:
10.1142/s0192415x05003041. [PMID: 16047561] - Patricia J M Best, Peter B Berger, Barry R Davis, Cindy L Grines, H Mehrdad Sadeghi, Brent A Williams, James T Willerson, Jeffrey R Granett, David R Holmes. Impact of mild or moderate chronic kidney disease on the frequency of restenosis: results from the PRESTO trial.
Journal of the American College of Cardiology.
2004 Nov; 44(9):1786-91. doi:
10.1016/j.jacc.2004.07.052. [PMID: 15519008] - Darren J Kelly, Yuan Zhang, Renae Gow, Richard E Gilbert. Tranilast attenuates structural and functional aspects of renal injury in the remnant kidney model.
Journal of the American Society of Nephrology : JASN.
2004 Oct; 15(10):2619-29. doi:
10.1097/01.asn.0000139066.77892.04. [PMID: 15466266] - Seung-Jung Kim, Takahisa Masaki, John K Leypoldt, Craig D Kamerath, S Fazal Mohammad, Alfred K Cheung. Arterial and venous smooth-muscle cells differ in their responses to antiproliferative drugs.
The Journal of laboratory and clinical medicine.
2004 Sep; 144(3):156-62. doi:
10.1016/j.lab.2004.06.002. [PMID: 15454885] - Toshiaki Makino, Yoshiaki Ito, Shin-ya Sasaki, Yuu Fujimura, Yoshihiro Kano. Preventive and curative effects of Gyokuheifu-san, a formula of traditional Chinese medicine, on allergic rhinitis induced with Japanese cedar pollens in guinea pig.
Biological & pharmaceutical bulletin.
2004 Apr; 27(4):554-8. doi:
10.1248/bpb.27.554. [PMID: 15056865] - Sheila A Doggrell, Janet C Wanstall. Vascular chymase: pathophysiological role and therapeutic potential of inhibition.
Cardiovascular research.
2004 Mar; 61(4):653-62. doi:
10.1016/j.cardiores.2003.11.029. [PMID: 14985062] - Takahisa Masaki, Craig D Kamerath, Seung-Jung Kim, John K Leypoldt, Syed F Mohammad, Alfred K Cheung. In vitro pharmacological inhibition of human vascular smooth muscle cell proliferation for the prevention of hemodialysis vascular access stenosis.
Blood purification.
2004; 22(3):307-12. doi:
10.1159/000078785. [PMID: 15256797] - F Bonnet, Z Cao, M E Cooper, A J Cox, D J Kelly, R E Gilbert. Tranilast attenuates vascular hypertrophy, matrix accumulation and growth factor overexpression in experimental diabetes.
Diabetes & metabolism.
2003 Sep; 29(4 Pt 1):386-92. doi:
10.1016/s1262-3636(07)70049-6. [PMID: 14526266] - Hayashi Komura, Hiroshi Matsushima, Kazunobu Ouchi, Mutsunori Shirai, Teruko Nakazawa, Susumu Furukawa. Effects of antiasthma drugs on the growth of Chlamydophila pneumoniae in HEp-2 cells.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2003 Jun; 9(2):160-4. doi:
10.1007/s10156-003-0239-5. [PMID: 12825116] - Toshiaki Makino, Yasuyuki Furuta, Hannosuke Wakushima, Hajime Fujii, Ken-ichi Saito, Yoshihiro Kano. Anti-allergic effect of Perilla frutescens and its active constituents.
Phytotherapy research : PTR.
2003 Mar; 17(3):240-3. doi:
10.1002/ptr.1115. [PMID: 12672153] - Hwa-Jin Chung, Dong-Wook Kim, Ikuro Maruyama, Tadato Tani. Effects of traditional Chinese formulations on rat carotid artery injured by balloon endothelial denudation.
The American journal of Chinese medicine.
2003; 31(2):201-12. doi:
10.1142/s0192415x03000941. [PMID: 12856859] - Sally Mifsud, Darren J Kelly, Weier Qi, Yuan Zhang, Carol A Pollock, Jennifer L Wilkinson-Berka, Richard E Gilbert. Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy.
Nephron. Physiology.
2003; 95(4):p83-91. doi:
10.1159/000074845. [PMID: 14694265] - Tsutoma Yasukawa, Hideya Kimura, Jin Dong, Yasuhiko Tabata, Hideki Miyamoto, Yoshihito Honda, Yuichiro Ogura. Effect of tranilast on proliferation, collagen gel contraction, and transforming growth factor beta secretion of retinal pigment epithelial cells and fibroblasts.
Ophthalmic research.
2002 Jul; 34(4):206-12. doi:
10.1159/000063884. [PMID: 12297693] - Sumiyo Kondo, Masayuki Yamamoto, Atsushi Takeuchi, Hiroko Suzuki, Masayoshi Iwaki. [Anti-allergic drugs inhibit the proliferation of human Tenon's capsule fibroblast and maintain the experimental filtering blebs on rabbit eyes].
Nippon Ganka Gakkai zasshi.
2002 Jun; 106(6):325-31. doi:
NULL. [PMID: 12138693] - Berthold Hocher, Michael Godes, Jan Olivier, Joachim Weil, Thomas Eschenhagen, Torsten Slowinski, Hans-H Neumayer, Christian Bauer, Martin Paul, Yigal M Pinto. Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension.
Journal of hypertension.
2002 Apr; 20(4):745-51. doi:
10.1097/00004872-200204000-00034. [PMID: 11910312] - Dong-Wook Kim, Hwa-Jin Chung, Katsuya Nose, Ikuro Maruyama, Tadato Tani. Preventive effects of a traditional Chinese formulation, Chaihu-jia-Longgu-Muli-tang, on intimal thickening of carotid artery injured by balloon endothelial denudation in rats.
The Journal of pharmacy and pharmacology.
2002 Apr; 54(4):571-5. doi:
10.1211/0022357021778691. [PMID: 11999136] - Jun Soma, Takashi Sugawara, Yee-Der Huang, Jun Nakajima, Minoru Kawamura. Tranilast slows the progression of advanced diabetic nephropathy.
Nephron.
2002; 92(3):693-8. doi:
10.1159/000064071. [PMID: 12372957] - H Suzuki, M Iwaki, M Imagawa, M Takeuchi. [Anti-allergic drugs inhibit the proliferation of bovine lens epithelial cells in culture].
Nippon Ganka Gakkai zasshi.
2001 Aug; 105(8):517-23. doi:
NULL. [PMID: 11558161] - A Miyajima, T Asano, T Asano, I Yoshimura, K Seta, M Hayakawa. Tranilast ameliorates renal tubular damage in unilateral ureteral obstruction.
The Journal of urology.
2001 May; 165(5):1714-8. doi:
NULL. [PMID: 11342962] - H Hibi, K Kato, K Mitsui, T Taki, Y Yamada, N Honda, H Fukatsu, M Yamamoto. The treatment with tranilast, a mast cell blocker, for idiopathic oligozoospermia.
Archives of andrology.
2001 Apr; 47(2):107-11. doi:
10.1080/014850101316901307. [PMID: 11554681] - K Yanagihara, K Matsuoka, N Hanaoka, K Toda, K Muro. Inflammatory endobronchial stenosis.
The Annals of thoracic surgery.
2001 Feb; 71(2):698-9. doi:
10.1016/s0003-4975(00)01942-1. [PMID: 11235731]
