RU 24969 (BioDeep_00000275623)

   


代谢物信息卡片


5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

化学式: C14H16N2O (228.12625659999998)
中文名称: 5-甲氧基-3-(1,2,3,6-四氢吡啶-4-基)-1H-吲哚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC2=C(C=C1)NC=C2C3=CCNCC3
InChI: InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3

描述信息

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion[1].

同义名列表

2 个代谢物同义名

5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole; RU 24969



数据库引用编号

8 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Kally C O'Reilly, Michelle Connor, Jamie Pierson, Lauren C Shuffrey, Randy D Blakely, Susanne E Ahmari, Jeremy Veenstra-VanderWeele. Serotonin 5-HT1B receptor-mediated behavior and binding in mice with the overactive and dysregulated serotonin transporter Ala56 variant. Psychopharmacology. 2021 Apr; 238(4):1111-1120. doi: 10.1007/s00213-020-05758-8. [PMID: 33511450]
  • Cecilia Mattsson, Peder Svensson, Henning Boettcher, Clas Sonesson. Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists. European journal of medicinal chemistry. 2013 May; 63(?):578-88. doi: 10.1016/j.ejmech.2013.03.006. [PMID: 23542166]
  • Nancy A Shanahan, Kerri A Holick Pierz, Virginia L Masten, Christian Waeber, Mark Ansorge, Jay A Gingrich, Mark A Geyer, Rene Hen, Stephanie C Dulawa. Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice. Biological psychiatry. 2009 Mar; 65(5):401-8. doi: 10.1016/j.biopsych.2008.09.026. [PMID: 19013555]
  • F J Bosker, K E van Esseveldt, A A Klompmakers, H G Westenberg. Chronic treatment with fluvoxamine by osmotic minipumps fails to induce persistent functional changes in central 5-HT1A and 5-HT1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats. Psychopharmacology. 1995 Feb; 117(3):358-63. doi: 10.1007/bf02246110. [PMID: 7770611]
  • P A Rittenhouse, E A Bakkum, A D Levy, Q Li, M Carnes, L D van de Kar. Evidence that ACTH secretion is regulated by serotonin2A/2C (5-HT2A/2C) receptors. The Journal of pharmacology and experimental therapeutics. 1994 Dec; 271(3):1647-55. doi: NULL. [PMID: 7996480]
  • P A Rittenhouse, E A Bakkum, A D Levy, Q Li, J M Yracheta, K Kunimoto, L D van de Kar. Central stimulation of renin secretion through serotonergic, noncardiovascular mechanisms. Neuroendocrinology. 1994 Aug; 60(2):205-14. doi: 10.1159/000126754. [PMID: 7969778]
  • P A Rittenhouse, A D Levy, Q Li, C L Bethea, L D Van de Kar. Neurons in the hypothalamic paraventricular nucleus mediate the serotonergic stimulation of prolactin secretion via 5-HT1c/2 receptors. Endocrinology. 1993 Aug; 133(2):661-7. doi: 10.1210/endo.133.2.8344205. [PMID: 8344205]
  • P A Rittenhouse, Q Li, A D Levy, L D Van de Kar. Neurons in the hypothalamic paraventricular nucleus mediate the serotonergic stimulation of renin secretion. Brain research. 1992 Oct; 593(1):105-13. doi: 10.1016/0006-8993(92)91270-o. [PMID: 1458311]
  • D Laude, V Baudrie, G R Martin, F Chaouloff. Effects of the 5-HT1 receptor agonists DP-5-CT, CGS 12066B, and RU 24969 on plasma adrenaline and glucose levels in the rat. Naunyn-Schmiedeberg's archives of pharmacology. 1990 Oct; 342(4):378-81. doi: 10.1007/bf00169452. [PMID: 2255331]
  • L D Van de Kar, M Carnes, R J Maslowski, A M Bonadonna, P A Rittenhouse, K Kunimoto, R A Piechowski, C L Bethea. Neuroendocrine evidence for denervation supersensitivity of serotonin receptors: effects of the 5-HT agonist RU 24969 on corticotropin, corticosterone, prolactin and renin secretion. The Journal of pharmacology and experimental therapeutics. 1989 Nov; 251(2):428-34. doi: NULL. [PMID: 2553918]
  • G Di Renzo, S Amoroso, M Taglialatela, L Canzoniero, V Basile, A Fatatis, L Annunziato. Pharmacological characterization of serotonin receptors involved in the control of prolactin secretion. European journal of pharmacology. 1989 Mar; 162(2):371-3. doi: 10.1016/0014-2999(89)90302-6. [PMID: 2524399]
  • L D Van de Kar, S A Lorens, J H Urban, C L Bethea. Effect of selective serotonin (5-HT) agonists and 5-HT2 antagonist on prolactin secretion. Neuropharmacology. 1989 Mar; 28(3):299-305. doi: 10.1016/0028-3908(89)90107-x. [PMID: 2524677]
  • C Euvrard, J R Boissier. Biochemical assessment of the central 5-HT agonist activity of RU 24969 (a piperidinyl indole). European journal of pharmacology. 1980 Apr; 63(1):65-72. doi: 10.1016/0014-2999(80)90117-x. [PMID: 6155275]