Pizotifen (BioDeep_00000275618)

   


代谢物信息卡片


Pizotyline

化学式: C19H21NS (295.13946260000006)
中文名称: 苯噻啶
谱图信息: 最多检出来源 Viridiplantae(plant) 65%

分子结构信息

SMILES: CN(C4)CCC(C4)=C(c21)c(c3)c(sc3)CCc(cccc2)1
InChI: InChI=1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
N - Nervous system > N02 - Analgesics > N02C - Antimigraine preparations
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
Pizotifen (Pizotyline) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.

同义名列表

3 个代谢物同义名

Pizotifen; Pizotyline; BC-105



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Angela A Huertas-Ceballos, Stuart Logan, Cathy Bennett, Colin Macarthur, Alice E Martin. WITHDRAWN: Pharmacological interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. The Cochrane database of systematic reviews. 2014 Feb; ?(2):CD003017. doi: 10.1002/14651858.cd003017.pub3. [PMID: 24532249]
  • A Huertas-Ceballos, S Logan, C Bennett, C Macarthur. Pharmacological interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. The Cochrane database of systematic reviews. 2008 Jan; ?(1):CD003017. doi: 10.1002/14651858.cd003017.pub2. [PMID: 18254013]
  • Arthur T Strachan, John B Leiper, Ronald J Maughan. Serotonin2C receptor blockade and thermoregulation during exercise in the heat. Medicine and science in sports and exercise. 2005 Mar; 37(3):389-94. doi: 10.1249/01.mss.0000155397.42481.53. [PMID: 15741836]
  • Feras Q Alali, Bassam M Tashtoush, Naji M Najib. Determination of ketotifen in human plasma by LC-MS. Journal of pharmaceutical and biomedical analysis. 2004 Jan; 34(1):87-94. doi: 10.1016/j.japna.2003.08.001. [PMID: 14738922]
  • Joy A Weydert, Thomas M Ball, Melinda F Davis. Systematic review of treatments for recurrent abdominal pain. Pediatrics. 2003 Jan; 111(1):e1-11. doi: 10.1542/peds.111.1.e1. [PMID: 12509588]
  • Piet Borgdorff, Durk Fekkes, Geert Jan Tangelder. Hypotension caused by extracorporeal circulation: serotonin from pump-activated platelets triggers nitric oxide release. Circulation. 2002 Nov; 106(20):2588-93. doi: 10.1161/01.cir.0000036082.04708.83. [PMID: 12427656]
  • A Huertas-Ceballos, C Macarthur, S Logan. Pharmacological interventions for recurrent abdominal pain (RAP) in childhood. The Cochrane database of systematic reviews. 2002; ?(1):CD003017. doi: 10.1002/14651858.cd003017. [PMID: 11869650]
  • T F Meert, W Melis, N Aerts, G Clincke. Antagonism of meta-chlorophenylpiperazine-induced inhibition of exploratory activity in an emergence procedure, the open field test, in rats. Behavioural pharmacology. 1997 Aug; 8(4):353-63. doi: 10.1097/00008877-199708000-00008. [PMID: 9832994]
  • J L Pannier, J J Bouckaert, R A Lefebvre. The antiserotonin agent pizotifen does not increase endurance performance in humans. European journal of applied physiology and occupational physiology. 1995; 72(1-2):175-8. doi: 10.1007/bf00964134. [PMID: 8789590]
  • D Collado, E Aguilar. Further evidence that prolactin secretion in adult female rats is differently modified after neonatal estrogenization or androgenization: responses to methysergide, quipazine, and pizotifen. Physiology & behavior. 1993 Jan; 53(1):161-5. doi: 10.1016/0031-9384(93)90025-b. [PMID: 8434056]
  • E Müller-Schweinitzer, J Rosenthaler. Dihydroergotamine: pharmacokinetics, pharmacodynamics, and mechanism of venoconstrictor action in beagle dogs. Journal of cardiovascular pharmacology. 1987 Jun; 9(6):686-93. doi: . [PMID: 2442535]
  • C M Banki, M Vojnik, Z Papp, Z Kovacs, M Arato. TRH-induced hormonal responses: the effect of pizotifene and naloxone. Pharmacopsychiatry. 1985 Jul; 18(4):267-71. doi: 10.1055/s-2007-1017379. [PMID: 3927332]
  • R Betti, F F Casanueva, S G Cella, E E Müller. Activation of the cholinergic system and growth hormone release in the dog: functional interactions with other neurotransmitters. Acta endocrinologica. 1985 Jan; 108(1):36-43. doi: 10.1530/acta.0.1080036. [PMID: 2982238]
  • R Dolecek, V Janstová. Long-term effect of pizotifen treatment on growth hormone levels of underweight children, including those with anorexia nervosa. Pharmatherapeutica. 1985; 4(2):81-7. doi: NULL. [PMID: 4059293]
  • E Jungmann, P H Althoff, G J Hermann, K Schöffling. The effect of pizotifen, a serotonin antagonist, and of pirenzepine, a muscarinic antagonist, on hormonal responses to metoclopramide in healthy subjects. Arzneimittel-Forschung. 1984; 34(9):1022-4. doi: . [PMID: 6391497]
  • J L Elghozi, D Laude, P Duprat, E Mignot. Pizotifen increases 5-HIAA urinary excretion in male healthy volunteers. European journal of clinical pharmacology. 1984; 27(2):191-6. doi: 10.1007/bf00544044. [PMID: 6209146]
  • G R Van Loon, A Shum, M J Sole. Decreased brain serotonin turnover after short term (two-hour) adrenalectomy in rats: a comparison of four turnover methods. Endocrinology. 1981 Apr; 108(4):1392-402. doi: 10.1210/endo-108-4-1392. [PMID: 6258905]
  • P Clarenbach, E Del Pozo, J Brownell, E Heredia, R Spiegel, H Cramer. Characterization of ergot and non-ergot serotonin antagonists by prolactin and growth hormone profiles during wakefulness and sleep. Brain research. 1980 Dec; 202(2):357-63. doi: 10.1016/0006-8993(80)90147-x. [PMID: 7437907]
  • J J Heikkila, I R Brown. Disaggregation of brain polysomes after LSD in vivo. Involvement of LSD-induced hyperthermia. Neurochemical research. 1979 Dec; 4(6):763-76. doi: 10.1007/bf00964473. [PMID: 44545]
  • G Jonderko, M Neumann, J Lewandowski, B Słowińska-Primus. [Effect of serotonin, histamine and acetylcholine antagonist on serum gastric level]. Polski tygodnik lekarski (Warsaw, Poland : 1960). 1979 Jun; 34(26):1037-8. doi: NULL. [PMID: 388370]
  • J Meier, E Schreier. Human plasma levels of some anti-migraine drugs. Headache. 1976 Jul; 16(3):96-104. doi: 10.1111/j.1526-4610.1976.hed1603096.x. [PMID: 965227]
  • A Fanchamps. [Mechanism of action of drugs currently used in the prevention of migraine]. Minerva medica. 1976 Jun; 67(28):1858-60. doi: NULL. [PMID: 59325]
  • B May. [Carcinoid: diagnosis and therapy]. Deutsche medizinische Wochenschrift (1946). 1975 Oct; 100(42):2163-5. doi: 10.1055/s-0028-1106517. [PMID: 1100341]