naftopidil (BioDeep_00000275603)
natural product
代谢物信息卡片
Naftopidil (Flivas)
化学式: C24H28N2O3 (392.20998180000004)
中文名称: 萘哌地尔
谱图信息:
最多检出来源 Astragalus membranaceus(plant) 75%
分子结构信息
SMILES: C1(=C2C(=CC=C1)C=CC=C2)OCC(CN3CCN(CC3)C4=CC=CC=C4OC)O
InChI: InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia[1][2].
同义名列表
4 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:31891
- KEGGdrug: D01674
- PubChem: 4418
- DrugBank: DB12092
- ChEMBL: CHEMBL142635
- CAS: 57149-07-2
- MoNA: FiehnHILIC002166
- MoNA: FiehnHILIC000598
- MoNA: CCMSLIB00000078448
- PMhub: MS000008298
- medchemexpress: HY-B0391
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Hirokazu Urushiyama, Yasuhiro Terasaki, Shinya Nagasaka, Nariaki Kokuho, Youko Endo, Mika Terasaki, Shinobu Kunugi, Kosuke Makita, Hideaki Isago, Keisuke Hosoki, Kunihiko Souma, Takashi Ishii, Hirotaka Matsuzaki, Yoshihisa Hiraishi, Yu Mikami, Satoshi Noguchi, Hiroyuki Tamiya, Akihisa Mitani, Yasuhiro Yamauchi, Akira Shimizu, Takahide Nagase. Naftopidil reduced the proliferation of lung fibroblasts and bleomycin-induced lung fibrosis in mice.
Journal of cellular and molecular medicine.
2019 05; 23(5):3563-3571. doi:
10.1111/jcmm.14255. [PMID: 30873733] - Hiroshi Takahashi, Shinichi Kubono, Takehiko Taneyama, Kiyotoshi Kuramoto, Hideki Mizutani, Noriko Tanaka, Masaki Yoshida. Post-Marketing Surveillance of Silodosin in Patients with Benign Prostatic Hyperplasia and Poor Response to Existing Alpha-1 Blockers: The SPLASH Study.
Drugs in R&D.
2019 Mar; 19(1):47-55. doi:
10.1007/s40268-018-0258-4. [PMID: 30607819] - Jin-Seok Choi, Jong Chan Byeon, Jeong-Sook Park. Naftopidil-fumaric acid interaction in a solid dispersion system: Improving the dissolution rate and oral absorption of naftopidil in rats.
Materials science & engineering. C, Materials for biological applications.
2019 Feb; 95(?):264-274. doi:
10.1016/j.msec.2018.10.089. [PMID: 30573249] - Yoshihisa Matsukawa, Tsuyoshi Majima, Shun Takai, Yasuhito Funahashi, Masashi Kato, Momokazu Gotoh. What Are Factors Contributing to Improvement of Overactive Bladder Symptoms after Alpha-1 Blocker Treatment in Patients with Both Storage and Voiding Symptoms?.
Urologia internationalis.
2019; 103(4):439-443. doi:
10.1159/000502661. [PMID: 31554005] - Eu Chang Hwang, Shreyas Gandhi, Jae Hung Jung, Mari Imamura, Myung Ha Kim, Ran Pang, Philipp Dahm. Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia.
The Cochrane database of systematic reviews.
2018 10; 10(?):CD007360. doi:
10.1002/14651858.cd007360.pub3. [PMID: 30306544] - Jun-Jun Huang, Zhi-Han Zhang, Fei He, Xia-Wen Liu, Xing-Jie Xu, Li-Jun Dai, Qi-Meng Liu, Mu Yuan. Novel naftopidil derivatives containing methyl phenylacetate and their blocking effects on α1D/1A-adrenoreceptor subtypes.
Bioorganic & medicinal chemistry letters.
2018 02; 28(4):547-551. doi:
10.1016/j.bmcl.2018.01.068. [PMID: 29422390] - Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto, Tsuyoshi Hattori. Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats.
Neurourology and urodynamics.
2017 03; 36(3):604-609. doi:
10.1002/nau.23028. [PMID: 27128660] - Xiawen Liu, Lijun Zhu, Biyun Huang, Junjun Huang, Yi Cai, Liu Zhu, Bo Wu, Xiaojing Fu, Xingfei Zhang, Yi Rong, Qing Xiao, Jiewen Guo, Arong Li, Yifei Guo, Mu Yuan. Poor and enantioselective bioavailability of naftopidil enantiomers is due to extensive and stereoselective metabolism in rat liver.
Journal of pharmaceutical and biomedical analysis.
2017 Jan; 132(?):165-172. doi:
10.1016/j.jpba.2016.09.038. [PMID: 27744175] - Jun-Jun Huang, Yi Cai, Yan-Zhen Yi, Min-Yi Huang, Liu Zhu, Fei He, Xia-Wen Liu, Bi-Yun Huang, Mu Yuan. Pharmaceutical evaluation of naftopidil enantiomers: Rat functional assays in vitro and estrogen/androgen induced rat benign prostatic hyperplasia model in vivo.
European journal of pharmacology.
2016 Nov; 791(?):473-481. doi:
10.1016/j.ejphar.2016.09.009. [PMID: 27615445] - Masaki Yamamoto, Takahiro Shimizu, Shogo Shimizu, Youichirou Higashi, Kumiko Nakamura, Mikiya Fujieda, Motoaki Saito. Effect of naftopidil on brain noradrenaline-induced decrease in arginine-vasopressin secretion in rats.
Journal of pharmacological sciences.
2016 Sep; 132(1):86-91. doi:
10.1016/j.jphs.2016.09.002. [PMID: 27666018] - Noriaki Utsunomiya, Keiyu Matsumoto, Hiroyuki Tsunemori, Koei Muguruma, Mutsushi Kawakita, Yuki Kamiyama, Sojun Kanamaru, Noriyuki Ito, Hideki Tsukazaki, Toshiaki Shirahase, Takeshi Takahashi. [A Crossover Comparison Study on Lower Urinary Tract Symptoms with Overactive Bladder Secondary to Benign Prostatic Hyperplasia: Naftopidil versus Tamsulosin with Solifenacin].
Hinyokika kiyo. Acta urologica Japonica.
2016 Jul; 62(7):341-7. doi:
10.14989/actauroljap_62_7_341. [PMID: 27569351] - Katsumi Kadekawa, Kimio Sugaya, Hideki Mukoyama, Misao Sakumoto, Hiroichi Shimabukuro, Syuichi Shimabukuro, Yukihide Matayoshi, Tomohiro Onaga, Katsuhiro Ashitomi, Saori Nishijima. Influence of Naftopidil on Plasma Monoamine Levels and Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia.
Lower urinary tract symptoms.
2016 May; 8(2):100-5. doi:
10.1111/luts.12079. [PMID: 27111621] - Saori Nishijima, Kimio Sugaya, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. Propiverine increases urethral wall catecholamine levels and bladder leak point pressure in rats.
International journal of urology : official journal of the Japanese Urological Association.
2016 Jan; 23(1):93-9. doi:
10.1111/iju.12991. [PMID: 26502799] - Jun Peng, Deli Xiao, Hua He, Hongyan Zhao, Cuixia Wang, Tian Shi, Kexin Shi. Molecularly imprinted polymeric stir bar: Preparation and application for the determination of naftopidil in plasma and urine samples.
Journal of separation science.
2016 Jan; 39(2):383-90. doi:
10.1002/jssc.201500751. [PMID: 26541792] - Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous congestion.
Biomedical research (Tokyo, Japan).
2016; 37(4):221-6. doi:
10.2220/biomedres.37.221. [PMID: 27544997] - Xiawen Liu, Xingfei Zhang, Junjun Huang, Yi Rong, Chengfeng Luo, Jiewen Guo, Liu Zhu, Biyun Huang, Mu Yuan. Enantiospecific determination of naftopidil by RRLC-MS/MS reveals stereoselective pharmacokinetics and tissue distributions in rats.
Journal of pharmaceutical and biomedical analysis.
2015 Aug; 112(?):147-54. doi:
10.1016/j.jpba.2015.04.034. [PMID: 25985066] - Junjun Huang, Fei He, Minyi Huang, Xiawen Liu, Yan Xiong, Yajian Huang, Liu Zhu, Ya Yang, Xingjie Xu, Mu Yuan. Novel naftopidil-related derivatives and their biological effects as alpha1-adrenoceptors antagonists and antiproliferative agents.
European journal of medicinal chemistry.
2015; 96(?):83-91. doi:
10.1016/j.ejmech.2015.04.005. [PMID: 25874333] - Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. Spinal mechanism of micturition reflex inhibition by naftopidil in rats.
Life sciences.
2014 Oct; 116(2):106-11. doi:
10.1016/j.lfs.2014.09.008. [PMID: 25258114] - Yun-Ying Zhang, Xia-Wen Liu, Li-Jun Zhu, Mu Yuan. Simultaneous stereoselective analysis of naftopidil and O-desmethyl naftopidil enantiomers in rat feces using an online column-switching high-performance liquid chromatography method.
Biomedical chromatography : BMC.
2014 Jul; 28(7):1030-5. doi:
10.1002/bmc.3112. [PMID: 24420149] - Toshiro Shirakawa, Takahiro Haraguchi, Katsumi Shigemura, Shinichi Morishita, Kohji Minayoshi, Jiro Miyazaki, Yuji Yamada, Hideaki Miyake, Kazushi Tanaka, Masato Fujisawa. Silodosin versus naftopidil in Japanese patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized multicenter study.
International journal of urology : official journal of the Japanese Urological Association.
2013 Sep; 20(9):903-10. doi:
10.1111/iju.12055. [PMID: 23252453] - Yoichi Iwamoto, Kenichiro Ishii, Takeshi Sasaki, Manabu Kato, Hideki Kanda, Yasushi Yamada, Kiminobu Arima, Taizo Shiraishi, Yoshiki Sugimura. Oral naftopidil suppresses human renal-cell carcinoma by inducing G(1) cell-cycle arrest in tumor and vascular endothelial cells.
Cancer prevention research (Philadelphia, Pa.).
2013 Sep; 6(9):1000-6. doi:
10.1158/1940-6207.capr-13-0095. [PMID: 23901046] - Katsumi Kadekawa, Kimio Sugaya, Saori Nishijima, Katsuhiro Ashitomi, Minoru Miyazato, Tomoyuki Ueda, Hideyuki Yamamoto. Effect of naftopidil, an alpha1D/A-adrenoceptor antagonist, on the urinary bladder in rats with spinal cord injury.
Life sciences.
2013 May; 92(20-21):1024-8. doi:
10.1016/j.lfs.2013.03.021. [PMID: 23583569] - Motoaki Saito, Shogo Shimizu, Fumiya Ohmasa, Ryo Oikawa, Panagiota Tsounapi, Fotios Dimitriadis, Yukako Kinoshita, Keisuke Satoh. Characterization of silodosin and naftopidil in the treatment of bladder dysfunction in the spontaneously hypertensive rat.
Neurourology and urodynamics.
2013 Apr; 32(4):393-8. doi:
10.1002/nau.22297. [PMID: 22907830] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Xiawen Liu, Yunying Zhang, Mu Yuan, Yinxiang Sun. Determination of naftopidil enantiomers in rat plasma using chiral solid phases and pre-column derivatization high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Oct; 907(?):140-5. doi:
10.1016/j.jchromb.2012.09.021. [PMID: 23026227] - Tomokazu Sazuka, Yoichi Kambara, Takuro Ishii, Kazuyoshi Nakamura, Shinichi Sakamoto, Yukio Naya, Tomonori Yamanishi, Tomohiko Ichikawa, Tatsuo Igarashi. Analysis of energy loss mediated by an alpha-1 blocker in patients with benign prostatic hyperplasia using a virtual urethra processed from an endoscopic video image.
Journal of endourology.
2012 Sep; 26(9):1216-20. doi:
10.1089/end.2012.0078. [PMID: 22486252] - Saori Nishijima, Kimio Sugaya, Katsumi Kadekawa, Katsuhiro Ashitomi, Hideyuki Yamamoto. Effect of chemical stimulation of the medial frontal lobe on the micturition reflex in rats.
The Journal of urology.
2012 Mar; 187(3):1116-20. doi:
10.1016/j.juro.2011.10.128. [PMID: 22266008] - Akinobu Gotoh, Hisao Nagaya, Takeshi Kanno, Tomoyuki Nishizaki. Antitumor action of α(1)-adrenoceptor blockers on human bladder, prostate and renal cancer cells.
Pharmacology.
2012; 90(5-6):242-6. doi:
10.1159/000342797. [PMID: 23007551] - Shui Gen Zhou, Jian Lin Lu, Ju Hong Hui. Comparing efficacy of α1D-receptor antagonist naftopidil and α1A/D-receptor antagonist tamsulosin in management of distal ureteral stones.
World journal of urology.
2011 Dec; 29(6):767-71. doi:
10.1007/s00345-011-0739-3. [PMID: 21845472] - Hideyasu Tsumura, Takefumi Satoh, Hiromichi Ishiyama, Ken-ichi Tabata, Shouko Kotani, Satoru Minamida, Masaki Kimura, Tetsuo Fujita, Kazumasa Matsumoto, Masashi Kitano, Kazushige Hayakawa, Shiro Baba. Comparison of prophylactic naftopidil, tamsulosin, and silodosin for 125I brachytherapy-induced lower urinary tract symptoms in patients with prostate cancer: randomized controlled trial.
International journal of radiation oncology, biology, physics.
2011 Nov; 81(4):e385-92. doi:
10.1016/j.ijrobp.2011.04.026. [PMID: 21664068] - Masayuki Takeda, Yukio Homma, Isao Araki, Hidehiro Kakizaki, Tomonori Yamanishi, Takashi Yokota, Momokazu Gotoh, Yasuhiko Igawa, Narihito Seki, Mineo Takei, Masaki Yoshida, Kimio Sugaya, Osamu Nishizawa. Predictive factors for the effect of the α1-D/A adrenoceptor antagonist naftopidil on subjective and objective criteria in patients with neurogenic lower urinary tract dysfunction.
BJU international.
2011 Jul; 108(1):100-7. doi:
10.1111/j.1464-410x.2010.09682.x. [PMID: 21062392] - Osamu Yokoyama, Yoshitaka Aoki, Akira Tsujimura, Tetsuya Takao, Mikio Namiki, Akihiko Okuyama. α(1)-adrenoceptor blocker naftopidil improves sleep disturbance with reduction in nocturnal urine volume.
World journal of urology.
2011 Apr; 29(2):233-8. doi:
10.1007/s00345-010-0544-4. [PMID: 20387069] - Teruhiko Yokoyama, Ryoei Hara, Kazuhiko Fukumoto, Tomohiro Fujii, Yoshimasa Jo, Yoshiyuki Miyaji, Atsushi Nagai, Atsushi Sone. Effects of three types of alpha-1 adrenoceptor blocker on lower urinary tract symptoms and sexual function in males with benign prostatic hyperplasia.
International journal of urology : official journal of the Japanese Urological Association.
2011 Mar; 18(3):225-30. doi:
10.1111/j.1442-2042.2010.02708.x. [PMID: 21272091] - Noritaka Kamimura, Shingo Hatakeyama, Shigemasa Kudo, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Shinya Takahashi, Chikara Ohyama. [Additional effect of propiverine for naftopidil-resistant nocturia in the patient with benign prostate hypertrophy].
Hinyokika kiyo. Acta urologica Japonica.
2011 Feb; 57(2):71-6. doi:
. [PMID: 21412038] - Kenji Ohgaki, Kazutaka Horiuchi, Norio Hikima, Yukihiro Kondo. Facilitation of expulsion of ureteral stones by addition of α1-blockers to conservative therapy.
Scandinavian journal of urology and nephrology.
2010 Dec; 44(6):420-4. doi:
10.3109/00365599.2010.497769. [PMID: 20604720] - Shugo Hanyu, Akihiko Hatano, Tsutomu Nishiyama, Kenji Obara, Kohta Takahashi. [A randomized controlled study comparing clinical effects of naftopidil and tamsulosin on benign prostatic hyperplasia].
Hinyokika kiyo. Acta urologica Japonica.
2010 Sep; 56(9):489-94. doi:
NULL. [PMID: 20940522] - Naoya Masumori, Taiji Tsukamoto, Masahiro Yanase, Hiroki Horita, Masaharu Aoki. The add-on effect of solifenacin for patients with remaining overactive bladder after treatment with tamsulosin for lower urinary tract symptoms suggestive of benign prostatic obstruction.
Advances in urology.
2010; ?(?):205251. doi:
10.1155/2010/205251. [PMID: 20981257] - Pranav S Garimella, Howard A Fink, Roderick Macdonald, Timothy J Wilt. Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia.
The Cochrane database of systematic reviews.
2009 Oct; ?(4):CD007360. doi:
10.1002/14651858.cd007360.pub2. [PMID: 19821408] - Masao Tsujihata, Kazuhiro Yoshimura, Yasuyuki Kojima, Masayoshi Oda, Osamu Miyake, Kinya Uchida, Akihiko Okuyama. [The clinical efficacy and safety of naftopidil 75 mg on benign prostatic hyperplasia patients with moderate or severe urinary disturbance].
Hinyokika kiyo. Acta urologica Japonica.
2009 Apr; 55(4):181-6. doi:
NULL. [PMID: 19462821] - Teruhiko Yokoyama, Katsutoshi Uematsu, Toyohiko Watanabe, Katsumi Sasaki, Hiromi Kumon, Atsushi Nagai. Naftopidil and propiverine hydrochloride for treatment of male lower urinary tract symptoms suggestive of benign prostatic hyperplasia and concomitant overactive bladder: a prospective randomized controlled study.
Scandinavian journal of urology and nephrology.
2009; 43(4):307-14. doi:
10.1080/00365590902836740. [PMID: 19396723] - Hitoshi Oh-oka. Usefulness of naftopidil for dysuria in benign prostatic hyperplasia and its optimal dose--comparison between 75 and 50 mg.
Urologia internationalis.
2009; 82(2):136-42. doi:
10.1159/000200787. [PMID: 19321997] - Yusuke Awa, Hiroyoshi Suzuki, Satoshi Hamano, Tatsuya Okano, Yuri Sakurayama, Takemasa Ohki, Ken-ichi Egoshi, Sho Ota, Ikuo Mori, Tomohiko Ichikawa. Clinical effect of alpha 1D/A adrenoceptor inhibitor naftopidil on benign prostatic hyperplasia: an international prostate symptom score and King's Health Questionnaire assessment.
International journal of urology : official journal of the Japanese Urological Association.
2008 Aug; 15(8):709-15. doi:
10.1111/j.1442-2042.2008.02097.x. [PMID: 18662175] - Takehito Naruoka, Yasuyuki Suzuki, Akira Furuta, Katsuhisa Endo, Shingo Sugaya, Shin Egawa. [Evaluation of supplemental administration of Eviprostat in patients with benign prostatic hyperplasia with persistent symptoms following treatment with alpha1-adrenoceptor blocker].
Hinyokika kiyo. Acta urologica Japonica.
2008 May; 54(5):341-4. doi:
". [PMID: 18546857] - Shinobu Kato, Mamoru Kusaka, Ryoichi Shiroki, Masanobu Izumitani, Haruyoshi Asano, Takahiro Ooki, Masanori Yanaoka, Kiyotaka Hoshinaga. [Clinical evaluation of supplemental administration of flavoxate hydrochloride in benign prostatic hyperplasia patients with nocturia resistant to an alpha1-adrenoceptor blocker].
Hinyokika kiyo. Acta urologica Japonica.
2008 Mar; 54(3):173-7. doi:
NULL. [PMID: 18411771] - Kimio Sugaya, Saori Nishijima, Shinsuke Tasaki, Katsumi Kadekawa, Minoru Miyazato, Yoshihide Ogawa. Effects of propiverine and naftopidil on the urinary ATP level and bladder activity after bladder stimulation in rats.
Neuroscience letters.
2007 Dec; 429(2-3):142-6. doi:
10.1016/j.neulet.2007.10.003. [PMID: 17997223] - Ning-chen Li, Shi-liang Wu, Jie Jin, Shao-peng Qiu, Chui-ze Kong, Yong-sheng Song, Zhang-qun Ye, Guang Sun, Ying-hao Sun, Yu-cheng Sun, Xiao-feng Wang, Yan-qun Na. [Comparison of different drugs on the treatment of benign prostate hyperplasia].
Zhonghua wai ke za zhi [Chinese journal of surgery].
2007 Jul; 45(14):947-50. doi:
. [PMID: 17961376] - Shigeru Kosugi, Isao Ikemoto, Akira Furuta, Tatsuya Shimomura, Hiroshi Kiyota, Yasuyuki Suzuki, Kouichi Kishimoto, Shin Egaway, Shinichiro Torii, Hitoshi Shirai, Hiroyuki Takeuchi, Kazuhiro Abe. [A comparative study assessing clinical effects of naftopidil and tamsulosin hydrochloride on benign prostatic hyperplasia with overactive bladder].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
2007 Jul; 98(5):691-9. doi:
10.5980/jpnjurol1989.98.691. [PMID: 17682448] - Hiroomi Nakatsu, Makito Naoi, Kazuya Sekiyama, Satoshi Hamano, Noriyuki Suzuki, Masashi Tanaka, Shino Murakami. [The effectiveness of naftopidil in patients with benign prostatic hyperplasia evaluated by QOL index].
Hinyokika kiyo. Acta urologica Japonica.
2007 Jan; 53(1):13-8. doi:
NULL. [PMID: 17310763] - Osamu Maruyama, Yoshio Kawachi, Kisaburo Hanazawa, Kazuo Koizumi, Ryo Yamashita, Sosuke Sugimura, Shin-ichi Honda, Yoshiki Sugiyama, Toshihiko Saitoh, Kensho Noto. Naftopidil monotherapy vs naftopidil and an anticholinergic agent combined therapy for storage symptoms associated with benign prostatic hyperplasia: A prospective randomized controlled study.
International journal of urology : official journal of the Japanese Urological Association.
2006 Oct; 13(10):1280-5. doi:
10.1111/j.1442-2042.2006.01538.x. [PMID: 17010005] - Shin-ichi Hisasue, Ryoji Furuya, Naoki Itoh, Ko Kobayashi, Seiji Furuya, Taiji Tsukamoto. Ejaculatory disorder caused by alpha-1 adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission.
International journal of urology : official journal of the Japanese Urological Association.
2006 Oct; 13(10):1311-6. doi:
10.1111/j.1442-2042.2006.01535.x. [PMID: 17010010] - Yuntao Jia, Xuehua Jiang, Jinsong Ding. [The study of the in vivo-in vitro correlation of the naftopidil sustained-release tablet in dog].
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.
2006 Aug; 23(4):826-8, 843. doi:
NULL. [PMID: 17002117] - Teruhiko Yokoyama, Hiromi Kumon, Yoshitsugu Nasu, Hitoshi Takamoto, Toyohiko Watanabe. Comparison of 25 and 75 mg/day naftopidil for lower urinary tract symptoms associated with benign prostatic hyperplasia: a prospective, randomized controlled study.
International journal of urology : official journal of the Japanese Urological Association.
2006 Jul; 13(7):932-8. doi:
10.1111/j.1442-2042.2006.01443.x. [PMID: 16882058] - Travis L Bullock, Gerald L Andriole. Emerging drug therapies for benign prostatic hyperplasia.
Expert opinion on emerging drugs.
2006 Mar; 11(1):111-23. doi:
10.1517/14728214.11.1.111. [PMID: 16503830] - Li Li, Xin Zhou, Mu Yuan, Hong Zhou, Dao-Ping Wang. [Metabolites of R, S-1-(2-methoxyphenyl)-4-[3-(naphtha-1-yl-oxy)-2-hydroxypropyl]-piperazin in rat plasma].
Yao xue xue bao = Acta pharmaceutica Sinica.
2006 Jan; 41(1):80-4. doi:
NULL. [PMID: 16683533] - Momokazu Gotoh, Osamu Kamihira, Tsuneo Kinukawa, Yoshinari Ono, Shinichi Ohshima, Hideki Origasa. Comparison of tamsulosin and naftopidil for efficacy and safety in the treatment of benign prostatic hyperplasia: a randomized controlled trial.
BJU international.
2005 Sep; 96(4):581-6. doi:
10.1111/j.1464-410x.2005.05688.x. [PMID: 16104914] - Steven A Kaplan. Single-blind, randomized controlled study of the clinical and urodynamic effects of an alpha-blocker (naftopidil) and phytotherapy (eviprostat) in the treatment of benign prostatic hyperplasia.
The Journal of urology.
2005 Sep; 174(3):1011. doi:
10.1097/01.ju.0000171855.70549.4e. [PMID: 16094031] - Tomonori Yamanishi, Kosaku Yasuda, Takao Kamai, Toshihiko Tsujii, Ryuji Sakakibara, Tomoyuki Uchiyama, Ken-Ichiro Yoshida. Single-blind, randomized controlled study of the clinical and urodynamic effects of an alpha-blocker (naftopidil) and phytotherapy (eviprostat) in the treatment of benign prostatic hyperplasia.
International journal of urology : official journal of the Japanese Urological Association.
2004 Jul; 11(7):501-9. doi:
10.1111/j.1442-2042.2004.00844.x. [PMID: 15242359] - Toshiyuki Akasaka, Hiroyoshi Funaki, Shigeru Hirano, Mitsuru Ohinata, Mikihiko Fujishima, Takuji Kudou, Akira Suzuki, Masahiro Iinuma. [Long-term efficacy of naftopidil for treatment of lower urinary tract symptoms with benign prostatic hyperplasia].
Hinyokika kiyo. Acta urologica Japonica.
2003 Apr; 49(4):189-93. doi:
NULL. [PMID: 12784711] - J A Murillo Pulgarín, A Alañón Molina, M T Alañón Pardo. The use of modified simplex method to optimize the room temperature phosphorescence variables in the determination of an antihypertensive drug.
Talanta.
2002 Jun; 57(4):795-805. doi:
10.1016/s0039-9140(02)00105-4. [PMID: 18968682] - Xiao-Bing Ju, Hong-Fei Wu, Jian-Tang Su. [The clinical efficacy of Naftopidil tablet in the treatment of benign prostatic hyperplasia].
Zhonghua nan ke xue = National journal of andrology.
2002; 8(4):286-8. doi:
NULL. [PMID: 12491697] - Tetsuo Hayashi, Yasuyuki Sakai, Kazutaka Saito, Gaku Arai, Nobuhiko Hyochi, Masahito Suzuki, Hitoshi Masuda, Satoru Kawakami, Tetsuo Okuno, Tsuyoshi Kobayashi, Yukio Kageyama, Kazunori Kihara. [A comparative study assessing clinical effects of naftopidil and tamsulosin hydrochloride on benign prostatic hyperplasia].
Hinyokika kiyo. Acta urologica Japonica.
2002 Jan; 48(1):7-11. doi:
NULL. [PMID: 11868386] - J A Murillo Pulgarín, A Alañón Molina, M T Alañón Pardo. Non-protected fluid room-temperature phosphorimetric procedure for the direct determination of naftopidil in biological fluids.
Fresenius' journal of analytical chemistry.
2001 Dec; 371(7):903-8. doi:
10.1007/s002160101055. [PMID: 11769798] - J S Ding, X H Jiang. [Pharmacokinetics of high-dosage naftopidil capsules in dogs].
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University.
2001 Oct; 26(5):425-7. doi:
NULL. [PMID: 12536488] - J S Ding, X H Jiang, M Yuan. [Improving bioavailability of naftopidil by using bioadhesion in dogs].
Yao xue xue bao = Acta pharmaceutica Sinica.
2001 May; 36(5):377-80. doi:
NULL. [PMID: 12584863] - J A Murillo Pulgarín, A Alañón Molina, M T Alañón Pardo. Direct determination of naftopidil by non-protected fluid room temperature phosphorescence.
The Analyst.
2001 Feb; 126(2):234-8. doi:
10.1039/b008541n. [PMID: 11235109] - M Yuan, L Tang, X Fu, J Shi, Z Zheng, X Liu. [Determination of naftopidil and its main metabolite in plasma by high-performance liquid chromatography].
Yao xue xue bao = Acta pharmaceutica Sinica.
1998 Oct; 33(10):768-71. doi:
NULL. [PMID: 12016931] - D Yu, L Wan, Y Lou. [Pharmacokinetic profile of naftopidil in rats].
Yao xue xue bao = Acta pharmaceutica Sinica.
1998 May; 33(5):335-8. doi:
NULL. [PMID: 12016999] - N A Alarayyed, B R Graham, B N Prichard, C C Smith. The potentiation of adrenaline-induced in vitro platelet aggregation by ADP, collagen and serotonin and its inhibition by naftopidil and doxazosin in normal human subjects.
British journal of clinical pharmacology.
1995 Apr; 39(4):369-74. doi:
10.1111/j.1365-2125.1995.tb04464.x. [PMID: 7640142] - K Yasuda, T Yamanishi, M Tojo, K Nagashima, S Akimoto, J Shimazaki. Effect of naftopidil on urethral obstruction in benign prostatic hyperplasia: assessment by urodynamic studies.
The Prostate.
1994 Jul; 25(1):46-52. doi:
10.1002/pros.2990250107. [PMID: 7517541] - M J Farthing, E M Alstead, S M Abrams, G Haug, A Johnston, R Hermann, G Niebch, P Ruus, K H Molz, P Turner. Pharmacokinetics of naftopidil, a novel anti-hypertensive drug, in patients with hepatic dysfunction.
Postgraduate medical journal.
1994 May; 70(823):363-6. doi:
10.1136/pgmj.70.823.363. [PMID: 8016009] - R Kirsten, M Breidert, K Nelson, A Heine, S Rosenkranz, B Erdeg, G Niebch, H O Borbe, M Siebert-Weigel, J Respondek. Naftopidil inhibits 5-hydroxytryptamine-induced platelet aggregation and 5-hydroxytryptamine uptake in platelets of healthy volunteers.
European journal of clinical pharmacology.
1994; 46(3):271-4. doi:
10.1007/bf00192561. [PMID: 8070510] - N Yamanaka, O Yamaguchi, H Kameoka, Y Fukaya, T Yokota, Y Shiraiwa, J Yokoyama, K Kumakawa, K Itou, Y Kuma. [Effect of KT-611 (Naftopidil) on the contraction of human prostatic tissue and its use in benign prostatic obstruction].
Hinyokika kiyo. Acta urologica Japonica.
1991 Dec; 37(12):1759-72. doi:
NULL. [PMID: 1723843] - G Niebch, M Locher, G Peter, H O Borbe. Metabolic fate of the novel antihypertensive drug naftopidil.
Arzneimittel-Forschung.
1991 Oct; 41(10):1027-32. doi:
NULL. [PMID: 1665973] - G Peter, G Niebch, M Locher, H O Borbe. Pharmacokinetic fate of the novel antihypertensive drug naftopidil.
Arzneimittel-Forschung.
1991 Sep; 41(9):924-31. doi:
NULL. [PMID: 1796920] - G Niebch, H O Borbe, E Besenfelder. High-performance liquid chromatography of naftopidil, a novel antihypertensive drug, and two metabolites in human plasma.
Journal of chromatography.
1990 Dec; 534(?):247-52. doi:
10.1016/s0378-4347(00)82170-2. [PMID: 2094714] - H Kawasaki, S Nakamura, K Takasaki, T Iwamoto, H Ohjimi, K Kushiku, T Furukawa. [Antihypertensive effect of naftopidil (KT-611), a novel alpha 1-adrenoceptor antagonist, in freely moving experimental hypertensive rats and dogs].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1990 Sep; 96(3):129-39. doi:
10.1254/fpj.96.3_129. [PMID: 1980256] - H O Borbe, G Peter. Radioreceptor assay for the determination of alpha 1-adrenoceptor-binding material in rat plasma following single oral administration of naftopidil.
Arzneimittel-Forschung.
1990 Mar; 40(3):253-6. doi:
NULL. [PMID: 1971750] - S Husted, T Hjort. Sperm antibodies in serum and seminal plasma.
International journal of fertility.
1975; 20(2):97-105. doi:
NULL. [PMID: 3485]