lomerizine (BioDeep_00000275586)
代谢物信息卡片
lomerizine
化学式: C27H30F2N2O3 (468.2224374)
中文名称: 洛美利嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)OC)OC
InChI: InChI=1S/C27H30F2N2O3/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20/h4-13,25H,14-18H2,1-3H3
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:94682
- PubChem: 3949
- DrugBank: DB14065
- ChEMBL: CHEMBL29188
- CAS: 101477-55-8
- MoNA: FiehnHILIC002062
- MoNA: FiehnHILIC000491
- PMhub: MS000008234
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Masato Okano, Mitsuhiko Sato, Shinji Kageyama. Lomerizine, trimetazidine and bis-(4-fluorophenyl)-methylpiperazine in human urine after oral administration of lomerizine dihydrochloride: analysis by liquid chromatography-high resolution-tandem mass spectrometry.
Drug testing and analysis.
2018 Nov; 10(11-12):1689-1697. doi:
10.1002/dta.2504. [PMID: 30240154] - Ryan L O'Hare Doig, Wissam Chiha, Marcus K Giacci, Nathanael J Yates, Carole A Bartlett, Nicole M Smith, Stuart I Hodgetts, Alan R Harvey, Melinda Fitzgerald. Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma.
BMC neuroscience.
2017 08; 18(1):62. doi:
10.1186/s12868-017-0380-1. [PMID: 28806920] - Ken Ikeda, Sayori Hanashiro, Yuichi Ishikawa, Masahiro Sawada, Maya Kyuzen, Harumi Morioka, Junya Ebina, Junpei Nagasawa, Masaru Yanagihashi, Ken Miura, Takehisa Hirayama, Takanori Takazawa, Osamu Kano, Kiyokazu Kawabe, Yasuo Iwasaki. Treatment with telmisartan, a long-acting angiotensin II receptor blocker, prevents migraine attacks in Japanese non-responders to lomerizine.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2017 May; 38(5):827-831. doi:
10.1007/s10072-017-2854-4. [PMID: 28224326] - Masato Okano, Mario Thevis, Mitsuhiko Sato, Shinji Kageyama. Analytical detection of trimetazidine produced by metabolic conversion of lomerizine in doping control analysis.
Drug testing and analysis.
2016 Aug; 8(8):869-74. doi:
10.1002/dta.1893. [PMID: 26560081] - Yulong Ren, Tianshun Liu, Guoxin Song, Yaoming Hu, Jianying Liang. Determination of lomerizine in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Feb; 947-948(?):96-102. doi:
10.1016/j.jchromb.2013.12.026. [PMID: 24412691] - Masakazu Ishii, Ryouta Iizuka, Yuji Kiuchi, Yasuo Mori, Shunichi Shimizu. Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.
Molecular and cellular biochemistry.
2011 Dec; 358(1-2):1-11. doi:
10.1007/s11010-011-0913-3. [PMID: 21656126] - Tomoko Hibino, Mitsutoshi Yuzurihara, Kiyoshi Terawaki, Hitomi Kanno, Yoshio Kase, Atsushi Takeda. Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood.
Journal of pharmacological sciences.
2008 Sep; 108(1):89-94. doi:
10.1254/jphs.08058fp. [PMID: 18776713] - Makoto Otani, Yoshiyuki Takimoto, Junko Moriya, Kazuhiro Yoshiuchi, Akira Akabayashi. Plasma intact fibroblast growth factor 23 levels in women with anorexia nervosa.
BioPsychoSocial medicine.
2008 Apr; 2(?):10. doi:
10.1186/1751-0759-2-10. [PMID: 18412981] - H Hara, M Shimazawa, M Sasaoka, C Yamada, Y Iwakura, T Sakai, Y Maeda, T Yamaguchi, T Sukamoto, M Hashimoto. Selective effects of lomerizine, a novel diphenylmethylpiperazine Ca2+ channel blocker, on cerebral blood flow in rats and dogs.
Clinical and experimental pharmacology & physiology.
1999 Nov; 26(11):870-6. doi:
10.1046/j.1440-1681.1999.03154.x. [PMID: 10561807] - M Shimazawa, T Sugiyama, I Azuma, M Araie, Y Iwakura, M Watari, T Sakai, H Hara. Effect of lomerizine, a new Ca(2+)channel blocker, on the microcirculation in the optic nerve head in conscious rabbits: a study using a laser speckle technique.
Experimental eye research.
1999 Aug; 69(2):185-93. doi:
10.1006/exer.1999.0689. [PMID: 10433855] - M Hashimoto, Y Yamamoto, H Takagi. Effects of KB-2796 on plasma extravasation following antidromic trigeminal stimulation in the rat.
Research communications in molecular pathology and pharmacology.
1997 Jul; 97(1):79-94. doi:
. [PMID: 9507571] - N Awata, T Sakai, O Satomi, T Kawashima. [Metabolism of lomerizine hydrochloride (KB-2796) in rats].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
1995 Feb; 115(2):120-9. doi:
10.1248/yakushi1947.115.2_120. [PMID: 7722879] - Y Fujishima, H Hara, M Shimazawa, K Yokota, T Sukamoto. [The effects of a novel Ca2+ channel blocker, KB-2796, on 5-HT-induced responses].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1994 Jul; 104(1):19-29. doi:
10.1254/fpj.104.19. [PMID: 8076888] - T Iwamoto, T Morita, T Sukamoto, K Ito. Effects of KB-2796, a new diphenylpiperazine calcium antagonist, on renal hemodynamics and urine formation in anesthetized dogs.
Japanese journal of pharmacology.
1992 Jun; 59(2):137-44. doi:
10.1254/jjp.59.137. [PMID: 1434110] - N Yamamoto, K Yokota, A Yamashita, K Ito. [Inhibition of platelet function by KB-2796].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1991 Nov; 98(5):337-44. doi:
10.1254/fpj.98.5_337. [PMID: 1813365] - T Kawashima, O Satomi, N Awata. Isolation and identification of the new metabolites of 1-[bis(4-fluorophenyl)-methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796) from rat bile, urine and feces.
Journal of pharmacobio-dynamics.
1991 Aug; 14(8):449-59. doi:
10.1248/bpb1978.14.449. [PMID: 1774621] - H Waki, K Kon, Y Tanaka, S Ando. Age-related changes in the uptake of calcium channel blockers by brain capillary endothelial cells and synaptosomal fractions.
Neuroscience letters.
1990 Aug; 116(3):367-71. doi:
10.1016/0304-3940(90)90103-g. [PMID: 2243616]