LOFEPRAMINE (BioDeep_00000275585)
代谢物信息卡片
化学式: C26H27ClN2O (418.1812)
中文名称: 洛非帕明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl
InChI: InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
同义名列表
1 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:47782
- KEGGdrug: D08140
- PubChem: 3947
- Metlin: METLIN1012
- DrugBank: DB13411
- ChEMBL: CHEMBL87708
- MeSH: Lofepramine
- CAS: 23047-25-8
- MoNA: FiehnHILIC002060
- MoNA: FiehnHILIC000489
- PMhub: MS000008232
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tatsuo Shinozuka, Masaru Terada, Einosuke Tanaka. Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method.
Forensic science international.
2006 Oct; 162(1-3):108-12. doi:
10.1016/j.forsciint.2006.03.038. [PMID: 16859851] - Manfred Kollroser, Caroline Schober. Simultaneous determination of seven tricyclic antidepressant drugs in human plasma by direct-injection HPLC-APCI-MS-MS with an ion trap detector.
Therapeutic drug monitoring.
2002 Aug; 24(4):537-44. doi:
10.1097/00007691-200208000-00013. [PMID: 12142640] - C Sánchez, J Hyttel. Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.
Cellular and molecular neurobiology.
1999 Aug; 19(4):467-89. doi:
10.1023/a:1006986824213. [PMID: 10379421] - M Tatsumi, K Groshan, R D Blakely, E Richelson. Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
European journal of pharmacology.
1997 Dec; 340(2-3):249-58. doi:
10.1016/s0014-2999(97)01393-9. [PMID: 9537821] - T Elm, E L Hansen. Simultaneous determination of lofepramine and desipramine by a high-performance liquid chromatographic method used for therapeutic drug monitoring.
Journal of chromatography. B, Biomedical applications.
1995 Mar; 665(2):355-61. doi:
10.1016/0378-4347(94)00540-l. [PMID: 7795815] - D J Nutt, S J Wilson, N J Coupland. Use of selective serotonin reuptake inhibitors and other serotonergic drugs in the biological dissection of affective disorders.
International clinical psychopharmacology.
1995 Jan; 9 Suppl 4(?):53-9. doi:
10.1097/00004850-199501004-00008. [PMID: 7622825] - C L Katona, M T Abou-Saleh, D A Harrison, B A Nairac, D R Edwards, T Lock, R A Burns, M M Robertson. Placebo-controlled trial of lithium augmentation of fluoxetine and lofepramine.
The British journal of psychiatry : the journal of mental science.
1995 Jan; 166(1):80-6. doi:
10.1192/bjp.166.1.80. [PMID: 7894881] - D Healy, J Calvin, A M Whitehouse, W White, H Wilton-Cox, A E Theodorou, K M Lawrence, R W Horton, E S Paykel. Alpha-1-acid glycoprotein in major depressive and eating disorders.
Journal of affective disorders.
1991 May; 22(1-2):13-20. doi:
10.1016/0165-0327(91)90078-7. [PMID: 1652602] - K Ghose, B P Spragg. Pharmacokinetics of lofepramine and amitriptyline in elderly healthy subjects.
International clinical psychopharmacology.
1989 Jul; 4(3):201-15. doi:
10.1097/00004850-198907000-00003. [PMID: 2677125] - A M Stephen, H S Wiggins, J H Cummings. Effect of changing transit time on colonic microbial metabolism in man.
Gut.
1987 May; 28(5):601-9. doi:
10.1136/gut.28.5.601. [PMID: 3596341] - K Ghose, E Sedman. A double-blind comparison of the pharmacodynamic effects of single doses of lofepramine, amitriptyline and placebo in elderly subjects.
European journal of clinical pharmacology.
1987; 33(5):505-9. doi:
10.1007/bf00544244. [PMID: 3428344] - H Stern, J Konetschny, L Herrmann, U Säwe, G G Belz. Cardiovascular effects of single doses of the antidepressants amitriptyline and lofepramine in healthy subjects.
Pharmacopsychiatry.
1985 Jul; 18(4):272-7. doi:
10.1055/s-2007-1017380. [PMID: 3895254] - J E Dutt. On the clinical response/serum level relationship for antidepressants II: Lofepramine and imipramine.
Psychopharmacology bulletin.
1982 Apr; 18(2):17-27. doi:
NULL. [PMID: 7111601]
