idebenone (BioDeep_00000275579)
natural product
代谢物信息卡片
idebenone
化学式: C19H30O5 (338.209313)
中文名称: 艾地苯醌
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(C(=C(C(C(=C1C)CCCCCCCCCCO)=O)OC)OC)=O
InChI: InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC50=16.65 μM)[1]. Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells[2]. Idebenone quickly crosses the blood-brain barrier.
同义名列表
1 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:31687
- KEGGdrug: D01750
- PubChem: 3686
- Metlin: METLIN757
- ChEMBL: CHEMBL252556
- CAS: 1189907-75-2
- CAS: 58186-27-9
- MoNA: FiehnHILIC002001
- MoNA: FiehnHILIC000429
- MoNA: CCMSLIB00000079031
- MoNA: CCMSLIB00000078528
- PMhub: MS000008199
- RefMet: Idebenone
- medchemexpress: HY-N0303
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yidan Zhang, Fan Yang, Jiahao Wu, Jianhong Huang, Peiqing Li, Guanqun Huang. Idebenone Exerts anti-Triple Negative Breast Cancer Effects via Dual Signaling Pathways of GADD45 and AMPK.
Nutrition and cancer.
2024; 76(4):379-392. doi:
10.1080/01635581.2024.2314320. [PMID: 38332562] - Federica De Gaetano, Angela Scala, Consuelo Celesti, Kim Lambertsen Larsen, Fabio Genovese, Corrado Bongiorno, Loredana Leggio, Nunzio Iraci, Nunzio Iraci, Antonino Mazzaglia, Cinzia Anna Ventura. Amphiphilic Cyclodextrin Nanoparticles as Delivery System for Idebenone: A Preformulation Study.
Molecules (Basel, Switzerland).
2023 Mar; 28(7):. doi:
10.3390/molecules28073023. [PMID: 37049785] - Demin Li, Ge Zhang, Zeyu Wang, Jiacheng Guo, Yu Liu, Yongzheng Lu, Zhen Qin, Yanyan Xu, Chang Cao, Bo Wang, Qianqian Guo, Yunzhe Wang, Guozhen Liu, Xiaolin Cui, Jinying Zhang, Junnan Tang. Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction.
European journal of pharmacology.
2023 Mar; 943(?):175569. doi:
10.1016/j.ejphar.2023.175569. [PMID: 36740037] - Erol Akpinar, Zerrin Kutlu, Duygu Kose, Pelin Aydin, Taha Tavaci, Zafer Bayraktutan, Tugba Nurcan Yuksel, Serkan Yildirim, Gizem Eser, Busra Dincer. Protective Effects of Idebenone against Sepsis Induced Acute Lung Damage.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2022 Mar; 35(3):560-568. doi:
10.1080/08941939.2021.1898063. [PMID: 33722148] - Walaa Yehia Abdelzaher, Gomaa Mostafa-Hedeab, Abdel Hamid Sayed AboBakr Ali, Michael Atef Fawzy, Amira F Ahmed, Mohamed Ahmed Bahaa El-Deen, Nermeen N Welson, Dina A Aly Labib. Idebenone regulates sirt1/Nrf2/TNF-α pathway with inhibition of oxidative stress, inflammation, and apoptosis in testicular torsion/detorsion in juvenile rats.
Human & experimental toxicology.
2022 Jan; 41(?):9603271221102515. doi:
10.1177/09603271221102515. [PMID: 35593271] - Nilima Pradhan, Charan Singh, Arti Singh. Coenzyme Q10 a mitochondrial restorer for various brain disorders.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 11; 394(11):2197-2222. doi:
10.1007/s00210-021-02161-8. [PMID: 34596729] - Abraham J Paredes-Fuentes, Sergi Cesar, Raquel Montero, Cristina Latre, Jordi Genovès, Loreto Martorell, Daniel Cuadras, Helena Colom, Mercè Pineda, Maria Del Mar O'Callaghan, Georgia Sarquella-Brugada, Alejandra Darling, Rafael Artuch. Plasma idebenone monitoring in Friedreich's ataxia patients during a long-term follow-up.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112143. doi:
10.1016/j.biopha.2021.112143. [PMID: 34507114] - Ivana Linenberg, Daiana Fornes, Romina Higa, Alicia Jawerbaum, Evangelina Capobianco. Intergenerational effects of the antioxidant Idebenone on the placentas of rats with gestational diabetes mellitus.
Reproductive toxicology (Elmsford, N.Y.).
2021 09; 104(?):16-26. doi:
10.1016/j.reprotox.2021.06.013. [PMID: 34175429] - Yuying Huang, Minchao Ma, Xiaolei Zhu, Mo Li, Mengran Guo, Peng Liu, Zhonggui He, Qiang Fu. Effectiveness of idebenone nanorod formulations in the treatment of Alzheimer's disease.
Journal of controlled release : official journal of the Controlled Release Society.
2021 08; 336(?):169-180. doi:
10.1016/j.jconrel.2021.06.024. [PMID: 34157335] - F A Lone, M Naikoo, S M Shah, S A Darzi, J Farooq. Effect of Idebenone, Resveratrol and Taurine on the Sperm Quality and Lipid Peroxidation of Cryopreserved Crossbred Ram Semen.
Cryo letters.
2021 May; 42(3):146-153. doi:
NULL. [PMID: 33970992] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Bahattin Avcı, Caner Günaydın, Tolga Güvenç, Canan Kulcu Yavuz, Nilufer Kuruca, S Sirri Bilge. Idebenone Ameliorates Rotenone-Induced Parkinson's Disease in Rats Through Decreasing Lipid Peroxidation.
Neurochemical research.
2021 Mar; 46(3):513-522. doi:
10.1007/s11064-020-03186-w. [PMID: 33247801] - Luz P Blanco, Hege L Pedersen, Xinghao Wang, Yaíma L Lightfoot, Nickie Seto, Carmelo Carmona-Rivera, Zu-Xi Yu, Victoria Hoffmann, Peter S T Yuen, Mariana J Kaplan. Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone.
Arthritis & rheumatology (Hoboken, N.J.).
2020 03; 72(3):454-464. doi:
10.1002/art.41128. [PMID: 31566908] - Fan-Xing Qi, Ying Hu, Li-Juan Kang, Pan Li, Tian-Chu Gao, Xin Zhang. Effects of Butyphthalide Combined with Idebenone on Inflammatory Cytokines and Vascular Endothelial Functions of Patients with Vascular Dementia.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2020 Jan; 30(1):23-27. doi:
10.29271/jcpsp.2020.01.23. [PMID: 31931927] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Farooz Ahmad Lone, Mehrajuddin Naikoo, Arjuma Khatun, Riaz Ahmad Shah, Zahoor Ahmad Pampori, Hilal Musadiq Khan, Azad Ahmad Ahanger. Idebenone improves quality of ram sperm by mitigating oxidative stress during cryopreservation.
Cryobiology.
2019 10; 90(?):15-20. doi:
10.1016/j.cryobiol.2019.09.004. [PMID: 31518561] - Mohsen Eslami, Navid Jahan-Roshan, Farhad Farrokhi-Ardabili. Influence of idebenone on ram semen quality stored at 4°C.
Reproduction in domestic animals = Zuchthygiene.
2019 Mar; 54(3):486-497. doi:
10.1111/rda.13379. [PMID: 30460718] - Elisabetta Damiani, Raif Yuecel, Heather M Wallace. Repurposing of idebenone as a potential anti-cancer agent.
The Biochemical journal.
2019 01; 476(2):245-259. doi:
10.1042/bcj20180384. [PMID: 30602587] - Giulio Kleiner, Emanuele Barca, Marcello Ziosi, Valentina Emmanuele, Yimeng Xu, Agustin Hidalgo-Gutierrez, Changhong Qiao, Saba Tadesse, Estela Area-Gomez, Luis C Lopez, Catarina M Quinzii. CoQ10 supplementation rescues nephrotic syndrome through normalization of H2S oxidation pathway.
Biochimica et biophysica acta. Molecular basis of disease.
2018 11; 1864(11):3708-3722. doi:
10.1016/j.bbadis.2018.09.002. [PMID: 30251690] - Alexey Tomilov, Sonia Allen, Chun Kiu Hui, Ahmed Bettaieb, Gino Cortopassi. Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition.
Pharmacological research.
2018 11; 137(?):89-103. doi:
10.1016/j.phrs.2018.09.024. [PMID: 30290222] - Jens Tiefenbach, Lilia Magomedova, Jiabao Liu, Arkadiy A Reunov, Ricky Tsai, Neena S Eappen, Rebecca A Jockusch, Corey Nislow, Carolyn L Cummins, Henry M Krause. Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases.
Disease models & mechanisms.
2018 08; 11(9):. doi:
10.1242/dmm.034801. [PMID: 30171034] - Lucia Montenegro, Maria N Modica, Loredana Salerno, Anna Maria Panico, Lucia Crascì, Giovanni Puglisi, Giuseppe Romeo. In Vitro Antioxidant Activity of Idebenone Derivative-Loaded Solid Lipid Nanoparticles.
Molecules (Basel, Switzerland).
2017 May; 22(6):. doi:
10.3390/molecules22060887. [PMID: 28555014] - Filomena Lauro, Sara Ilari, Luigino Antonio Giancotti, Cinzia Anna Ventura, Chiara Morabito, Micaela Gliozzi, Valentina Malafoglia, Ernesto Palma, Donatella Paolino, Vincenzo Mollace, Carolina Muscoli. Pharmacological effect of a new idebenone formulation in a model of carrageenan-induced inflammatory pain.
Pharmacological research.
2016 09; 111(?):767-773. doi:
10.1016/j.phrs.2016.07.043. [PMID: 27480201] - Victoria Gómez-Murcia, Alejandro Torrecillas, Ana M de Godos, Senena Corbalán-García, Juan C Gómez-Fernández. Both idebenone and idebenol are localized near the lipid-water interface of the membrane and increase its fluidity.
Biochimica et biophysica acta.
2016 Jun; 1858(6):1071-81. doi:
10.1016/j.bbamem.2016.02.034. [PMID: 26926421] - Pengfei Lin, Junling Liu, Ming Ren, Kunqian Ji, Ling Li, Bin Zhang, Yaoqin Gong, Chuanzhu Yan. Idebenone protects against oxidized low density lipoprotein induced mitochondrial dysfunction in vascular endothelial cells via GSK3β/β-catenin signalling pathways.
Biochemical and biophysical research communications.
2015 Sep; 465(3):548-55. doi:
10.1016/j.bbrc.2015.08.058. [PMID: 26284974] - Abhay Y Kyadarkunte, Milind S Patole, Varsha B Pokharkar. Cellular interactions and photoprotective effects of idebenone-loaded nanostructured lipid carriers stabilized using PEG-free surfactant.
International journal of pharmaceutics.
2015 Feb; 479(1):77-87. doi:
10.1016/j.ijpharm.2014.12.044. [PMID: 25545795] - Samy A Abdelazim, Hebatallah A Darwish, Sanaa A Ali, Maha Z Rizk, Mai O Kadry. Potential antifibrotic and angiostatic impact of idebenone, carnosine and vitamin E in nano-sized titanium dioxide-induced liver injury.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 35(6):2402-11. doi:
10.1159/000374041. [PMID: 25896716] - Antonio Leonardi, Lucia Crasci', Annamaria Panico, Rosario Pignatello. Antioxidant activity of idebenone-loaded neutral and cationic solid-lipid nanoparticles.
Pharmaceutical development and technology.
2015; 20(6):716-23. doi:
10.3109/10837450.2014.915572. [PMID: 24799075] - Maria Grazia Sarpietro, Maria Lorena Accolla, Giovanni Puglisi, Francesco Castelli, Lucia Montenegro. Idebenone loaded solid lipid nanoparticles: calorimetric studies on surfactant and drug loading effects.
International journal of pharmaceutics.
2014 Aug; 471(1-2):69-74. doi:
10.1016/j.ijpharm.2014.05.019. [PMID: 24845103] - I P Hargreaves. Coenzyme Q10 as a therapy for mitochondrial disease.
The international journal of biochemistry & cell biology.
2014 Apr; 49(?):105-11. doi:
10.1016/j.biocel.2014.01.020. [PMID: 24495877] - Maha Ali Eissa Ahmed. Neuroprotective effects of idebenone against pilocarpine-induced seizures: modulation of antioxidant status, DNA damage and Na(+), K (+)-ATPase activity in rat hippocampus.
Neurochemical research.
2014 Feb; 39(2):394-402. doi:
10.1007/s11064-014-1236-z. [PMID: 24414170] - Carole Grasso, Lesley Larsen, Melanie McConnell, Robin A J Smith, Michael V Berridge. Anti-leukemic activity of ubiquinone-based compounds targeting trans-plasma membrane electron transport.
Journal of medicinal chemistry.
2013 Apr; 56(8):3168-76. doi:
10.1021/jm301585z. [PMID: 23432053] - Nouf M Al-Rasheed, L M Faddah, Azza M Mohamed, Nayira A Abdel Baky, Nawal M Al-Rasheed, Raeesa A Mohammad. Potential impact of quercetin and idebenone against immuno- inflammatory and oxidative renal damage induced in rats by titanium dioxide nanoparticles toxicity.
Journal of oleo science.
2013; 62(11):961-71. doi:
10.5650/jos.62.961. [PMID: 24200945] - Claudia Carbone, Rosario Pignatello, Teresa Musumeci, Giovanni Puglisi. Chemical and technological delivery systems for idebenone: a review of literature production.
Expert opinion on drug delivery.
2012 Nov; 9(11):1377-92. doi:
10.1517/17425247.2012.724396. [PMID: 23083453] - Lucia Montenegro, Chiara Sinico, Ines Castangia, Claudia Carbone, Giovanni Puglisi. Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: in vitro evaluation.
International journal of pharmaceutics.
2012 Sep; 434(1-2):169-74. doi:
10.1016/j.ijpharm.2012.05.046. [PMID: 22659127] - Lucia Montenegro, Sara Ottimo, Giovanni Puglisi, Francesco Castelli, Maria Grazia Sarpietro. Idebenone loaded solid lipid nanoparticles interact with biomembrane models: calorimetric evidence.
Molecular pharmaceutics.
2012 Sep; 9(9):2534-41. doi:
10.1021/mp300149w. [PMID: 22894135] - Pablo M Arce, Ruth Goldschmidt, Omar M Khdour, Manikandadas M Madathil, Jennifer Jaruvangsanti, Sriloy Dey, David M Fash, Jeffrey S Armstrong, Sidney M Hecht. Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection.
Bioorganic & medicinal chemistry.
2012 Sep; 20(17):5188-201. doi:
10.1016/j.bmc.2012.07.005. [PMID: 22883028] - Bei Li, Zhi-Qiang Ge. Nanostructured lipid carriers improve skin permeation and chemical stability of idebenone.
AAPS PharmSciTech.
2012 Mar; 13(1):276-83. doi:
10.1208/s12249-011-9746-3. [PMID: 22234598] - L Montenegro, A Trapani, A Latrofa, G Puglisi. In vitro evaluation on a model of blood brain barrier of idebenone-loaded solid lipid nanoparticles.
Journal of nanoscience and nanotechnology.
2012 Jan; 12(1):330-7. doi:
10.1166/jnn.2012.5174. [PMID: 22523983] - Yukio Nohara, Junko Suzuki, Yoji Yamazaki, Hiroaki Kubo. Determination of idebenone in plasma by HPLC with post-column fluorescence derivatization using 2-cyanoacetamide.
Chemical & pharmaceutical bulletin.
2012; 60(5):598-602. doi:
10.1248/cpb.60.598. [PMID: 22689397] - Michael Erb, Barbara Hoffmann-Enger, Holger Deppe, Michael Soeberdt, Roman H Haefeli, Christian Rummey, Achim Feurer, Nuri Gueven. Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I.
PloS one.
2012; 7(4):e36153. doi:
10.1371/journal.pone.0036153. [PMID: 22558363] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Yi Chang, Yu-Wan Lin, Su-Jane Wang. Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A.
Naunyn-Schmiedeberg's archives of pharmacology.
2011 Jul; 384(1):59-70. doi:
10.1007/s00210-011-0630-1. [PMID: 21541760] - Lucia Montenegro, Agata Campisi, Maria Grazia Sarpietro, Claudia Carbone, Rosaria Acquaviva, Giuseppina Raciti, Giovanni Puglisi. In vitro evaluation of idebenone-loaded solid lipid nanoparticles for drug delivery to the brain.
Drug development and industrial pharmacy.
2011 Jun; 37(6):737-46. doi:
10.3109/03639045.2010.539231. [PMID: 21204752] - Daniel Velasco-Sánchez, Asuncion Aracil, Raquel Montero, Ana Mas, Lorenzo Jiménez, Mar O'Callaghan, Maria Tondo, Antoni Capdevila, Josep Blanch, Rafael Artuch, Mercedes Pineda. Combined therapy with idebenone and deferiprone in patients with Friedreich's ataxia.
Cerebellum (London, England).
2011 Mar; 10(1):1-8. doi:
10.1007/s12311-010-0212-7. [PMID: 20865357] - Rosario Pignatello, Rosaria Acquaviva, Agata Campisi, Giuseppina Raciti, Teresa Musumeci, Giovanni Puglisi. Effects of liposomal encapsulation on the antioxidant activity of lipophilic prodrugs of idebenone.
Journal of liposome research.
2011 Mar; 21(1):46-54. doi:
10.3109/08982101003735996. [PMID: 20429811] - Claudia Becker, Katharine Bray-French, Juergen Drewe. Pharmacokinetic evaluation of idebenone.
Expert opinion on drug metabolism & toxicology.
2010 Nov; 6(11):1437-44. doi:
10.1517/17425255.2010.530656. [PMID: 20955109] - Nayira A Abdel Baky, Zeenat F Zaidi, Amal J Fatani, Mohamed M Sayed-Ahmed, Hazar Yaqub. Nitric oxide pros and cons: The role of L-arginine, a nitric oxide precursor, and idebenone, a coenzyme-Q analogue in ameliorating cerebral hypoxia in rat.
Brain research bulletin.
2010 Aug; 83(1-2):49-56. doi:
10.1016/j.brainresbull.2010.07.004. [PMID: 20637840] - Luis C López, Catarina M Quinzii, Estela Area, Ali Naini, Shamima Rahman, Markus Schuelke, Leonardo Salviati, Salvatore Dimauro, Michio Hirano. Treatment of CoQ(10) deficient fibroblasts with ubiquinone, CoQ analogs, and vitamin C: time- and compound-dependent effects.
PloS one.
2010 Jul; 5(7):e11897. doi:
10.1371/journal.pone.0011897. [PMID: 20689595] - Bart E Drinkard, Randall E Keyser, Scott M Paul, Ross Arena, Jonathan F Plehn, Jack A Yanovski, Nicholas A Di Prospero. Exercise capacity and idebenone intervention in children and adolescents with Friedreich ataxia.
Archives of physical medicine and rehabilitation.
2010 Jul; 91(7):1044-50. doi:
10.1016/j.apmr.2010.04.007. [PMID: 20599042] - David Pascoe, Linda Moreau, Denis Sasseville. Emergent and unusual allergens in cosmetics.
Dermatitis : contact, atopic, occupational, drug.
2010 May; 21(3):127-37. doi:
10.2310/6620.2010.09099. [PMID: 20487655] - Michael Bodmer, Pierre Vankan, Manfred Dreier, Klaus W Kutz, Jürgen Drewe. Pharmacokinetics and metabolism of idebenone in healthy male subjects.
European journal of clinical pharmacology.
2009 May; 65(5):493-501. doi:
10.1007/s00228-008-0596-1. [PMID: 19125241] - Klaus Kutz, Jürgen Drewe, Pierre Vankan. Pharmacokinetic properties and metabolism of idebenone.
Journal of neurology.
2009 Mar; 256 Suppl 1(?):31-5. doi:
10.1007/s00415-009-1006-z. [PMID: 19283348] - Hongbo Zhai, Manuel Cordoba-Diaz, Chrystal Wa, Xiaoying Hui, Howard I Maibach. Determination of the antioxidative capacity of an antioxidant complex and idebenone: an in vitro rapid and sensitive method.
Journal of cosmetic dermatology.
2008 Jun; 7(2):96-100. doi:
10.1111/j.1473-2165.2008.00370.x. [PMID: 18482011] - Tanja Heller, Anna Geide, Ulrike Bonitz, Ulrike Wegner, Hermann-Josef Gröne, Victor W Armstrong, Michael Oellerich. Effect of the antioxidant idebenone on adverse events under mycophenolate mofetil therapy in a rat model.
Transplantation.
2008 Mar; 85(5):739-47. doi:
10.1097/tp.0b013e3181664e54. [PMID: 18337669] - András Nemes, László Czibula, Csaba Szántay, Anikó Gere, Béla Kiss, Judit Laszy, István Gyertyán, Zsolt Szombathelyi, Csaba Szántay. Synthesis and evaluation of 2'-hydroxyethyl trans-apovincaminate derivatives as antioxidant and cognitive enhancer agents.
Journal of medicinal chemistry.
2008 Feb; 51(3):479-86. doi:
10.1021/jm070618k. [PMID: 18183943] - Isuke Imada, Eisuke F Sato, Yukimi Kira, Masayasu Inoue. Effect of CoQ homologues on reactive oxygen generation by mitochondria.
BioFactors (Oxford, England).
2008; 32(1-4):41-8. doi:
10.1002/biof.5520320106. [PMID: 19096099] - Nicholas A Di Prospero, Angela Baker, Neal Jeffries, Kenneth H Fischbeck. Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial.
The Lancet. Neurology.
2007 Oct; 6(10):878-86. doi:
10.1016/s1474-4422(07)70220-x. [PMID: 17826341] - Kelly K Dong, Niusha Damaghi, Jeannie Kibitel, Matthew T Canning, Kenneth A Smiles, Daniel B Yarosh. A comparison of the relative antioxidant potency of L-ergothioneine and idebenone.
Journal of cosmetic dermatology.
2007 Sep; 6(3):183-8. doi:
10.1111/j.1473-2165.2007.00330.x. [PMID: 17760697] - Patricia Farris. Idebenone, green tea, and Coffeeberry extract: new and innovative antioxidants.
Dermatologic therapy.
2007 Sep; 20(5):322-9. doi:
10.1111/j.1529-8019.2007.00146.x. [PMID: 18045357] - Nicholas A Di Prospero, Charlotte J Sumner, Scott R Penzak, Bernard Ravina, Kenneth H Fischbeck, J Paul Taylor. Safety, tolerability, and pharmacokinetics of high-dose idebenone in patients with Friedreich ataxia.
Archives of neurology.
2007 Jun; 64(6):803-8. doi:
10.1001/archneur.64.6.803. [PMID: 17562928] - M V Ershova, S N Illarioshkin, V S Sukhorukov. [The use of noben for correction of mitochondrial disorders in Friedrich's disease].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2007; 107(9):32-7. doi:
". [PMID: 18379460] - R Artuch, A Aracil, A Mas, E Monrós, M A Vilaseca, M Pineda. Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients.
Neuropediatrics.
2004 Apr; 35(2):95-8. doi:
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