actarit (BioDeep_00000275558)

   


代谢物信息卡片


4-Acetylaminophenylacetic acid

化学式: C10H11NO3 (193.0738896)
中文名称: 阿克他利
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC1=CC=C(C=C1)CC(=O)O
InChI: InChI=1S/C10H11NO3/c1-7(12)11-9-4-2-8(3-5-9)6-10(13)14/h2-5H,6H2,1H3,(H,11,12)(H,13,14)

描述信息

C29629 - Combination Medication > C29634 - Antirheumatic Preparation
D018501 - Antirheumatic Agents
CONFIDENCE standard compound; INTERNAL_ID 1198; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6156; ORIGINAL_PRECURSOR_SCAN_NO 6153
CONFIDENCE standard compound; INTERNAL_ID 1198; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6166; ORIGINAL_PRECURSOR_SCAN_NO 6164
CONFIDENCE standard compound; INTERNAL_ID 1198; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6183; ORIGINAL_PRECURSOR_SCAN_NO 6181
CONFIDENCE standard compound; INTERNAL_ID 1198; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6180; ORIGINAL_PRECURSOR_SCAN_NO 6179
CONFIDENCE standard compound; INTERNAL_ID 1198; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6189; ORIGINAL_PRECURSOR_SCAN_NO 6187
CONFIDENCE standard compound; INTERNAL_ID 1198; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6191; ORIGINAL_PRECURSOR_SCAN_NO 6190

同义名列表

2 个代谢物同义名

actarit; 4-Acetylaminophenylacetic acid



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Rachumallu Ramakrishna, Manisha Bhateria, Santosh Kumar Puttrevu, Yarra Durga Prasad, Rajbir Singh, Rabi Sankar Bhatta. A liquid chromatography-tandem mass spectrometry method for the quantitation of actarit in rabbit plasma: application to pharmacokinetics and metabolic stability. Journal of mass spectrometry : JMS. 2016 Jan; 51(1):69-78. doi: 10.1002/jms.3730. [PMID: 26757074]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Shin Takusagawa, Jan Jaap van Lier, Katsuhiro Suzuki, Masanori Nagata, John Meijer, Walter Krauwinkel, Marloes Schaddelee, Mitsuhiro Sekiguchi, Aiji Miyashita, Takafumi Iwatsubo, Marcel van Gelderen, Takashi Usui. Absorption, metabolism and excretion of [(14)C]mirabegron (YM178), a potent and selective β(3)-adrenoceptor agonist, after oral administration to healthy male volunteers. Drug metabolism and disposition: the biological fate of chemicals. 2012 Apr; 40(4):815-24. doi: 10.1124/dmd.111.043588. [PMID: 22269146]
  • P Loya, M N Saraf. Determination of actarit from human plasma for bioequivalence studies. Indian journal of pharmaceutical sciences. 2010 Nov; 72(6):726-31. doi: 10.4103/0250-474x.84581. [PMID: 21969744]
  • Jiesheng Ye, Qun Wang, Xuefeng Zhou, Na Zhang. Injectable actarit-loaded solid lipid nanoparticles as passive targeting therapeutic agents for rheumatoid arthritis. International journal of pharmaceutics. 2008 Mar; 352(1-2):273-9. doi: 10.1016/j.ijpharm.2007.10.014. [PMID: 18054182]
  • Eiji Torikai, Yasunori Kageyama, Masaaki Takahashi, Akira Nagano. The effect of methotrexate on bone metabolism markers in patients with rheumatoid arthritis. Modern rheumatology. 2006; 16(6):350-4. doi: 10.1007/s10165-006-0517-z. [PMID: 17164995]
  • Hiroki Tanaka, Takashi Abe, Susumu Nishimura, Hajime Sakai, Hirokazu Kimura, Mariko Oki, Masanori Nojima, Masako Taga, Shin-ichiroh Matsumoto, Hiroki Takahashi, Kohzoh Imai. [A case of rheumatoid arthritis/Sjogren's syndrome with acute renal failure due to hyperuricemia associated with mizoribine therapy]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology. 2004 Jun; 27(3):171-6. doi: 10.2177/jsci.27.171. [PMID: 15291254]
  • H Nakamura, Y Ueki, S Sakito, K Matsumoto, M Yano, S Miyake, Y Tominaga, K Eguchi. Clinical effects of actarit in rheumatoid arthritis: improvement of early disease activity mediated by reduction of serum concentrations of nitric oxide. Clinical and experimental rheumatology. 2000 Jul; 18(4):445-50. doi: NULL. [PMID: 10949718]
  • H Fujisawa, T Nishimura, M Inaba, S Ikehara. Suppressive effect of actarit on IgA production in mice: activation of CD4+ suppressor T-cells in Peyer's patches. International journal of immunopharmacology. 1995 Jul; 17(7):611-7. doi: 10.1016/0192-0561(95)00044-3. [PMID: 8586490]
  • H Fujisawa, T Nishimura, A Motonaga, Y Inoue, K Inoue, H Suzuka, H Yoshifusa, K Kimura, M Muramatsu. Effect of actarit on type II collagen-induced arthritis in mice. Arzneimittel-Forschung. 1994 Jan; 44(1):64-8. doi: NULL. [PMID: 8135880]
  • K Sugihara, A Morino, A Nomura, S Iida, M Sugiyama. Pharmacokinetics of 4-acetylaminophenylacetic acid. 1st communication: absorption, distribution, metabolism and excretion in mice, rats, dogs and monkeys after single administration of 14C-labeled compound. Arzneimittel-Forschung. 1990 Jul; 40(7):800-5. doi: NULL. [PMID: 2222556]
  • K Sugihara, A Morino, M Sugiyama, S Iida, A Nomura. Pharmacokinetics of 4-acetylaminophenylacetic acid. 2nd communication: tissue accumulation and enzyme induction in rats after repeated administration, and placental and milk transfer after single dosing. Arzneimittel-Forschung. 1990 Jul; 40(7):806-10. doi: NULL. [PMID: 2222557]
  • H Fujisawa, T Nishimura, Y Inoue, S Ogaya, Y Shibata, Y Nakagawa, S Sato, K Kimura. Antiinflammatory properties of the new antirheumatic agent 4-acetylaminophenylacetic acid. Arzneimittel-Forschung. 1990 Jun; 40(6):693-7. doi: NULL. [PMID: 2168705]