2-((3,5-Dihydroxyphenyl)amino)acetic acid (BioDeep_00000275544)
代谢物信息卡片
2-((3,5-Dihydroxyphenyl)amino)acetic acid
化学式: C8H9NO4 (183.0532)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(not specific) 33.33%
分子结构信息
SMILES: C1=C(C=C(C=C1O)O)NCC(=O)O
InChI: InChI=1S/C8H9NO4/c10-6-1-5(2-7(11)3-6)9-4-8(12)13/h1-3,9-11H,4H2,(H,12,13)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Kidney international.
2012 Mar; 81(5):458-68. doi:
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Molecular brain.
2010 Jan; 3(?):4. doi:
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Frontiers in molecular neuroscience.
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009 Jul; 29(29):9148-62. doi:
10.1523/jneurosci.0660-09.2009. [PMID: 19625506] - Gentaroh Suzuki, Hiroko Kawagoe-Takaki, Takao Inoue, Toshifumi Kimura, Hirohiko Hikichi, Takashi Murai, Akio Satow, Mikiko Hata, Shunsuke Maehara, Satoru Ito, Hiroshi Kawamoto, Satoshi Ozaki, Hisashi Ohta. Correlation of receptor occupancy of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse brain with in vivo activity of allosteric mGluR1 antagonists.
Journal of pharmacological sciences.
2009 Jul; 110(3):315-25. doi:
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Endocrinology.
2009 Mar; 150(3):1369-76. doi:
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Neuroscience.
2008 Jun; 154(2):653-66. doi:
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2007 Aug; 27(33):8845-56. doi:
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Journal of neurochemistry.
2007 Apr; 101(2):411-21. doi:
10.1111/j.1471-4159.2006.04377.x. [PMID: 17402970] - Paola Bonsi, Giuseppe Sciamanna, Darlene A Mitrano, Dario Cuomo, Giorgio Bernardi, Paola Platania, Yoland Smith, Antonio Pisani. Functional and ultrastructural analysis of group I mGluR in striatal fast-spiking interneurons.
The European journal of neuroscience.
2007 Mar; 25(5):1319-31. doi:
10.1111/j.1460-9568.2007.05383.x. [PMID: 17425558] - Antje Lindecke, Martin Korte, Marta Zagrebelsky, Volker Horejschi, Margitta Elvers, Darius Widera, Maria Prüllage, Julia Pfeiffer, Barbara Kaltschmidt, Christian Kaltschmidt. Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1.
The European journal of neuroscience.
2006 Jul; 24(2):555-63. doi:
10.1111/j.1460-9568.2006.04909.x. [PMID: 16903857] - Yuh-Jiin I Jong, Vikas Kumar, Ann E Kingston, Carmelo Romano, Karen L O'Malley. Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand.
The Journal of biological chemistry.
2005 Aug; 280(34):30469-80. doi:
10.1074/jbc.m501775200. [PMID: 15958386] - Eleonora Aronica, Jan A Gorter, Annemieke J Rozemuller, Bulent Yankaya, Dirk Troost. Interleukin-1 beta down-regulates the expression of metabotropic glutamate receptor 5 in cultured human astrocytes.
Journal of neuroimmunology.
2005 Mar; 160(1-2):188-94. doi:
10.1016/j.jneuroim.2004.11.015. [PMID: 15710472] - E Aronica, J A Gorter, A J Rozemuller, B Yankaya, D Troost. Activation of metabotropic glutamate receptor 3 enhances interleukin (IL)-1beta-stimulated release of IL-6 in cultured human astrocytes.
Neuroscience.
2005; 130(4):927-33. doi:
10.1016/j.neuroscience.2004.10.024. [PMID: 15652990] - Valerie J Collett, Graham L Collingridge. Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells.
British journal of pharmacology.
2004 Jul; 142(6):991-1001. doi:
10.1038/sj.bjp.0705861. [PMID: 15210575] - Meir Aridor, Amy K Guzik, Anna Bielli, Kenneth N Fish. Endoplasmic reticulum export site formation and function in dendrites.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004 Apr; 24(15):3770-6. doi:
10.1523/jneurosci.4775-03.2004. [PMID: 15084657] - Sang Jeong Kim, Yu Shin Kim, Joseph P Yuan, Ronald S Petralia, Paul F Worley, David J Linden. Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1.
Nature.
2003 Nov; 426(6964):285-91. doi:
10.1038/nature02162. [PMID: 14614461] - Hui Zhang, David Sulzer. Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2003 Nov; 23(33):10585-92. doi:
10.1523/jneurosci.23-33-10585.2003. [PMID: 14627643] - Eleonora Aronica, Jan A Gorter, Helen Ijlst-Keizers, Annemieke J Rozemuller, Bulent Yankaya, Sieger Leenstra, Dirk Troost. Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins.
The European journal of neuroscience.
2003 May; 17(10):2106-18. doi:
10.1046/j.1460-9568.2003.02657.x. [PMID: 12786977] - Itsunari Minami, Mineko Kengaku, Peter Sillevis Smitt, Ryuichi Shigemoto, Tomoo Hirano. Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons.
The European journal of neuroscience.
2003 Mar; 17(5):1023-32. doi:
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Pharmacology, biochemistry, and behavior.
2002 Sep; 73(2):475-84. doi:
10.1016/s0091-3057(02)00836-5. [PMID: 12117603] - Elena Meli, Roberta Picca, Sabina Attucci, Andrea Cozzi, Fiamma Peruginelli, Flavio Moroni, Domenico E Pellegrini-Giampietro. Activation of mGlu1 but not mGlu5 metabotropic glutamate receptors contributes to postischemic neuronal injury in vitro and in vivo.
Pharmacology, biochemistry, and behavior.
2002 Sep; 73(2):439-46. doi:
10.1016/s0091-3057(02)00834-1. [PMID: 12117599] - Valerie Heidinger, Pat Manzerra, Xue Qing Wang, Uta Strasser, Shan-Ping Yu, Dennis W Choi, M Margarita Behrens. Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons.
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2001 Oct; 94(1-2):75-84. doi:
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2001 Oct; 276(42):38370-7. doi:
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Journal of neuroendocrinology.
2001 Aug; 13(8):670-7. doi:
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2001 Jul; 133(6):815-24. doi:
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