4-Chlorophenylbiguanide (BioDeep_00000275227)
代谢物信息卡片
化学式: C8H10ClN5 (211.0625)
中文名称: 1-(4-氯苯基)双胍
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1N=C(N)N=C(N)N)Cl
InChI: InChI=1S/C8H10ClN5/c9-5-1-3-6(4-2-5)13-8(12)14-7(10)11/h1-4H,(H6,10,11,12,13,14)
描述信息
D007004 - Hypoglycemic Agents > D001645 - Biguanides
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Chiara Tommasi, Rita Bellagamba, Massimo Tempestilli, Antonio D'Avolio, Anna L Gallo, Jelena Ivanovic, Emanuele Nicastri, Leopoldo P Pucillo, Pasquale Narciso. Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis.
Malaria journal.
2011 May; 10(?):141. doi:
10.1186/1475-2875-10-141
. [PMID: 21600016] - Hetty Jolink, Jan den Hartigh, Leo G Visser, Cees van Nieuwkoop. Pancytopenia due to proguanil toxicity in a returning traveller with fever.
European journal of clinical pharmacology.
2010 Aug; 66(8):811-2. doi:
10.1007/s00228-010-0824-3
. [PMID: 20407763] - Nathalie L Leveque, William N Charman, Francis C K Chiu. Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Jan; 830(2):314-21. doi:
10.1016/j.jchromb.2005.11.004
. [PMID: 16310420] - Janelle M Hoskins, Gillian M Shenfield, Annette S Gross. Concordance between proguanil phenotype and CYP2C19 genotype in Chinese.
European journal of clinical pharmacology.
2003 Nov; 59(8-9):611-4. doi:
10.1007/s00228-003-0665-4
. [PMID: 13680037] - Tashinga E Bapiro, Tommy B Andersson, Charlotta Otter, Julia A Hasler, Collen M Masimirembwa. Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells.
European journal of clinical pharmacology.
2002 Nov; 58(8):537-42. doi:
10.1007/s00228-002-0512-z
. [PMID: 12451431] - Jean François Chaulet, Patrice Nony, Fabien Bévalot, Pascal Girard, Sylvie Chabaud, Cyril Mounier, Pascal Clair, Jean Pierre Boissel, Gilles Grelaud. Bioequivalence evaluation of a fixed combination of chloroquine and proguanil in a capsule formulation versus a standard medication.
Arzneimittel-Forschung.
2002; 52(5):407-12. doi:
10.1055/s-0031-1299906
. [PMID: 12087928] - R B Taylor, R G Reid, A S Low. Analysis of proguanil and its metabolites by application of the sweeping technique in micellar electrokinetic chromatography.
Journal of chromatography. A.
2001 May; 916(1-2):201-6. doi:
10.1016/s0021-9673(00)01035-9
. [PMID: 11382292] - Y Bergqvist, L Funding, B Krysèn, T Leek, K Yvell. Improved validated assay for the determination of proguanil and its metabolites in plasma, whole blood, and urine using solid-phase extraction and high-performance liquid chromatography.
Therapeutic drug monitoring.
1998 Jun; 20(3):325-30. doi:
10.1097/00007691-199806000-00014
. [PMID: 9631931] - U Jeppesen, B B Rasmussen, K Brøsen. Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide.
Clinical pharmacology and therapeutics.
1997 Sep; 62(3):279-86. doi:
10.1016/s0009-9236(97)90030-8
. [PMID: 9333103] - M Kusaka, R Setiabudy, K Chiba, T Ishizaki. Simultaneous measurement of proguanil and its metabolites in human plasma and urine by reversed-phase high-performance liquid chromatography, and its preliminary application in relation to genetically determined S-mephenytoin 4'-hydroxylation status.
The American journal of tropical medicine and hygiene.
1996 Feb; 54(2):189-96. doi:
10.4269/ajtmh.1996.54.189
. [PMID: 8619446] - J A Kolawole, R B Taylor, R R Moody. Determination of proguanil and metabolites in small sample volumes of whole blood stored on filter paper by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications.
1995 Dec; 674(1):149-54. doi:
10.1016/0378-4347(95)00293-3
. [PMID: 8749264] - R Setiabudy, M Kusaka, K Chiba, I Darmansjah, T Ishizaki. Metabolic disposition of proguanil in extensive and poor metabolisers of S-mephenytoin 4'-hydroxylation recruited from an Indonesian population.
British journal of clinical pharmacology.
1995 Mar; 39(3):297-303. doi:
10.1111/j.1365-2125.1995.tb04452.x
. [PMID: 7619672] - K Brøsen, E Skjelbo, H Flachs. Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark.
British journal of clinical pharmacology.
1993 Aug; 36(2):105-8. doi:
10.1111/j.1365-2125.1993.tb04204.x
. [PMID: 8398577] - N A Helsby, G Edwards, A M Breckenridge, S A Ward. The multiple dose pharmacokinetics of proguanil.
British journal of clinical pharmacology.
1993 Jun; 35(6):653-6. doi:
10.1111/j.1365-2125.1993.tb04197.x
. [PMID: 8329294] - J Wangboonskul, N J White, F Nosten, F ter Kuile, R R Moody, R B Taylor. Single dose pharmacokinetics of proguanil and its metabolites in pregnancy.
European journal of clinical pharmacology.
1993; 44(3):247-51. doi:
10.1007/bf00271366
. [PMID: 8491239] - I Bygbjerg, P Ravn, A Rønn, H Flachs, E F Hvidberg. Human pharmacokinetics of proguanil and its metabolites.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ).
1987 Jun; 38(2):77-80. doi:
NULL
. [PMID: 3629140] - R B Taylor, R R Moody, N A Ochekpe. Determination of proguanil and its metabolites cycloguanil and 4-chlorophenylbiguanide in plasma, whole blood and urine by high-performance liquid chromatography.
Journal of chromatography.
1987 May; 416(2):394-9. doi:
10.1016/0378-4347(87)80526-1
. [PMID: 3611272] - R R Moody, A B Selkirk, R B Taylor. High-performance liquid chromatography of proguanil, cycloguanil and 4-chlorophenylbiguanide using hydrophobic pairing ion and its application to serum assay.
Journal of chromatography.
1980 Jun; 182(3-4):359-67. doi:
10.1016/s0378-4347(00)81485-1
. [PMID: 7391178]