cystamine (BioDeep_00000274707)
代谢物信息卡片
cystamine
化学式: C4H12N2S2 (152.0442)
中文名称: 胱胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CSSCCN)N
InChI: InChI=1S/C4H12N2S2/c5-1-3-7-8-4-2-6/h1-6H2
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D013439 - Sulfhydryl Reagents
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
D004791 - Enzyme Inhibitors
Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [1][2][3].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:78757
- PubChem: 2915
- Metlin: METLIN55
- ChEMBL: CHEMBL61350
- MeSH: Cystamine
- CAS: 51-85-4
- PMhub: MS000006696
- RefMet: Cystamine
- medchemexpress: HY-124476
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Hongge Wang, Ming-Jie Hou, Lixi Liao, Peng Li, Tongxiang Chen, Pan Wang, Bao Ting Zhu. Strong Protection by 4-Hydroxyestrone against Erastin-Induced Ferroptotic Cell Death in Estrogen Receptor-Negative Human Breast Cancer Cells: Evidence for Protein Disulfide Isomerase as a Mechanistic Target for Protection.
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Life sciences.
2023 Mar; 321(?):121564. doi:
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Pesticide biochemistry and physiology.
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Molecular and cellular biology.
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PMC biophysics.
2008 Dec; 1(1):6. doi:
10.1186/1757-5036-1-6. [PMID: 19351428] - Lanae M Joubert, Melinda M Manore. The role of physical activity level and B-vitamin status on blood homocysteine levels.
Medicine and science in sports and exercise.
2008 Nov; 40(11):1923-31. doi:
10.1249/mss.0b013e31817f36f9. [PMID: 18845970] - Paweł Kubalczyk, Edward Bald. Method for determination of total cysteamine in human plasma by high performance capillary electrophoresis with acetonitrile stacking.
Electrophoresis.
2008 Sep; 29(17):3636-40. doi:
10.1002/elps.200800034. [PMID: 18803177] - A Bromberg, J Levine, B Nemetz, R H Belmaker, G Agam. No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients.
Schizophrenia research.
2008 Apr; 101(1-3):50-7. doi:
10.1016/j.schres.2008.01.009. [PMID: 18276118] - George Suji, S Sivakami. Malondialdehyde, a lipid-derived aldehyde alters the reactivity of Cys34 and the esterase activity of serum albumin.
Toxicology in vitro : an international journal published in association with BIBRA.
2008 Apr; 22(3):618-24. doi:
10.1016/j.tiv.2007.12.003. [PMID: 18206343] - Yukiko Nakano, William N Addison, Mari T Kaartinen. ATP-mediated mineralization of MC3T3-E1 osteoblast cultures.
Bone.
2007 Oct; 41(4):549-61. doi:
10.1016/j.bone.2007.06.011. [PMID: 17669706] - Di Ding, Daphna Sagher, Edith Laugier, Pascal Rey, Herbert Weissbach, Xing-Hai Zhang. Studies on the reducing systems for plant and animal thioredoxin-independent methionine sulfoxide reductases B.
Biochemical and biophysical research communications.
2007 Sep; 361(3):629-33. doi:
10.1016/j.bbrc.2007.07.072. [PMID: 17673175] - Paul L Wood, M Amin Khan, Joseph R Moskal. Cellular thiol pools are responsible for sequestration of cytotoxic reactive aldehydes: central role of free cysteine and cysteamine.
Brain research.
2007 Jul; 1158(?):158-63. doi:
10.1016/j.brainres.2007.05.007. [PMID: 17555724] - Jeffrey S Moffit, Petra H Koza-Taylor, Ricky D Holland, Michael S Thibodeau, Richard D Beger, Michael P Lawton, José E Manautou. Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate.
Toxicology and applied pharmacology.
2007 Jul; 222(2):169-79. doi:
10.1016/j.taap.2007.04.008. [PMID: 17585979] - Miroslav Pohanka, Oto Pavlis, Petr Skládal. Diagnosis of tularemia using piezoelectric biosensor technology.
Talanta.
2007 Feb; 71(2):981-5. doi:
10.1016/j.talanta.2006.05.074. [PMID: 19071403] - Alexandre Rodrigues Guerzoni, Erika Cristina Pavarino-Bertelli, Moacir Fernandes de Godoy, Carla Renata Graça, Patrícia Matos Biselli, Dorotéia Rossi Silva Souza, Eny Maria Goloni Bertollo. Methylenetetrahydrofolate reductase gene polymorphism and its association with coronary artery disease.
Sao Paulo medical journal = Revista paulista de medicina.
2007 Jan; 125(1):4-8. doi:
10.1590/s1516-31802007000100002. [PMID: 17505678] - Neeraj Kohli, Brian L Hassler, Lavanya Parthasarathy, Rudy J Richardson, Robert Y Ofoli, Robert M Worden, Ilsoon Lee. Tethered lipid bilayers on electrolessly deposited gold for bioelectronic applications.
Biomacromolecules.
2006 Dec; 7(12):3327-35. doi:
10.1021/bm0603995. [PMID: 17154460] - Rima Dardik, Aida Inbal. Complex formation between tissue transglutaminase II (tTG) and vascular endothelial growth factor receptor 2 (VEGFR-2): proposed mechanism for modulation of endothelial cell response to VEGF.
Experimental cell research.
2006 Oct; 312(16):2973-82. doi:
10.1016/j.yexcr.2006.05.019. [PMID: 16914140] - Wei Gao, Yu-Sheng Wang, Peng Zhang, Hai-Yan Wang. Hyperhomocysteinemia and low plasma folate as risk factors for central retinal vein occlusion: a case-control study in a Chinese population.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.
2006 Oct; 244(10):1246-9. doi:
10.1007/s00417-005-0191-4. [PMID: 16538453] - Tianyi Ke, Yi Feng, Junyu Guo, Dennis L Parker, Zheng-Rong Lu. Biodegradable cystamine spacer facilitates the clearance of Gd(III) chelates in poly(glutamic acid) Gd-DO3A conjugates for contrast-enhanced MR imaging.
Magnetic resonance imaging.
2006 Sep; 24(7):931-40. doi:
10.1016/j.mri.2006.03.009. [PMID: 16916710] - Lane V Christensen, Chien-Wen Chang, Won Jong Kim, Sung Wan Kim, Zhiyuan Zhong, Chao Lin, Johan F J Engbersen, Jan Feijen. Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery.
Bioconjugate chemistry.
2006 Sep; 17(5):1233-40. doi:
10.1021/bc0602026. [PMID: 16984133] - Marie-Eve Tremblay, Martine Saint-Pierre, Emmanuelle Bourhis, Daniel Lévesque, Claude Rouillard, Francesca Cicchetti. Neuroprotective effects of cystamine in aged parkinsonian mice.
Neurobiology of aging.
2006 Jun; 27(6):862-70. doi:
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The Journal of clinical investigation.
2006 May; 116(5):1410-24. doi:
10.1172/jci27607. [PMID: 16604191] - John T Pinto, Jeremy M Van Raamsdonk, Blair R Leavitt, Michael R Hayden, Thomas M Jeitner, Howard T Thaler, Boris F Krasnikov, Arthur J L Cooper. Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease.
Journal of neurochemistry.
2005 Aug; 94(4):1087-101. doi:
10.1111/j.1471-4159.2005.03255.x. [PMID: 15992377] - Krzysztof Kuśmierek, Rafał Głowacki, Edward Bald. Determination of total cysteamine in human plasma in the form of its 2-S-quinolinium derivative by high performance liquid chromatography.
Analytical and bioanalytical chemistry.
2005 May; 382(1):231-3. doi:
10.1007/s00216-005-3166-8. [PMID: 15900477] - Xinghe Wang, Yi Feng, Tianyi Ke, Matthias Schabel, Zheng-Rong Lu. Pharmacokinetics and tissue retention of (Gd-DTPA)-cystamine copolymers, a biodegradable macromolecular magnetic resonance imaging contrast agent.
Pharmaceutical research.
2005 Apr; 22(4):596-602. doi:
10.1007/s11095-005-2489-7. [PMID: 15846467] - Juan-C Vidal, Javier Espuelas, Juan-R Castillo. Amperometric cholesterol biosensor based on in situ reconstituted cholesterol oxidase on an immobilized monolayer of flavin adenine dinucleotide cofactor.
Analytical biochemistry.
2004 Oct; 333(1):88-98. doi:
10.1016/j.ab.2004.06.005. [PMID: 15351284] - Hadj Khatir, Abdelhaq Anouassi, Ahmed Tibary. Production of dromedary (Camelus dromedarius) embryos by IVM and IVF and co-culture with oviductal or granulosa cells.
Theriogenology.
2004 Oct; 62(7):1175-85. doi:
10.1016/j.theriogenology.2004.01.016. [PMID: 15325545] - Joseph M Jez, Rebecca E Cahoon, Sixue Chen. Arabidopsis thaliana glutamate-cysteine ligase: functional properties, kinetic mechanism, and regulation of activity.
The Journal of biological chemistry.
2004 Aug; 279(32):33463-70. doi:
10.1074/jbc.m405127200. [PMID: 15180996] - Maria Th Ochsenkühn-Petropoulou, Fotios N Tsopelas. Separation of organoselenium compounds and their electrochemical detection.
Analytical and bioanalytical chemistry.
2004 Jul; 379(5-6):770-6. doi:
10.1007/s00216-004-2511-7. [PMID: 14963635] - Petr Skládal, Carla dos Santos Riccardi, Hideko Yamanaka, Paulo Inácio da Costa. Piezoelectric biosensors for real-time monitoring of hybridization and detection of hepatitis C virus.
Journal of virological methods.
2004 May; 117(2):145-51. doi:
10.1016/j.jviromet.2004.01.005. [PMID: 15041211] - Amir Sharabi, Eytan Cohen, Jaqueline Sulkes, Moshe Garty. Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route.
British journal of clinical pharmacology.
2003 Dec; 56(6):635-8. doi:
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Bioconjugate chemistry.
2003 Jul; 14(4):715-9. doi:
10.1021/bc0340464. [PMID: 12862423] - Isabella Fermo, Cinzia Arcelloni, Rita Paroni. High-performance liquid chromatographic method to quantify total cysteine excretion in urine.
Analytical biochemistry.
2002 Aug; 307(1):181-3. doi:
10.1016/s0003-2697(02)00029-5. [PMID: 12137797] - Christian K Riener, Gerald Kada, Hermann J Gruber. Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'-dithiodipyridine.
Analytical and bioanalytical chemistry.
2002 Jul; 373(4-5):266-76. doi:
10.1007/s00216-002-1347-2. [PMID: 12110978] - Shu-Fen Chou, Win-Lin Hsu, Jing-Min Hwang, Chien-Yuan Chen. Determination of alpha-fetoprotein in human serum by a quartz crystal microbalance-based immunosensor.
Clinical chemistry.
2002 Jun; 48(6 Pt 1):913-8. doi:
10.1093/clinchem/48.6.913. [PMID: 12029008] - Cunchang Wang, Hua Wang, Zhaoyang Wu, Guoli Shen, Ruqin Yu. A piezoelectric immunoassay based on self-assembled monolayers of cystamine and polystyrene sulfonate for determination of Schistosoma japonicum antibodies.
Analytical and bioanalytical chemistry.
2002 Apr; 373(8):803-9. doi:
10.1007/s00216-002-1389-5. [PMID: 12194042] - Jennifer A Fraser, Robert D C Saunders, Lesley I McLellan. Drosophila melanogaster glutamate-cysteine ligase activity is regulated by a modifier subunit with a mechanism of action similar to that of the mammalian form.
The Journal of biological chemistry.
2002 Jan; 277(2):1158-65. doi:
10.1074/jbc.m106683200. [PMID: 11698394] - Chi-Ming Yam, Claire-Marie Pradier, Michèle Salmain, Nathalie Fischer-Durand, Gérard Jaouen. Molecular recognition of avidin on biotin-functionalized gold surfaces detected by FT-IRRAS and use of metal carbonyl probes.
Journal of colloid and interface science.
2002 Jan; 245(1):204-7. doi:
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Analytical biochemistry.
2001 Dec; 299(2):130-5. doi:
10.1006/abio.2001.5409. [PMID: 11730334] - R J Mallis, J E Buss, J A Thomas. Oxidative modification of H-ras: S-thiolation and S-nitrosylation of reactive cysteines.
The Biochemical journal.
2001 Apr; 355(Pt 1):145-53. doi:
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International journal of pharmaceutics.
2000 Dec; 211(1-2):67-78. doi:
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