Bis(7-methyloctyl) Cyclohexane-1,2-dicarboxylate (BioDeep_00000274660)
代谢物信息卡片
Bis(7-methyloctyl) Cyclohexane-1,2-dicarboxylate
化学式: C26H48O4 (424.3552408)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCCCCOC(=O)C1CCCCC1C(=O)OCCCCCCC(C)C
InChI: InChI=1S/C26H48O4/c1-21(2)15-9-5-7-13-19-29-25(27)23-17-11-12-18-24(23)26(28)30-20-14-8-6-10-16-22(3)4/h21-24H,5-20H2,1-4H3
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bélinda Crobeddu, Antoine Jutras-Carignan, Élise Kolasa, Catherine Mounier, Bernard Robaire, Isabelle Plante. Gestational and Lactational Exposure to the Emergent Alternative Plasticizer 1,2-Cyclohexane Dicarboxylic Acid Diisononyl Ester (DINCH) Impairs Lipid Metabolism to a Greater Extent Than the Commonly Used Di(2-Ethylhexyl) Phthalate (DEHP) in the Adult Rat Mammary Gland.
Toxicological sciences : an official journal of the Society of Toxicology.
2022 09; 189(2):268-286. doi:
10.1093/toxsci/kfac076. [PMID: 35861430] - V Plichta, W Völkel, L Fembacher, M Wöckner, D Nowak, H Fromme. The oral bioavailability of di-2-ethylhexyl phthalate (DEHP), di-isononyl phthalate (DiNP) and di-(isononyl)-cyclohexane-1,2-dicarboxylate (DINCH®) in house dust.
Toxicology letters.
2022 Feb; 355(?):82-87. doi:
10.1016/j.toxlet.2021.11.010. [PMID: 34801639] - Gerda Schwedler, André Conrad, Enrico Rucic, Holger M Koch, Gabriele Leng, Christine Schulz, Maria I H Schmied-Tobies, Marike Kolossa-Gehring. Hexamoll® DINCH and DPHP metabolites in urine of children and adolescents in Germany. Human biomonitoring results of the German Environmental Survey GerES V, 2014-2017.
International journal of hygiene and environmental health.
2020 08; 229(?):113397. doi:
10.1016/j.ijheh.2019.09.004. [PMID: 31585790] - Amandine Descat, Marie Lecoeur, Mostafa Kouach, Laurence Goossens, Aurélie Thelliez, Pascal Odou, Bertrand Decaudin, Jean-François Goossens. Simultaneous determination of di(2-ethylhexyl) phthalate and diisononylcyclohexane-1,2-dicarboxylate and their monoester metabolites in four labile blood products by liquid chromatography tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2020 Mar; 181(?):113063. doi:
10.1016/j.jpba.2019.113063. [PMID: 31927338] - V Plichta, W Völkel, L Fembacher, M Spolders, M Wöckner, B Aschenbrenner, H Schafft, H Fromme. Bioavailability of phthalate and DINCH® plasticizers, after oral administration of dust to piglets.
Toxicology letters.
2019 Oct; 314(?):82-88. doi:
10.1016/j.toxlet.2019.07.018. [PMID: 31306742] - Monika Kasper-Sonnenberg, Holger M Koch, Petra Apel, Maria Rüther, Claudia Pälmke, Thomas Brüning, Marike Kolossa-Gehring. Time trend of exposure to the phthalate plasticizer substitute DINCH in Germany from 1999 to 2017: Biomonitoring data on young adults from the Environmental Specimen Bank (ESB).
International journal of hygiene and environmental health.
2019 09; 222(8):1084-1092. doi:
10.1016/j.ijheh.2019.07.011. [PMID: 31378638] - Katerina Urbancova, Darina Lankova, Radim J Sram, Jana Hajslova, Jana Pulkrabova. Urinary metabolites of phthalates and di-iso-nonyl cyclohexane-1,2-dicarboxylate (DINCH)-Czech mothers' and newborns' exposure biomarkers.
Environmental research.
2019 06; 173(?):342-348. doi:
10.1016/j.envres.2019.03.067. [PMID: 30953948] - Rosie M Martinez, Russ Hauser, Liming Liang, Abdallah Mansur, Michal Adir, Laura Dioni, Catherine Racowsky, Valentina Bollati, Andrea A Baccarelli, Ronit Machtinger. Urinary concentrations of phenols and phthalate metabolites reflect extracellular vesicle microRNA expression in follicular fluid.
Environment international.
2019 02; 123(?):20-28. doi:
10.1016/j.envint.2018.11.043. [PMID: 30481674] - Ana Luísa Vasconcelos, Maria João Silva, Henriqueta Louro. In vitro exposure to the next-generation plasticizer diisononyl cyclohexane-1,2-dicarboxylate (DINCH): cytotoxicity and genotoxicity assessment in human cells.
Journal of toxicology and environmental health. Part A.
2019; 82(9):526-536. doi:
10.1080/15287394.2019.1634376. [PMID: 31242819] - Angelika Langsch, Raymond M David, Steffen Schneider, Saskia Sperber, Volker Haake, Hennicke Kamp, Edgar Leibold, Bennard van Ravenzwaay, Rainer Otter. Hexamoll® DINCH: Lack of in vivo evidence for obesogenic properties.
Toxicology letters.
2018 May; 288(?):99-110. doi:
10.1016/j.toxlet.2018.02.008. [PMID: 29474903] - Anika Engel, Thorsten Buhrke, Stefanie Kasper, Anne-Cathrin Behr, Albert Braeuning, Sönke Jessel, Albrecht Seidel, Wolfgang Völkel, Alfonso Lampen. The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ.
Toxicology letters.
2018 May; 287(?):83-91. doi:
10.1016/j.toxlet.2018.02.006. [PMID: 29421333] - Chia-Lung Shih, Pao-Mei Liao, Jen-Yi Hsu, Yi-Ning Chung, Victor G Zgoda, Pao-Chi Liao. Exposure marker discovery of di(isononyl)cyclohexane-1,2-dicarboxylate using two mass spectrometry-based metabolite profiling data processing methods.
Environmental science and pollution research international.
2018 Apr; 25(12):11999-12011. doi:
10.1007/s11356-018-1484-6. [PMID: 29450778] - Stefanie Baldofski, Carsten Jörg Canitz, Leif-Alexander Garbe, Rudolf J Schneider. Studies on the development of antibodies for the highly hydrophobic plasticizers DINCH and DEHT.
Analytical biochemistry.
2018 02; 543(?):90-96. doi:
10.1016/j.ab.2017.12.006. [PMID: 29233681] - Enrico Campioli, Sunghoon Lee, Matthew Lau, Lucas Marques, Vassilios Papadopoulos. Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism.
Scientific reports.
2017 09; 7(1):11072. doi:
10.1038/s41598-017-11325-7. [PMID: 28894178] - Luísa Correia-Sá, André Schütze, Sónia Norberto, Conceição Calhau, Valentina F Domingues, Holger M Koch. Exposure of Portuguese children to the novel non-phthalate plasticizer di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH).
Environment international.
2017 May; 102(?):79-86. doi:
10.1016/j.envint.2017.02.001. [PMID: 28188053] - André Schütze, Rainer Otter, Hendrik Modick, Angelika Langsch, Thomas Brüning, Holger M Koch. Additional oxidized and alkyl chain breakdown metabolites of the plasticizer DINCH in urine after oral dosage to human volunteers.
Archives of toxicology.
2017 Jan; 91(1):179-188. doi:
10.1007/s00204-016-1688-9. [PMID: 26976210] - Georgios Giovanoulis, Andreia Alves, Eleni Papadopoulou, Anna Palm Cousins, André Schütze, Holger M Koch, Line S Haug, Adrian Covaci, Jörgen Magnér, Stefan Voorspoels. Evaluation of exposure to phthalate esters and DINCH in urine and nails from a Norwegian study population.
Environmental research.
2016 Nov; 151(?):80-90. doi:
10.1016/j.envres.2016.07.025. [PMID: 27466754] - Lidia Mínguez-Alarcón, Irene Souter, Yu-Han Chiu, Paige L Williams, Jennifer B Ford, Xiaoyun Ye, Antonia M Calafat, Russ Hauser. Urinary concentrations of cyclohexane-1,2-dicarboxylic acid monohydroxy isononyl ester, a metabolite of the non-phthalate plasticizer di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), and markers of ovarian response among women attending a fertility center.
Environmental research.
2016 Nov; 151(?):595-600. doi:
10.1016/j.envres.2016.08.012. [PMID: 27591839] - Wolfgang Völkel, Mandy Kiranoglu, Gerhard Dettbarn, Andrea John, Sönke Jessel, Albrecht Seidel, Hermann Fromme. Urinary toxicokinetics of di-(isononyl)-cyclohexane-1,2-dicarboxylate (DINCH(®)) in humans following single oral administration.
Toxicology letters.
2016 Apr; 248(?):16-24. doi:
10.1016/j.toxlet.2016.02.010. [PMID: 26915627] - M J Gomez Ramos, A L Heffernan, L M L Toms, A M Calafat, X Ye, P Hobson, S Broomhall, J F Mueller. Concentrations of phthalates and DINCH metabolites in pooled urine from Queensland, Australia.
Environment international.
2016 Mar; 88(?):179-186. doi:
10.1016/j.envint.2015.12.016. [PMID: 26760715] - H Fromme, A Schütze, T Lahrz, M Kraft, L Fembacher, S Siewering, R Burkardt, S Dietrich, H M Koch, W Völkel. Non-phthalate plasticizers in German daycare centers and human biomonitoring of DINCH metabolites in children attending the centers (LUPE 3).
International journal of hygiene and environmental health.
2016 Jan; 219(1):33-9. doi:
10.1016/j.ijheh.2015.08.002. [PMID: 26338253] - Raymond M David, Randy D White, Michael J Larson, Jay K Herman, Rainer Otter. Toxicity of Hexamoll(®) DINCH(®) following intravenous administration.
Toxicology letters.
2015 Oct; 238(2):100-9. doi:
10.1016/j.toxlet.2015.07.013. [PMID: 26211741] - Andre Schütze, Matthew Lorber, Katarzyna Gawrych, Marike Kolossa-Gehring, Petra Apel, Thomas Brüning, Holger M Koch. Development of a multi-compartment pharmacokinetic model to characterize the exposure to Hexamoll® DINCH®.
Chemosphere.
2015 Jun; 128(?):216-24. doi:
10.1016/j.chemosphere.2015.01.056. [PMID: 25710321] - Johan W Lagerberg, Eric Gouwerok, Richard Vlaar, Mya Go, Dirk de Korte. In vitro evaluation of the quality of blood products collected and stored in systems completely free of di(2-ethylhexyl)phthalate-plasticized materials.
Transfusion.
2015 Mar; 55(3):522-31. doi:
10.1111/trf.12870. [PMID: 25331824] - NULL. [Monograph for 1,2-cyclohexane-di-isononyl (Hexamoll® DINCH®) - HBM values for the sum of metabolites of cyclohexane-1,2-dicarboxylic acid mono-hydroxyisononylester (OH MINCH) and cyclohexane-1,2-dicarboxylic acid mono-carboxy acid isooctyl ester (cx-MINCH) in the urine of adults and children: Commission Opinion 'Human Biomonitoring' UBA].
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz.
2014 Dec; 57(12):1451-61. doi:
10.1007/s00103-014-2069-2. [PMID: 25428837] - André Schütze, Marike Kolossa-Gehring, Petra Apel, Thomas Brüning, Holger M Koch. Entering markets and bodies: increasing levels of the novel plasticizer Hexamoll® DINCH® in 24 h urine samples from the German Environmental Specimen Bank.
International journal of hygiene and environmental health.
2014 Mar; 217(2-3):421-6. doi:
10.1016/j.ijheh.2013.08.004. [PMID: 24029725] - Virunya S Bhat, Jennifer L Durham, Gwendolyn L Ball, J Caroline English. Derivation of an oral reference dose (RfD) for the nonphthalate alternative plasticizer 1,2-cyclohexane dicarboxylic acid, di-isononyl ester (DINCH).
Journal of toxicology and environmental health. Part B, Critical reviews.
2014; 17(2):63-94. doi:
10.1080/10937404.2013.876288. [PMID: 24627975] - Manori J Silva, Tao Jia, Ella Samandar, James L Preau, Antonia M Calafat. Environmental exposure to the plasticizer 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH) in U.S. adults (2000-2012).
Environmental research.
2013 Oct; 126(?):159-63. doi:
10.1016/j.envres.2013.05.007. [PMID: 23777640] - Holger M Koch, André Schütze, Claudia Pälmke, Jürgen Angerer, Thomas Brüning. Metabolism of the plasticizer and phthalate substitute diisononyl-cyclohexane-1,2-dicarboxylate (DINCH(®)) in humans after single oral doses.
Archives of toxicology.
2013 May; 87(5):799-806. doi:
10.1007/s00204-012-0990-4. [PMID: 23203454] - Larry J Dumont, Sharry Baker, Deborah F Dumont, Louise Herschel, Susan Waters, Kristin Calcagni, Craig Sandford, Katherine Radwanski, Kyungyoon Min, Raymond M David, Rainer Otter. Exploratory in vitro study of red blood cell storage containers formulated with an alternative plasticizer.
Transfusion.
2012 Jul; 52(7):1439-45. doi:
10.1111/j.1537-2995.2011.03506.x. [PMID: 22211692] - André Schütze, Claudia Pälmke, Jürgen Angerer, Tobias Weiss, Thomas Brüning, Holger M Koch. Quantification of biomarkers of environmental exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) in urine via HPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 May; 895-896(?):123-30. doi:
10.1016/j.jchromb.2012.03.030. [PMID: 22503746] - Manori J Silva, Johnathan Furr, James L Preau, Ella Samandar, L Earl Gray, Antonia M Calafat. Identification of potential biomarkers of exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), an alternative for phthalate plasticizers.
Journal of exposure science & environmental epidemiology.
2012 Mar; 22(2):204-11. doi:
10.1038/jes.2011.43. [PMID: 22252281]